2024

• Minnai, Francesca; Shkodra, Morena; Noci, Sara; Brunelli, Cinzia; Pigni, Alessandra; Zecca, Ernesto. (2024) Genomic Study in Opioid-Treated Cancer Patients Identifies Variants Associated With Nausea-Vomiting. Journal of Pain and Symptom Management
  Academic article
• Brenne, Siv Stakset; Madsen, Poul Henning; Pedersen, Inge Søkilde; Hveem, Kristian; Skorpen, Frank; Krarup, Henrik Bygum. (2024) The prognostic role of circulating tumour DNA detected prior to clinical diagnosis of colorectal cancer in the HUNT study. BMC Cancer
  Academic article

2023

• Brenne, Siv Stakset; Madsen, Poul Henning; Pedersen, Inge Søkilde; Hveem, Kristian; Skorpen, Frank; Krarup, Henrik Bygum. (2023) Colorectal cancer detected by liquid biopsy 2 years prior to clinical diagnosis in the HUNT study. British Journal of Cancer
  Academic article

2021

• Sun, Yi-Qian; Richmond, Rebecca C.; Suderman, Matthew; Min, Josine L; Battram, Thomas; Flatberg, Arnar. (2021) Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study. International Journal of Epidemiology
  Academic article

2020

• Laugsand, Eivor Alette; Brenne, Siv Sellæg; Skorpen, Frank. (2020) DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples. International Journal of Colorectal Disease
  Academic literature review
• Colombo, Francesca; Pintarelli, Giulia; Galvan, Antonella; Noci, Sara; Corli, Oscar; Skorpen, Frank. (2020) Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients. Scientific Reports
  Academic article
• Ottestad, Anine Larsen; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Skorpen, Frank; Hong, Yan Dai. (2020) The relevance of tumor mutation profiling in interpretation of NGS data from cell-free DNA in non-small cell lung cancer patients. Experimental and molecular pathology (Print)
  Academic article
• Balstad, Trude Rakel; Brunelli, Cinzia; Pettersen, Caroline Hild; Schønberg, Svanhild Margrethe Arentz; Skorpen, Frank; Fallon, Marie T.. (2020) Power comparisons and clinical meaning of outcome measures in assessing treatment effect in cancer cachexia: secondary analysis from a randomised pilot multimodal intervention trial . Frontiers in Nutrition
  Academic article

2018

• Sun, Yi-Qian; Brumpton, Ben Michael; Bonilla, Carolina; Lewis, Sarah J.; Burgess, Stephen; Skorpen, Frank. (2018) Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomization analysis of the HUNT study. European Respiratory Journal
  Academic article
• Johnsen, Marianne Bakke; Winsvold, Bendik K S; Børte, Sigrid; Vie, Gunnhild Åberge; Pedersen, Linda Margareth; Storheim, Kjersti. (2018) The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT Study. European Journal of Neurology
  Academic article
• Estrup Olesen, Anne; Grønlund, Debbie; Gram, Mikkel; Skorpen, Frank; Drewes, Asbjørn Mohr; Klepstad, Pål. (2018) Prediction of opioid dose in cancer pain patients using genetic profiling: not yet an option with support vector machine learning. BMC Research Notes
  Academic article

2017

• Wang, Yufei; McKay, James D.; Rafnar, Thorunn; Wang, Zhaoming; Timofeeva, Maria N.; Broderick, Peter. (2017) Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer (Nature Genetics (2014) 46 (736-741)). Nature Genetics
  Errata
• Sun, Yi-Qian; Chen, Yue; Langhammer, Arnulf; Skorpen, Frank; Wu, Chunsen; Mai, Xiao-Mei. (2017) Passive smoking in relation to lung cancer incidence and histologic types in Norwegian adults: the HUNT study. European Respiratory Journal
  Letter to the editor
• Sun, Yi-Qian; Langhammer, Arnulf; Wu, Chunsen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund. (2017) Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study. European Journal of Epidemiology (EJE)
  Academic article
• Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.. (2017) Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium. Scientific Reports
  Academic article
• Johnsen, Marianne Bakke; Vie, Gunnhild Åberge; Winsvold, Bendik K S; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad. (2017) The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study. Osteoarthritis and Cartilage
  Academic article
• Sun, Yi-Qian; Langhammer, Arnulf; Skorpen, Frank; Chen, Yue; Mai, Xiao-Mei. (2017) Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway. BMJ Open
  Academic article
• Pettersen, Kristine; Andersen, Sonja Benedikte; Degen, Simone; Tadini, Valentina; Grosjean, Joël; Hatakeyama, Shinji. (2017) Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling. Scientific Reports
  Academic article
• Skogholt, Anne Heidi; Ryeng, Einar; Erlandsen, Sten Even; Skorpen, Frank; Arentz Schønberg, Svanhild Margrethe; Sætrom, Pål. (2017) Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks. BMC Research Notes
  Academic article

2016

• Skorpen, Frank; von Hofacker, Sebastian; Bjørngaard, Mads; Skogholt, Anne Heidi; Dale, Ola; Kaasa, Stein. (2016) The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses. Acta Anaesthesiologica Scandinavica
  Academic article
• Klepstad, Pål; Skorpen, Frank. (2016) Genetic findings related to pain and analgesics-why are they so inconsistent?. Pain
  Book review
• Skorpen, Frank. (2016) Molekylærgenetikk i smertebehandling. Gyldendal Akademisk
  Chapter
• Skorpen, Frank. (2016) Kap 27: Molekylærgenetikk i smertebehandling. Gyldendal Akademisk
  Chapter
• Kurita, Geana Paula; Ekholm, Ola; Kaasa, Stein; Klepstad, Pål; Skorpen, Frank; Sjøgren, Per. (2016) Genetic variation and cognitive dysfunction in opioid-treated patients with cancer. Brain and Behavior
  Academic article

2015

• Klepstad, Pål; Skorpen, Frank. (2015) Genetic variability of pain - a patient focused endpoint. Scandinavian Journal of Pain
  Editorial
• Klepstad, Pål; Skorpen, Frank. (2015) Genetic findings related to pain and analgesics – why are they so inconsistent?. Pain
  Editorial
• Brenner, Darren. R.; Amos, Christopher I.; Brhane, Yonathan; Timofeeva, Maria N.; Caporaso, Neil; Wang, Yufei. (2015) Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis
  Academic article
• Laugsand, Eivor Alette; Skorpen, Frank; Kaasa, Stein; Sabatowski, Rainer; Strasser, Florian; Fayers, Peter. (2015) Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids. Clinical and Translational Gastroenterology
  Academic article
• Sørgjerd, Elin Pettersen; Thorsby, Per Medbøe; Torjesen, Peter A; Skorpen, Frank; Kvaløy, Kirsti; Grill, Valdemar Erik Robert. (2015) Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study. BMJ Open Diabetes Research & Care
  Academic article

2014

• Taylor, Amy E; Fluharty, Meg; Bjørngaard, Johan Håkon; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Marioni, Riccardo R.. (2014) Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. BMJ Open
  Academic article
• Wang, Yufei; McKay, JD; Rafnar, T; Wang, Z; Timofeeva, MN; Broderick, P. (2014) Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nature Genetics
  Academic article
• Scarpi, E; Calistri, D; Klepstad, Pål; Kaasa, Stein; Skorpen, Frank; Habberstad, Ragnhild Hansdatter. (2014) Clinical and genetic factors related to cancer-induced bone pain and bone pain relief. The Oncologist
  Academic article
• Åsvold, Bjørn Olav; Bjørngaard, Johan Håkon; Carslake, D; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Smith, GD. (2014) Causal associations of tobacco smoking with cardiovascular risk factors: a Mendelian randomization analysis of the HUNT Study in Norway. International Journal of Epidemiology
  Academic article
• Holmen, Oddgeir; Zhang, He; Zhou, Wei; Schmidt, Ellen; Hovelson, Daniel H; Langhammer, Arnulf. (2014) No large-effect low-frequency coding variation found for myocardial infarction. Human Molecular Genetics
  Academic article
• Holmen, Oddgeir; Zhang, He; Fan , Yanbo; Hovelson, Daniel H; Schmidt, EM; Zhou , Wei. (2014) Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature Genetics
  Academic article

2013

• Bjørngaard, Johan Håkon; Gunnell, David; Gabrielsen, Maiken Elvestad; Davey Smith, George; Skorpen, Frank; Krokan, Hans Einar. (2013) The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study. Psychological Medicine
  Academic article
• Sørgjerd, Elin Pettersen; Skorpen, Frank; Kvaløy, Kirsti; Midthjell, Kristian; Grill, Valdemar. (2013) Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes. Results from the HUNT study, Norway. Autoimmunity
  Academic article
• Fladvad, Torill; Klepstad, Pål; Langaas, Mette; Dale, Ola; Kaasa, Stein; Caraceni, Augusto. (2013) Variability in UDP-glucuronosyltransferase genes and morphine metabolism. Observations from a cross-sectional multicenter study in advanced cancer patients with pain. Pharmacogenetics & Genomics
  Academic article
• Andersen, Sonja; Baar, Cecilie Christensen; Fladvad, Torill; Laugsand, Eivor Alette; Skorpen, Frank. (2013) The N-Terminally Truncated mu 3 and mu 3-Like Opioid Receptors Are Transcribed from a Novel Promoter Upstream of Exon 2 in the Human OPRM1 Gene. PLOS ONE
  Academic article
• Roten, Linda Tømmerdal; Johnson, Matthew; Thomsen, Liv Cecilie Vestrheim; Gundersen, Astrid S.; Solberg, Per; Tollaksen, Kjersti. (2013) A preeclampsia genome-wide linkage scan in Norwegian families. Pregnancy Hypertension
  Abstract
• Storm, Hanne; Støen, Randi; Klepstad, Pål; Skorpen, Frank; Qvigstad, Erik; Ræder, Johan. (2013) Nociceptive stimuli responses at different levels of general anaesthesia and genetic variability. Acta Anaesthesiologica Scandinavica
  Academic article
• Gabrielsen, Maiken Elvestad; Romundstad, Pål Richard; Langhammer, Arnulf; Krokan, Hans Einar; Skorpen, Frank. (2013) Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway. European Journal of Human Genetics
  Academic article

2012

• Sørgjerd, Elin Pettersen; Skorpen, Frank; Kvaløy, Kirsti; Midthjell, Kristian; Grill, Valdemar. (2012) Time dynamics of autoantibodies are coupled to phenotypes and add to the heterogeneity of autoimmune diabetes in adults: the HUNT study, Norway. Diabetologia
  Academic article
• Tesfahun, Almaz Nigatu; Skorpen, Frank; Andersen, Sonja Benedikte. (2012) Exploring Biomarkers for Weight Loss in Cancer Cachexia: the prognostic value of serum sP-selectin, activin A and autophagy-stimulatory activity. NTNU - Trondheim
  Masters thesis
• Galvan, A; Fladvad, Torill; Skorpen, Frank; Gao, X; Klepstad, Pål; Kaasa, Stein. (2012) Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry. The Pharmacogenomics Journal
  Academic article
• Timofeeva, MN; Hung, RJ; Rafnar, T; Christiani, DC; Field, JK; Bickeboller, H. (2012) Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Human Molecular Genetics
  Academic article
• Solheim, Tora Skeidsvoll; Fayers, Peter; Fladvad, Torill; Tan, Ben; Skorpen, Frank; Fearon, Kenneth C.. (2012) Is there a genetic cause of appetite loss? - An explorative study in 1853 cancer patients. Journal of Cachexia, Sarcopenia and Muscle
  Academic article
• Fladvad, Torill; Fayers, Peter; Skorpen, Frank; Kaasa, Stein; Klepstad, Pål. (2012) Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer disease –The European Pharmacogenetic Opioid Study (EPOS). BMJ Supportive & Palliative Care
  Academic article
• Kazma, R; Babron, MC; Gaborieau, Valerie; Génin, E; Brennan, P; Hung, Rayjean J.. (2012) Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. Carcinogenesis
  Academic article
• Tan, Benjamin HL; Fladvad, Torill; Braun, TP; Vigano, Antonio A.L.; Strasser, Florian; Deans, DAC. (2012) P-selectin genotype is associated with the development of cancer cachexia. EMBO Molecular Medicine
  Academic article
• Hals, Ingrid Katrin; Ogata, Hirotaka; Pettersen, Elin Lunde; Ma, ZH; Bjørklund, A; Skorpen, Frank. (2012) Marked over expression of uncoupling protein-2 in beta cells exerts minor effects on mitochondrial metabolism. Biochemical and Biophysical Research Communications - BBRC
  Academic article

2011

• Roten, Linda Tømmerdal; Fenstad, Mona Høysæter; Forsmo, Siri; Johnson, MP; Moses, EK; Austgulen, Rigmor. (2011) A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2). Molecular human reproduction
  Academic article
• Laugsand, Eivor Alette; Klepstad, Pål; Skorpen, Frank; Kaasa, Stein. (2011) Symptoms in patients receiving opioids for cancer pain - clinical and pharmacogenetic aspects. NTNU - Trondheim
  Doctoral dissertation
• Solheim, Tora Skeidsvoll; Fayers, Peter; Fladvad, Torill; Tan, B; Skorpen, Frank; Fearon, Ken. (2011) Is there a genetic cause for cancer cachexia? A clinical validation study in 1797 patients. British Journal of Cancer
  Academic article
• Chan, Y; Holmen, Oddgeir; Dauber, A; Vatten, Lars Johan; Havulinna, AS; Skorpen, Frank. (2011) Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genetics
  Academic article
• Galvan, A; Skorpen, Frank; Klepstad, Pål; Knudsen, Anne Kari; Fladvad, Torill; Falvella, Felicia S. (2011) Multiple Loci Modulate Opioid Therapy Response for Cancer Pain. Clinical Cancer Research
  Academic article
• Tan, Benjamin HL; Fladvad, Torill; Baracos, Vickie; Deans, DAC; Skorpen, Frank; Fearon, KCH. (2011) A P-selectin polymophism is associated with the development of cancer cachexia: Results of a candidate gene association study. British Journal of Surgery
  Abstract
• Boger, CA; Chen, MH; Tin, A; Olden, M; Koettgen, A; de Boer, IH. (2011) CUBN Is a Gene Locus for Albuminuria. Journal of the American Society of Nephrology
  Academic article
• Laugsand, Eivor Alette; Fladvad, Torill; Skorpen, Frank; Maltoni, M; Kaasa, Stein; Fayers, Peter. (2011) Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids. European Journal of Cancer
  Academic article
• Klepstad, Pål; Fladvad, Torill; Skorpen, Frank; Bjordal, Kristin; Caraceni, Augusto; Dale, Ola. (2011) Influence from genetic variability on opioid use for cancer pain: A European genetic association study of 2294 cancer pain patients. Pain
  Academic article
• Tan, Benjamin HL; Ross, JA; Kaasa, Stein; Skorpen, Frank; Fearon, KC. (2011) Identification of possible genetic polymorphisms involved in cancer cachexia: a systematic review. Journal of Genetics
  Academic literature review

2010

• Laugsand, Eivor Alette; Sprangers, MAG; Bjordal, Kristin; Skorpen, Frank; Kaasa, Stein; Klepstad, Pål. (2010) Health Care Providers Underestimate Symptom Intensities of Cancer Patients Recieving Palliative Care. Palliative Medicine
  Abstract
• Klepstad, Pål; Fladvad, Torill; Skorpen, Frank; Bjordal, Kristin; Caraceni, Augusto; Dale, Ola. (2010) The European Pharmacogenetic Opioid Study (EPOS): Influence from Genetic Variability on Opioid Use un 2209 Cancer Pain Patients. Palliative Medicine
  Abstract
• Tan, B; Fladvad, Torill; Baracos, Vickie; Kaasa, Stein; Skorpen, Frank; Fearon, Ken. (2010) Is there a genetic predisposition to cachexia?. Palliative Medicine
  Academic article
• Lips, EH; Gaborieau, V; Mckay, JD; Chabrier, A; Hung, RJ; Boffetta, P. (2010) Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. International Journal of Epidemiology
  Academic article
• Pettersen, Elin; Skorpen, Frank; Kvaløy, Kirsti; Midthjell, Kristian; Grill, Valdemar. (2010) Genetic heterogeneity in latent autoimmune diabetes (LADA) is linked to a varying degree of autoimmune activity. Results from the Nord-Trondelag Health Study. Diabetes
  Academic article
• Laugsand, Eivor Alette; Sprangers, Mirjam A. G.; Bjordal, Kristin; Skorpen, Frank; Kaasa, Stein; Klepstad, Pål. (2010) Health care providers underestimate symptom intensities of cancer patients: A multicenter European study. Health and Quality of Life Outcomes
  Academic article

2009

• Andersen, Sonja Benedikte; Skorpen, Frank. (2009) Variation in the COMT gene: Implications for Pain Perception and Pain Treatment. Pharmacogenomics (London)
  Academic literature review
• Aas, Per Arne; Diaz, Javier Pena; Liabakk, Nina-Beate; Krokan, Hans Einar; Skorpen, Frank. (2009) Overexpression of transcription factor AP-2 stimulates the P-A promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression. DNA Repair
  Academic article
• Skorpen, Frank; Lene, Trondsetås. (2009) Studie av genetiske polymorfismer med mulig relevans for symptomer og morfindosebehov hos palliative kreftpasienter. Tapir Akademisk Forlag Tapir Akademisk Forlag
  Masters thesis
• Landi, MT; Chatterjee, N; Yu, K; Goldin, LR; Goldstein, AM; Rotunno, M. (2009) A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma. American Journal of Human Genetics
  Academic article

2008

• Pettersen, E; Grill, V; Kvaloy, K; Skorpen, Frank. (2008) Genetic risk factors for patients with Latent Autoimmune Diabetes (LADA) including insulin resistance genes. Results from the HUNT Study. Diabetologia
  Abstract
• Skorpen, Frank. (2008) Variable response to opioid treatment: genetic predictors within sight?. The FEBS Journal
  Abstract
• Storm, Hanne; Skorpen, Frank; Klepstad, Pål; Støen, Randi; Ræder, Johan. (2008) Genetically variation influence the skin conductance response to nociceptive pain in anesthetized patients. NAForum
  Abstract
• Skorpen, Frank; Laugsand, Eivor Alette; Klepstad, Pål; Kaasa, Stein. (2008) Variable response to opioid treatment: any genetic predictors within sight?. Palliative Medicine
  Abstract
• Skorpen, Frank. (2008) Plenary session abstract: Translational pain research - from molecular biology to the clinic. Palliative Medicine
  Abstract
• Skorpen, Frank. (2008) Banking on Europe's Biobanks. Science
  Interview Journal
• Andersen, Sonja Benedikte; Krokan, Hans Einar; Baar, Cecilie Christensen; Rakvag, Trude Teoline; Laugsand, Eivor Alette; Kvam, Tor-Morten. (2008) Identification of an alternative, putative promoter and new alternatively spliced transcripts from the human µ opioid receptor gene, OPRM1. Palliative Medicine
  Abstract
• Rakvag, Trude Teoline; Kaasa, Stein; Skorpen, Frank; Ross, Joy; Sato, H; Klepstad, Pål. (2008) Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients. Palliative Medicine
  Academic article
• Heath, SC; Gut, IG; Brennan, P; Mckay, JD; Bencko, V; Fabianova, E. (2008) Investigation of the fine structure of European populations with applications to disease association studies. European Journal of Human Genetics
  Academic article
• McKay, JD; Mckay, JD; Hung, RJ; Gaborieau, V; Boffetta, Paolo; Chabrier, Amelie. (2008) Lung cancer susceptibility locus at 5p15.33. Nature Genetics
  Academic article
• Hagen, Knut; Stovner, Lars Jacob; Skorpen, Frank; Pettersen, Elin; Zwart, John-Anker. (2008) COMT genotypes and use of antipsychotic medication: linking population-based prescription database to the HUNT study. Pharmacoepidemiology and Drug Safety
  Academic article
• Hung, RJ; Mckay, JD; Gaborieau, V; Boffetta, P; Hashibe, M; Zaridze, D. (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature
  Academic article
• Rakvag, Trude Teoline; Ross, Joy R; Sato, Hiroe; Skorpen, Frank; Kaasa, Stein; Klepstad, Pål. (2008) Genetic variation in the Catechol-O-Methyltransferase (COMT) gene and morphine requirements in cancer pain patients. Molecular Pain
  Academic article
• Bœkken, Petter; Skorpen, Frank; Stordal, Eystein; Zwart, John-Anker; Hagen, Knut. (2008) Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT). BMC Psychiatry
  Academic article
• Ursin, Lars Øystein; Solberg, Berge; Skolbekken, John-Arne; Skorpen, Frank. (2008) The informed consenters : biobank research and the ethics of recruitment and participation. NTNU-trykk
  Doctoral dissertation
• Skorpen, Frank. (2008) Gode biobanker - bedre helse. Norges forskningsråd Norges forskningsråd
  Report
• Laugsand, Eivor Alette; Skorpen, Frank; Klepstad, Pål; Kaasa, Stein. (2008) Opioids in pain treatment - pharmacologic, genetic and clinical aspects. NTNU
  Medical Student Research Thesis
• Bækken, Petter; Skorpen, Frank; Stordal, Eystein; Zwart, John-Anker; Hagen, Knut. (2008) Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT). BMC Psychiatry
  Academic article
• Hagen, Knut; Stovner, Lars Jacob; Skorpen, Frank; Pettersen, Elin; Zwart, John-Anker. (2008) COMT genotypes and use of antipsychotic medication: linking population-based prescription database to the HUNT study. Pharmacoepidemiology and Drug Safety
  Academic article
• Skorpen, Frank; Laugsand, Eivor Alette; Klepstad, Pål; Kaasa, Stein. (2008) Variable response to opioid treatment: any genetic predictors within sight?. Palliative Medicine
  Academic article

2007

• Ogata, Hirotaka; Petersen, E; Jørgensen, Ingrid Katrin Hals; Skorpen, Frank; Ma, Z; Bjorklund, A. (2007) Moderate over expression of UCP-2 in beta cells reduces ROS formation and protects against H2O2-but not cytokine-induced toxicity and aggravates toxicity due to NO. Diabetologia
  Abstract
• Hagen, Knut; Stovner, Lars Jacob; Skorpen, Frank; Pettersen, Elin; Zwart, John-Anker. (2007) The impact of the Catechol-O-methyltransferase Val158Met polymorhism on survival in the general population -The HUNT study. BMC Medical Genetics
  Academic article
• Hagen, Knut; Pettersen, Elin; Stovner, Lars Jacob; Skorpen, Frank; Holmen, Jostein; Zwart, John-Anker. (2007) High Systolic Blood Pressure Is Associated With Val/Val Genotype in the Catechol-O-Methyltransferase Gene The Nord-Trondelag Health Study (HUNT). American Journal of Hypertension
  Academic article
• Reyes-Gibby, CC; Shete, S; Rakvag, Trude Teoline; Bhat, SV; Skorpen, Frank; Bruera, Eduardo. (2007) Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain
  Academic article
• Skorpen, Frank. (2007) Molekylærgengenetikk i smertebehandling. Gyldendal Akademisk
  Academic chapter/article/Conference paper

2006

• Hagen, Knut; Pettersen, Elin; Stovner, Lars Jacob; Skorpen, Frank; Zwart, John-Anker. (2006) The association between headache and Val/Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT Study. The Journal of Headache and Pain
  Abstract
• Reyes-Gibby, Cielito C; Shete, Sanjay; Rakvag, Trude Teoline; Bhat, Samrat V; Skorpen, Frank; Bruera, Eduardo. (2006) Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain
  Academic article
• Dale, Ola; Nilsen, Turid; Olaussen, Gry; Tvedt, Kåre E; Skorpen, Frank; Smidsrød, Olav. (2006) Transepithelial transport of morphine and mannitol in Caco-2 cells: the influence of chitosans of different molecular weights and degrees of acetylation. Journal of Pharmacy and Pharmacology (JPP)
  Academic article
• Hagen, Knut; Pettersen, Elin; Stovner, Lars Jacob; Skorpen, Frank; Zwart, John-Anker. (2006) No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. Hhe HUNT Study. BMC Musculoskeletal Disorders
  Academic article

2005

• Klepstad, Pål; Dale, Ola; Borchgrevink, Petter Chr.; Kaasa, Stein; Skorpen, Frank. (2005) Genetisk variasjon - viktig for klinisk virkning av opioider?. Tidsskrift for Den norske legeforening
  Academic article
• Akbari, Mansour; Hansen, Marianne Dore; Halgunset, Jostein; Skorpen, Frank; Krokan, Hans Einar. (2005) Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner. Journal of Molecular Diagnostics
  Academic article
• Klepstad, Pål; Dale, Ola; Borchgrevink, Petter Chr.; Kaasa, Stein; Skorpen, Frank. (2005) Genetic variability and clinical efficacy of morphine. Acta Anaesthesiologica Scandinavica
  Academic article
• Rakvag, Trude Teoline; Klepstad, Pål; Baar, Cecilie Christensen; Kvam, Tor-Morten; Dale, Ola; Kaasa, Stein. (2005) The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain
  Academic article

2004

• Kvam, TM; Baar, Cecilie Christensen; Raakvag, Trude Teoline; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2004) Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing. Journal of Molecular Medicine
  Academic article
• Klepstad, Pål; Rakvag, TT; Kaasa, Stein; Holthe, Monica; Dale, Ola; Borchgrevink, Petter Chr.. (2004) The 118 A>G polymorphism in the human mu-opioid receptor gene may increase morphins requirements in patients with pain caused by malignant disease. Acta Anaesthesiologica Scandinavica
  Academic article
• Klepstad, Pål; Rakvag, Trude Teoline; Kaasa, Stein; Holthe, Monica; Dale, Ola; Borchgrevink, Petter Chr.. (2004) The 118 A>G polymorphism in the human µ-opioidreceptor gene may increase morphine requrements in patients with pain caused by malignant disease. Acta Anaesthesiologica Scandinavica
  Academic article
• Duguay, Y; Baar, Cecilie Christensen; Skorpen, Frank; Guillemette, C. (2004) A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity. Clinical Pharmacology and Therapeutics
  Academic article
• Solberg, Berge; Lindmo, Tore; Bratbergsengen, Kjell; Drabløs, Finn; Holmen, Jostein; Hveem, Kristian. (2004) Medical technology: Health surveys and biobanking. A Foresight analysis towards 2020. NTNU, Tapir
  Report

2003

• Holthe, M.; Rakvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar. (2003) Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. The Pharmacogenomics Journal
  Academic article
• Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature
  Academic article
• Holthe, Monica; Råkvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar. (2003) Identification of 10 novel single nucleotide polymorphisms and analysis of their relevance to morphine glucuronidation. The Pharmacogenomics Journal
  Academic article

2002

• Holthe, Monica; Klepstad, Pål; Zahlsen, Kolbjørn; Borchgrevink, Petter Chr.; Hagen, Lars; Dale, Ola. (2002) Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1a1*28 polymorphisms in cancer patients on chronic morphine therapy. European Journal of Clinical Pharmacology
  Academic article
• Li, Lixin; Skorpen, Frank; Egeberg, Kjartan Wøllo; Jørgensen, Ingrid Katrin Hals; Grill, Valdemar. (2002) Induction of UCP-2 mRNA in beta cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. Endocrinology
  Academic article
• Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry
  Academic article
• Holthe, Monica; Råkvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar. (2002) Sequence variationin the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphins (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. The Pharmacogenomics Journal
  Academic article

2001

• Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology
  Academic article
• Li, Li Xin; Skorpen, Frank; Egeberg, Kjartan Wøllo; Jørgensen, Ingrid Katrin Hals; Grill, Valdemar. (2001) Uncoupling protein 2 participates in cellular defense against oxidative stress in clonal beta cells. Biochemical and Biophysical Research Communications - BBRC
  Academic article

2000

• Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters
  Academic article
• Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters
  Academic article

1999

• Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences
  Academic article

1998

• Skorpen, Frank; Alm, B.; Skjelbred, Camilla; Aas, P.A.; Krokan, Hans Einar. (1998) Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells. Chemico-Biological Interactions
  Academic article
• Haug, T.; Skorpen, Frank; Aas, P.A.; Malm, V; Skjelbred, Camilla; Krokan, Hans Einar. (1998) Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase. Nucleic Acids Research (NAR)
  Academic article
• Skorpen, Frank; Skjelbred, Camilla; Aas, P.A.; Alm, B.; Schønberg, S.A.; Krokan, Hans Einar. (1998) Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus. Mutation Research (DNA Repair)
  Academic article
• Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bharati, S; Steinsbekk, Kristin; Nilsen, Hilde. (1998) Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis. DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
  Non-fiction book
• Skorpen, Frank. (1998) Genetic and funkctional analyses of dna repair in human cells. ntnu
  Doctoral dissertation

1997

• Nilsen, H.; Otterlei, Marit; Haug, T.; Solum, K.; Nagelhus, T.A; Skorpen, Frank. (1997) Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Research (NAR)
  Academic article
• Nagelhus, T.; Haug, T.; Singh, K.K.; Keshav, K.F.; Skorpen, Frank; Bharati, S.. (1997) A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A. Journal of Biological Chemistry
  Academic article
• Schønberg, Svanhild Arentz; Skorpen, Frank. (1997) Paracetamol counteracts docosahexaenoid acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro. Anticancer Research
  Academic article
• Schønberg, Svanhild A.; Rudra, Parveen K.; Nøding, Randi; Skorpen, Frank; Bjerve, Kristian S; Krokan, Hans Einar. (1997) Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids. Carcinogenesis
  Academic article
• Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases.
  Academic chapter/article/Conference paper

1996

• Haug, Terje; Skorpen, Frank; Kvaløy, Kirsti; Eftedal, Ingrid; Lund, Henning; Krokan, Hans Einar. (1996) Human uracil-DNA glycosylase gene : sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Genomics
  Academic article
• Haug, T.; Skorpen, Frank; Lund, H.; Eftedal, I.; Kvaløy, K.; Krokan, Hans Einar. (1996) Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Genomics, Society and Policy
  Academic article