Main research topics:

WP5-1: Multimodal imaging and 3D volume registration in cardiology

In this project we will develop and investigate methods for multimodal imaging in cardiology and associated interventions such as transcatheter aortic valve implantation, mitral clipping, and left atrial appendage closure. We will focus on utilising the strengths of the different modalities for imaging, flow quantification, and efficient workflow. An important application is 3D coronary angiography with anatomical information from CT or ultrasound, and functional information such as strain and coronary flow reserve measurements from ultrasound, MR late-enhancement imaging, or PET.

WP5-2: Multimodal imaging for image guided surgery

Fusing preoperative MR, PET and/or CT images with intraoperative ultrasound imaging is an area of active research for several partners. This project aims to develop improved methods and establish new applications of intraoperative ultrasound, where important aims include improved methods for co-registration of images and improved workflow during procedures. Examples of applications include neurosurgery and thoracic surgery.

WP5-3: Multimodal US and PET-MR for improved diagnosis in brain and heart disease

The unique combination of ultrasound and PET-MR system will be explored for applications in brain and heart disease. Aims include investigating the added value of ultrasound and PET-MR in diagnosis of inflammation of the heart, and related to selection for surgical treatment through new diagnostic criteria such as cerebral blood flow and inflammation, and embolus risk quantification in carotid stenosis. Finally, evaluation of vascular graft infections with PET-MR compared to ultrasound images obtained intravascular and non-invasively.

WP5-4: Ultrasound imaging and manipulation in targeted drug delivery

This project aims to deliver ultrasound imaging technology for targeted drug delivery (TDD). Initial trials will include preclinical studies using novel contrast agents and nanoparticles for TDD and for transient blood-brain-barrier (BBB) opening based on ultrasound manipulation. This research is from the CIUS start a preclinical activity, but it is a goal during the CIUS lifetime to obtain in vivo proof-of-principle in selected patient groups.