Course - Molecular Mechanisms of Inflammation - MOL8009
MOL8009 - Molecular Mechanisms of Inflammation
About
Examination arrangement
Course content
The course will give an overview of mechanisms and signaling pathways involved in inflammatory processes, mainly connected to activities at Centre of Molecular Inflammation Research (CEMIR, NTNU). This is inflammation related to infections, but also sterile inflammation (that can be observed during e.g. autoimmune diseases, heart infarction/failure and obesity). Innate and adaptive immune responses will be discussed, with an emphasis on innate immunity. Cell types that are involved include macrophages, monocytes, dendritic cells, neutrophils, dendritic cells, T cells, B cells, osteoblasts, osteoclasts. Recognition- and signaling mechanisms include complement, interactions between complement and other signals, phagocytosis, Toll-like receptors (TLRs), inflammasomes, RIG-I family and other helicases, cGAS, C-type lectin receptors, autophagy, responses to different types of bacteria, viruses, protozoan parasites and fungi, sterile inflammation, vaccines/adjuvants, inflammatory cytokines. Inflammatory signals will be discussed in relation to clinical situations such as infections, immunodeficiencies, inflammation during pregnancy, inflammatory bowel disease, heart failure and bone inflammation.
Learning outcome
After completing the course the student:
- has insight into basal mechanisms of inflammation, much of this in relation to research conducted at Centre for Molecular Inflammation Research (CEMIR) and the Department of Clinical and Molecular Medicine.
- will know how the body fight infection with many classes of pathogens, both with respect to different cell types involved and also recognition mechanisms and signaling pathways within those cells.
- understand similarities between sterile inflammation and inflammation induced by infections.
- know how innate immunity instructs adaptive immunity.
- has increased understanding of the possibilities biological research on cell- and molecular level has on development of disease prevention and therapies.
Learning methods and activities
Lectures (mandatory), group discussions/group work (mandatory, 30 % of grade), self study.
Compulsory assignments
- Attendance in lectures
Further on evaluation
Retake of the exam: The student must have completed the mandatory activities and assignments to take the exam. If the assignment is passed in a previous semester, it is sufficient to retake the written exam.
Recommended previous knowledge
Fundamental skills in medicine, immunology, cell biology and molecular biology at master degree level.
Required previous knowledge
Masters degree in biology, chemistry, physics. Medical Doctors degree. Or medical students at The Student Research Programme. Candidates with other or lower degree will be assessed individually.
Credit reductions
| Course code | Reduction | From | To |
|---|---|---|---|
| MOL8002 | 7.5 | AUTUMN 2013 |
No
Version: 1
Credits:
7.5 SP
Study level: Doctoral degree level
Term no.: 1
Teaching semester: AUTUMN 2024
Language of instruction: English
Location: Trondheim
- Molecular Medicine
Department with academic responsibility
Department of Clinical and Molecular Medicine
Examination
Examination arrangement: Aggregate score
- Term Status code Evaluation Weighting Examination aids Date Time Examination system Room *
-
Autumn
ORD
Home examination
7/10
A
Release
2024-12-16Submission
2024-12-16
09:00
INSPERA
12:00 -
Room Building Number of candidates -
Autumn
ORD
Assignment
3/10
A
Submission
2024-12-16
09:00 -
Room Building Number of candidates - Spring UTS Home examination 7/10 A INSPERA
-
Room Building Number of candidates - Spring UTS Assignment 3/10 A
-
Room Building Number of candidates
- * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
For more information regarding registration for examination and examination procedures, see "Innsida - Exams"