Measuring metabolism in the human brain: Translational challenges and opportunities

Seminar

Measuring metabolism in the human brain: Translational challenges and opportunities

8th and 9th of April 2024 | St. Olavs Hospital - Trondheim University Hospital 


Logo organisers

Kavli webpage

Norwegian 7tmr center NTNU webpage

NTNU webpage

St. Olavs Hospital webpage

Introduction


For the first time, the K. G. Jebsens Centre for Alzheimer’s Disease (JCA), the Norwegian Center for Headache Research (NorHead) and the Norwegian 7T MR Center will host a two-day seminar in translational neurometabolism.

We are grateful to be joined by excellent speakers who are international experts in their fields. They will cover a range of topics, including:

  • State-of-the art magnetic resonance spectroscopy of the human brain: 1H MRS, 31P MRS, 2H MRS, MRSI, DW-MRS, fMRS
  • Using PET to study metabolism in the human brain
  • 13C MRS and genetic tools to study brain metabolism in animals and neural cell culture
  • Multi-cellular brain energy metabolism – the astrocyte-neuron lactate shuttle
  • Neurometabolism in neurodegenerative diseases
  • Neurometabolism in headache disorders
  • Clinical applications of magnetic resonance spectroscopy

The seminar is open to everyone with a research or clinical interest in brain metabolism. 

Register for the seminar 

Programme

Programme 

 

The seminar sessions will take place in 1902-bygget, room 02S21 

 

Day one: April 8th

09:00-09:45
Introduction to the seminar. Principles of translational neurometabolism.
Axel Karl Gottfrid Nyman, Erling Tronvik, Johanna Vannesjö and Asgeir Kobro-Flatmoen

09:45-10:45
Introduction to magnetic resonance spectroscopy.
Presenter: Guglielmo Genovese

10:45-11:00
First abstract presentation

11:00-11:15
Break

11:15-13:00
The astrocyte-neuron lactate shuttle. Evidence from cell, animal and human studies.
Presenters: Luc Pellerin and Anne-Karine Bouzier-Sore

13:00-14:30
Lunch, Fred Kavli building

14:30-15:30
31P and 2H MRS to measure human brain metabolism
Presenter: Jeanine Prompers

15:30-15:45
Second abstract presentation

15:45-16:00
Break

16:00-17:00
Using PET to measure glucose and oxygen consumption in the human brain
Presenter: Manu Goyal

17:00-19:00
Social program/leisure time (TBA) 

19:00
Dinner, To Rom og Kjøkken
 

Day Two: April 9th

09:00-10:00
Diffusion MRS: Cell-specific morphology and metabolism
Presenter: Itamar Ronen

10:00-11:00
Mitochondrial dysfunction in Parkinson’s disease
Presenter: Charalampos ”Haris” Tzoulis

10:45-11:00
Third abstract presentation

11:00-11:15
Break

11:15-12:15
MRS in migraine

Presenter: Samaira Younis

12:15-12:45
Clinical application of MRS
Presenter: Elise Sandsmark

13:00-14:30
Lunch, Fred Kavli building

14:30-14:45
Announcement and presentation of the prize for the best abstract presentation

Axel Nyman

14:45-16:00
Panel discussion

All invited speakers

16:00
Closing remarks

Axel Nyman

Speakers

Luc PellerinProfessor in cell biology
Université de Poitiers, France

Jeanine Prompers

Jeanine PrompersAssociate Professor Magnetic Resonance Metabolic Imaging.
7T MR group, UMC Uthrecht, the Netherlands

Manu GoyalAssociate Professor radiology and principal investigator in the Neuroimaging Labs Research Center for Mallinckrodt Institute of Radiology at Washington University School of Medicine in St. Louis, USA

Itamar RonenChair in Medical Physics and Academic Director of CISC (Clinical Neuroscience), Brighton and Sussex Medical School, UK.

Anne-Karine Bouzier-SorePhD DR CNRS deputy director of the CRMSB at French National Centre for Scientific Research, University of Bordeaux, France

Charalampos “Haris” TzoulisProfessor, Neurology and Neurodegeneration, UiB, Norway

Elise SandsmarkMD, PhD Medical Doctor/Assoc. Professor at St. Olavs Hospital, Norway

Samaira YounisMD, PhD Fellow, Human Migraine Research Unit, The Danish Headache Center, Rigshospitalet, Denmark

Guglielmo Genovese - portrait

Guglielmo Genovese, PhD, Associate Professor, Department of Neuromedicine and Movement Science, NTNU, Norway.