Miroslava Kissova
About
As a PhD in Italy (DNA enzymology and Molecular Virology lab, University of Pavia) I focused on advanced kinetic studies of kinase inhibitors for antitumoral, -neurodegenerative and -viral therapy. During my postdoc in the same lab I studied alternative end-joining DNA repair pathway and mechanisms of alternative telomere lengthening in tumours. In 2019 I joined Bjørås group (Cellular responses to DNA damage, IKOM) as a researcher working on the validation of glycosylase inhibitors for anticancer and stroke therapy in cellular models. Since 2021 we have extended our research expertise to patient-derived models and established a glioblastoma biobank in collaboration with St Olavs Hospital composed of patient-derived glioblastoma organoids and cells used as preclinical models to monitor drug response for targeted glioblastoma therapy.
Projects:
- Investigation of drug response in preclincal patient-derived glioblastoma organoids
- DNA glycosylase inhibitors for anticancer therapy
- Targeting DNA glycosylases as novel approach for stroke therapy
Publications
2023
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Academic article
2021
-
Mentegari, Elisa;
Bertoletti, Federica;
Kissova, Miroslava;
Zucca, Elisa;
Galli, Silvia;
Tagliavini, Giulia.
(2021)
A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.
International Journal of Molecular Sciences
Academic article
2019
-
Fallacara, Anna Lucia;
Passannanti, Raffaele;
Mori, Mattia;
Iovenitti, Giulia;
Musumeci, Francesca;
Greco, Chiara.
(2019)
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines.
European Journal of Medicinal Chemistry
Academic article
-
Tassini, Sabrina;
Langron, Emily;
Delang, Leen;
Mirabelli, Carmen;
Lanko, Kristina;
Crespan, Emmanuele.
(2019)
Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach.
Journal of Medicinal Chemistry
Academic article
2018
-
Molinari, Alessandro;
Fallacara, Anna Lucia;
Di Maria, Salvatore;
Zamperini, Claudio;
Poggialini, Federica;
Musumeci, Francesca.
(2018)
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.
Bioorganic & Medicinal Chemistry Letters
Academic article
2017
-
Musumeci, Francesca;
Fallacara, Anna Lucia;
Brullo, Chiara;
Grossi, Giancarlo;
Botta, Lorenzo;
Calandro, Pierpaolo.
(2017)
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma.
European Journal of Medicinal Chemistry
Academic article
-
Mentegari, Elisa;
Crespan, Emmanuele;
Bavagnoli, Laura;
Kissova, Miroslava;
Bertoletti, Federica;
Sabbioneda, Simone.
(2017)
Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.
Nucleic Acids Research (NAR)
Academic article
-
Tassini, Sabrina;
Sun, Liang;
Lanko, Kristina;
Crespan, Emmanuele;
Langron, Emily;
Falchi, Federico.
(2017)
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.
Journal of Medicinal Chemistry
Academic article
2016
-
Kissova, Miroslava;
Crespan, Emmanuele;
Maga, Giovanni.
(2016)
The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: implications for drug design.
Bioorganic & Medicinal Chemistry
Academic article
-
Samir M, El-Moghazy;
Riham F, George;
Essam Eldin A, Osman;
Ahmed A, Elbatrawy;
Kissova, Miroslava;
Colombo, Ambra.
(2016)
Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line.
European Journal of Medicinal Chemistry
Academic article
-
Mentegari, Elisa;
Kissova, Miroslava;
Bavagnoli, Laura;
Maga, Giovanni;
Crespan, Emmanuele.
(2016)
DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair.
Genes
Academic literature review
-
Radi, Marco;
Schneider, Ralf;
Fallacara, Anna Lucia;
Botta, Lorenzo;
Crespan, Emmanuele;
Tintori, Cristina.
(2016)
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.
Bioorganic & Medicinal Chemistry Letters
Academic article
2014
-
Vignaroli, Giulia;
Mencarelli, Martina;
Sementa, Deborah;
Crespan, Emmanuele;
Kissova, Miroslava;
Maga, Giovanni.
(2014)
Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.
Journal of combinatorial chemistry
Academic article
2013
-
Vignaroli, Giulia;
Zamperini, Claudio;
Dreassi, Elena;
Radi, Marco;
Angelucci, Adriano;
Sanità, Patrizia.
(2013)
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors.
ACS Medicinal Chemistry Letters
Academic article
-
Mori, Mattia;
Tintori, Cristina;
Christopher, Robert Selwyne Arul;
Radi, Marco;
Schenone, Silvia;
Musumeci, Francesca.
(2013)
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.
ChemMedChem
Academic article
-
Zucca, Elisa;
Crespan, Emmanuele;
Bertoletti, Federica;
Kissova, Miroslava;
Maga, Giovanni;
Bonavida, Benjamin.
(2013)
Book title: Molecular mechanisms of tumor cell resistance to chemotherapy. Book subtitle: Targeted therapies to reverse resistance. Chapter title: Two birds with a stone: Molecular cancer therapy targeting signal transduction and DNA repair pathways.
Springer Science+Business Media B.V.
Springer Science+Business Media B.V.
Textbook
-
Tintori, Cristina;
Laurenzana, Ilaria;
La Rocca, Francesco;
Falchi, Federico;
Carraro, Fabio;
Ruiz, Alba.
(2013)
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.
ChemMedChem
Academic article
2012
-
Moukova, Lucie;
Vranova, Vladimira;
Slamova, Iva;
Kissova, Miroslava;
Kuglik, Petr.
(2012)
Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in Czech Republic.
European Oncology and Haematology
Academic article
Journal publications
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Academic article
-
Mentegari, Elisa;
Bertoletti, Federica;
Kissova, Miroslava;
Zucca, Elisa;
Galli, Silvia;
Tagliavini, Giulia.
(2021)
A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.
International Journal of Molecular Sciences
Academic article
-
Fallacara, Anna Lucia;
Passannanti, Raffaele;
Mori, Mattia;
Iovenitti, Giulia;
Musumeci, Francesca;
Greco, Chiara.
(2019)
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines.
European Journal of Medicinal Chemistry
Academic article
-
Tassini, Sabrina;
Langron, Emily;
Delang, Leen;
Mirabelli, Carmen;
Lanko, Kristina;
Crespan, Emmanuele.
(2019)
Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach.
Journal of Medicinal Chemistry
Academic article
-
Molinari, Alessandro;
Fallacara, Anna Lucia;
Di Maria, Salvatore;
Zamperini, Claudio;
Poggialini, Federica;
Musumeci, Francesca.
(2018)
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.
Bioorganic & Medicinal Chemistry Letters
Academic article
-
Musumeci, Francesca;
Fallacara, Anna Lucia;
Brullo, Chiara;
Grossi, Giancarlo;
Botta, Lorenzo;
Calandro, Pierpaolo.
(2017)
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma.
European Journal of Medicinal Chemistry
Academic article
-
Mentegari, Elisa;
Crespan, Emmanuele;
Bavagnoli, Laura;
Kissova, Miroslava;
Bertoletti, Federica;
Sabbioneda, Simone.
(2017)
Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.
Nucleic Acids Research (NAR)
Academic article
-
Tassini, Sabrina;
Sun, Liang;
Lanko, Kristina;
Crespan, Emmanuele;
Langron, Emily;
Falchi, Federico.
(2017)
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.
Journal of Medicinal Chemistry
Academic article
-
Kissova, Miroslava;
Crespan, Emmanuele;
Maga, Giovanni.
(2016)
The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: implications for drug design.
Bioorganic & Medicinal Chemistry
Academic article
-
Samir M, El-Moghazy;
Riham F, George;
Essam Eldin A, Osman;
Ahmed A, Elbatrawy;
Kissova, Miroslava;
Colombo, Ambra.
(2016)
Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line.
European Journal of Medicinal Chemistry
Academic article
-
Mentegari, Elisa;
Kissova, Miroslava;
Bavagnoli, Laura;
Maga, Giovanni;
Crespan, Emmanuele.
(2016)
DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair.
Genes
Academic literature review
-
Radi, Marco;
Schneider, Ralf;
Fallacara, Anna Lucia;
Botta, Lorenzo;
Crespan, Emmanuele;
Tintori, Cristina.
(2016)
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.
Bioorganic & Medicinal Chemistry Letters
Academic article
-
Vignaroli, Giulia;
Mencarelli, Martina;
Sementa, Deborah;
Crespan, Emmanuele;
Kissova, Miroslava;
Maga, Giovanni.
(2014)
Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.
Journal of combinatorial chemistry
Academic article
-
Vignaroli, Giulia;
Zamperini, Claudio;
Dreassi, Elena;
Radi, Marco;
Angelucci, Adriano;
Sanità, Patrizia.
(2013)
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors.
ACS Medicinal Chemistry Letters
Academic article
-
Mori, Mattia;
Tintori, Cristina;
Christopher, Robert Selwyne Arul;
Radi, Marco;
Schenone, Silvia;
Musumeci, Francesca.
(2013)
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.
ChemMedChem
Academic article
-
Tintori, Cristina;
Laurenzana, Ilaria;
La Rocca, Francesco;
Falchi, Federico;
Carraro, Fabio;
Ruiz, Alba.
(2013)
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.
ChemMedChem
Academic article
-
Moukova, Lucie;
Vranova, Vladimira;
Slamova, Iva;
Kissova, Miroslava;
Kuglik, Petr.
(2012)
Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in Czech Republic.
European Oncology and Haematology
Academic article
Books
-
Zucca, Elisa;
Crespan, Emmanuele;
Bertoletti, Federica;
Kissova, Miroslava;
Maga, Giovanni;
Bonavida, Benjamin.
(2013)
Book title: Molecular mechanisms of tumor cell resistance to chemotherapy. Book subtitle: Targeted therapies to reverse resistance. Chapter title: Two birds with a stone: Molecular cancer therapy targeting signal transduction and DNA repair pathways.
Springer Science+Business Media B.V.
Springer Science+Business Media B.V.
Textbook
Knowledge Transfer
poster
M Kissova, M Vestvik, HLB Lervåg, M Bjørås et al. Drug-screening on patient-derived glioblastoma organoids uncovers synergies between DNA glycosylase inhibitors and G-quadruplex ligands potentiating cancer cell death. SNOG, Gothenburg, Sweden (04/2024)