Axel Karl Gottfrid Nyman
About
Medical doctor and postdoctor at NTNU. I research Alzheimer's disease at the K.G. Jebsen center for Alzheimer's disease at NTNU. Resident at the Neurological Department, St Olavs Hospital.
Born: 1989
Present position: Postdoctor
Research interests
- Experimental models of brain diseases
- Image guided therapy of brain diseases
- Treatment of brain diseases with melatonin
- Neurodegeneration
- Advanced MR-techniques in brain disorders
Current research projects
Advanced MR-techniques for discovery of biomarkers of early Alzheimer's disease
Metabolic changes in the brain during transient global amnesia
Previous research projects
Melatonin treatment of hypoxic-ischemic brain injury in neonatal rats
Lipid based nanoparticles for delivery of melatonin to the brain
Intermittent hyperoxia-hypoxia: Effect on cerebral vascularization, brain development and locomotor function in neonatal rats.
MRI of stem cell treatment of hypoxic-ischemic brain injury in neonatal and adult rats.
Education
2009-16: Medical student, NTNU, Trondheim, Norway
2011-15: Medical research student, NTNU, Trondheim, Norway
2016-21: PhD-student, NTNU, Trondheim, Norway
Publications
2020
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Molska, Alicja;
Nyman, Axel Karl Gottfrid;
Sofias, Alexandros Marios;
Kristiansen, Kåre Andre;
Hak, Sjoerd;
Widerøe, Marius.
(2020)
In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations.
European journal of pharmaceutics and biopharmaceutics
Academic article
2019
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Berger, Hester Rijkje;
Nyman, Axel Karl Gottfrid;
Morken, Tora Sund;
Widerøe, Marius.
(2019)
Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats.
PLOS ONE
Academic article
2017
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Berger, Hester Rijkje;
Nyman, Axel Karl Gottfrid;
Morken, Tora Sund;
Vettukattil, Muhammad Riyas;
Brubakk, Ann-Mari;
Widerøe, Marius.
(2017)
Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy.
PLOS ONE
Academic article
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Augestad, Ingrid Lovise;
Nyman, Axel Karl Gottfrid;
Costa, Alex Ignatius;
Barnett, Susan Carol;
Sandvig, Axel;
Håberg, Asta.
(2017)
Effects of neural stem cell and olfactory ensheathing cell co-transplants on tissue remodelling after transient focal cerebral ischemia in the adult rat.
Neurochemical Research
Academic article
2013
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Morken, Tora Sund;
Nyman, Axel Karl Gottfrid;
Sandvig, Ioanna;
Torp, Sverre Helge;
Skranes, Jon Sverre;
Goa, Pål Erik.
(2013)
Brain Development after Neonatal Intermittent Hyperoxia-Hypoxia in the Rat Studied by Longitudinal MRI and Immunohistochemistry.
PLOS ONE
Academic article
2012
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Nyman, Axel Karl Gottfrid.
(2012)
In Bloom.
Visual Arts
Journal publications
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Molska, Alicja;
Nyman, Axel Karl Gottfrid;
Sofias, Alexandros Marios;
Kristiansen, Kåre Andre;
Hak, Sjoerd;
Widerøe, Marius.
(2020)
In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations.
European journal of pharmaceutics and biopharmaceutics
Academic article
-
Berger, Hester Rijkje;
Nyman, Axel Karl Gottfrid;
Morken, Tora Sund;
Widerøe, Marius.
(2019)
Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats.
PLOS ONE
Academic article
-
Berger, Hester Rijkje;
Nyman, Axel Karl Gottfrid;
Morken, Tora Sund;
Vettukattil, Muhammad Riyas;
Brubakk, Ann-Mari;
Widerøe, Marius.
(2017)
Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy.
PLOS ONE
Academic article
-
Augestad, Ingrid Lovise;
Nyman, Axel Karl Gottfrid;
Costa, Alex Ignatius;
Barnett, Susan Carol;
Sandvig, Axel;
Håberg, Asta.
(2017)
Effects of neural stem cell and olfactory ensheathing cell co-transplants on tissue remodelling after transient focal cerebral ischemia in the adult rat.
Neurochemical Research
Academic article
-
Morken, Tora Sund;
Nyman, Axel Karl Gottfrid;
Sandvig, Ioanna;
Torp, Sverre Helge;
Skranes, Jon Sverre;
Goa, Pål Erik.
(2013)
Brain Development after Neonatal Intermittent Hyperoxia-Hypoxia in the Rat Studied by Longitudinal MRI and Immunohistochemistry.
PLOS ONE
Academic article
Artistic productions
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Nyman, Axel Karl Gottfrid.
(2012)
In Bloom.
Visual Arts
Knowledge Transfer
2024
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PosterJohannessen, Fredrik Røkke; Andreassen, Trygve; Scheffler, Katja; Nyman, Axel Karl Gottfrid. (2024) Development of a Translational Metabolic Platform for Brain Disorders, Exemplified by Preclinical Alzheimer's Disease. 4th Nordic Neuroscience Meeting 2024-01-15 - 2024-01-17
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PosterNyman, Axel Karl Gottfrid; Johannessen, Fredrik Røkke; Andreassen, Trygve; Bonnevie, Tora; Genovese, Guglielmo; Scheffler, Katja. (2024) A personalized in vitro metabolic model of preclincal Alzheimer's disease. Trondheim fMRI group, MiDT national research centre, St. Olav's Hospital, and Department of Neuromedicine and Movement Science, NTNU The Aging Brain Conference , Union Hotel Geiranger 2024-06-12 - 2024-06-14
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Academic lectureNyman, Axel Karl Gottfrid; Johannessen, Fredrik Røkke; Andreassen, Trygve; Bonnevie, Tora; Genovese, Guglielmo; Scheffler, Katja. (2024) A Personalized in vitro Metabolic Model of Preclinical Alzheimer’s Disease. ICBEM 15th International Conference on Brain Energy Metabolism (ICBEM) , Grand Hotel Union in Ljubljana, Slovenia 2024-09-17 - 2024-09-21
2023
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Academic lectureJohannessen, Fredrik Røkke; Andreassen, Trygve; Scheffler, Katja; Nyman, Axel Karl Gottfrid. (2023) Investigation of Metabolism in Cerebral Organoids Derived from Patients with Preclinical Alzheimer's Disease. Frampeik 2023-09-30 - 2023-09-30
2017
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LectureMolska, Alicja; Sofias, Alexandros Marios; Nyman, Axel Karl Gottfrid; Hak, Sjoerd; Widerøe, Marius. (2017) Melatonin treatment for hypoxic-ischemic brain injury. Lipid-based nanoparticles as a platform for drug delivery. NRSN The 5th National PhD Conference in Neuroscience , Sommarøy 2017-09-20 - 2017-09-22
2015
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Academic lectureBerger, Hester Rijkje; Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Vettukattil, Muhammad Riyas; Brubakk, Ann-Mari; Widerøe, Marius. (2015) Early prognostic metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo proton MR spectroscopy. Norwegian Research School in Medical Imaging MedIm PhD conference , Oslo 2015-11-16 - 2015-11-17
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Academic lectureBerger, Hester Rijkje; Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Vettukattil, Muhammad Riyas; Brubakk, Ann-Mari; Widerøe, Marius. (2015) In-vivo MR metabolomics; A potential biomarker for neonatal hypoxic-ischemic brain injury?. Torstein Vik Cerebral Palsy masterclass , NTNU, Trondheim 2015-09-10 - 2015-09-10
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Academic lectureAugestad, Ingrid Lovise; Nyman, Axel Karl Gottfrid; Widerøe, Marius; Sandvig, Axel; Håberg, Asta; Sandvig, Ioanna. (2015) Anatomical, cellular and structural effects of neural stem cell and/or olfactory ensheathing cell grafts in a rat model of focal cerebral ischemia with reperfusion. ASNTR 22nd Annual Conference of the American Society of Neural Therapy and Repair , Tampa, Florida 2015-04-30 - 2015-05-02
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PosterNyman, Axel Karl Gottfrid; Augestad, Ingrid Lovise; Widerøe, Marius; Sandvig, Axel; Håberg, Asta; Sandvig, Ioanna. (2015) Cellular, anatomical, and functional effects of neural stem cell and olfactory ensheathing cell co-grafts in a rat model of transient cerebral ischemia. Scandinavian Physiological Society Nordic Neuroscience 2015 , Trondheim 2015-06-10 - 2016-06-12
2014
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LectureBerger, Hester Rijkje; Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Brubakk, Ann-Mari; Widerøe, Marius. (2014) Effects of melatonin on brain development after hypoxic-ischemic brain injury in neonatal rats. PAS/ASAP Pediatric Academic Societies and Asian Society For Pediatric Research , Vancouver 2014-05-03 - 2014-05-06
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PosterBerger, Hester Rijkje; Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Brubakk, Ann-Mari; Widerøe, Marius. (2014) The effects of melatonin on brain development after hypoxic-ischemic brain injury in neonatal rats: A longitudinal MR study. Johns Hopkins University School of Medicine 9th Hershey Conference on Developmental Brain Injury , Maryland 2014-06-03 - 2014-06-06
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LectureBerger, Hester Rijkje; Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Brubakk, Ann-Mari; Widerøe, Marius. (2014) The effects of melatonin on brain development after hypoxic-ischemic brain injury in neonatal rats: Preliminary results from a longitudinal MR study. Norsk Perinatalmedisinsk Forening (NPF) Perinatal asphyxia seminar , Trondheim 2014-11-10 - 2014-11-10
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LectureBerger, Hester Rijkje; Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Brubakk, Ann-Mari; Widerøe, Marius. (2014) The effect of melatonin on brain development after hypoxic-ischemic brain injury in neonatal rats. Norsk Selskap for Magnetisk Resonans (NSMR) 13th National MR Meeting , Trondheim 2014-01-14 - 2014-01-15
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LectureNyman, Axel Karl Gottfrid; Sandvig, Ioanna; Widerøe, Marius. (2014) In vivo visualization of stem cell therapy in the hypoxic-ischemic neonatal brain using MRI. Frampeik 2014 - legestudentenes forskningskonferanse , Trondheim 2014-10-24 - 2014-10-26
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PosterNyman, Axel Karl Gottfrid; Sandvig, Ioanna; Widerøe, Marius. (2014) In vivo visualisation of stem cell therapy in the hypoxic-ischemic neonatal brain using MRI. NRSN Norwegian Research School in Neuroscience Annual Meeting , Stiklestad 2014-09-22 - 2014-09-24
2013
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InterviewNyman, Axel Karl Gottfrid. (2013) Hjerneslaget på Stiklestad. Adresseavisen Adresseavisen [Newspaper] 2013-09-13
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PosterNyman, Axel Karl Gottfrid; Modo, Mike; Widerøe, Marius; Haraldseth, Olav; Håberg, Asta; Sandvig, Ioanna. (2013) Co-transplantation of neural stem cells and olfactory ensheathing cells in an adult rat stroke model. NRSN The 1st National PhD Conference in Neuroscience , Stiklestad 2013-09-10 - 2013-09-11
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Academic lectureMorken, Tora Sund; Nyman, Axel Karl Gottfrid; Widerøe, Marius; Sandvig, Ioanna; Torp, Sverre Helge; Skranes, Jon. (2013) Exposure of long-term intermittent hypoxia-hyperoxia in newborn rats: effects on brain development. Pediatric Academic Society 2013-05-04 - 2013-05-07
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PosterBerger, Hester Rijkje; Sonnewald, Ursula; Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Brubakk, Ann-Mari; Widerøe, Marius. (2013) The effect of melatonin on brain development after hypoxic-ischemic brain injury in neonatal rats: Preliminary results from a longitudinal MR study. NRSN NRSN PhD Conference , Stiklestad 2013-09-10 - 2013-09-11
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LectureBerger, Hester Rijkje; Sonnewald, Ursula; Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Brubakk, Ann-Mari; Widerøe, Marius. (2013) The effect of melatonin on brain development after hypoxic-ischemic brain injury in neonatal rats:Preliminary results from a longitudinal MR study. MedIm PhD Conference in Medical Imaging , Tromsø 2013-10-02 - 2013-10-03
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PosterNyman, Axel Karl Gottfrid; Modo, Michel; Sandvig, Axel; Widerøe, Marius; Haraldseth, Olav; Håberg, Asta. (2013) Co-transplantation of neural stem cells and olfactory ensheathing cells in an adult rat stroke model. Norwegian Research School in Medical Imaging 5th Norwegian PhD Conference in Medical Imaging , Tromsø 2013-10-02 - 2013-10-03
2012
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PosterNyman, Axel Karl Gottfrid; Widerøe, Marius; Haraldseth, Olav. (2012) Longitudinal visualization of stem cell therapy in the hypoxic-ischemic premature brain using MRI. The 4th National PhD Conference in Medical Imaging 2012-11-28 - 2012-11-29