GWAS

Genome-Wide Association Study (GWAS)

Genome-Wide Association Study (GWAS)

The impact on medical care from genome-wide association studies can be substantial, laying the groundwork for implementing personalized medicine, based on studies of genetic variation on a population level.

Great improvements have been made in the cost and efficiency of genome-wide scans and other innovative technologies, using such tools to provide patients with individualized information about their risk of developing certain diseases and to tailor prevention programs to each person's unique genetic makeup.

When a person reaches a disease endpoint, GWAS-based approaches may be used to select the treatments most likely to be effective. Since most inactivating mutations are rare due to negative natural selection, statistical power remains a challenge. To address this, we are well placed to coordinate collaborations with other large-scale studies, and we plan to do reciprocal look-up and meta-analyze results with studies of similar size to improve power. We will also participate in a range of consortia focused on discovery for a wide variety of traits.

Projects

Projects

HUNT MCE run a large project called ALL-IN where we look at a wide range of diseases. This is done in close collaboration with clinicians and researchers who specialize in the different areas.

ALL-IN Projects

Contact: John-Anker Zwart, MD, PhD, FORMI/UIO

  • Cognitive impairment
  • Common psychiatric conditions
  • Eating disorders
  • Epilepsy
  • Headache and migraine
  • Surgical treatment of neck and back disorders
  • Neurodegenerative diseases
  • Pain conditions
  • Parkinsons disease
  • Sleep conditions
  • Cerebrovascular disease
  • Brain tumour

Research activity

Result 30 of 133 for
Publications Authors Journal Year
Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study M. Denos, Y.-Q. Sun, B. Brumpton, Y. Li, D. Albanes, A. Burnett-Hartman, P.T. Campbell, S. Kury, C.I. Li, E. White, ...more authors Scientific Reports 2024
Dispensed prescription medications and short-term risk of pulmonary embolism in Norway and Sweden D. Aune, I. Vardaxis, B.H. Lindqvist, B. Brumpton, L.B. Strand, J.W. Horn, I.J. Bakken, P.R. Romundstad, K.J. Mukamal, R. Ljung, ...more authors Scientific Reports 2024
Genetic architecture reconciles linkage and association studies of complex traits J. Sidorenko, B. Couvy-Duchesne, K.E. Kemper, G.-H. Moen, L. Bhatta, B.O. Asvold, R. Magi, A. Ani, R. Wang, I.M. Nolte, ...more authors Nature Genetics 2024
Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study K. Ovretveit, E.M.L. Ingestrom, M. Spitieris, V. Tragante, L.F. Thomas, I. Steinsland, B. Brumpton, D.F. Gudbjartsson, H. Holm, K. Stefansson, ...more authors Journal of the American Heart Association 2024
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease A.N. Nordeidet, M. Klevjer, K. Ovretveit, E. Madssen, U. Wisloff, B. Brumpton, A. Bye ...more authors European Journal of Preventive Cardiology 2024
Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score study N. Hernandez-Pacheco, A. Kilanowski, A. Kumar, J. Curtin, N. Olvera, S. Kress, X. Bertels, L. Lahousse, L. Bhatta, R. Granell, ...more authors eClinicalMedicine 2024
Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolism M.C.B. Tan, C.A. Isom, Y. Liu, D.-A. Tregouet, S. Lindstrom, L. Wang, E.N. Smith, W. Gordon, Hylckama Vlieg A. Van, Andrade M. De, ...more authors eBioMedicine 2024
Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight (Nature Genetics, (2023), 55, 4, (559-567), 10.1038/s41588-023-01343-9) P. Sole-Navais, C. Flatley, V. Steinthorsdottir, M. Vaudel, J. Juodakis, J. Chen, T. Laisk, A.L. LaBella, D. Westergaard, J. Bacelis, ...more authors Nature Genetics 2023
Polygenic prediction of preeclampsia and gestational hypertension M.C. Honigberg, B. Truong, R.R. Khan, B. Xiao, L. Bhatta, H.M.T. Vy, R.F. Guerrero, A. Schuermans, M.S. Selvaraj, A.P. Patel, ...more authors Nature Medicine 2023
Self-reported insomnia symptoms, sleep duration, chronotype and the risk of acute myocardial infarction (AMI): a prospective study in the UK Biobank and the HUNT Study N. Arora, R.C. Richmond, B. Brumpton, B.O. Asvold, H. Dalen, E.S. Skarpsno, L.B. Strand ...more authors European Journal of Epidemiology 2023
Genetic effects on the timing of parturition and links to fetal birth weight P. Sole-Navais, C. Flatley, V. Steinthorsdottir, M. Vaudel, J. Juodakis, J. Chen, T. Laisk, A.L. LaBella, D. Westergaard, J. Bacelis, ...more authors Nature Genetics 2023
A fast linkage method for population GWAS cohorts with related individuals G.J.M. Zajac, Taliun S.A. Gagliano, C. Sidore, S.E. Graham, B.O. Asvold, B. Brumpton, J.B. Nielsen, W. Zhou, M.E. Gabrielsen, A.H. Skogholt, ...more authors Genetic Epidemiology 2023
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity M.K. Bakker, J.P. Kanning, G. Abraham, A.E. Martinsen, B. Winsvold, J.-A. Zwart, R. Bourcier, T. Sawada, M. Koido, Y. Kamatani, ...more authors Stroke 2023
Cohort Profile Update: The HUNT Study, Norway B.O. Asvold, A. Langhammer, T.A. Rehn, G. Kjelvik, T.V. Grontvedt, E.P. Sorgjerd, J. Fenstad, J. Heggland, O.L. Holmen, M.C. Stuifbergen, ...more authors International Journal of Epidemiology 2023
Using Genomic Structural Equation Modeling to Partition the Genetic Covariance Between Birthweight and Cardiometabolic Risk Factors into Maternal and Offspring Components in the Norwegian HUNT Study G.-H. Moen, M.G. Nivard, L. Bhatta, N.M. Warrington, C.J. Willer, B.O. Asvold, B. Brumpton, D.M. Evans ...more authors Behavior Genetics 2023
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts Y. Wang, S. Namba, E. Lopera, S. Kerminen, K. Tsuo, K. Lall, M. Kanai, W. Zhou, K.-H. Wu, M.-J. Fave, ...more authors Cell Genomics 2023
Genome-wide association study of susceptibility to hospitalised respiratory infections A.T. Williams, N. Shrine, Gijzel H. Naghra-van, J.C. Betts, J. Chen, E.M. Hessel, C. John, R. Packer, N.F. Reeve, A.J. Yeo, ...more authors Wellcome Open Research 2023
Reproductive Factors in Relation to Incidence of Lung and Colorectal Cancers in a Cohort of Norwegian Women: The HUNT Study M. Denos, Y.-Q. Sun, B. Brumpton, A. Langhammer, Y. Chen, X.M. Mai ...more authors Journal of the Endocrine Society 2023
Vitamin D Status Over Time and Cognitive Function in Norwegian Older Adults: A Prospective Cohort of the HUNT Study E.O. Asante, X.M. Mai, R.S. Eldholm, H. Skjellegrind, M. Kolberg, B. Brumpton, G. Selboek, Y. Chen, Y.-Q. Sun ...more authors Journal of Nutrition, Health and Aging 2023
Meta-analysis fine-mapping is often miscalibrated at single-variant resolution M. Kanai, R. Elzur, W. Zhou, K.-H.H. Wu, H. Rasheed, K. Tsuo, J.B. Hirbo, Y. Wang, A. Bhattacharya, H. Zhao, ...more authors Cell Genomics 2022
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis S. Kanoni, S.E. Graham, Y. Wang, I. Surakka, S. Ramdas, X. Zhu, S.L. Clarke, K.F. Bhatti, S. Vedantam, T.W. Winkler, ...more authors Genome Biology 2022
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants K.G. Aragam, T. Jiang, A. Goel, S. Kanoni, B.N. Wolford, D.S. Atri, E.M. Weeks, M. Wang, G. Hindy, W. Zhou, ...more authors Nature Genetics 2022
Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches L. Jiang, Y.-Q. Sun, B. Brumpton, A. Langhammer, Y. Chen, X.M. Mai ...more authors BMC Cancer 2022
ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma K. Praveen, G.C. Patel, L. Gurski, A.H. Ayer, T. Persaud, M.D. Still, L. Miloscio, Zyl T. Van, Gioia S.A. Di, B. Brumpton, ...more authors Communications Biology 2022
The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization R. Korologou-Linden, L. Bhatta, B. Brumpton, L.D. Howe, L.A.C. Millard, K. Kolaric, Y. Ben-Shlomo, D.M. Williams, G.D. Smith, E.L. Anderson, ...more authors Nature Communications 2022
Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT M.R. Moksnes, S.E. Graham, K.-H. Wu, A.F. Hansen, Taliun S.A. Gagliano, W. Zhou, K. Thorstensen, L.G. Fritsche, D. Gill, A.M. Mason, ...more authors Communications Biology 2022
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals T.W. Winkler, H. Rasheed, A. Teumer, M. Gorski, K.J. Stanzick, L.F. Thomas, A. Tin, A. Hoppmann, A.Y. Chu, B.O. Tayo, ...more authors Communications Biology 2022
Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases H. Zhao, H. Rasheed, T.H. Nost, Y. Cho, Y. Liu, L. Bhatta, A. Bhattacharya, G. Hemani, Smith G. Davey, B. Brumpton, ...more authors Cell Genomics 2022
A saturated map of common genetic variants associated with human height L. Yengo, S. Vedantam, E. Marouli, J. Sidorenko, E. Bartell, S. Sakaue, M. Graff, A.U. Eliasen, Y. Jiang, S. Raghavan, ...more authors Nature 2022
Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors F. Thibord, D. Klarin, J.A. Brody, M.-H. Chen, M.G. Levin, D.I. Chasman, E.L. Goode, K. Hveem, M. Teder-Laving, A. Martinez-Perez, ...more authors Circulation 2022
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