course-details-portlet

KLMED8019

Survival analysis

Choose study year
Credits 3
Level Doctoral degree level
Course start Autumn 2024
Duration 1 semester
Language of instruction English
Location Trondheim
Examination arrangement Home examination

About

About the course

Course content

This course cover standard statistical methods for analysis of failure- or survival time data (Kaplan-Meier cumulative survival probabilities, Nelson-Aalen cumulative hazard estimate, and the semi-parametric Cox proportional hazard regression model). Simple calculations of cumulative survival probabilities and Nelson-Aalen estimate will be covered. For the Cox PH regression model, focus will be on application, including evaluation of inherent assumptions on the regression model, and what do if the assumptions are not met. Choice of time scale, use of time-dependent covariates, and modelling of time-dependent effects in a parametric survival analysis model (Poisson regression analysis), will also be covered by this course. Survival analyses techniques are appropriate to apply for all types of follow-up studies, including randomized, controlled clinical trials and population-based, prospective epidemiological studies. The Cox PH regression model is often used in studies based on data from HUNT and other public health surveys. The aim of these types of studies is often to identify risk or prognostic factors, or the interaction between different exposure factors.

Learning outcome

Knowledge

After successful completion of this course, the student should

  • have gained sufficient theoretical knowledge to be able to correctly apply the statistical methods and models covered by this course in a research project on PhD level

Skills

The student should

  • be able to select an appropriate method or model to evaluate simple and more complex scientific questions within medicine and health science
  • be able to independently perform the statistical data analyses by means of a statistical program package
  • be able to evaluate the assumptions on the applied method or model
  • be able to interpret and critically evaluate the result from the statistical analyses
  • be able to present the results from the statistical data analyses in a format applicable in a scientific medical journal

General competence

The student should

  • be able to apply, evaluate and discuss application of the statistical methods covered by this course in medical research projects

Learning methods and activities

Lectures and exercises. Practical data analyses by means of SPSS and/or STATA.

Course materials

Lecture notes and other learning material posted by teacher.

Textbook by Kirkwood and Sterne 2003; Essential medical statistics, second edition

Credit reductions

Course code Reduction From
KLMED8005 1.5 sp Autumn 2022
This course has academic overlap with the course in the table above. If you take overlapping courses, you will receive a credit reduction in the course where you have the lowest grade. If the grades are the same, the reduction will be applied to the course completed most recently.

Subject areas

  • Medicine
  • Statistics

Contact information

Course coordinator

Department with academic responsibility

Department of Public Health and Nursing