Our objective is to understand the role of DNA repair factors in generating antibody diversity during the adaptive immune response, and how failure/dysregulation of these pathways lead to genome instability and cancer (B cell lymphoma). Sentral in our research is to study regulation and targeting of the DNA deaminase mutator enzyme AID, which induce uracil in the genome, and the DNA-repair enzyme UNG, which excise uracil from the genome. The outcome of this project has contributed significantly to research field