Pål Sætrom
About
Pål Sætrom works to develop and use computational models to predict how changes in gene regulation can control development and cause disease.
Research
Sætrom’s research focuses on non-coding RNAs (ncRNAs) and their roles in gene regulation and disease. Three major areas of research are (i) developing and validating computer models that can predict how genetic variation affects gene regulation (Nucleic Acids Res, 2011; PLoS Comput Biol, 2012; Bioinformatics, 2014); (ii) understanding the roles of ncRNAs in epigenetics and cell cycle regulation (Nucleic Acids Res, 2013; DNA Repair, 2015); and (iii) designing artificial RNAs for targeted gene regulation and therapy (Mol Ther, 2010; RNA, 2010; Hepatology, 2014).
Biographical Sketch
Education/training
| YEAR(s) | INSTITUTION AND LOCATION | DEGREE | FIELD OF STUDY |
| 2005 | NTNU, Trondheim, Norway | DPhil | Computer science (bioinformatics) |
| 1996-2001 | NTNU, Trondheim, Norway | M.Sc. | Computer science (algorithms) |
Positions and Employment
| 2013-present | Adjunct Professor, Faculty of Biosciences and Aquaculture, University of Nordland, Norway |
| 2012-present | Professor in bioinformatics, Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway |
| 2011-present | Professor in bioinformatics, Department of Computer and Information Science, NTNU, Trondheim, Norway |
| 2011 | Guest researcher, Unit for Clinical Systems Biology, University of Gothenburg, Gothenburg, Sweden with Dr. Mikael Benson |
| 2008-2011 | Adjunct Associate Professor, Department of Computer and Information Science, NTNU, Trondheim, Norway |
| 2007-2011 | Post doctoral fellowship (Career development fellowships from NTNU and the Norwegian Research Council), Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway |
| 2007 | Adjunct Senior Lecturer, Department of Computer and Information Science, NTNU, Trondheim, Norway |
| 2006-2007 | Post doctoral fellowship (Leiv Erikson research scholarship from the Norwegian Research Council), Department of Molecular and Cellular Biology, City of Hope, Duarte, CA (12 months) with Prof. John J. Rossi |
| 2002-2006 | Research scientist, Interagon AS, Trondheim, Norway |
| 2001-2002 | Software Developer, Fast Search & Transfer ASA, Trondheim, Norway |
Honors
| 2014 | Outstanding Academic Fellow, NTNU |
| 2008 | PNAS Cozzarelli Prize in Biological Sciences (with D.H. Kim, O. Snøve, Jr., and J.J. Rossi) |
| 2007-2010 | Career research fellowship, Norwegian Functional Genomics Program (FUGE), Norwegian Research Council (NRC) |
| 2007-2009 | Career fellowship in Medical Technology, NTNU |
| 2006 | Research scholarship, FUGE, NRC |
| 2006 | Leiv Erikson research scholarship, NRC |
Publications listed in publication databases
Publications
2024
-
Bordin, Diana Lilian;
Grooms, Kayla Mae;
Montaldo, Nicola Pietro;
Fordyce Martin, Sarah L.;
Sætrom, Pål;
Samson, Leona D..
(2024)
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory.
DNA Repair
Academic article
-
Neurauter, Christine Gran;
Pannone, Marco;
Sousa, Mirta;
Wang, Wei;
Kusnierczyk, Anna;
Luna, Luisa.
(2024)
Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells.
Free Radical Biology & Medicine
Academic article
-
Glærum, Ingvild Lynneberg;
Dunville, Keagan;
Moan, Kristian Magnus;
Krause, Maike;
Montaldo, Nicola Pietro;
Kirikae, Hinaco.
(2024)
Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit.
Development
Academic article
-
Bugaj, Anna Maria;
Kunath, Nicolas;
Saasen, Vidar Langseth;
Fernandez-Berrocal, Marion S.;
Vankova, Ana;
Sætrom, Pål.
(2024)
Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion.
Progress in Neurobiology
Academic article
-
Potenza, Maria Letizia;
Blankvoort, Stefan Matthias Adriaan;
Carvalho, Miguel;
Grimstvedt, Joachim Schweder;
Di Maria, Valentina;
Moan, Kristian Magnus.
(2024)
Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection.
Frontiers in Neuroscience
Academic article
2023
-
Olsen, Lene Christin;
Galler, Meital;
Witter, Menno Peter;
Sætrom, Pål;
O'Reilly, Kally C.
(2023)
Transcriptional development of the hippocampus and the dorsal–intermediate–ventral axis in rats.
Hippocampus
Academic article
-
Rocque, Mariève;
Leipart, Vilde;
Singh, Ashish Kumar;
Mur, Pilar;
Olsen, Maren Fridtjofsen;
Engebretsen, Lars Fredri.
(2023)
Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk.
Molecular Genetics and Genomics
Academic article
-
Baiju, Nikita;
Rylander, Karin Charlotta Maria;
Sætrom, Pål;
Sandanger, Torkjel M;
Nøst, Therese Haugdahl.
(2023)
Associations of gene expression in blood with BMI and weight changes among women in the Norwegian Women and Cancer postgenome cohort.
Obesity
Academic article
-
Lefol, Yohan Pierre;
Korfage, Tom;
Mjelle, Robin;
Prebensen, Christian Haugland;
Lüders, Torben;
Müller, Bruno.
(2023)
TiSA: TimeSeriesAnalysis - A pipeline for the analysis of longitudinal transcriptomics data.
NAR Genomics and Bioinformatics
Academic article
-
Konstantinidis, Ioannis;
Sætrom, Pål;
Fernandes, Jorge Manuel de Oliveira.
(2023)
Genome-wide hydroxymethylation profiles in liver of female Nile tilapia with distinct growth performance.
Scientific Data
Academic article
-
Konstantinidis, Ioannis;
Sætrom, Pål;
Brieuc, Marine Servane Ono;
Jakobsen, Kjetill Sigurd;
Liedtke, Hannes;
Pohlmann, Caroline.
(2023)
DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden.
Epigenetics
Academic article
-
Urbarova, Ilona Halva;
Skogholt, Anne Heidi;
Sun, Yi-Qian;
Mai, Xiao-Mei;
Grønberg, Bjørn Henning;
Sandanger, Torkjel Manning.
(2023)
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis.
Scientific Reports
Academic article
-
Lien, Hilde Julie Tokle;
Pedersen, Tina Therese;
Jakobsen, Bente;
Flatberg, Arnar;
Chawla, Konika;
Sætrom, Pål.
(2023)
Single-cell resolution of longitudinal blood transcriptome profiles in rheumatoid arthritis, systemic lupus erythematosus and healthy control pregnancies.
Annals of the Rheumatic Diseases
Academic article
-
Andersson-Rusch, Clara Leticia;
Quist-Løkken, Ingrid;
Sætrom, Pål;
Beisvag, Vidar;
Rolinski, Milosz;
Aas, Per Arne.
(2023)
Genome-Wide CRISPR/Cas9 Knock-out Screen Identifies Apoptosis-Relevant Genes in Multiple Myeloma.
Blood
Abstract
-
Moholdt, Trine;
Ashby, Emily Rose;
Tømmerdal, Karina Hammer;
Lemoine, Maeliss Cynthia Chloe;
Holm, Rebecca Lyng;
Sætrom, Pål.
(2023)
Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial
.
BMJ Open sport & exercise medicine
Academic article
-
Pettersen, Caroline Hild Hakvåg;
Samdal, Helle;
Sætrom, Pål;
Wibe, Arne;
Hermansen, Erland;
Schønberg, Svanhild Margrethe Arentz.
(2023)
The Salmon Oil OmeGo Reduces Viability of Colorectal Cancer Cells and Potentiates the Anti-Cancer Effect of 5-FU.
Marine Drugs
Academic article
2022
-
Røe, Oluf Dimitri;
Fotopoulos, I;
Nguyen, Olav Toai Duc;
Nøst, Therese Haugdahl;
Markaki, M;
Lagani, Vincenzo.
(2022)
Common MicroRNAs in Pre-diagnostic Serum Associated with Lung Cancer in Two Cohorts up to Eight Years Before Diagnosis: A HUNT Study.
Journal of Thoracic Oncology
Abstract
-
Nøst, Therese Haugdahl;
Skogholt, Anne Heidi;
Urbarova, Ilona Halva;
Mjelle, Robin;
Paulsen, Erna-Elise;
Dønnem, Tom.
(2022)
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer.
Molecular Oncology
Academic article
-
Grapotte, Mathys;
Saraswat, Manu;
Bessière, Chloé;
Menichelli, Christophe;
Ramilowski, Jordan A.;
Severin, Jessica.
(2022)
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7).
Nature Communications
Errata
2021
-
Solvin, Åshild Øksnevad;
Chawla, Konika;
Olsen, Lene Christin;
Hegre, Siv Anita;
Danielsen, Kjersti;
Jenssen, Marita.
(2021)
MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity.
Experimental Dermatology
Academic article
-
Konstantinidis, Ioannis;
Anastasiadi, Dafni;
Sætrom, Pål;
Nedoluzhko, Artem;
Mjelle, Robin;
Podgorniak, Tomasz.
(2021)
Epigenetic mapping of the somatotropic axis in Nile tilapia reveals differential DNA hydroxymethylation marks associated with growth.
Genomics
Academic article
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology
Academic article
-
Hegre, Siv Anita;
Samdal, Helle;
Klima, Antonin;
Stovner, Endre Bakken;
Nørsett, Kristin Gabestad;
Liabakk, Nina-Beate.
(2021)
Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation.
Scientific Reports
Academic article
-
Tingö, Lina;
Ahlberg, Emelie;
Johansson, Lovisa;
Pedersen, Sindre Andre;
Chawla, Konika;
Sætrom, Pål.
(2021)
Non-coding RNAs in human breast milk: A systematic review.
Frontiers in Immunology
Academic literature review
-
Samdal, Helle;
Olsen, Lene Christin;
Grøn, Knut Sverre;
Røyset, Elin Synnøve;
Høiem, Therese Stork;
Nervik, Ingunn.
(2021)
Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids.
Biomedicines
Academic article
-
Baiju, Nikita;
Sandanger, Torkjel M;
Sætrom, Pål;
Nøst, Therese Haugdahl.
(2021)
Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort.
Scientific Reports
Academic article
-
Rolinski, Milosz;
Montaldo, Nicola Pietro;
Aksu, Merdane Ezgi;
Martin, Sarah Fordyce;
Brambilla, Alessandro;
Kunath, Nicolas.
(2021)
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation.
Nucleic Acids Research (NAR)
Academic article
2020
-
Konstantinidis, Ioannis;
Sætrom, Pål;
Mjelle, Robin;
Nedoluzhko, Artem;
Robledo, Diego;
Fernandes, Jorge Manuel de Oliveira.
(2020)
Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication.
Epigenetics
Academic article
-
Sarker, Debashis;
Plummer, Ruth;
Meyer, Tim;
Sodergren, Mikael H;
Basu, Bristi;
Chee, Cheng Ean.
(2020)
MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial.
Clinical Cancer Research
Academic article
-
Mjelle, Robin;
Aass, Kristin Roseth;
Sjursen, Wenche;
Hofsli, Eva;
Sætrom, Pål.
(2020)
sMETASeq: combined profiling of microbiota and host small RNAs.
iScience
Academic article
-
Huang, Kai-Wen;
Reebye, Vikash;
Czysz, Katherine;
Ciriello, Simona;
Dorman, Stephanie;
Reccia, Isabella.
(2020)
Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile.
Molecular Therapy Nucleic Acids
Academic article
2019
-
Stovner, Endre Bakken;
Sætrom, Pål.
(2019)
PyRanges: efficient comparison of genomic intervals in Python.
Bioinformatics
Academic article
-
Solvin, Åshild Øksnevad;
Chawla, Konika;
Olsen, Lene Christin;
Danielsen, Kjersti;
Jenssen, Marita;
Furberg, Anne-Sofie.
(2019)
Differentially Expressed miRNAs and mRNAs in Psoriatic Skin.
Journal of Investigative Dermatology
Abstract
-
Solvin, Åshild Øksnevad;
Chawla, Konika;
Olsen, Lene Christin;
Danielsen, Kjersti;
Jenssen, Marita;
Furberg, Anne-Sofie.
(2019)
Combined mRNA and miRNA Analysis of Psoriatic Skin.
Forum for Nordic Dermato-Venereology
Abstract
-
Larose, Tricia L;
Sætrom, Pål;
Martinussen, Marit;
Skogseth, Haakon;
Sandanger, Torkjel M;
Scélo, Ghislaine.
(2019)
In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol.
Journal of Public Health Research
Academic article
-
Mjelle, Robin;
Sjursen, Wenche;
Thommesen, Liv;
Sætrom, Pål;
Hofsli, Eva.
(2019)
Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location.
BMC Cancer
Academic article
-
Zhao, Xiaoyang;
Reebye, Vikash;
Hitchen, Paul;
Fan, Jia;
Jiang, Hongchi;
Sætrom, Pål.
(2019)
Mechanisms involved in the activation of C/EBP? by small activating RNA in hepatocellular carcinoma.
Oncogene
Academic article
-
Kroustallaki, Pinelopi;
Lirussi, Lisa;
Carracedo Huroz, Sergio;
You, Panpan;
Esbensen, Qin Ying;
Götz, Alexandra.
(2019)
SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing.
Cell reports
Academic article
-
Mjelle, Robin;
Dima, Simona O;
Bacalbasa, Nicolae;
Chawla, Konika;
Sorop, Andrei;
Cucu, Dana.
(2019)
Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients.
BMC Cancer
Academic article
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Academic article
-
Stovner, Endre Bakken;
Sætrom, Pål.
(2019)
epic2 efficiently finds diffuse domains in ChIP-seq data .
Bioinformatics
Academic article
-
Brian, Ben F;
Jolicoeur, Adrienne S;
Guerrero, Candace R.;
Nunez, Myra G;
Sychev, Zoi E;
Hegre, Siv Anita.
(2019)
Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.
eLIFE
Academic article
2018
-
Sarno, Antonio;
Sætrom, Pål;
Kavli, Bodil Merete;
Pettersen, Henrik Sahlin.
(2018)
Genomic Uracil and Cancer.
World Scientific
Chapter
-
Reebye, Vikash;
Huang, Kai-Wen;
Lin, Vivian;
Jarvis, Sheba;
Cutilas, Pedro;
Dorman, Stephanie.
(2018)
Gene activation of CEBPA using saRNA: Preclinical studies of the first in human saRNA drug candidate for liver cancer.
Oncogene
Academic article
2017
-
de rie, D;
Abugesaissa, I;
Alam, T;
Arner, E;
Ashoor, H;
Åström, G.
(2017)
An integrated expression atlas of miRNAs and their promoters in human and mouse.
Nature Biotechnology
Academic article
-
Voutila, Jon;
Reebye, Vikash;
Roberts, Thomas C.;
Protopapa, Pantelitsa;
Andrikakou, Pinelopi;
Blakey, David C..
(2017)
Development and mechanism of small activating RNA targeting CEBPA, a novel therapeutic in clinical trials for liver cancer.
Molecular Therapy
Academic article
-
Olsen, Maria Belland;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Vinge, Leif Erik;
Alfsnes, Katrine;
Palibrk, Vuk.
(2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell reports
Academic article
-
Olsen, Lene Christin;
O'Reilly, Kally;
Liabakk, Nina-Beate;
Witter, Menno;
Sætrom, Pål.
(2017)
MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex.
Brain Structure and Function
Academic article
-
Skogholt, Anne Heidi;
Ryeng, Einar;
Erlandsen, Sten Even;
Skorpen, Frank;
Arentz Schønberg, Svanhild Margrethe;
Sætrom, Pål.
(2017)
Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks.
BMC Research Notes
Academic article
-
Mjelle, Robin;
Sellæg, Kjersti;
Sætrom, Pål;
Thommesen, Liv;
Sjursen, Wenche;
Hofsli, Eva.
(2017)
Identification of metastasis-associated microRNAs in serum from rectal cancer patients.
OncoTarget
Academic article
-
Landfors, Miriam;
Johansen, Jostein;
Aronsen, Jan Magnus;
Vågbø, Cathrine Broberg;
Doré, Louis C.;
He, Chuan.
(2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discovery
Academic article
2016
-
Yoon, Sorah;
Huang, Kai-Wen;
Reebye, Vikash;
Mintz, Paul;
Tien, Yu-Wen;
Lai, Hong-Shiee.
(2016)
Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth in Vivo.
Molecular Therapy
Academic article
-
Stracquadanio, Giovanni;
Wang, Xuting;
Wallace, Marsha D;
Grawenda, Anna M.;
Zhang, Ping;
Hewitt, Juliet.
(2016)
The importance of p53 pathway genetics in inherited and somatic cancer genomes.
Nature Reviews Cancer
Academic article
-
Langkilde, Ane;
Olsen, Lene Christin;
Sætrom, Pål;
Drabløs, Finn Sverre;
Besenbacher, Søren;
Raaby, Line.
(2016)
Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α.
PLOS ONE
Academic article
-
Robles, Ana I.;
Olsen, Karina Standahl;
Tsui, Dana W.T.;
Georgoulias, Vassilis;
Creaney, Jenette;
Dobra, Katalin.
(2016)
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway.
Journal of Translational Medicine
Academic article
-
Røe, Oluf Dimitri;
Mjelle, Robin;
Sætrom, Pål;
Andreassen, Trygve;
Bathen, Tone Frost;
Hveem, Kristian.
(2016)
Serum microRNAs/enriched pathways in lung cancer 1-4 years before diagnosis: A pilot study from the HUNT Biobank, Norway.
Journal of Clinical Oncology
Abstract
2015
-
Achar, Avinash;
Sætrom, Pål.
(2015)
RNA motif discovery: a computational overview.
Biology Direct
Academic literature review
-
Simpson, Melanie Rae;
Brede, Gaute;
Johansen, Jostein;
Johnsen, Roar;
Storrø, Ola;
Sætrom, Pål.
(2015)
Human breast milk miRNA, maternal probiotic supplementation and atopic dermatitis in offspring.
PLOS ONE
Academic article
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Academic article
-
Hansen, Maren Fridtjofsen;
Johansen, Jostein;
Bjørnevoll, Inga;
Sylvander, Anna Elisabeth;
Steinsbekk, Kristin Solum;
Sætrom, Pål.
(2015)
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine.
Familial Cancer
Academic article
-
Mjelle, Robin;
Hegre, Siv Anita;
Aas, Per Arne;
Slupphaug, Geir;
Drabløs, Finn;
Sætrom, Pål.
(2015)
Cell cycle regulation of human DNA repair and chromatin remodeling genes.
DNA Repair
Academic article
-
Hansen, Maren Fridtjofsen;
Johansen, Jostein;
Bjørnevoll, Inga;
Sylvander, Anna Elisabeth;
Steinsbekk, Kristin Solum;
Sætrom, Pål.
(2015)
A novel POLE variant, identified by exome sequencing, causes colorectal- and extra-colonic cancers.
Familial Cancer
Abstract
2014
-
Razick, Sabry;
Mocnik, Rok;
Thomas, Laurent;
Ryeng, Einar;
Drabløs, Finn;
Sætrom, Pål.
(2014)
The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences.
Database: The Journal of Biological Databases and Curation
Academic article
-
Reddy, MA;
Chen, Z;
Park, JT;
Wang, M;
Lanting, L;
Zhang, Q.
(2014)
Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA.
Diabetes
Academic article
-
Razick, Sabry;
Sætrom, Pål.
(2014)
The eGenVar Data Management System.
Software
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Academic article
-
Lange, LA;
Hu, Y;
Zhang, H;
Xue, C;
Schmidt, EM;
Tang, ZZ.
(2014)
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.
American Journal of Human Genetics
Academic article
-
Mintz, PJ;
Huang, KW;
Reebye, V;
Nteliopoulos, G;
Lai, HS;
Sætrom, Pål.
(2014)
Exploiting Human CD34(+) Stem Cell-conditioned Medium for Tissue Repair.
Molecular Therapy
Academic article
-
Reebye, V;
Sætrom, Pål;
Mintz, PJ;
Huang, KW;
Swiderski, P;
Peng, L.
(2014)
A Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis In Vivo.
Hepatology
Academic article
-
Thomas, Laurent;
Sætrom, Pål.
(2014)
Circular RNAs are depleted of polymorphisms at microRNA binding sites.
Bioinformatics
Academic article
-
Johnsen, Ingvild Bjellmo;
Løvstakken, Lasse;
Åsvold, Bjørn Olav;
Høydal, Morten;
Sætrom, Pål;
Bonnevie, Tora.
(2014)
NTNUs stjerneforskere.
Adresseavisen
Interview Journal
2013
-
Leung, A;
Trac, C;
Jin, W;
Lanting, L;
Akbany, A;
Sætrom, Pål.
(2013)
Novel Long Noncoding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle Cells.
Circulation Research
Academic article
-
Sætrom, Pål.
(2013)
Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and microRNA-like targeting.
Methods in molecular biology
Academic article
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Academic article
-
Diaz, Javier Pena;
Hegre, Siv Anita;
Anderssen, Endre;
Aas, Per Arne;
Mjelle, Robin;
Gilfillan, Gregor Duncan.
(2013)
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
Nucleic Acids Research (NAR)
Academic article
-
Chavali, Sreenivas;
Bruhn, Sören;
Tiemann, Katrin;
Sætrom, Pål;
Barrenäs, Fredrik;
Saito, Takaya.
(2013)
MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases.
RNA: A publication of the RNA Society
Academic article
-
Lundbæk, Marie B;
Sætrom, Pål.
(2013)
RNAi Screening and Assays.
John Wiley & Sons
Academic chapter/article/Conference paper
-
Reebye, Vikash;
Sætrom, Pål;
Mintz, Paul J;
Rossi, JJ;
Kasahara, Noriyuki;
Nteliopoulos, G.
(2013)
A short-activating RNA oligonucleotide targeting the islet β-cell transcriptional factor MafA in CD34(+) cells.
Molecular Therapy Nucleic Acids
Academic article
2012
-
Sjögren, A.-K.M.;
Barrenäs, Fredrik;
Muraro, Antonella;
Gustafsson, M;
Sætrom, Pål;
Wang, H.
(2012)
Monozygotic twins discordant for intermittent allergic rhinitis differ in mRNA and protein levels.
Allergy. European Journal of Allergy and Clinical Immunology
Academic article
-
Thomas, Laurent;
Sætrom, Pål.
(2012)
Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation.
PLoS Computational Biology
Academic article
-
Mintz, Paul J;
Sætrom, Pål;
Reebye, Vikash;
Lundbæk, Marie Benner;
Lao, Kaiqin;
Rossi, John J.
(2012)
MicroRNA-181a* Targets Nanog in a Subpopulation of CD34+ Cells Isolated From Peripheral Blood.
Molecular Therapy Nucleic Acids
Academic article
-
Voutila, J;
Sætrom, Pål;
Mintz, Paul J;
Sun, Guihua;
Alluin, Jessica;
Rossi, JJ.
(2012)
Gene expression profile changes after short-activating RNA-mediated induction of endogenous pluripotency factors in human mesenchymal stem cells.
Molecular Therapy Nucleic Acids
Academic article
-
Saito, Takaya;
Sætrom, Pål.
(2012)
Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments.
Silence
Academic article
-
Håndstad, Tony;
Rye, Morten Beck;
Mocnik, Rok;
Drabløs, Finn;
Sætrom, Pål.
(2012)
Cell-type specificity of ChIP-predicted transcription factor binding sites.
BMC Genomics
Academic article
2011
-
Rye, Morten Beck;
Sætrom, Pål;
Drabløs, Finn.
(2011)
A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs.
Nucleic Acids Research (NAR)
Academic article
-
Rye, Morten Beck;
Sætrom, Pål;
Håndstad, Tony;
Drabløs, Finn.
(2011)
Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements.
BMC Biology
Academic article
-
Lundbæk, Marie Benner;
Sætrom, Pål.
(2011)
Unconventional RNA interference – recent approaches to robust RNAi.
European Pharmaceutical Review
Article in business/trade/industry journal
-
Håndstad, Tony;
Rye, Morten Beck;
Drabløs, Finn;
Sætrom, Pål.
(2011)
A ChIP-Seq Benchmark Shows That Sequence Conservation Mainly Improves Detection of Strong Transcription Factor Binding Sites.
PLOS ONE
Academic article
-
Thomas, Laurent;
Saito, Takaya;
Sætrom, Pål.
(2011)
Inferring causative variants in microRNA target sites.
Nucleic Acids Research (NAR)
Academic article
2010
-
Saito, Takaya;
Sætrom, Pål.
(2010)
A two-step site and mRNA-level model for predicting microRNA targets.
BMC Bioinformatics
Academic article
-
Saito, Takaya;
Sætrom, Pål.
(2010)
MicroRNAs – targeting and target prediction.
New Biotechnology
Academic literature review
-
Ehsani, A;
Sætrom, Pål;
Zhang, J;
Alluin, J;
Li, HT;
Snøve, Ola.
(2010)
Rational Design of Micro-RNA-like Bifunctional siRNAs Targeting HIV and the HIV Coreceptor CCR5.
Molecular Therapy
Academic article
-
Tiemann, Katrin;
Höhn, Britta;
Ehsani, Ali;
Forman, Stephen J.;
Rossi, John J.;
Sætrom, Pål.
(2010)
Dual-targeting siRNAs.
RNA: A publication of the RNA Society
Academic article
-
Matveeva, OV;
Kang, YB;
Spiridonov, AN;
Sætrom, Pål;
Nemtsov, VA;
Ogurtsov, AY.
(2010)
Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design.
PLOS ONE
Academic article
2009
-
Sætrom, Pål;
Klein, Joern.
(2009)
miRNA and viral infections in vertebrates.
European Pharmaceutical Review
Academic literature review
-
Sætrom, Pål;
Biesinger, Jacob;
Li, Sierra M.;
Smith, David;
Thomas, Laurent Francois;
Majzoub, Karim.
(2009)
A Risk Variant in an miR-125b Binding Site in BMPR1B Is Associated with Breast Cancer Pathogenesis.
Cancer Research
Academic article
-
Snøve, Ola;
Sætrom, Pål.
(2009)
Animal MicroRNA gene prediction.
CRC Press
Academic chapter/article/Conference paper
2008
-
Kim, Daniel H.;
S�trom, P�l;
Sn�ve, Ola;
Rossi, John J..
(2008)
MicroRNA-directed transcriptional gene silencing in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Academic article
-
Soifer, Harris S.;
Sano, Masayuki;
Sakurai, Kumi;
Chomchan, Pritsana;
S�trom, P�l;
Sherman, Mark A..
(2008)
A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs.
Nucleic Acids Research (NAR)
Academic article
-
Aagaard, Lars;
Zhang, J;
von Eije, K J;
Li, H;
Saetrom, P;
S�trom, P�l.
(2008)
Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs.
Gene Therapy
Academic article
-
Lee, N.S.;
Kim, J.S.;
Cho, W.J.;
Lee, M.R.;
Steiner, R.;
Gompers, A..
(2008)
miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression.
Biochemical and Biophysical Research Communications - BBRC
Academic article
-
Smith, DD;
Sætrom, Pål;
Snøve, Ola;
Lundberg, C;
Rivas, GE;
Glackin, C.
(2008)
Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation.
BMC Bioinformatics
Academic article
2007
-
Sætrom, Pål;
Snøve, Ola;
Rossi, John J..
(2007)
Epigenetics and MicroRNAs.
Pediatric Research
Academic literature review
-
Soifer, Harris S.;
Rossi, John J.;
Sætrom, Pål.
(2007)
MicroRNAs in Disease and Potential Therapeutic Applications.
Molecular Therapy
Academic literature review
-
Von Eije, KJ;
Aagaard, Lars;
Sætrom, Pål;
Amarzguioui, M;
Li, HT;
Rossi, JJ.
(2007)
Prevention of HIV-1 viral escape upon RNAi treatment: Expression systems that generate multiple anti-HIV siRNAs.
Human Gene Therapy
Abstract
-
Helvik, Snorre Andreas;
Snøve, Ola;
Sætrom, Pål.
(2007)
Reliable prediction of Drosha processing sites improves microRNA gene prediction.
Bioinformatics
Academic article
-
Sætrom, Pål;
Snøve, Ola.
(2007)
Robust machine learning algorithms predict microRNA genes and targets.
Methods in Enzymology
Academic article
-
Håndstad, Tony;
Hestnes, Arne Johan Husebø;
Sætrom, Pål.
(2007)
Motif kernel generated by genetic programming improves remote homology and fold detection.
BMC Bioinformatics
Academic article
-
Matveeva, Olga;
Nechipurenko, Yury;
Rossi, Leo;
Moore, Barry;
Sætrom, Pål;
Ogurtsov, Aleksey Y..
(2007)
Comparison of approaches for rational siRNA design leading to a new efficient and transparent method.
Nucleic Acids Research (NAR)
Academic article
-
Sætrom, Pål;
Heale, Bret S.;
Snøve, Ola;
Aagaard, Lars;
Alluin, Jessica;
Rossi, John J..
(2007)
Distance constraints between microRNA target sites dictate efficacy and cooperativity.
Nucleic Acids Research (NAR)
Academic article
-
Sætrom, Pål.
(2007)
Hardware accelerated genetic programming for pattern mining in strings.
Doktoravhandlinger ved NTNU (197)
Doctoral dissertation
-
Sætrom, Pål;
Snøve, Ola.
(2007)
Machine learning predicts microRNA target sites.
Cambridge University Press
Academic chapter/article/Conference paper
-
Sætrom, Pål;
Birkeland, Olaf René;
Snøve, Ola.
(2007)
Boosting Improves Stability and Accuracy of Genetic Programming in Biological Sequence Classification.
Springer
Academic chapter/article/Conference paper
2006
-
Snøve, Ola;
Sætrom, Pål.
(2006)
Nobelpris for RNA-interferens.
Tidsskrift for Den norske legeforening
Editorial
-
Helvik, Snorre Andreas;
Snøve, Ola;
Sætrom, Pål.
(2006)
Reliable prediction of Drosha processing sites improves microRNA gene prediction.
Bioinformatics
Academic article
-
Birkeland, Olaf René;
Snøve, Ola;
Halaas, Arne;
Nedland, Magnar;
Sætrom, Pål.
(2006)
The petacomp Machine - A MIMD Cluster for parallel pattern-mining.
Proceedings IEEE International Conference on Cluster Computing
Academic article
2005
-
Sætrom, Pål.
(2005)
Hardware accelerated genetic programming for pattern mining in strings.
Doktoravhandlinger ved NTNU (2005:197)
Doctoral dissertation
Journal publications
-
Bordin, Diana Lilian;
Grooms, Kayla Mae;
Montaldo, Nicola Pietro;
Fordyce Martin, Sarah L.;
Sætrom, Pål;
Samson, Leona D..
(2024)
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory.
DNA Repair
Academic article
-
Neurauter, Christine Gran;
Pannone, Marco;
Sousa, Mirta;
Wang, Wei;
Kusnierczyk, Anna;
Luna, Luisa.
(2024)
Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells.
Free Radical Biology & Medicine
Academic article
-
Glærum, Ingvild Lynneberg;
Dunville, Keagan;
Moan, Kristian Magnus;
Krause, Maike;
Montaldo, Nicola Pietro;
Kirikae, Hinaco.
(2024)
Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit.
Development
Academic article
-
Bugaj, Anna Maria;
Kunath, Nicolas;
Saasen, Vidar Langseth;
Fernandez-Berrocal, Marion S.;
Vankova, Ana;
Sætrom, Pål.
(2024)
Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion.
Progress in Neurobiology
Academic article
-
Potenza, Maria Letizia;
Blankvoort, Stefan Matthias Adriaan;
Carvalho, Miguel;
Grimstvedt, Joachim Schweder;
Di Maria, Valentina;
Moan, Kristian Magnus.
(2024)
Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection.
Frontiers in Neuroscience
Academic article
-
Olsen, Lene Christin;
Galler, Meital;
Witter, Menno Peter;
Sætrom, Pål;
O'Reilly, Kally C.
(2023)
Transcriptional development of the hippocampus and the dorsal–intermediate–ventral axis in rats.
Hippocampus
Academic article
-
Rocque, Mariève;
Leipart, Vilde;
Singh, Ashish Kumar;
Mur, Pilar;
Olsen, Maren Fridtjofsen;
Engebretsen, Lars Fredri.
(2023)
Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk.
Molecular Genetics and Genomics
Academic article
-
Baiju, Nikita;
Rylander, Karin Charlotta Maria;
Sætrom, Pål;
Sandanger, Torkjel M;
Nøst, Therese Haugdahl.
(2023)
Associations of gene expression in blood with BMI and weight changes among women in the Norwegian Women and Cancer postgenome cohort.
Obesity
Academic article
-
Lefol, Yohan Pierre;
Korfage, Tom;
Mjelle, Robin;
Prebensen, Christian Haugland;
Lüders, Torben;
Müller, Bruno.
(2023)
TiSA: TimeSeriesAnalysis - A pipeline for the analysis of longitudinal transcriptomics data.
NAR Genomics and Bioinformatics
Academic article
-
Konstantinidis, Ioannis;
Sætrom, Pål;
Fernandes, Jorge Manuel de Oliveira.
(2023)
Genome-wide hydroxymethylation profiles in liver of female Nile tilapia with distinct growth performance.
Scientific Data
Academic article
-
Konstantinidis, Ioannis;
Sætrom, Pål;
Brieuc, Marine Servane Ono;
Jakobsen, Kjetill Sigurd;
Liedtke, Hannes;
Pohlmann, Caroline.
(2023)
DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden.
Epigenetics
Academic article
-
Urbarova, Ilona Halva;
Skogholt, Anne Heidi;
Sun, Yi-Qian;
Mai, Xiao-Mei;
Grønberg, Bjørn Henning;
Sandanger, Torkjel Manning.
(2023)
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis.
Scientific Reports
Academic article
-
Lien, Hilde Julie Tokle;
Pedersen, Tina Therese;
Jakobsen, Bente;
Flatberg, Arnar;
Chawla, Konika;
Sætrom, Pål.
(2023)
Single-cell resolution of longitudinal blood transcriptome profiles in rheumatoid arthritis, systemic lupus erythematosus and healthy control pregnancies.
Annals of the Rheumatic Diseases
Academic article
-
Andersson-Rusch, Clara Leticia;
Quist-Løkken, Ingrid;
Sætrom, Pål;
Beisvag, Vidar;
Rolinski, Milosz;
Aas, Per Arne.
(2023)
Genome-Wide CRISPR/Cas9 Knock-out Screen Identifies Apoptosis-Relevant Genes in Multiple Myeloma.
Blood
Abstract
-
Moholdt, Trine;
Ashby, Emily Rose;
Tømmerdal, Karina Hammer;
Lemoine, Maeliss Cynthia Chloe;
Holm, Rebecca Lyng;
Sætrom, Pål.
(2023)
Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial
.
BMJ Open sport & exercise medicine
Academic article
-
Pettersen, Caroline Hild Hakvåg;
Samdal, Helle;
Sætrom, Pål;
Wibe, Arne;
Hermansen, Erland;
Schønberg, Svanhild Margrethe Arentz.
(2023)
The Salmon Oil OmeGo Reduces Viability of Colorectal Cancer Cells and Potentiates the Anti-Cancer Effect of 5-FU.
Marine Drugs
Academic article
-
Røe, Oluf Dimitri;
Fotopoulos, I;
Nguyen, Olav Toai Duc;
Nøst, Therese Haugdahl;
Markaki, M;
Lagani, Vincenzo.
(2022)
Common MicroRNAs in Pre-diagnostic Serum Associated with Lung Cancer in Two Cohorts up to Eight Years Before Diagnosis: A HUNT Study.
Journal of Thoracic Oncology
Abstract
-
Nøst, Therese Haugdahl;
Skogholt, Anne Heidi;
Urbarova, Ilona Halva;
Mjelle, Robin;
Paulsen, Erna-Elise;
Dønnem, Tom.
(2022)
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer.
Molecular Oncology
Academic article
-
Grapotte, Mathys;
Saraswat, Manu;
Bessière, Chloé;
Menichelli, Christophe;
Ramilowski, Jordan A.;
Severin, Jessica.
(2022)
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7).
Nature Communications
Errata
-
Solvin, Åshild Øksnevad;
Chawla, Konika;
Olsen, Lene Christin;
Hegre, Siv Anita;
Danielsen, Kjersti;
Jenssen, Marita.
(2021)
MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity.
Experimental Dermatology
Academic article
-
Konstantinidis, Ioannis;
Anastasiadi, Dafni;
Sætrom, Pål;
Nedoluzhko, Artem;
Mjelle, Robin;
Podgorniak, Tomasz.
(2021)
Epigenetic mapping of the somatotropic axis in Nile tilapia reveals differential DNA hydroxymethylation marks associated with growth.
Genomics
Academic article
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology
Academic article
-
Hegre, Siv Anita;
Samdal, Helle;
Klima, Antonin;
Stovner, Endre Bakken;
Nørsett, Kristin Gabestad;
Liabakk, Nina-Beate.
(2021)
Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation.
Scientific Reports
Academic article
-
Tingö, Lina;
Ahlberg, Emelie;
Johansson, Lovisa;
Pedersen, Sindre Andre;
Chawla, Konika;
Sætrom, Pål.
(2021)
Non-coding RNAs in human breast milk: A systematic review.
Frontiers in Immunology
Academic literature review
-
Samdal, Helle;
Olsen, Lene Christin;
Grøn, Knut Sverre;
Røyset, Elin Synnøve;
Høiem, Therese Stork;
Nervik, Ingunn.
(2021)
Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids.
Biomedicines
Academic article
-
Baiju, Nikita;
Sandanger, Torkjel M;
Sætrom, Pål;
Nøst, Therese Haugdahl.
(2021)
Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort.
Scientific Reports
Academic article
-
Rolinski, Milosz;
Montaldo, Nicola Pietro;
Aksu, Merdane Ezgi;
Martin, Sarah Fordyce;
Brambilla, Alessandro;
Kunath, Nicolas.
(2021)
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation.
Nucleic Acids Research (NAR)
Academic article
-
Konstantinidis, Ioannis;
Sætrom, Pål;
Mjelle, Robin;
Nedoluzhko, Artem;
Robledo, Diego;
Fernandes, Jorge Manuel de Oliveira.
(2020)
Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication.
Epigenetics
Academic article
-
Sarker, Debashis;
Plummer, Ruth;
Meyer, Tim;
Sodergren, Mikael H;
Basu, Bristi;
Chee, Cheng Ean.
(2020)
MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial.
Clinical Cancer Research
Academic article
-
Mjelle, Robin;
Aass, Kristin Roseth;
Sjursen, Wenche;
Hofsli, Eva;
Sætrom, Pål.
(2020)
sMETASeq: combined profiling of microbiota and host small RNAs.
iScience
Academic article
-
Huang, Kai-Wen;
Reebye, Vikash;
Czysz, Katherine;
Ciriello, Simona;
Dorman, Stephanie;
Reccia, Isabella.
(2020)
Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile.
Molecular Therapy Nucleic Acids
Academic article
-
Stovner, Endre Bakken;
Sætrom, Pål.
(2019)
PyRanges: efficient comparison of genomic intervals in Python.
Bioinformatics
Academic article
-
Solvin, Åshild Øksnevad;
Chawla, Konika;
Olsen, Lene Christin;
Danielsen, Kjersti;
Jenssen, Marita;
Furberg, Anne-Sofie.
(2019)
Differentially Expressed miRNAs and mRNAs in Psoriatic Skin.
Journal of Investigative Dermatology
Abstract
-
Solvin, Åshild Øksnevad;
Chawla, Konika;
Olsen, Lene Christin;
Danielsen, Kjersti;
Jenssen, Marita;
Furberg, Anne-Sofie.
(2019)
Combined mRNA and miRNA Analysis of Psoriatic Skin.
Forum for Nordic Dermato-Venereology
Abstract
-
Larose, Tricia L;
Sætrom, Pål;
Martinussen, Marit;
Skogseth, Haakon;
Sandanger, Torkjel M;
Scélo, Ghislaine.
(2019)
In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol.
Journal of Public Health Research
Academic article
-
Mjelle, Robin;
Sjursen, Wenche;
Thommesen, Liv;
Sætrom, Pål;
Hofsli, Eva.
(2019)
Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location.
BMC Cancer
Academic article
-
Zhao, Xiaoyang;
Reebye, Vikash;
Hitchen, Paul;
Fan, Jia;
Jiang, Hongchi;
Sætrom, Pål.
(2019)
Mechanisms involved in the activation of C/EBP? by small activating RNA in hepatocellular carcinoma.
Oncogene
Academic article
-
Kroustallaki, Pinelopi;
Lirussi, Lisa;
Carracedo Huroz, Sergio;
You, Panpan;
Esbensen, Qin Ying;
Götz, Alexandra.
(2019)
SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing.
Cell reports
Academic article
-
Mjelle, Robin;
Dima, Simona O;
Bacalbasa, Nicolae;
Chawla, Konika;
Sorop, Andrei;
Cucu, Dana.
(2019)
Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients.
BMC Cancer
Academic article
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Academic article
-
Stovner, Endre Bakken;
Sætrom, Pål.
(2019)
epic2 efficiently finds diffuse domains in ChIP-seq data .
Bioinformatics
Academic article
-
Brian, Ben F;
Jolicoeur, Adrienne S;
Guerrero, Candace R.;
Nunez, Myra G;
Sychev, Zoi E;
Hegre, Siv Anita.
(2019)
Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.
eLIFE
Academic article
-
Reebye, Vikash;
Huang, Kai-Wen;
Lin, Vivian;
Jarvis, Sheba;
Cutilas, Pedro;
Dorman, Stephanie.
(2018)
Gene activation of CEBPA using saRNA: Preclinical studies of the first in human saRNA drug candidate for liver cancer.
Oncogene
Academic article
-
de rie, D;
Abugesaissa, I;
Alam, T;
Arner, E;
Ashoor, H;
Åström, G.
(2017)
An integrated expression atlas of miRNAs and their promoters in human and mouse.
Nature Biotechnology
Academic article
-
Voutila, Jon;
Reebye, Vikash;
Roberts, Thomas C.;
Protopapa, Pantelitsa;
Andrikakou, Pinelopi;
Blakey, David C..
(2017)
Development and mechanism of small activating RNA targeting CEBPA, a novel therapeutic in clinical trials for liver cancer.
Molecular Therapy
Academic article
-
Olsen, Maria Belland;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Vinge, Leif Erik;
Alfsnes, Katrine;
Palibrk, Vuk.
(2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell reports
Academic article
-
Olsen, Lene Christin;
O'Reilly, Kally;
Liabakk, Nina-Beate;
Witter, Menno;
Sætrom, Pål.
(2017)
MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex.
Brain Structure and Function
Academic article
-
Skogholt, Anne Heidi;
Ryeng, Einar;
Erlandsen, Sten Even;
Skorpen, Frank;
Arentz Schønberg, Svanhild Margrethe;
Sætrom, Pål.
(2017)
Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks.
BMC Research Notes
Academic article
-
Mjelle, Robin;
Sellæg, Kjersti;
Sætrom, Pål;
Thommesen, Liv;
Sjursen, Wenche;
Hofsli, Eva.
(2017)
Identification of metastasis-associated microRNAs in serum from rectal cancer patients.
OncoTarget
Academic article
-
Landfors, Miriam;
Johansen, Jostein;
Aronsen, Jan Magnus;
Vågbø, Cathrine Broberg;
Doré, Louis C.;
He, Chuan.
(2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discovery
Academic article
-
Yoon, Sorah;
Huang, Kai-Wen;
Reebye, Vikash;
Mintz, Paul;
Tien, Yu-Wen;
Lai, Hong-Shiee.
(2016)
Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth in Vivo.
Molecular Therapy
Academic article
-
Stracquadanio, Giovanni;
Wang, Xuting;
Wallace, Marsha D;
Grawenda, Anna M.;
Zhang, Ping;
Hewitt, Juliet.
(2016)
The importance of p53 pathway genetics in inherited and somatic cancer genomes.
Nature Reviews Cancer
Academic article
-
Langkilde, Ane;
Olsen, Lene Christin;
Sætrom, Pål;
Drabløs, Finn Sverre;
Besenbacher, Søren;
Raaby, Line.
(2016)
Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α.
PLOS ONE
Academic article
-
Robles, Ana I.;
Olsen, Karina Standahl;
Tsui, Dana W.T.;
Georgoulias, Vassilis;
Creaney, Jenette;
Dobra, Katalin.
(2016)
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway.
Journal of Translational Medicine
Academic article
-
Røe, Oluf Dimitri;
Mjelle, Robin;
Sætrom, Pål;
Andreassen, Trygve;
Bathen, Tone Frost;
Hveem, Kristian.
(2016)
Serum microRNAs/enriched pathways in lung cancer 1-4 years before diagnosis: A pilot study from the HUNT Biobank, Norway.
Journal of Clinical Oncology
Abstract
-
Achar, Avinash;
Sætrom, Pål.
(2015)
RNA motif discovery: a computational overview.
Biology Direct
Academic literature review
-
Simpson, Melanie Rae;
Brede, Gaute;
Johansen, Jostein;
Johnsen, Roar;
Storrø, Ola;
Sætrom, Pål.
(2015)
Human breast milk miRNA, maternal probiotic supplementation and atopic dermatitis in offspring.
PLOS ONE
Academic article
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Academic article
-
Hansen, Maren Fridtjofsen;
Johansen, Jostein;
Bjørnevoll, Inga;
Sylvander, Anna Elisabeth;
Steinsbekk, Kristin Solum;
Sætrom, Pål.
(2015)
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine.
Familial Cancer
Academic article
-
Mjelle, Robin;
Hegre, Siv Anita;
Aas, Per Arne;
Slupphaug, Geir;
Drabløs, Finn;
Sætrom, Pål.
(2015)
Cell cycle regulation of human DNA repair and chromatin remodeling genes.
DNA Repair
Academic article
-
Hansen, Maren Fridtjofsen;
Johansen, Jostein;
Bjørnevoll, Inga;
Sylvander, Anna Elisabeth;
Steinsbekk, Kristin Solum;
Sætrom, Pål.
(2015)
A novel POLE variant, identified by exome sequencing, causes colorectal- and extra-colonic cancers.
Familial Cancer
Abstract
-
Razick, Sabry;
Mocnik, Rok;
Thomas, Laurent;
Ryeng, Einar;
Drabløs, Finn;
Sætrom, Pål.
(2014)
The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences.
Database: The Journal of Biological Databases and Curation
Academic article
-
Reddy, MA;
Chen, Z;
Park, JT;
Wang, M;
Lanting, L;
Zhang, Q.
(2014)
Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA.
Diabetes
Academic article
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Academic article
-
Lange, LA;
Hu, Y;
Zhang, H;
Xue, C;
Schmidt, EM;
Tang, ZZ.
(2014)
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.
American Journal of Human Genetics
Academic article
-
Mintz, PJ;
Huang, KW;
Reebye, V;
Nteliopoulos, G;
Lai, HS;
Sætrom, Pål.
(2014)
Exploiting Human CD34(+) Stem Cell-conditioned Medium for Tissue Repair.
Molecular Therapy
Academic article
-
Reebye, V;
Sætrom, Pål;
Mintz, PJ;
Huang, KW;
Swiderski, P;
Peng, L.
(2014)
A Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis In Vivo.
Hepatology
Academic article
-
Thomas, Laurent;
Sætrom, Pål.
(2014)
Circular RNAs are depleted of polymorphisms at microRNA binding sites.
Bioinformatics
Academic article
-
Johnsen, Ingvild Bjellmo;
Løvstakken, Lasse;
Åsvold, Bjørn Olav;
Høydal, Morten;
Sætrom, Pål;
Bonnevie, Tora.
(2014)
NTNUs stjerneforskere.
Adresseavisen
Interview Journal
-
Leung, A;
Trac, C;
Jin, W;
Lanting, L;
Akbany, A;
Sætrom, Pål.
(2013)
Novel Long Noncoding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle Cells.
Circulation Research
Academic article
-
Sætrom, Pål.
(2013)
Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and microRNA-like targeting.
Methods in molecular biology
Academic article
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Academic article
-
Diaz, Javier Pena;
Hegre, Siv Anita;
Anderssen, Endre;
Aas, Per Arne;
Mjelle, Robin;
Gilfillan, Gregor Duncan.
(2013)
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
Nucleic Acids Research (NAR)
Academic article
-
Chavali, Sreenivas;
Bruhn, Sören;
Tiemann, Katrin;
Sætrom, Pål;
Barrenäs, Fredrik;
Saito, Takaya.
(2013)
MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases.
RNA: A publication of the RNA Society
Academic article
-
Reebye, Vikash;
Sætrom, Pål;
Mintz, Paul J;
Rossi, JJ;
Kasahara, Noriyuki;
Nteliopoulos, G.
(2013)
A short-activating RNA oligonucleotide targeting the islet β-cell transcriptional factor MafA in CD34(+) cells.
Molecular Therapy Nucleic Acids
Academic article
-
Sjögren, A.-K.M.;
Barrenäs, Fredrik;
Muraro, Antonella;
Gustafsson, M;
Sætrom, Pål;
Wang, H.
(2012)
Monozygotic twins discordant for intermittent allergic rhinitis differ in mRNA and protein levels.
Allergy. European Journal of Allergy and Clinical Immunology
Academic article
-
Thomas, Laurent;
Sætrom, Pål.
(2012)
Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation.
PLoS Computational Biology
Academic article
-
Mintz, Paul J;
Sætrom, Pål;
Reebye, Vikash;
Lundbæk, Marie Benner;
Lao, Kaiqin;
Rossi, John J.
(2012)
MicroRNA-181a* Targets Nanog in a Subpopulation of CD34+ Cells Isolated From Peripheral Blood.
Molecular Therapy Nucleic Acids
Academic article
-
Voutila, J;
Sætrom, Pål;
Mintz, Paul J;
Sun, Guihua;
Alluin, Jessica;
Rossi, JJ.
(2012)
Gene expression profile changes after short-activating RNA-mediated induction of endogenous pluripotency factors in human mesenchymal stem cells.
Molecular Therapy Nucleic Acids
Academic article
-
Saito, Takaya;
Sætrom, Pål.
(2012)
Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments.
Silence
Academic article
-
Håndstad, Tony;
Rye, Morten Beck;
Mocnik, Rok;
Drabløs, Finn;
Sætrom, Pål.
(2012)
Cell-type specificity of ChIP-predicted transcription factor binding sites.
BMC Genomics
Academic article
-
Rye, Morten Beck;
Sætrom, Pål;
Drabløs, Finn.
(2011)
A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs.
Nucleic Acids Research (NAR)
Academic article
-
Rye, Morten Beck;
Sætrom, Pål;
Håndstad, Tony;
Drabløs, Finn.
(2011)
Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements.
BMC Biology
Academic article
-
Lundbæk, Marie Benner;
Sætrom, Pål.
(2011)
Unconventional RNA interference – recent approaches to robust RNAi.
European Pharmaceutical Review
Article in business/trade/industry journal
-
Håndstad, Tony;
Rye, Morten Beck;
Drabløs, Finn;
Sætrom, Pål.
(2011)
A ChIP-Seq Benchmark Shows That Sequence Conservation Mainly Improves Detection of Strong Transcription Factor Binding Sites.
PLOS ONE
Academic article
-
Thomas, Laurent;
Saito, Takaya;
Sætrom, Pål.
(2011)
Inferring causative variants in microRNA target sites.
Nucleic Acids Research (NAR)
Academic article
-
Saito, Takaya;
Sætrom, Pål.
(2010)
A two-step site and mRNA-level model for predicting microRNA targets.
BMC Bioinformatics
Academic article
-
Saito, Takaya;
Sætrom, Pål.
(2010)
MicroRNAs – targeting and target prediction.
New Biotechnology
Academic literature review
-
Ehsani, A;
Sætrom, Pål;
Zhang, J;
Alluin, J;
Li, HT;
Snøve, Ola.
(2010)
Rational Design of Micro-RNA-like Bifunctional siRNAs Targeting HIV and the HIV Coreceptor CCR5.
Molecular Therapy
Academic article
-
Tiemann, Katrin;
Höhn, Britta;
Ehsani, Ali;
Forman, Stephen J.;
Rossi, John J.;
Sætrom, Pål.
(2010)
Dual-targeting siRNAs.
RNA: A publication of the RNA Society
Academic article
-
Matveeva, OV;
Kang, YB;
Spiridonov, AN;
Sætrom, Pål;
Nemtsov, VA;
Ogurtsov, AY.
(2010)
Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design.
PLOS ONE
Academic article
-
Sætrom, Pål;
Klein, Joern.
(2009)
miRNA and viral infections in vertebrates.
European Pharmaceutical Review
Academic literature review
-
Sætrom, Pål;
Biesinger, Jacob;
Li, Sierra M.;
Smith, David;
Thomas, Laurent Francois;
Majzoub, Karim.
(2009)
A Risk Variant in an miR-125b Binding Site in BMPR1B Is Associated with Breast Cancer Pathogenesis.
Cancer Research
Academic article
-
Kim, Daniel H.;
S�trom, P�l;
Sn�ve, Ola;
Rossi, John J..
(2008)
MicroRNA-directed transcriptional gene silencing in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Academic article
-
Soifer, Harris S.;
Sano, Masayuki;
Sakurai, Kumi;
Chomchan, Pritsana;
S�trom, P�l;
Sherman, Mark A..
(2008)
A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs.
Nucleic Acids Research (NAR)
Academic article
-
Aagaard, Lars;
Zhang, J;
von Eije, K J;
Li, H;
Saetrom, P;
S�trom, P�l.
(2008)
Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs.
Gene Therapy
Academic article
-
Lee, N.S.;
Kim, J.S.;
Cho, W.J.;
Lee, M.R.;
Steiner, R.;
Gompers, A..
(2008)
miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression.
Biochemical and Biophysical Research Communications - BBRC
Academic article
-
Smith, DD;
Sætrom, Pål;
Snøve, Ola;
Lundberg, C;
Rivas, GE;
Glackin, C.
(2008)
Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation.
BMC Bioinformatics
Academic article
-
Sætrom, Pål;
Snøve, Ola;
Rossi, John J..
(2007)
Epigenetics and MicroRNAs.
Pediatric Research
Academic literature review
-
Soifer, Harris S.;
Rossi, John J.;
Sætrom, Pål.
(2007)
MicroRNAs in Disease and Potential Therapeutic Applications.
Molecular Therapy
Academic literature review
-
Von Eije, KJ;
Aagaard, Lars;
Sætrom, Pål;
Amarzguioui, M;
Li, HT;
Rossi, JJ.
(2007)
Prevention of HIV-1 viral escape upon RNAi treatment: Expression systems that generate multiple anti-HIV siRNAs.
Human Gene Therapy
Abstract
-
Helvik, Snorre Andreas;
Snøve, Ola;
Sætrom, Pål.
(2007)
Reliable prediction of Drosha processing sites improves microRNA gene prediction.
Bioinformatics
Academic article
-
Sætrom, Pål;
Snøve, Ola.
(2007)
Robust machine learning algorithms predict microRNA genes and targets.
Methods in Enzymology
Academic article
-
Håndstad, Tony;
Hestnes, Arne Johan Husebø;
Sætrom, Pål.
(2007)
Motif kernel generated by genetic programming improves remote homology and fold detection.
BMC Bioinformatics
Academic article
-
Matveeva, Olga;
Nechipurenko, Yury;
Rossi, Leo;
Moore, Barry;
Sætrom, Pål;
Ogurtsov, Aleksey Y..
(2007)
Comparison of approaches for rational siRNA design leading to a new efficient and transparent method.
Nucleic Acids Research (NAR)
Academic article
-
Sætrom, Pål;
Heale, Bret S.;
Snøve, Ola;
Aagaard, Lars;
Alluin, Jessica;
Rossi, John J..
(2007)
Distance constraints between microRNA target sites dictate efficacy and cooperativity.
Nucleic Acids Research (NAR)
Academic article
-
Snøve, Ola;
Sætrom, Pål.
(2006)
Nobelpris for RNA-interferens.
Tidsskrift for Den norske legeforening
Editorial
-
Helvik, Snorre Andreas;
Snøve, Ola;
Sætrom, Pål.
(2006)
Reliable prediction of Drosha processing sites improves microRNA gene prediction.
Bioinformatics
Academic article
-
Birkeland, Olaf René;
Snøve, Ola;
Halaas, Arne;
Nedland, Magnar;
Sætrom, Pål.
(2006)
The petacomp Machine - A MIMD Cluster for parallel pattern-mining.
Proceedings IEEE International Conference on Cluster Computing
Academic article
Part of book/report
-
Sarno, Antonio;
Sætrom, Pål;
Kavli, Bodil Merete;
Pettersen, Henrik Sahlin.
(2018)
Genomic Uracil and Cancer.
World Scientific
Chapter
-
Lundbæk, Marie B;
Sætrom, Pål.
(2013)
RNAi Screening and Assays.
John Wiley & Sons
Academic chapter/article/Conference paper
-
Snøve, Ola;
Sætrom, Pål.
(2009)
Animal MicroRNA gene prediction.
CRC Press
Academic chapter/article/Conference paper
-
Sætrom, Pål;
Snøve, Ola.
(2007)
Machine learning predicts microRNA target sites.
Cambridge University Press
Academic chapter/article/Conference paper
-
Sætrom, Pål;
Birkeland, Olaf René;
Snøve, Ola.
(2007)
Boosting Improves Stability and Accuracy of Genetic Programming in Biological Sequence Classification.
Springer
Academic chapter/article/Conference paper
Report
-
Sætrom, Pål.
(2007)
Hardware accelerated genetic programming for pattern mining in strings.
Doktoravhandlinger ved NTNU (197)
Doctoral dissertation
-
Sætrom, Pål.
(2005)
Hardware accelerated genetic programming for pattern mining in strings.
Doktoravhandlinger ved NTNU (2005:197)
Doctoral dissertation
PRODUKT
-
Razick, Sabry;
Sætrom, Pål.
(2014)
The eGenVar Data Management System.
Software
Teaching
Courses
Knowledge Transfer
2023
-
Academic lectureHaslene-Hox, Hanne; Chahal, Aman Singh; Arlov, Øystein; Øynebråten, Ingrid Ryge; Zaytseva-Zotova, Daria; Vikenes, Anette. (2023) Alginate hydrogel characteristics regulate fibroblast biology. Norsk Biokjemisk selskap Norsk Biokjemisk selskaps kontaktmøte 2023 , Storefjell 2023-01-19 - 2023-01-22
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PosterZaytseva-Zotova, Daria; Haslene-Hox, Hanne; Arlov, Øystein; Hoel, Andrea Draget; Mjelle, Robin; Strand, Wenche. (2023) Alginate hydrogel characteristics regulate NHDF biology. ESB European Society for Biomaterials , Davos, Switzerland 2023-09-03 - 2023-09-08
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PosterStrand, Berit Løkensgard; Haslene-Hox, Hanne; Sætrom, Pål; Zaytseva-Zotova, Daria; Mjelle, Robin; Arlov, Øystein. (2023) Alginate hydrogel characteristics regulate NHDF biology. Scandinavian Society of Biomaterials ScSB 2023 , Røros, Norway 2023-03-21 - 2023-08-24
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PosterAndersson-Rusch, Clara Leticia; Quist-Løkken, Ingrid; Sætrom, Pål; Beisvag, Vidar; Rolinski, Milosz; Møen, Johanna. (2023) Genome-Wide CRISPR/Cas9 Knock-out Screen Identifies Apoptosis-Relevant Genes in Multiple Myeloma. American Society of Hematology 65th ASH Annual Meeting and Exposition 2023-12-09 - 2023-12-12
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PosterBösl, Korbinian; Bianchini, Federico; Fatima, Nazeefa; Keyvani, Pedram A; Kalhovd, Siri; Tekle, Kidane M. (2023) End-to-end data management tool assembly for Norwegian life scientist. ELIXIR ELIXIR All Hands 2023 , Dublin 2023-06-06 -
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PosterLund-Hanssen, Charlotte; Olsen, Lene Christin; Thomas, Laurent Francois; O'Reilly, Kally; Witter, Menno Peter; Sætrom, Pål. (2023) The Conserved Expression of Long Non-Coding RNAs in the Entorhinal Cortex During Postnatal Development. EMBO Gene Regulatory Mechanisms in Neural Fate Decisions , Alicante, Spain 2023-09-07 - 2023-09-10
2022
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PosterNøst, Therese Haugdahl; Urbarova, Ilona Halva; Skogholt, Anne Heidi; Mjelle, Robin; Paulsen, Erna Elise; Dønnem, Tom. (2022) Increased levels of mRNAs and miRNAs associated with imminent and advanced lung cancer. The International Association for the Study of Lung Cancer IASLC 2022 World Conference on Lung Cancer , Wien 2022-08-06 - 2022-08-09
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LectureChahal, Aman S; Strand, Berit Løkensgard; Haslene-Hox, Hanne; Sætrom, Pål. (2022) An out of body experience: Cell culture in 3D. Digital Life Norway Forskning for folket , Trondheim 2022-10-19 - 2022-10-19
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PosterLund-Hanssen, Charlotte; Olsen, Lene Christin; Thomas, Laurent Francois; Sætrom, Pål. (2022) The Conserved Expression of Long Non-Coding RNAs in the Entorhinal Cortex During Postnatal Development. NORBIS, MedBioInfo 8th Annual NORBIS Conference , Rosendal, Norway 2022-10-24 - 2022-10-28
2021
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Academic lectureNøst, Therese Haugdahl; Skogholt, Anne Heidi; Mjelle, Robin; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål. (2021) microRNA levels in serum at diagnosis are predictive for lung cancer. Kreftforeningen, Nasjonal ekspertgruppe for lungekreftforskning Forskningskonferansen for Kreftforeningens nasjonale ekspertgruppe for lungekreftforskning , Gardermoen 2021-08-26 - 2021-08-27
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Academic lectureKonstantinidis, Ioannis; Sætrom, Pål; Brieuc, Marine Servane Ono; Jakobsen, Kjetill Sigurd; Liedtke, Hannes; Pohlmann, Caroline. (2021) DNA hydroxymethylation is linked to higher growth rate in Nile tilapia. X FIRMA 2021 2021-02-07 - 2021-02-12
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Academic lectureKonstantinidis, Ioannis; Sætrom, Pål; Liedtke, Hannes; Pohlmann, Caroline; Tsoulia, Thomais; Fernandes, Jorge Manuel de Oliveira. (2021) Differences in liver DNA hydroxymethylation reflect the growth phenotype. 6th Genomics in Aquaculture Symposium 2021-05-05 - 2021-05-07
2019
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Academic lectureSolvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Danielsen, Kjersti; Jenssen, Marita; Furberg, Anne-Sofie. (2019) Combined mRNA and miRNA Analysis of Psoriatic Skin. The 34th Nordic Congress of Dermatology & Venereology , Gøteborg 2019-05-08 - 2019-05-10
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LectureZaytseva-Zotova, Daria; Ruohola, Rita; Strand, Wenche Iren; Akbarzadeh, Anita; Haslene-Hox, Hanne; Arlov, Øystein. (2019) Alginate hydrogels with tailored mechanical and biological properties for 3D fibroblast culture . DigitalLife 2019 2019-09-05 - 2019-09-06
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PosterSolvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Danielsen, Kjersti; Jenssen, Marita; Furberg, Anne-Sofie. (2019) Differentially Expressed miRNAs and mRNAs in Psoriatic Skin. European Society for Dermatological Research European Society for Dermatological Research Annual Meeting , Bordeaux 2019-09-18 - 2019-09-21
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PosterLøset, Mari; Solvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Danielsen, Kjersti; Jenssen, Marita. (2019) Differentially Expressed miRNAs and mRNAs in Psoriatic Skin . American Society for Human Genetics American Society for Human Genetics Annual Meeting , Houston, TX 2019-10-15 - 2019-10-19
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PosterSkogholt, Anne Heidi; Jensen, Espen Drevland; Ryeng, Einar; Grønberg, Bjørn Henning; Skorpen, Frank; Schønberg, Svanhild Margrethe Arentz. (2019) Robust messenger RNA (mRNA) markers in blood for lung cancer diagnosis. ASHG , Houston 2019-10-18 - 2019-10-18
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Academic lectureKonstantinidis, Ioannis; Sætrom, Pål; Fernandes, Jorge Manuel de Oliveira. (2019) Tissue-specific hydroxymethylome profiles of Nile tilapia Oreochromis niloticus at single nucleotide resolution. Aquaculture 2019 2019-03-07 - 2019-03-11
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PosterSamdal, Helle; Hegre, Siv Anita; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate. (2019) Functional evaluation of long non-coding RNAs with potential roles during cell replication. Keystone symposia on molecular and cellular biology Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics , Whistler 2019-02-24 - 2019-02-28
2018
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PosterBlankvoort, Stefan; Thomas, Laurent; Witter, Menno; Sætrom, Pål; cotney, Justin; Kentros, Clifford. (2018) The marked diversity of unique cortical enhancers enables neuron-specific tools by Enhancer-Driven Gene Expression (EDGE). Federation of European Neuroscience FENS 2018 , Berlin 2018-07-07 - 2018-07-11
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PosterHalaas, Øyvind; Sætrom, Pål; Arlov, Øystein; Haslene-Hox, Hanne; Beisvag, Vidar; Aachmann, Finn Lillelund. (2018) 3DLife – Emulating life in 3D with digital and experimental tissue models. Digital Life Norway DigitalLife 2018 , Bergen 2018-03-20 - 2018-03-21
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PosterHegre, Siv Anita; Klima, Antonin; Stovner, Endre Bakken; Samdal, Helle; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate. (2018) Long non-coding RNAs in epigenetic inheritance. Keystone Symposia on Molecular and Cellular Biology Noncoding RNAs: Form, Function, Physiology , Keystone, Colorado 2018-02-25 - 2018-03-01
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PosterOlsen, Lene Christin; Sætrom, Pål; Witter, Menno. (2018) Detecting early molecular events in a mouse model of Alzheimer’s disease (AD) using single cell RNA sequencing. NORBIS NORBIS annual conference , Voss 2018-10-17 - 2018-10-19
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Academic lectureKonstantinidis, Ioannis; Sætrom, Pål; Fernandes, Jorge Manuel de Oliveira. (2018) Fast muscle hydroxymethylation patterns in wild and captive Nile tilapia (Oreochromis niloticus) provide insights into fish domestication. GIA2018: 5th International Symposium on Genomics in Aquaculture , Albufeira 2018-03-21 - 2018-03-23
2017
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PosterHegre, Siv Anita; Samdal, Helle; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin; Aas, Per Arne. (2017) Long non-coding RNAs in epigenetic inheritance * Won Poster prize of 250 EUR at the EMBO|EMBL Symposium. EMBL EMBO EMBL Symposium "The Non-Coding genome" , Heidelberg 2017-09-13 - 2017-09-16
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PosterHegre, Siv Anita; Klima, Antonin; Aas, Per Arne; Liabakk, Nina-Beate; Sætrom, Pål. (2017) Meta-Analysis of RNA expression identifies human cell-cycle genes. Keystone Symposia Keystone Symposia "Noncoding RNAs: From Disease to Targeted Therapeutics" , Banff 2017-02-05 -
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PosterHegre, Siv Anita; Stovner, Endre Bakken; Sætrom, Pål. (2017) Find diffusely enriched chromatin domains in ChIP-seq data with epic. Keystone Symposia Keystone Symposia "Noncoding RNAs: From disease to targeted therapeutics" , Banff 2017-02-05 - 2017-02-09
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LectureKonstantinidis, Ioannis; Fernandes, Jorge Manuel de Oliveria; Sætrom, Pål. (2017) The first hydroxymethylation map of fast muscle in Nile tilapia (Oreochromis niloticus). European Aquaculture Society Aquaculture Europe 2017 , Dubrovnik 2017-10-17 - 2017-10-20
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PosterKlima, Antonin; Hegre, Siv Anita; Aas, Per Arne; Liabakk, Nina-Beate; Sætrom, Pål. (2017) Meta-analysis of RNA expression identifies human cell-cycle genes. Norbis – Annual National Conference 2017-11-08 - 2017-11-10
2016
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PosterJohansen, Jostein; Chawla, Konika; Olsen, Lene Christin; Sætrom, Pål. (2016) Bioinformatics Core Facility. NTNU Seminar for staff at the future Faculty of Medicine and Health Sciences , Trondheim 2016-11-10 - 2016-11-11
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Academic lectureKrokan, Hans Einar; Kavli, Bodil Merete; Pettersen, Henrik Sahlin; Sætrom, Pål; Galashevskaya, Anastasia; Sarno, Antonio. (2016) Genomic Uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan , Matsue 2016-11-13 - 2016-11-17
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Academic lectureKrokan, Hans Einar; Pettersen, Henrik Sahlin; Mjelle, Robin; Hegre, Siv Anita; Sætrom, Pål; Drabløs, Finn Sverre. (2016) REGULATION OF BASE EXCISION REPAIR – CANONICAL AND NON-CANONICAL PROCESSING OF GENOMIC URACIL. Russian Academy of Sciences, Siberian branch 10th International Multiconference on Bioinformatics of Genome Regulation and Structure\Systems Biology , Akademorodok, Novosibirsk 2016-08-29 - 2016-09-03
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LectureKrokan, Hans Einar; Slupphaug, Geir; Sætrom, Pål; Sarno, Antonio; Galashevskaya, Anastasia; Lundbæk, Marie Benner. (2016) Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Turkish Society of Toxicology. Eurotox 2016 , Sivilla 2016-09-04 -
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Academic lectureKlima, Antonin; Sætrom, Pål. (2016) Transcriptome-Wide Discovery of Cell-Cycle Genes. Norbis – Annual National Conference 2016-09-14 - 2016-09-16
2015
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Academic lectureSimpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Storrø, Ola; Johnsen, Roar; Sætrom, Pål. (2015) Human breast milk miRNA, maternal probiotic supplementation and atopic dermatitis (oral presentation). International Milk Genomics Consortium 12th International Symposium on Milk Genomics and Human Health , Sydney 2015-10-26 - 2015-10-28
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PosterSimpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Storrø, Ola; Johnsen, Roar; Sætrom, Pål. (2015) Human breast milk miRNA, maternal probiotics supplementation and atopic dermatitis in offspring (poster). International Milk Genomics Consortium 12th International Symposium on Milk Genomics and Human Health , Sydney 2015-10-26 - 2015-10-28
2014
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Interview
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Academic lectureSætrom, Pål. (2014) Management and Analyses of Population Data on Genetic Variation. 2nd Annual Next Generation Sequencing Data Congress 2014-05-19 - 2014-05-20
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LectureRazick, Sabry; Sætrom, Pål. (2014) Data advertising and managing platform for biobanks - a use case for the eGenVar data management system. European, Middle Eastern and Afran Society for Biopreservati European, Middle Eastern and Afran Society for Biopreservation & Biobanking , Leipzig 2014-10-21 - 2014-10-24
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Academic lectureHansen, Maren Fridtjofsen; Johansen, Jostein; Bjørnevoll, Inga; Sylvander, Anna Elisabeth; Steinsbekk, Kristin Solum; Sætrom, Pål. (2014) Using exome sequencing for identification of high-risk genetic variants in a family predisposed for colorectal cancer. COST Action BM1206 Meeting , Leiden 2014-09-04 - 2014-09-04
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Academic lectureSætrom, Pål. (2014) The effect of the core RISC-component Ago2 on microRNA composition and regulation. Illumina Sequencing Seminar 2014-02-13 -
2013
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Academic lectureSætrom, Pål; Thomas, Laurent. (2013) Finding SNPs that affect microRNA regulation. 10th International RNAi, MicroRNAs & Single Cell Biology – 2013 Meeting 2013-05-01 - 2013-05-02
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Academic lectureSætrom, Pål. (2013) Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is up-regulated during DNA replication. Department of Molecular Biology, University of Bergen Department seminar , Bergen 2013-04-26 - 2013-04-26
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InterviewSætrom, Pål. (2013) Innebygd klokke måler alder til menneskeleg vev. forskning.no forskning.no [Internet] 2013-10-24
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PosterPena-Diaz, Javier; Hegre, Siv Anita; Anderssen, Endre; Aas, Per Arne; Mjelle, Robin; Gilfillan, Gregor Duncan. (2013) Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication. Norwegian Biochemical Society Norwegian Biochemical Society Contact Meeting , Lillehammer 2013-01-31 - 2013-02-03
2012
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InterviewTorheim, Norunn K.; Sætrom, Pål. (2012) Nye verktøy i jakten på sykdomsårsaker. www.forskning.no www.forskning.no [Internet] 2012-05-24
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Popular scientific lectureSætrom, Pål. (2012) Født sånn eller blitt sånn? Hvordan samvirker gener og miljø. Lions medlemsmøte 2012-03-05 - 2012-03-05
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Academic lectureSætrom, Pål. (2012) Epigenetics and the human cell-division cycle. Department seminar 2012-04-25 - 2012-04-25
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Academic lectureDrabløs, Finn; Rye, Morten Beck; Klepper, Kjetil; Sætrom, Pål. (2012) Definition and analysis of gene sets from time series data. FANTOM RIKEN FANTOM time-courses meeting , Yokohama 2012-10-29 - 2012-11-02
2011
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Academic lectureSætrom, Pål. (2011) Tools for analyzing and designing small RNA-mediated gene regulation. Department of Biology, University of Copenhagen Invited seminar 2011-08-16 - 2011-08-16
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Academic lectureSætrom, Pål. (2011) Analyzing and designing small RNA-mediated gene regulation. Bioinformatics for Regulatory Genomics (BioRegSIG) - Special Interest Group (SIG) at Intelligent Systems for Molecular Biology , Wienna 2011-07-16 -
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Academic lectureSætrom, Pål. (2011) Handling, integrating, and analysing biobank data in a hypothesis-driven framework. Department of Informatics, University of Oslo Bioinformatics Seminars 2011-09-23 -
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PosterRye, Morten Beck; Drabløs, Finn; Sætrom, Pål; Håndstad, Tony. (2011) Epigenetic Influence on Cell-type specific peaks from ChIP-Seq data. Keystone Symposia Histone code: Fact or fiction? , Midway, Utah 2011-01-10 - 2011-01-15
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PosterRye, Morten Beck; Sætrom, Pål; Håndstad, Tony; Drabløs, Finn. (2011) Clusters of ChIP-Seq defined transcription factor binding sites map regulatory elelemnts in the human genome. Cambridge Research Institute Unanswered Questions in Transcription, Annual international Symposium , Cambridge 2011-11-04 - 2011-11-05
2010
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Academic lectureSætrom, Pål. (2010) Bioinformatics of small RNA-mediated gene regulation. Systems Biology meetings at NTNU 2010-10-08 - 2010-10-08
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Academic lectureSætrom, Pål. (2010) Epigenetic and microRNA regulation of the cell cycle. Onsdagsmøte IKM 2010-12-01 - 2010-12-01
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Academic lectureSætrom, Pål. (2010) Bioinformatics of small RNA-mediated gene regulation. Seminar at Science for Life Laboratory (SciLifeLab) 2010-10-05 - 2010-10-05
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Academic lectureSætrom, Pål. (2010) Tools for analyzing and designing small RNA-mediated gene regulation. City of Hope’s Beckman Research Institute seminar series 2010-05-04 - 2010-05-04
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PosterSaito, Takaya; Sætrom, Pål. (2010) Poster presentation: A two-step site and mRNA-level model for predicting microRNA target. Norwegian Radium Hospital / Max Planck Institute RECOMB Computational Cancer Biology , Oslo 2010-06-24 - 2010-06-25
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PosterThomas, Laurent Francois; Saito, Takaya; Sætrom, Pål. (2010) Identifying causative variants in microRNA target sites. Norwegian Radium Hospital / University of Oslo RECOMB Computational Cancer Biology , Oslo 2010-06-24 - 2010-06-25
2009
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Academic lectureSætrom, Pål. (2009) Synergistic regulation by microRNAs. Third Bertinoro Systems Biology Workshop , Bertinoro 2009-03-29 - 2009-04-03
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PosterHegre, Siv Anita; Sætrom, Pål; Aas, Per Arne; Olsen, Lene Christin; Lundbæk, Marie Benner; Diaz, Javier Pena. (2009) Multiple microRNAs appear to regulate the DNA repair enzyme UNG2 during the cell cycle. Keystone Symposia MicroRNA and Cancer Conference , Keystone, Colorado 2009-06-10 - 2009-06-15
2008
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Academic lectureS�trom, P�l. (2008) Cooperative microRNA Targeting and Regulation – Applications in siRNA Design. NMC Møte , Selbu 2008-11-24 - 2008-11-25
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Academic lectureSætrom, Pål. (2008) Synergistic microRNA-like targeting by short interfering RNAs can give robust HIV-inhibition. Joint Centre for Bioinformatics in Oslo, UiO Bioinformatics Wednesday seminars , Oslo 2008-12-03 - 2008-12-03
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Academic lectureSætrom, Pål. (2008) Cooperative microRNA Targeting and Regulation. Norwegian Bioinformatics Forum 2008 , Bergen 2008-10-09 - 2008-10-10
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Academic lectureSætrom, Pål. (2008) Cooperative microRNA Targeting and Regulation. Bioinformatics-meeting 2008 2008-09-30 - 2008-09-30
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Academic lectureSætrom, Pål. (2008) Gene regulation by microRNAs and microRNA regulation of DNA repair. Genes, Genomes and Evolution: Structure and Hyperstructure , Geiranger 2008-08-12 - 2008-08-16
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Academic lectureSætrom, Pål. (2008) Cooperative microRNA Targeting and Regulation. RNAi Europe , Stockholm 2008-09-16 - 2008-09-18
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Academic lectureSætrom, Pål. (2008) Cooperative microRNA Targeting and Regulation. Current Topics in RNA Biology 2008-09-27 - 2008-09-29
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Popular scientific lectureSætrom, Pål. (2008) Små RNA - viktige i sykdom og lovende terapeutiske kandidater. Norges forskningsråd Sluttrapporteringsseminar for FUGE , Oslo 2008-05-21 - 2008-05-21
2007
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Academic lectureSætrom, Pål. (2007) The roles of microRNAs and transcription factors in gene regulation and tissue specific expression. Department of Biomedicine, University of Bergen BBB Seminars - The BioMedical and BioSciences Lecture Series , Bergen 2007-09-20 - 2007-09-20
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Academic lectureSætrom, Pål. (2007) Distance Constraints Between MicroRNA Target Sites Dictate Efficacy and Cooperativity. GeneExpression Systems (USA), University of Cambridge (UK) MicroRNAs Europe 2007 Meeting on MicroRNAs: Biology to Development and Disease , Cambridge 2007-11-01 - 2007-11-02
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Academic lectureSætrom, Pål. (2007) Cooperative microRNA targeting and robust inhibition of HIV. siRNAsense 2nd RNA Interference Conference , Oslo 2007-05-14 - 2007-05-14
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Academic lectureSætrom, Pål; Heale, Bret S.; Snøve, Ola; Aagaard, Lars; Alluin, Jessica; Rossi, John J.. (2007) Distance Constraints Between MicroRNA Target Sites Dictate Efficacy and Cooperativity. RNA 2007 - Twelfth Annual Meeting of the RNA Society , Madison, WI 2007-05-29 - 2007-06-03
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Academic lectureSætrom, Pål. (2007) The roles of microRNAs and transcription factors in gene regulation and tissue specific expression. FUGE Midt-Norge FUGE seminar , Trondheim 2007-12-17 - 2007-12-17
2006
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Academic lectureSætrom, Pål; Birkeland, Olaf René; Snøve, Ola. (2006) Boosting improves stability and accuracy of genetic programming in biological sequence classification. University of Michigan Genetic Programming Theory and Practice IV , Ann Arbor 2006-05-11 - 2006-05-13
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Academic lectureSætrom, Pål. (2006) Predicting microRNA targets - challenges and solutions. Society for Bioinformatics in the Nordic Countries (SocBiN) Bioinformatics 2006 , Århus 2006-06-15 - 2006-06-18