Course content

• Glycobiology (glycoconjugates and the sugar code)
• Biosynthesis and degradation of amino acids and nucleotides
• Biosynthesis and degradation of glycogen
• Biosynthesis of: ketone bodies, triglycerides, phospholipids and isopentenyl derived lipids.
• Some enzyme mechanisms
• Regulation of enzyme activities on different levels: regulation of transcription and protein synthesis, allosteric and covalent modifications, degradation.
• Signal transduction and hormonal control of the carbon metabolism.
• The interplay between the metabolism in the whole body and in single organs.

Learning outcome

After finishing this course the students are expected to:

• Have an overview of the metabolisms of the most important groups of biomolecules (reactions and coenzymes).
• Have a basic understanding of the mechanisms that regulate these processes on different levels.
• Have knowledge about some basic biochemical methods/techniques.
• Have developed the ability to use this knowledge and understanding to solve relevant problems.

Learning methods and activities

Guided pre-lecture preparations. Lectures with discussions. Mandatory exercises with approved reports. Self-study. The expected number of hours spent on organized activities (lectures and exercises) + self-study is 210 hours.

Compulsory assignments

• Exercises

Recommended previous knowledge

TBT4102 Biochemistry 1 and approved laboratory course in TBT4102 Biochemistry 1 or equivalent knowledge and laboratory practice.

Course materials

D. L. Nelson, & M.M. Cox: Lehninger. Principles of Biochemistry, 8th edition. W.H. Freeman, 2021, with the e-learning tool Achieve.

Credit reductions