course-details-portlet

FY8919 - Biophysics of Ionizing Radiation

About

Examination arrangement

Examination arrangement: Oral exam
Grade: Passed / Not Passed

Evaluation Weighting Duration Grade deviation Examination aids
Oral exam 100/100 1 hours E

Course content

This course gives an introduction to the deposition of energy from ionizing radiation in biologic materials. Topics presented includes direct and indirect radiation effects, radiation-induced DNA damage and repair, mechanisms of cell death following radiation, quantitative models of cell kill and cell survival, dose-response relationships, tumor and normal tissue responses to radiation, main principles for use of ionizing radiation in cancer therapy, the 5 R's of fractionation, time-dose fractionation, therapeutic ratio, the linear-quadratic model, tumor control probability and normal tissue complication probability models, the dose-rate effect, the volume effect, the oxygen effect, tumor microenvironment and hypoxia, combination of radiotherapy with chemotherapy and molecularly targeted agents, sensitizing and protective agents, hyperthermia, proton and ion therapy.

Learning outcome

Knowledge

The candidate should have knowledge about:

  • The interaction of ionizing radiation with biological materials.
  • Mechanisms behind the induction and repair of radiation-induced molecular and cellular effects.
  • The use of ionizing radiation in cancer therapy.

Skills

The candidate should be able to:

  • The use of various mathematical models for the estimation of cell kill and cell survival after irradiation of ionizing radiation.

General competence

The candidate should be able to:

  • Interpretation and presentation of scientific data obtained during the practical work in the laboratory, computer simulations and group work.
  • Reading and presenting research literature.

Learning methods and activities

Lectures, compulsory laboratory exercises/demonstrations, and compulsory project work in groups with presentation. Teaching will be in English if students on international master programs are attending the course. The re-sit examination may be changed from written to oral.

Compulsory assignments

  • Laboratory
  • Project with presentation

Further on evaluation

Evaluation is made based on a final oral exam (100%).

Specific conditions

Admission to a programme of study is required:
Biophysics (PHBIFY)

Course materials

To be announced at the start of the semester.

Credit reductions

Course code Reduction From To
TFY4315 7.5 AUTUMN 2017
FY6024 7.5 AUTUMN 2021
More on the course

No

Facts

Version: 1
Credits:  7.5 SP
Study level: Doctoral degree level

Coursework

Term no.: 1
Teaching semester:  AUTUMN 2024

Language of instruction: English

Location: Trondheim

Subject area(s)
  • Biophysics and Medical Technology
  • Physics
Contact information
Course coordinator: Lecturer(s):

Department with academic responsibility
Department of Physics

Timetable

List view
Calendar view

Examination

Examination arrangement: Oral exam

Term Status code Evaluation Weighting Examination aids Date Time Examination system Room *
Autumn ORD Oral exam 100/100 E

2024-12-03 - 2024-12-04

09:00
Room Building Number of candidates
Spring ORD Oral exam 100/100 E
Room Building Number of candidates
  • * The location (room) for a written examination is published 3 days before examination date. If more than one room is listed, you will find your room at Studentweb.
Examination

For more information regarding registration for examination and examination procedures, see "Innsida - Exams"

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