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TKJ4102

Basic Organic Chemistry

Choose study year
Credits 7.5
Level Intermediate course, level II
Course start Autumn 2020
Duration 1 semester
Language of instruction Norwegian
Location Trondheim
Examination arrangement Portfolio assessment

About

About the course

Course content

Basic organic chemical concepts, such as chemical structures and nomenclature, physical properties, stereochemistry and relationship between structure and reactivity will be presented. Reaction mechanisms will be presented to give insight in chemical transformations. Alkanes and cycloalkanes: Conformations and cis-trans stereoisomers. Stereochemistry: Geometric isomers, conformation isomers, configuration isomers and pro-chirality. Absolute and relative configuration, R/S notational system for chiral C-atoms, optical activity (specific rotation), enantiomers, diastereomers, meso compounds, three-dimensional projections of molecule´s atoms, stereochemistry in chemical reactions. Alcohols and alkyl halides: Substitution (SN1/SN2), elimination (E1/E2), potential energy diagrams for multiple step reactions, carbocations and rearrangements. Nucleophilic substitution (SN2): Nucleophilic reagents, nucleophilicity versus basicity, solvent effects, leaving group, functionalization and stereochemistry. Structure and preparation of alkenes: Elimination reactions. Addition reactions of alkenes: (i) Hydrogenation, (ii) electrophilic addition of hydrogen halides (Markovnikov's rule and mechanism), (iii) acid-catalyzed hydration, i(v) hydroboration-oxidation to alcohols (anti-Markovinkov), (v) epoxidation. Alkynes: Preparation, acid-base properties, alkylation of terminal alkynes. Addition reactions of alkynes. Alcohols: Preparation by (i) reduction of carbonyl compounds, (ii) ring opening of epoxides, (iii) dihydroxylation of alkenes. Reactions of alcohols: (i) Preparation of ethers, (ii) preparation of esters and (iii) oxidation to aldehyde/carboxylic acid/ketone. Grignard reagents and organolitium (organometallic compounds): Preparation, reactivity and reactions (base and addition to carbonyl compounds). Conjugation in alkadienes and allylic systems, allylic carbocations, resonance (electron delocalization), stability, isolated dienes, conjugated dienes, cumulated dienes. Conjugated dienes: (i) Preparation, (ii) addition of hydrogen halide, The Diels-Alder reaction. Arenes and aromaticity. Reactions of arenes: Electrophilic aromatic substitution. Radical halogenation of alkylbenzenes. Aldehydes and ketones: (i) Structure and reactivity, (ii) The Wittig reaction, (iii) preparation of imine, (iv) acetal formation, (v) enols and enolates, (vi) alkylation of enolates, (vii) aldol condensation. Carboxylic acids: (i) Acidity, (ii) preparation and (iii) reactions (ester formation). Carboxylic acid derivatives: (i) Esters, (ii) acid anhydrides, (iii) acid halides. Hydrolysis of carboxylic acid derivatives. Interpretation of simple proton NMR spectra.

Learning outcome

After completing this course the student will, in relation to the content of the subject: (i) be able to understand and communicate nomenclature and structure of organic chemical compounds, (ii) know basic principles for reactions in organic chemistry, (iii) be able to account for and derive mechanistic features of the reactions, (iv) be able to predict competing reactions, (v) be able to name central reactions, (vi) have a basic knowledge of how functional groups affect electron density, properties and reactivity in organic compounds, (vii) be able to estimate pKa values for carboxylic acids, amines, alcohols and ketones in the presence of different functional groups. Interpretation of simple proton NMR spectra.

Learning methods and activities

TKJ4102 is the theoretical course in basic organic chemistry for students enrolled in the Ms. Tech. program. TKJ4102 consists of lectures (4 hours per week) and exercises (2 hours per week). 67% of the exercises must be approved by submission of answers in WileyPLUS digital learning platform.

Compulsory assignments

  • Minimum 67% approved exercises

Further on evaluation

The final grade is based on portfolio assessment. The portfolio includes written exam (80%) and semester assignment (20%). The evaluation of the different parts is given in %-points, while the entire portfolio is given a letter grade.
The re-sit examination may be changed from written to oral. When the exam is repeated the semester assingnment (the mid-term exam) must be repeated.

Course materials

Solomons, Fryhle, Snyder: "Organic chemistry", 12th ed. Wiley, 2017.
Compulsory exercises require access (purchase) of code to WileyPLUS digital learning with digital textbook, reaction videos, exercises and ORION self-training tools.

Credit reductions

Course code Reduction From
TKJ4100 7.5 sp
KJ1020 7.5 sp
TBT4160 3.7 sp
SIK3020 7.5 sp
HBIO1005 3.5 sp
HBIO2007 3.5 sp
MK101309 3.5 sp
TKJE2001 7.5 sp
TMAT1009 7.5 sp
KJ1022 6 sp
This course has academic overlap with the courses in the table above. If you take overlapping courses, you will receive a credit reduction in the course where you have the lowest grade. If the grades are the same, the reduction will be applied to the course completed most recently.

Subject areas

  • Organic Chemistry
  • Chemistry

Contact information

Course coordinator

Department with academic responsibility

Department of Chemistry