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Miroslava Kissova

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Miroslava Kissova


miroslava.kissova@ntnu.no
Laboratoriesenteret, Øya
About Publications Outreach

About

As a PhD in Italy (DNA enzymology and Molecular Virology lab, University of Pavia) I focused on advanced kinetic studies of kinase inhibitors for antitumoral, -neurodegenerative and -viral therapy. During my postdoc in the same lab I studied alternative end-joining DNA repair pathway and mechanisms of alternative telomere lengthening in tumours. In 2019 I joined Bjørås group (Cellular responses to DNA damage, IKOM) as a researcher working on the validation of glycosylase inhibitors for anticancer and stroke therapy in cellular models. Since 2021 we have extended our research expertise to patient-derived models and established a glioblastoma biobank in collaboration with St Olavs Hospital composed of patient-derived glioblastoma organoids and cells used as preclinical models to monitor drug response for targeted glioblastoma therapy.

Projects:

  1. Investigation of drug response in preclincal patient-derived glioblastoma organoids
  2. DNA glycosylase inhibitors for anticancer therapy
  3. Targeting DNA glycosylases as novel approach for stroke therapy 

Competencies

  • biochemistry
  • drug screening
  • glioblastoma organoids
  • inhibition assays
  • patient-derived models

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2023

  • Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi. (2023) A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment. Genome Biology
    Academic article

2021

  • Mentegari, Elisa; Bertoletti, Federica; Kissova, Miroslava; Zucca, Elisa; Galli, Silvia; Tagliavini, Giulia. (2021) A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres. International Journal of Molecular Sciences
    Academic article

2019

  • Fallacara, Anna Lucia; Passannanti, Raffaele; Mori, Mattia; Iovenitti, Giulia; Musumeci, Francesca; Greco, Chiara. (2019) Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines. European Journal of Medicinal Chemistry
    Academic article
  • Tassini, Sabrina; Langron, Emily; Delang, Leen; Mirabelli, Carmen; Lanko, Kristina; Crespan, Emmanuele. (2019) Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach. Journal of Medicinal Chemistry
    Academic article

2018

  • Molinari, Alessandro; Fallacara, Anna Lucia; Di Maria, Salvatore; Zamperini, Claudio; Poggialini, Federica; Musumeci, Francesca. (2018) Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment. Bioorganic & Medicinal Chemistry Letters
    Academic article

2017

  • Musumeci, Francesca; Fallacara, Anna Lucia; Brullo, Chiara; Grossi, Giancarlo; Botta, Lorenzo; Calandro, Pierpaolo. (2017) Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma. European Journal of Medicinal Chemistry
    Academic article
  • Mentegari, Elisa; Crespan, Emmanuele; Bavagnoli, Laura; Kissova, Miroslava; Bertoletti, Federica; Sabbioneda, Simone. (2017) Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity. Nucleic Acids Research (NAR)
    Academic article
  • Tassini, Sabrina; Sun, Liang; Lanko, Kristina; Crespan, Emmanuele; Langron, Emily; Falchi, Federico. (2017) Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. Journal of Medicinal Chemistry
    Academic article

2016

  • Kissova, Miroslava; Crespan, Emmanuele; Maga, Giovanni. (2016) The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: implications for drug design. Bioorganic & Medicinal Chemistry
    Academic article
  • Samir M, El-Moghazy; Riham F, George; Essam Eldin A, Osman; Ahmed A, Elbatrawy; Kissova, Miroslava; Colombo, Ambra. (2016) Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line. European Journal of Medicinal Chemistry
    Academic article
  • Mentegari, Elisa; Kissova, Miroslava; Bavagnoli, Laura; Maga, Giovanni; Crespan, Emmanuele. (2016) DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair. Genes
    Academic literature review
  • Radi, Marco; Schneider, Ralf; Fallacara, Anna Lucia; Botta, Lorenzo; Crespan, Emmanuele; Tintori, Cristina. (2016) A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant. Bioorganic & Medicinal Chemistry Letters
    Academic article

2014

  • Vignaroli, Giulia; Mencarelli, Martina; Sementa, Deborah; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni. (2014) Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl. Journal of combinatorial chemistry
    Academic article

2013

  • Vignaroli, Giulia; Zamperini, Claudio; Dreassi, Elena; Radi, Marco; Angelucci, Adriano; Sanità, Patrizia. (2013) Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors. ACS Medicinal Chemistry Letters
    Academic article
  • Mori, Mattia; Tintori, Cristina; Christopher, Robert Selwyne Arul; Radi, Marco; Schenone, Silvia; Musumeci, Francesca. (2013) A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. ChemMedChem
    Academic article
  • Zucca, Elisa; Crespan, Emmanuele; Bertoletti, Federica; Kissova, Miroslava; Maga, Giovanni; Bonavida, Benjamin. (2013) Book title: Molecular mechanisms of tumor cell resistance to chemotherapy. Book subtitle: Targeted therapies to reverse resistance. Chapter title: Two birds with a stone: Molecular cancer therapy targeting signal transduction and DNA repair pathways. Springer Science+Business Media B.V. Springer Science+Business Media B.V.
    Textbook
  • Tintori, Cristina; Laurenzana, Ilaria; La Rocca, Francesco; Falchi, Federico; Carraro, Fabio; Ruiz, Alba. (2013) Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. ChemMedChem
    Academic article

2012

  • Moukova, Lucie; Vranova, Vladimira; Slamova, Iva; Kissova, Miroslava; Kuglik, Petr. (2012) Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in Czech Republic. European Oncology and Haematology
    Academic article

Journal publications

  • Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi. (2023) A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment. Genome Biology
    Academic article
  • Mentegari, Elisa; Bertoletti, Federica; Kissova, Miroslava; Zucca, Elisa; Galli, Silvia; Tagliavini, Giulia. (2021) A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres. International Journal of Molecular Sciences
    Academic article
  • Fallacara, Anna Lucia; Passannanti, Raffaele; Mori, Mattia; Iovenitti, Giulia; Musumeci, Francesca; Greco, Chiara. (2019) Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines. European Journal of Medicinal Chemistry
    Academic article
  • Tassini, Sabrina; Langron, Emily; Delang, Leen; Mirabelli, Carmen; Lanko, Kristina; Crespan, Emmanuele. (2019) Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach. Journal of Medicinal Chemistry
    Academic article
  • Molinari, Alessandro; Fallacara, Anna Lucia; Di Maria, Salvatore; Zamperini, Claudio; Poggialini, Federica; Musumeci, Francesca. (2018) Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment. Bioorganic & Medicinal Chemistry Letters
    Academic article
  • Musumeci, Francesca; Fallacara, Anna Lucia; Brullo, Chiara; Grossi, Giancarlo; Botta, Lorenzo; Calandro, Pierpaolo. (2017) Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma. European Journal of Medicinal Chemistry
    Academic article
  • Mentegari, Elisa; Crespan, Emmanuele; Bavagnoli, Laura; Kissova, Miroslava; Bertoletti, Federica; Sabbioneda, Simone. (2017) Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity. Nucleic Acids Research (NAR)
    Academic article
  • Tassini, Sabrina; Sun, Liang; Lanko, Kristina; Crespan, Emmanuele; Langron, Emily; Falchi, Federico. (2017) Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. Journal of Medicinal Chemistry
    Academic article
  • Kissova, Miroslava; Crespan, Emmanuele; Maga, Giovanni. (2016) The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: implications for drug design. Bioorganic & Medicinal Chemistry
    Academic article
  • Samir M, El-Moghazy; Riham F, George; Essam Eldin A, Osman; Ahmed A, Elbatrawy; Kissova, Miroslava; Colombo, Ambra. (2016) Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line. European Journal of Medicinal Chemistry
    Academic article
  • Mentegari, Elisa; Kissova, Miroslava; Bavagnoli, Laura; Maga, Giovanni; Crespan, Emmanuele. (2016) DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair. Genes
    Academic literature review
  • Radi, Marco; Schneider, Ralf; Fallacara, Anna Lucia; Botta, Lorenzo; Crespan, Emmanuele; Tintori, Cristina. (2016) A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant. Bioorganic & Medicinal Chemistry Letters
    Academic article
  • Vignaroli, Giulia; Mencarelli, Martina; Sementa, Deborah; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni. (2014) Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl. Journal of combinatorial chemistry
    Academic article
  • Vignaroli, Giulia; Zamperini, Claudio; Dreassi, Elena; Radi, Marco; Angelucci, Adriano; Sanità, Patrizia. (2013) Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors. ACS Medicinal Chemistry Letters
    Academic article
  • Mori, Mattia; Tintori, Cristina; Christopher, Robert Selwyne Arul; Radi, Marco; Schenone, Silvia; Musumeci, Francesca. (2013) A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. ChemMedChem
    Academic article
  • Tintori, Cristina; Laurenzana, Ilaria; La Rocca, Francesco; Falchi, Federico; Carraro, Fabio; Ruiz, Alba. (2013) Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. ChemMedChem
    Academic article
  • Moukova, Lucie; Vranova, Vladimira; Slamova, Iva; Kissova, Miroslava; Kuglik, Petr. (2012) Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in Czech Republic. European Oncology and Haematology
    Academic article

Books

  • Zucca, Elisa; Crespan, Emmanuele; Bertoletti, Federica; Kissova, Miroslava; Maga, Giovanni; Bonavida, Benjamin. (2013) Book title: Molecular mechanisms of tumor cell resistance to chemotherapy. Book subtitle: Targeted therapies to reverse resistance. Chapter title: Two birds with a stone: Molecular cancer therapy targeting signal transduction and DNA repair pathways. Springer Science+Business Media B.V. Springer Science+Business Media B.V.
    Textbook

Outreach

poster

M Kissova, M Vestvik, HLB Lervåg, M Bjørås et al. Drug-screening on patient-derived glioblastoma organoids uncovers synergies between DNA glycosylase inhibitors and G-quadruplex ligands potentiating cancer cell death. SNOG, Gothenburg, Sweden (04/2024)

2024

  • Poster
    Bali, Nesrine; Kissova, Miroslava; Bjørås, Magnar; Bandyopadhyay, Sulalit. (2024) Kinetically Controlled Loading of Hydrophilic Iron Oxide Nanoclusters in Hydrophobic Polymeric Nanoparticles through Flash Nanoprecipitation . NanoBioTech-Montreux Conference 2024 , Montreux 2024-11-11 - 2024-11-13
  • Poster
    Bali, Nesrine; Kissova, Miroslava; Bjørås, Magnar; Bandyopadhyay, Sulalit. (2024) Kinetically Controlled Loading of Hydrophilic Iron Oxide Nanoclusters in Hydrophobic Polymeric Nanoparticles through Flash Nanoprecipitation. Particle Engineering Days 2024 - 4th Annual Meeting , Trondheim 2024-12-09 - 2024-12-10

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