course-details-portlet

TKJ4150

Organic Synthesis I

Choose study year
Credits 7.5
Level Third-year courses, level III
Course start Spring 2025
Duration 1 semester
Language of instruction Norwegian
Location Trondheim
Examination arrangement School exam

About

About the course

Course content

The subject covers principals, reaction types, reagents and mechanism for preparation of organic molecules with applications in medicinal and material sciences. Processes with specific safety, waste and environmental issues are highlighted. Details: Reagent selection, reaction mechanisms, pKa and choice of base, solvent effects, alkylation of carbonyl compounds, nitriles, nitro-compounds, imines and enamines, metal enolates, enol ethers, kinetic and thermodynamic control, modern Aldol type reactions, condensation reactions with carbonyl compounds, alkenes from carbonyl compounds, phosphorus ylides, phosphonate anions, sulphur ylides and their reactivity, conjugated addition. Transformation of functional groups by substitution reactions, protecting groups, electrophilic addition to C-C double and triple bonds, hydroboration, reactions with organoboranes, reduction of carbonyl, C-C double and triple bonds, hydrogenation, hydride reductions. Pericyclic reactions: cycloadditions, sigmaotroptic rearrangements, electrocyclic reactions, group transfer reactions, frontier molecular orbital theory. Introduction to retro synthesis

Learning outcome

Upon completion of the coarse the student should within the framework of the coarse content: - Be able to plan the synthesis of organic molecules with respect to reagents and reaction conditions. - Should know and be able to explain reaction mechanisms. - Should be able to identify major by-products in reactions. - Be able to use frontier molecular orbital theory to predict the outcome of pericyclic reactions. - Be able to name important reactions. - Should understand how functional groups affect electron density, properties and reactivity in organic compounds. - Should be able to estimate the pKa values for carboxylic acids, amines, alcohols and ketones in the presence of various functionalities. - Be able to explain how the choice of base affects reactivity, hazard of operation and the price of processes. -Be able to identify processes/reactions that give a lot of waste. -Know which metals are environmentally problematic.

Learning methods and activities

Lectures and exercises.

Expected work load in the course is 200-225 hours.

Further on evaluation

If there is a re-sit examination, the examination form may be changed from written to oral.

Course materials

1. Carey and Sundberg; Advanced Organic Chemistry, B. 5.ed.

2. Theoretical exercises

3. Compendia from lecturer

Credit reductions

Course code Reduction From
TKJ4111 3.5 sp Autumn 2012
TKJ4135 3.5 sp Spring 2013
This course has academic overlap with the courses in the table above. If you take overlapping courses, you will receive a credit reduction in the course where you have the lowest grade. If the grades are the same, the reduction will be applied to the course completed most recently.

Subject areas

  • Organic Chemistry
  • Chemistry
  • Technological subjects

Contact information

Course coordinator

Lecturers

Department with academic responsibility

Department of Chemistry