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Språkvelger

Norsk

Siver Andreas Moestue

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Siver Andreas Moestue

Professor
Department of Clinical and Molecular Medicine
Faculty of Medicine and Health Sciences

siver.a.moestue@ntnu.no
+4773551353 +4791111174 MTFS, del 1, Øya
MR Cancer Group
About Publications Teaching

About

I earned my PhD at the Norwegian University of Science and Technology (NTNU), and am now a research professor at the Dept. of Clinical and Molecular Medicine.  Trained a MSc. Pharm at the University of Oslo, I  started my career as a preclinical researcher in GE Healthcare. Here, I was involved in development of molecularly targeted contrast agents for SPECT/PET, and development of the Sonazoid® microbubble for diagnostic ultrasound imaging of liver cancer.  In my current research, I study the role of metabolism in cancer, with focus on diagnostic and therapeutic applications in breast cancer. In an ongoing project funded by the Norwegian Research Council, I study the effect drugs inhibiting the metabolic enzyme cPLA2 in an aggressive subtype of breast cancer. Realizing the importance of the tumor microenvironment, I also have established activities in the interface between immunology, metabolism and metastasis. 

 

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2017

  • Euceda, Leslie R.; Hill, Deborah Katherine; Stokke, Endre Røsstad; Hatem, Rana; El Botty, Rania; Bieche, Ivan. (2017) Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts. Journal of Proteome Research
    Academic article

2016

  • Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost. (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. OncoTarget
    Academic article
  • Jia, Min; Andreassen, Trygve; Jensen, Lasse; Bathen, Tone Frost; Sinha, Indranil; Gao, Hui. (2016) Estrogen receptor α promotes breast cancer by reprogramming choline metabolism. Cancer Research
    Academic article
  • Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø. (2016) Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model. BMC Cancer
    Academic article

2015

  • Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja. (2015) MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity. British Journal of Cancer
    Academic article
  • Esmaeili, Morteza; Moestue, Siver Andreas; Hamans, Bob C.; Veltien, Andor; Kristian, Alexandr; Engebråten, Olav. (2015) In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts. Journal of Magnetic Resonance Imaging
    Academic article
  • Burggraf, Jacobus; Kamerling, Ingrid; Gordon, Paul B.; Schrier, Lennecke; de Kam, Marijke; Kales, Andrea J. (2015) Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nature Medicine
    Academic article
  • Gorad, Saurabh Sayajirao; Ellingsen, Christine; Bathen, Tone Frost; Mathiesen, Berit Synnøve; Moestue, Siver Andreas; Rofstad, Einar K. (2015) Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS. Neoplasia
    Academic article

2014

  • Esmaeili, Morteza; Bathen, Tone Frost; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Moestue, Siver Andreas. (2014) Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts. Magnetic Resonance in Medicine
    Academic article
  • Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr. (2014) Interplay of choline metabolites and genes in patient-derived breast cancer xenografts. Breast Cancer Research
    Academic article

2013

  • Moestue, Siver Andreas; Huuse, Else Marie; Lindholm, Evita Maria; Bofin, Anna M.; Engebråten, Olav; Mælandsmo, Gunhild. (2013) Low-molecular contrast agent DCE-MRI and DW-MRI in early assessment of bevacizumab treatment in breast cancer xenografts. Journal of Magnetic Resonance Imaging
    Academic article
  • Moestue, Siver Andreas; Dam, Cornelia Gerarda; Gorad, Saurabh Sayajirao; Kristian, Alexandr; Bofin, Anna M.; Mælandsmo, Gunhild. (2013) Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer. Breast Cancer Research
    Academic article

2012

  • Moestue, Siver Andreas; Giskeødegård, Guro F.; Cao, Maria Dung; Bathen, Tone Frost; Gribbestad, Ingrid S. (2012) Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
    Reader opinion piece

2011

  • Glunde, Kristine; Jiang, Liu; Moestue, Siver Andreas; Gribbestad, Ingrid S. (2011) MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer. NMR in Biomedicine
    Academic literature review

2010

  • Moestue, Siver Andreas; Borgan, Eldrid; Huuse, Else Marie; Lindholm, Evita Maria; Sitter, Beathe; Børresen-Dale, Anne-Lise . (2010) Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models. BMC Cancer
    Academic article

Journal publications

  • Euceda, Leslie R.; Hill, Deborah Katherine; Stokke, Endre Røsstad; Hatem, Rana; El Botty, Rania; Bieche, Ivan. (2017) Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts. Journal of Proteome Research
    Academic article
  • Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost. (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. OncoTarget
    Academic article
  • Jia, Min; Andreassen, Trygve; Jensen, Lasse; Bathen, Tone Frost; Sinha, Indranil; Gao, Hui. (2016) Estrogen receptor α promotes breast cancer by reprogramming choline metabolism. Cancer Research
    Academic article
  • Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø. (2016) Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model. BMC Cancer
    Academic article
  • Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja. (2015) MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity. British Journal of Cancer
    Academic article
  • Esmaeili, Morteza; Moestue, Siver Andreas; Hamans, Bob C.; Veltien, Andor; Kristian, Alexandr; Engebråten, Olav. (2015) In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts. Journal of Magnetic Resonance Imaging
    Academic article
  • Burggraf, Jacobus; Kamerling, Ingrid; Gordon, Paul B.; Schrier, Lennecke; de Kam, Marijke; Kales, Andrea J. (2015) Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nature Medicine
    Academic article
  • Gorad, Saurabh Sayajirao; Ellingsen, Christine; Bathen, Tone Frost; Mathiesen, Berit Synnøve; Moestue, Siver Andreas; Rofstad, Einar K. (2015) Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS. Neoplasia
    Academic article
  • Esmaeili, Morteza; Bathen, Tone Frost; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Moestue, Siver Andreas. (2014) Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts. Magnetic Resonance in Medicine
    Academic article
  • Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr. (2014) Interplay of choline metabolites and genes in patient-derived breast cancer xenografts. Breast Cancer Research
    Academic article
  • Moestue, Siver Andreas; Huuse, Else Marie; Lindholm, Evita Maria; Bofin, Anna M.; Engebråten, Olav; Mælandsmo, Gunhild. (2013) Low-molecular contrast agent DCE-MRI and DW-MRI in early assessment of bevacizumab treatment in breast cancer xenografts. Journal of Magnetic Resonance Imaging
    Academic article
  • Moestue, Siver Andreas; Dam, Cornelia Gerarda; Gorad, Saurabh Sayajirao; Kristian, Alexandr; Bofin, Anna M.; Mælandsmo, Gunhild. (2013) Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer. Breast Cancer Research
    Academic article
  • Moestue, Siver Andreas; Giskeødegård, Guro F.; Cao, Maria Dung; Bathen, Tone Frost; Gribbestad, Ingrid S. (2012) Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
    Reader opinion piece
  • Glunde, Kristine; Jiang, Liu; Moestue, Siver Andreas; Gribbestad, Ingrid S. (2011) MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer. NMR in Biomedicine
    Academic literature review
  • Moestue, Siver Andreas; Borgan, Eldrid; Huuse, Else Marie; Lindholm, Evita Maria; Sitter, Beathe; Børresen-Dale, Anne-Lise . (2010) Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models. BMC Cancer
    Academic article

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  • FARM3901 - Thesis in Pharmacy
  • MEDT8010 - Metabolomics- Methods and Applications
  • FARM3009 - Pharmacotherapy in cancer
  • FARM3003 - Pharmaceutical Innovation

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