Marie Klevjer
About
Research
Publications
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study
In contrast with the current observational knowledge of RHR and AF, an inverse causal association between RHR and AF was demonstrated in both linear and non-linear MR for RHR values up to 90 bpm.
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study
We identified 38 novel SNP associated with V̇O 2peak in HUNT. Two SNP were nominally replicated in UKB. Several interesting genes emerged from the functional analyses, among them one previously reported to be associated with CVD and another with CRF.
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease
Our findings provide insight into the pleiotropic effects of the RHR variants, contributing towards an improved understanding of mechanisms linking RHR and disease.
2025
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Consortium, FinnGen.
(2025)
Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts.
British Journal of Sports Medicine
Academic article
2024
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Klevjer, Marie.
(2024)
Genetic liability to sedentary behavior increases the risk of cardiovascular disease incidence: Evidence from the FinnGen cohort with 293,250 individuals.
medRxiv
Academic article
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Øvretveit, Karsten;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2024)
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.
European Journal of Preventive Cardiology (EJPC)
Academic article
2023
-
Klevjer, Marie;
Rasheed, Humaira;
Romundstad, Pål Richard;
Madssen, Erik;
Brumpton, Ben Michael;
Bye, Anja.
(2023)
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study.
Europace
Academic article
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory
fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Academic literature review
-
Tynkkynen, Niko Paavo;
Törmäkangas, Timo;
Palviainen, Teemu;
Hyvärinen, Matti;
Klevjer, Marie;
Joensuu, Laura.
(2023)
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study.
European Journal of Epidemiology (EJE)
Academic article
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Wisløff, Ulrik;
Langaas, Mette;
Bye, Anja.
(2023)
Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study.
Physiological Genomics
Academic article
-
Sperstad, Sigri Bakken;
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Røsbjørgen, Ragnhild.
(2023)
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study.
PLOS ONE
Academic article
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Academic literature review
2022
-
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Gigante, Bruna;
Gjære, Sigrid.
(2022)
Small LDL subfractions are associated with coronary atherosclerosis despite nodifferences in conventional lipids.
Physiological Genomics
Academic article
-
Nodeland, Markus;
Klevjer, Marie;
Sæther, Julie Caroline;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Wisløff, Ulrik.
(2022)
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study.
Atherosclerosis
Academic article
-
Benegiamo, Giorgia;
Bou Sleiman, Maroun;
Wohlwend, Martin;
Rodríguez-López, Sandra;
Goeminne, Ludger J. E.;
Laurila, Pirkka-Pekka.
(2022)
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Nature Metabolism
Academic article
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Hansen, Ailin Falkmo;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2022)
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study.
Medicine & Science in Sports & Exercise
Academic article
2020
-
Bye, Anja;
Klevjer, Marie;
Ryeng, Einar;
Silva, Gustavo Jose Justo;
Moreira, Jose Bianco Nascimento;
Stensvold, Dorthe.
(2020)
Identification of novel genetic variants associated with cardiorespiratory fitness.
Progress in cardiovascular diseases
Academic literature review
2019
-
De Soysa, Ann Kristin Hjelle;
Klevjer, Marie;
Grill, Valdemar Erik Robert;
Mostad, Ingrid Løvold.
(2019)
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3.
Metabolism: Clinical and Experimental
Academic article
Journal publications
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Consortium, FinnGen.
(2025)
Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts.
British Journal of Sports Medicine
Academic article
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Klevjer, Marie.
(2024)
Genetic liability to sedentary behavior increases the risk of cardiovascular disease incidence: Evidence from the FinnGen cohort with 293,250 individuals.
medRxiv
Academic article
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Øvretveit, Karsten;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2024)
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.
European Journal of Preventive Cardiology (EJPC)
Academic article
-
Klevjer, Marie;
Rasheed, Humaira;
Romundstad, Pål Richard;
Madssen, Erik;
Brumpton, Ben Michael;
Bye, Anja.
(2023)
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study.
Europace
Academic article
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory
fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Academic literature review
-
Tynkkynen, Niko Paavo;
Törmäkangas, Timo;
Palviainen, Teemu;
Hyvärinen, Matti;
Klevjer, Marie;
Joensuu, Laura.
(2023)
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study.
European Journal of Epidemiology (EJE)
Academic article
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Wisløff, Ulrik;
Langaas, Mette;
Bye, Anja.
(2023)
Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study.
Physiological Genomics
Academic article
-
Sperstad, Sigri Bakken;
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Røsbjørgen, Ragnhild.
(2023)
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study.
PLOS ONE
Academic article
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Academic literature review
-
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Gigante, Bruna;
Gjære, Sigrid.
(2022)
Small LDL subfractions are associated with coronary atherosclerosis despite nodifferences in conventional lipids.
Physiological Genomics
Academic article
-
Nodeland, Markus;
Klevjer, Marie;
Sæther, Julie Caroline;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Wisløff, Ulrik.
(2022)
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study.
Atherosclerosis
Academic article
-
Benegiamo, Giorgia;
Bou Sleiman, Maroun;
Wohlwend, Martin;
Rodríguez-López, Sandra;
Goeminne, Ludger J. E.;
Laurila, Pirkka-Pekka.
(2022)
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Nature Metabolism
Academic article
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Hansen, Ailin Falkmo;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2022)
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study.
Medicine & Science in Sports & Exercise
Academic article
-
Bye, Anja;
Klevjer, Marie;
Ryeng, Einar;
Silva, Gustavo Jose Justo;
Moreira, Jose Bianco Nascimento;
Stensvold, Dorthe.
(2020)
Identification of novel genetic variants associated with cardiorespiratory fitness.
Progress in cardiovascular diseases
Academic literature review
-
De Soysa, Ann Kristin Hjelle;
Klevjer, Marie;
Grill, Valdemar Erik Robert;
Mostad, Ingrid Løvold.
(2019)
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3.
Metabolism: Clinical and Experimental
Academic article
Outreach
2024
-
PosterKlevjer, Marie; Øvretveit, Karsten; Brumpton, Ben Michael; Wisløff, Ulrik; Hveem, Kristian; Bye, Anja. (2024) Polygenic prediction of cardiorespiratory fitness: The HUNT Study. Nordic Society of Human Genetics and Precision Medicine og Biobank Norway Nordic Conference on Future Health , Trondheim 2024-09-09 - 2024-09-12
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Programme participationKlevjer, Marie. (2024) Populærvitenskapelig innslag om hvilepuls i programmet "God ettermiddag Trøndelag" på NRK P1 Trøndelag. NRK P1 Trøndelag NRK P1 Trøndelag [Radio] 2024-10-22
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InterviewKlevjer, Marie. (2024) "Et sprekere liv" . Nyhetsbrev Sprek abonnementer Nyhetsbrev Sprek abonnementer [Newspaper] 2024-10-28
2023
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PosterSæther, Julie Caroline; Follestad, Turid; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna. (2023) Circulating lipoprotein subfractions and microRNAs as potential biomarkers for improved risk prediction of myocardial infarction: the HUNT study. Norwegian University of Science and Technology 3rd Nordic Metabolomics Conference , Trondheim 2023-10-18 - 2023-10-20
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PosterNordeidet, Ada Nilsen; Bye, Anja; Klevjer, Marie; Brumpton, Ben Michael; Wisløff, Ulrik; Madssen, Erik. (2023) Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease. NTNU Health A HEALTHY FUTURE , Trondheim 2023-10-05 -
2022
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PosterNordeidet, Ada Nilsen; Bye, Anja; Klevjer, Marie; Langaas, Mette. (2022) Cardiovascular disease-wide association study to investigate shared genetics with peak oxygen uptake. European Society of Cardiology ESC Congress 2022 , Barcelona 2022-08-26 - 2022-08-29
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Academic lectureKlevjer, Marie; Nordeidet, Ada Nilsen; Hansen, Ailin Falkmo; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael. (2022) Genome-wide association study identify new genetic determinants of cardiorespiratory fitness: The HUNT Study . ESC Preventive Cardiology 2022 2022-04-07 - 2022-04-09
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Academic lectureKlevjer, Marie; Nordeidet, Ada Nilsen; Hansen, Ailin Falkmo; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael. (2022) New genetic determinants of VO2max-level identified by GWAS: The HUNT Study. Frontiers in Cardiovascular Biomedicine 2022-04-29 - 2022-05-01
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PosterSæther, Julie Caroline; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Brune; Gjære, Sigrid. (2022) Small LDL-5 subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids. European Atherosclerosis Society EAS Congress 2022 , Milano 2022-05-22 - 2022-05-25
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PosterKlevjer, Marie; Nordeidet, Ada Nilsen; Bye, Anja. (2022) Genome-wide association study indentify new genetic determinants of resting heart rate. Nordic Society of Human Genetics and Precision Medicine 2022-11-03 - 2022-11-04
2020
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Programme participationKlevjer, Marie. (2020) Vi har lenge mistenkt at kondis går i arv. Nå er det bevist.» . NRK P2 - Studio 2 NRK P2 - Studio 2 [Radio] 2020-03-04
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Academic lectureKlevjer, Marie; Brumpton, Ben Michael; Madssen, Erik; Bye, Anja. (2020) Identifying new genetic markers for maximal oxygen uptake. EPINOR EPINOR Online Conference 2020-11-09 - 2020-11-09
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PosterKlevjer, Marie; Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna. (2020) LDL-5 are elevated in patients with coronary atherosclerosis, despite no increase in total levels of LDL-cholesterol. European Society of Cardiology ESC Congress 2020 - The digital experience 2020-08-29 - 2020-09-01
2019
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Academic lectureBye, Anja; Klevjer, Marie; Ryeng, Einar; da Silva, Gustavo Justo; Moreira, Jose Bianco Nascimento; Stensvold, Dorthe. (2019) Identification of genetic variants associated with the cardiovascular disease risk factor, low aerobic fitness - The HUNT study. European Society of Cardiology European Society of Cardiology Congress 2019 , Paris 2019-08-30 - 2019-09-05