Background

Experience-dependent synaptic plasticity underpins the enormous capacity of the brain for adaptation and information processing, as in learning and memory. Excitatory glutamatergic synapses are capable of many different types of plasticity, including strengthening in long-term potentiation (LTP), weakening in long-term depression (LTD), and homeostatic synaptic scaling. The protein Arc is implicated as a master regulator of plasticity and long-term memory. However, we do not know how the Arc protein works. A better understanding of Arc molecular function may help to explain how different types of plasticity are controlled and implemented in memory formation and other functions.

Research question

How do Arc protein domains contribute to specific regulation of synaptic plasticity?

How are Arc functions implemented in specific neuronal cell types?

Objective and methods

Genetic and pharmacological tools will be developed and used to assess Arc domain-specific functions and mechanisms in vitro and in vivo.