course-details-portlet

FY8919

Biophysics of Ionizing Radiation

Choose study year
Credits 7.5
Level Doctoral degree level
Course start Autumn 2024
Duration 1 semester
Language of instruction English
Location Trondheim
Examination arrangement Oral exam

About

About the course

Course content

This course gives an introduction to the deposition of energy from ionizing radiation in biologic materials. Topics presented includes direct and indirect radiation effects, radiation-induced DNA damage and repair, mechanisms of cell death following radiation, quantitative models of cell kill and cell survival, dose-response relationships, tumor and normal tissue responses to radiation, main principles for use of ionizing radiation in cancer therapy, the 5 R's of fractionation, time-dose fractionation, therapeutic ratio, the linear-quadratic model, tumor control probability and normal tissue complication probability models, the dose-rate effect, the volume effect, the oxygen effect, tumor microenvironment and hypoxia, combination of radiotherapy with chemotherapy and molecularly targeted agents, sensitizing and protective agents, hyperthermia, proton and ion therapy.

Learning outcome

Knowledge

The candidate should have knowledge about:

  • The interaction of ionizing radiation with biological materials.
  • Mechanisms behind the induction and repair of radiation-induced molecular and cellular effects.
  • The use of ionizing radiation in cancer therapy.

Skills

The candidate should be able to:

  • The use of various mathematical models for the estimation of cell kill and cell survival after irradiation of ionizing radiation.

General competence

The candidate should be able to:

  • Interpretation and presentation of scientific data obtained during the practical work in the laboratory, computer simulations and group work.
  • Reading and presenting research literature.

Learning methods and activities

Lectures, compulsory laboratory exercises/demonstrations, and compulsory project work in groups with presentation. Teaching will be in English if students on international master programs are attending the course. The re-sit examination may be changed from written to oral.

Compulsory assignments

  • Laboratory
  • Project with presentation

Further on evaluation

Evaluation is made based on a final oral exam (100%).

Specific conditions

Admission to a programme of study is required:
Biophysics (PHBIFY)

Course materials

To be announced at the start of the semester.

Credit reductions

Course code Reduction From
TFY4315 7.5 sp Autumn 2017
FY6024 7.5 sp Autumn 2021
This course has academic overlap with the courses in the table above. If you take overlapping courses, you will receive a credit reduction in the course where you have the lowest grade. If the grades are the same, the reduction will be applied to the course completed most recently.

Subject areas

  • Biophysics and Medical Technology
  • Physics

Contact information

Course coordinator

Lecturers

Department with academic responsibility

Department of Physics