Course - Organic Synthesis I - TKJ4150
TKJ4150 - Organic Synthesis I
About
Examination arrangement
Examination arrangement: School exam
Grade: Letter grades
| Evaluation | Weighting | Duration | Grade deviation | Examination aids |
|---|---|---|---|---|
| School exam | 100/100 | 4 hours | D |
Course content
The subject covers principals, reaction types, reagents and mechanism for preparation of organic molecules with applications in medicinal and material sciences. Processes with specific safety, waste and environmental issues are highlighted. Details: Reagent selection, reaction mechanisms, pKa and choice of base, solvent effects, alkylation of carbonyl compounds, nitriles, nitro-compounds, imines and enamines, metal enolates, enol ethers, kinetic and thermodynamic control, modern Aldol type reactions, condensation reactions with carbonyl compounds, alkenes from carbonyl compounds, phosphorus ylides, phosphonate anions, sulphur ylides and their reactivity, conjugated addition. Transformation of functional groups by substitution reactions, protecting groups, electrophilic addition to C-C double and triple bonds, hydroboration, reactions with organoboranes, reduction of carbonyl, C-C double and triple bonds, hydrogenation, hydride reductions. Pericyclic reactions: cycloadditions, sigmaotroptic rearrangements, electrocyclic reactions, group transfer reactions, frontier molecular orbital theory. Introduction to retro synthesis
Learning outcome
Upon completion of the coarse the student should within the framework of the coarse content: - Be able to plan the synthesis of organic molecules with respect to reagents and reaction conditions. - Should know and be able to explain reaction mechanisms. - Should be able to identify major by-products in reactions. - Be able to use frontier molecular orbital theory to predict the outcome of pericyclic reactions. - Be able to name important reactions. - Should understand how functional groups affect electron density, properties and reactivity in organic compounds. - Should be able to estimate the pKa values for carboxylic acids, amines, alcohols and ketones in the presence of various functionalities. - Be able to explain how the choice of base affects reactivity, hazard of operation and the price of processes. -Be able to identify processes/reactions that give a lot of waste. -Know which metals are environmentally problematic.
Learning methods and activities
Lectures and exercises.
Expected work load in the course is 200-225 hours.
Further on evaluation
If there is a re-sit examination, the examination form may be changed from written to oral.
Recommended previous knowledge
Basic knowledge in organic chemistry corresponding to TKJ4102 and KJ1021.
Course materials
1. Carey and Sundberg; Advanced Organic Chemistry, B. 5.ed.
2. Theoretical exercises
3. Compendia from lecturer
Credit reductions
| Course code | Reduction | From | To |
|---|---|---|---|
| TKJ4111 | 3.5 | AUTUMN 2012 | |
| TKJ4135 | 3.5 | SPRING 2013 |
No
Version: 1
Credits:
7.5 SP
Study level: Third-year courses, level III
Term no.: 1
Teaching semester: SPRING 2025
Language of instruction: Norwegian
Location: Trondheim
- Organic Chemistry
- Chemistry
- Technological subjects
Examination
Examination arrangement: School exam
- Term Status code Evaluation Weighting Examination aids Date Time Examination system Room *
- Spring ORD School exam 100/100 D INSPERA
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Room Building Number of candidates - Summer UTS School exam 100/100 D INSPERA
-
Room Building Number of candidates
- * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
For more information regarding registration for examination and examination procedures, see "Innsida - Exams"