Successful preventive action to improve public health requires valid knowledge on modifiable causes of disease, without bias due to confounding or reverse causation. In Mendelian Randomization (MR), genetic variation at the population level is utilized to improve causal inference necessary for public health decision-making. 

MR can inform preventive action by providing the most solid causal evidence where randomized trials are not ethical or feasible, and by helping prioritize trials.  

How our genes conduct randomized clinical trials

Want to know more? George Davey Smith, a collaborating Professor in Clinical Epidemiology at the University of Bristol, gives a lecture at NTNU about Mendelian Randomization and how our genes conduct randomized clinical trials.