Nathalie Jurisch-Yaksi

About

Nathalie Jurisch-Yaksi is a group leader at the Department of Clinical and Molecular Medicine (IKOM) at NTNU, an Associate Professor (10% FTE) at the Kavli Institute for Systems Neuroscience at NTNU, and a Mercator Fellow at the German Research Foundation (DFG) Research Unit FOR5547.

The main scientific goal of her laboratory is to understand the principles underlying the function and development of neural circuits in health and disease.

Her research program focuses on 4 major topics:

1. The role of cilia and cerebrospinal fluid in the development and function of the nervous system. The cilium is a small cellular appendage projecting from the surface of most cells, like a tiny antenna. It can generate flow or play a structural, sensory or signaling role. In the brain, primary cilia play important development and signaling roles, while motile cilia are involved in the movement and homeostasis of cerebrospinal fluid. We study how ciliary motility and signaling regulate the development and physiology of the nervous system.

2. The mechanisms underlying seizure generations. During epileptic seizures, the brain switches from a balanced to a hyperactive and hypersynchronous state. Many factors can induce epileptic seizures, which include brain trauma, developmental disorders, infections or genetic mutations. We are interested to understand the cellular and molecular mechanisms leading to seizures using various pharmacological and genetic models of seizures.

3. The role of glia in brain physiology and pathophysiology. While neurons have been at the center stage of brain research for decades, glial cells are increasingly recognized for their roles in the development, maturation, and physiology of brain circuits. We study how glia modulate neuronal activity and brain homeostasis at the brain barriers.

4. Personalized medicine. We are developing personalized medicine approaches for the diagnostics and treatment of glioblastoma, ciliopathies, hydrocephalus and epilepsy .

To address these questions, her laboratory uses the genetically tractable small model organism zebrafish and a combination of techniques including genetics, molecular and cell biology, functional imaging, quantitative behavioral assays and applied mathematics.

Current Team Members

Postdoc: Dr Inyoung Jung

PhD students: Mert Ege and Percival D’Gama

Current funding:

2024-2028: Mercator Fellow, German Research Foundation (DFG), Research Unit FOR5547
2023-2026: ERA-PerMed consortium "Glioma PerMed: Glioma invasion assays as a predictive tool for personalized glioma medicine" (ERA-PerMed, 300K EUR)
2021-2024: Researcher project for scientific renewal (NFR, 12M NOK)
2021-2024: NTNU enabling technology program (4 years PhD position)

Publications

2024

Rayamajhi, Dheeraj; Ege, Mert; Ukhanov, Kirill; Ringers, Christa Nelleke; Zhang, Yiliu; Jeong, Inyoung. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology
Academic article
Jurisch-Yaksi, Nathalie; Wachten, Dagmar; Gopalakrishnan, Jay. (2024) The neuronal cilium – a highly diverse and dynamic organelle involved in sensory detection and neuromodulation. Trends in Neurosciences
Academic literature review
Jeong, Inyoung; Andreassen, Søren N.; Hoang, Linh; Poulain, Morgane; Seo, Yongbo; Park, Hae-Chul. (2024) The evolutionarily conserved choroid plexus contributes to the homeostasis of brain ventricles in zebrafish. Cell reports
Academic article
Tayran, Hüseyin; Yilmaz, Elanur; Bhattarai, Prabesh; Min, Yuhao; Wang, Xue; Ma, Yiyi. (2024) ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. Cell Genomics
Academic article
D'Gama, Percival P.; Jeong, Inyoung; Nygård, Andreas Moe; Trinh, Anh Tuan; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2024) Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish. iScience
Academic article

2023

Ringers, Christa Nelleke; Bialonski, Stephan; Ege, Mert; Solovev, Anton; Hansen, Jan Niklas; Jeong, Inyoung. (2023) Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia. eLIFE
Academic article
Dgama, Percival Paul Menino; Jurisch-Yaksi, Nathalie. (2023) Methods to study motile ciliated cell types in the zebrafish brain. Methods in Cell Biology
Academic literature review
Jeong, Inyoung; Jurisch-Yaksi, Nathalie. (2023) Boosting NKCC1 in the choroid plexus: From CSF clearance to a potential therapy for posthemorrhagic hydrocephalus. Neuron
Academic literature review
Gopalakrishnan, Jay; Feistel, Kerstin; Friedrich, Benjamin M; Grapin-Botton, Anne; Jurisch-Yaksi, Nathalie; Mass, Elvira. (2023) Emerging principles of primary cilia dynamics in controlling tissue organization and function. EMBO Journal
Academic literature review
Birdal, Günes; D'Gama, Percival Paul Menino; Jurisch-Yaksi, Nathalie; Korsching, Sigrun I.. (2023) Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish. Chemical Senses
Academic article

2022

Myren-Svelstad, Sverre; Jamali, Ahmed; Ophus, Sunniva Sofie; Dgama, Percival Paul Menino; Ostenrath, Anna Maria; Mutlu, Aytac Kadir. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia
Academic article
Jeong, Inyoung; Hansen, Jan Niklas; Wachten, Dagmar; Jurisch-Yaksi, Nathalie. (2022) Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon. STAR Protocols
Academic article
Salman, Huseyin Enes; Jurisch-Yaksi, Nathalie; Yalcin, Huseyin Cagatay. (2022) Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo. Bioengineering
Academic article

2021

Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia
Academic article
Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell reports
Academic article
Hansen, Jan Niklas; Rassmann, Sebastian; Stüven, Birthe; Jurisch-Yaksi, Nathalie; Wachten, Dagmar. (2021) CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images. The European Physical Journal E : Soft matter
Academic article
Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie. (2021) Past, present and future of zebrafish in epilepsy research. The FEBS Journal
Academic literature review

2020

Ringers, Christa; Jurisch-Yaksi, Nathalie. (2020) Development: How the Reissner Fiber Keeps Our Back Straight. Current Biology
Academic article
Jurisch-Yaksi, Nathalie; Yaksi, Emre; Kizil, Caghan. (2020) Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia. Glia
Academic literature review
Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE
Academic article
Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Serneels, Bram; Faturos, Nicholas Guy. (2020) Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis. Science Advances
Academic article
Hansen, Jan; Kaiser, Fabian; Klausen, Christina; Stüven, Birthe; Chong, Raymond; Bönigk, Wolfgang. (2020) Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. eLIFE
Academic article

2019

Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Evelien, Van Hoeymissen; Deneubourg, Celine; van Derhaeghe, Silke. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. Nature Communications
Academic article
Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan Niklas; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar. (2019) Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Current Biology
Academic article
Ringers, Christa; Olstad, Emile Willoch; Jurisch-Yaksi, Nathalie. (2019) The role of motile cilia in the development and physiology of the nervous system. Philosophical Transactions of the Royal Society of London. Biological Sciences
Academic literature review

2018

Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Nathalie Jurisch-Yaksi and Emre Yaksi. Current Biology
Short communication

2017

Reiten, Ingrid; Uslu, Fazil Emre; Forè, Stèphanie; Pelgrims, Robbrecht; Ringers, Christa; Diaz Verdugo, Carmen. (2017) Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations. Current Biology
Academic article

2016

Bugge, Steffen; Buene, Audun Formo; Jurisch-Yaksi, Nathalie; Moen, Ingri Ullestad; Skjønsfjell, Ellen Martine; Sundby, Eirik. (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry
Academic article

Journal publications

Rayamajhi, Dheeraj; Ege, Mert; Ukhanov, Kirill; Ringers, Christa Nelleke; Zhang, Yiliu; Jeong, Inyoung. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology
Academic article
Jurisch-Yaksi, Nathalie; Wachten, Dagmar; Gopalakrishnan, Jay. (2024) The neuronal cilium – a highly diverse and dynamic organelle involved in sensory detection and neuromodulation. Trends in Neurosciences
Academic literature review
Jeong, Inyoung; Andreassen, Søren N.; Hoang, Linh; Poulain, Morgane; Seo, Yongbo; Park, Hae-Chul. (2024) The evolutionarily conserved choroid plexus contributes to the homeostasis of brain ventricles in zebrafish. Cell reports
Academic article
Tayran, Hüseyin; Yilmaz, Elanur; Bhattarai, Prabesh; Min, Yuhao; Wang, Xue; Ma, Yiyi. (2024) ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. Cell Genomics
Academic article
D'Gama, Percival P.; Jeong, Inyoung; Nygård, Andreas Moe; Trinh, Anh Tuan; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2024) Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish. iScience
Academic article
Ringers, Christa Nelleke; Bialonski, Stephan; Ege, Mert; Solovev, Anton; Hansen, Jan Niklas; Jeong, Inyoung. (2023) Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia. eLIFE
Academic article
Dgama, Percival Paul Menino; Jurisch-Yaksi, Nathalie. (2023) Methods to study motile ciliated cell types in the zebrafish brain. Methods in Cell Biology
Academic literature review
Jeong, Inyoung; Jurisch-Yaksi, Nathalie. (2023) Boosting NKCC1 in the choroid plexus: From CSF clearance to a potential therapy for posthemorrhagic hydrocephalus. Neuron
Academic literature review
Gopalakrishnan, Jay; Feistel, Kerstin; Friedrich, Benjamin M; Grapin-Botton, Anne; Jurisch-Yaksi, Nathalie; Mass, Elvira. (2023) Emerging principles of primary cilia dynamics in controlling tissue organization and function. EMBO Journal
Academic literature review
Birdal, Günes; D'Gama, Percival Paul Menino; Jurisch-Yaksi, Nathalie; Korsching, Sigrun I.. (2023) Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish. Chemical Senses
Academic article
Myren-Svelstad, Sverre; Jamali, Ahmed; Ophus, Sunniva Sofie; Dgama, Percival Paul Menino; Ostenrath, Anna Maria; Mutlu, Aytac Kadir. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia
Academic article
Jeong, Inyoung; Hansen, Jan Niklas; Wachten, Dagmar; Jurisch-Yaksi, Nathalie. (2022) Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon. STAR Protocols
Academic article
Salman, Huseyin Enes; Jurisch-Yaksi, Nathalie; Yalcin, Huseyin Cagatay. (2022) Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo. Bioengineering
Academic article
Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia
Academic article
Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell reports
Academic article
Hansen, Jan Niklas; Rassmann, Sebastian; Stüven, Birthe; Jurisch-Yaksi, Nathalie; Wachten, Dagmar. (2021) CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images. The European Physical Journal E : Soft matter
Academic article
Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie. (2021) Past, present and future of zebrafish in epilepsy research. The FEBS Journal
Academic literature review
Ringers, Christa; Jurisch-Yaksi, Nathalie. (2020) Development: How the Reissner Fiber Keeps Our Back Straight. Current Biology
Academic article
Jurisch-Yaksi, Nathalie; Yaksi, Emre; Kizil, Caghan. (2020) Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia. Glia
Academic literature review
Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE
Academic article
Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Serneels, Bram; Faturos, Nicholas Guy. (2020) Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis. Science Advances
Academic article
Hansen, Jan; Kaiser, Fabian; Klausen, Christina; Stüven, Birthe; Chong, Raymond; Bönigk, Wolfgang. (2020) Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. eLIFE
Academic article
Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Evelien, Van Hoeymissen; Deneubourg, Celine; van Derhaeghe, Silke. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. Nature Communications
Academic article
Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan Niklas; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar. (2019) Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Current Biology
Academic article
Ringers, Christa; Olstad, Emile Willoch; Jurisch-Yaksi, Nathalie. (2019) The role of motile cilia in the development and physiology of the nervous system. Philosophical Transactions of the Royal Society of London. Biological Sciences
Academic literature review
Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Nathalie Jurisch-Yaksi and Emre Yaksi. Current Biology
Short communication
Reiten, Ingrid; Uslu, Fazil Emre; Forè, Stèphanie; Pelgrims, Robbrecht; Ringers, Christa; Diaz Verdugo, Carmen. (2017) Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations. Current Biology
Academic article
Bugge, Steffen; Buene, Audun Formo; Jurisch-Yaksi, Nathalie; Moen, Ingri Ullestad; Skjønsfjell, Ellen Martine; Sundby, Eirik. (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry
Academic article

Teaching

Courses

Knowledge Transfer

2022

Poster

Lal, Pradeep; Fiskum, Vegard; Kermen, Florence; Ostenrath, Anna Maria; Palumbo, Fabrizio; Jurisch-Yaksi, Nathalie. (2022) The role of GnRH3 neurons in modulating olfactory computations and odor induced feeding behaviors. NTNU Imaging Structure and Function of the Zebrafish Brain Conference , Trondheim 2022-07-30 - 2022-08-01

2019

Interview

Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Brandslet, Steinar. (2019) Hjernens forsvar bryter sammen ved epilepsi. Gemini.no Gemini.no [Internet] 2019-08-23
Academic lecture

Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Muto, Akira; Kawakami, Koichi. (2019) Glia-neuron interactions underlie state transitions to generalized seizures. EAN 5th Congress of the European Academy of Neurology , Oslo 2019-06-29 - 2019-07-02

2018

Academic lecture

Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Neuron-glia interactions underlie state transitions to generalized seizures. Norsk Epilepsiselskap Norwegian Epilepsy Society Annual Meeting , Trondheim 2018-05-31 - 2018-06-02
Poster

Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Homeostatic interactions within neuron-glia networks underlie state transitions to generalized seizures. American Epilepsy Society American Epilepsy Society Annual Meeting , New Orleans 2018-11-30 - 2018-12-04
Lecture

Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar. (2018) The function of motile-cilia driven flow in the nervous system. cilia 2018 2018-10-02 - 2018-10-06
Poster

Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Brandt, Cecilia; Wachten, Dagmar. (2018) Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. 5th Imaging Structure and Function in the Zebrafish Brain Conference 2018 , Brighton 2018-11-30 - 2018-12-02
Poster

Olstad, Emilie Willoch; Ringers, Christa; Wens, Adinda; Hansen, Jan; Brandt, Cecilia; Yaksi, Emre. (2018) Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. FENS 11th FENS Forum of Neuroscience 2018 , Berlin 2018-07-07 - 2018-07-11
Academic lecture

Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Deneubourg, Celine; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2018) Homeostatic interactions within neuron-glia networks underlie state transitions to generalized seizures. NRSN The 6th NRSN National PhD Conference in Neuroscience , Inderøya 2018-09-19 - 2018-09-21
Poster

Lal, Pradeep; Weth-Malsch, Daniela; Fiskum, Vegard; Kermen, Florence; Palumbo, Fabrizio; Pelgrims, Robbrecht. (2018) Gonadotropin-releasing hormone (GnRH) neuromodulation of olfactory computations in zebrafish brain. The 11th FENS Forum of Neuroscience 2018 2018-07-07 - 2018-07-11
Poster

Lal, Pradeep; Weth-Malsch, Daniela; Fiskum, Vegard; Palumbo, Fabrizio; Kermen, Florence; Pelgrims, Robbrecht. (2018) The function of gonadotropin-releasing hormone (GnRH) neurons in olfactory computations. The European Chemoreception Research Organization (ECRO) 2018 2018-09-05 - 2018-09-05
Lecture

Olstad, Emilie Willoch; Ringers, Christa; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) The function of motile-cilia driven flow in the nervous system. zebrafish PI meeting 2018 2018-02-20 - 2018-02-23
Poster

Ringers, Christa; Hansen, Jan; Reiten, Ingrid; Pelgrims, Robbrecht; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) The role of second messengers in the regulation of ciliary beating. SPP 1726 Microswimmers , Bonn 2018-04-26 - 2018-04-27
Poster

Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Yaksi, Emre; Jurisch-Yaksi, Nathalie. (2018) Cilia-driven flow in the zebrafish brain ventricles. EMBO cilia meeting 2018-10-02 - 2018-10-05

2017

Poster

Myren-Svelstad, Sverre; Diaz Verdugo, Carmen; Pelgrims, Robbrecht; Jurisch-Yaksi, Nathalie; Yaksi, Emre. (2017) Studying neural circuit activity and connectivity during epileptogenesis in zebrafish brain. American Epilepsy Society American Epilepsy Society Annual Meeting , Washington D.C. 2017-12-01 - 2017-12-05

Språkvelger

Nathalie Jurisch-Yaksi