Rypdal is a postdoctoral researcher at the K.G. Jebsen Center for Cardiac Biomarkers (UiO) and the Oslo Center for Clinical Heart Research (Oslo-CCHR) at OUS Ullevål. She obtained her Master of Science in Molecular Medicine from the Norwegian University of Science and Technology (NTNU) and St. Olavs Hospital in Trondheim in 2015, where she conducted high-throughput DNA sequencing of patients with Lynch Syndrome, a common hereditary colorectal cancer, for her thesis. Following her graduation, Karoline worked at the Department of Medical Genetics at OUS Ullevål.

She then pursued a PhD in Translational Cardiology at the Institute for Experimental Medical Research (IEMR), UiO and OUS. She successfully defended her PhD thesis in 2022, which focused on the molecular mechanisms of cardiovascular disease, particularly the roles of ADAMTSL proteins in heart failure and cardiac fibrosis. During her PhD, Karoline collaborated with leading researchers, including Dr. Suneel Apte at the Lerner Research Institute, Cleveland Clinic, Ohio, and Prof. Dirk Hubmacher at the Icahn School of Medicine, Mount Sinai Hospital, New York. Her research on the novel functions of ADAMTSL proteins in the heart earned her several awards at national and international conferences.

As a postdoctoral researcher, Karoline's work spans basic science to clinical research, involving cell culture, genetic mouse models, and genetic analyses, as well as the study of blood and tissue biomarkers in patients. Her primary research area is cardiovascular disease, and she is actively involved in Work Package 5 at the Jebsen Center, aiming to discover novel biomarkers of cardiac fibrosis.

Karoline is passionate about research communication and manages the Instagram account @hjerteforsk, where she shares knowledge-based information on cardiovascular disease with the public.