Felicity Jayne Ashcroft
About
I am currently working as a post-doc in the department of Biology at NTNU as part of a collaboration with Coegin Pharma to develop treatments for chronic inflammatory diseases. After completing a Ph.D. in Cell and Molecular Biology in the Physiology department at the University of Liverpool, UK, I worked at Baylor College of Medicine, Houston, Texas, where I completed my post-doctoral fellowship in the department of Molecular and Cell Biology establishing high-content imaging approaches to identify and characterize environmental estrogens.
My research has spanned several fields of cell biology but with the common goal of understanding how signaling events are coordinated to control cell fate decisions in human health and disease. I am particularly interested in the development of cell-based assays to enable improved characterization of complex cell behaviors in response to endogenous and exogenous perturbations, while reducing the use of experimental animals.
Research projects
My current research concerns understanding the cellular and molecular mechanisms that regulate inflammation. Ongoing projects include...
Publications
Stossi F, Bolt MJ, Ashcroft FJ, Lamerdin JE, Melnick JS, Powell RT, Dandekar RD, Mancini MG, Walker CL, Westwick JK, Mancini MA. Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays. Chem Biol. 2014 Jun 19;21(6):743-53
Ashcroft FJ, Newberg JY, Jones ED, Mikic I, Mancini MA. High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes. Gene. 2011 May 15;477(1-2):42-52
Chao WT, Ashcroft F, Daquinag AC, Vadakkan T, Wei Z, Zhang P, Dickinson ME, Kunz J. Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis. Mol Cell Biol. 2010 Sep;30(18):4463-79
Chao WT, Daquinag AC, Ashcroft F, Kunz J. Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. J Cell Biol. 2010 Jul 26;190(2):247-62. Erratum in: J Cell Biol. 2010 Aug 9;190(3):479
Long W, Yi P, Amazit L, LaMarca HL, Ashcroft F, Kumar R, Mancini MA, Tsai SY, Tsai MJ, O'Malley BW. SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration. Mol Cell. 2010 Feb 12;37(3):321-32
Nedjadi T, Kitteringham N, Campbell F, Jenkins RE, Park BK, Navarro P, Ashcroft F, Tepikin A, Neoptolemos JP, Costello E. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer. 2009 Oct 6;101(7):1145-54
Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A, Jenkins RE, Lemoine NR, Crnogorac-Jurcevic T, Yin HL, Costello E. Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. Gut. 2007 Jan;56(1):95-106
Ashcroft FJ, Varro A, Dimaline R, Dockray GJ. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochem J ;381:397-403
Pagliocca A, Wroblewski LE, Ashcroft FJ, Noble, PJ, Dockray, GJ, & Varro A. (2002). Stimulation of the gastrin-cholecystokinin(B) receptor promotes branching morphogenesis in gastric AGS cells. Am.J.Physiol Gastrointest.Liver Physiol 283, G292-G299
Publications
2025
-
Johansen, Berit;
Naini, Said Movahedini;
Selvik, Linn-Karina M.;
Feuerherm, Astrid Jullumstrø;
Ashcroft, Felicity;
Wang, C.
(2025)
Group IVA cytosolic phospholipase A2 (cPLA2α): pharmacological
inhibition attenuates kidney inflammation and fibrosis.
Journal of the American Society of Nephrology
Academic article
-
Ashcroft, Felicity Jayne;
Bourmpoula, Asimina;
Mahammad, Nur;
Barbayianni, Efrosini;
Feuerherm, Astrid Jullumstrø;
Nguyen, Thank Thuy Thi.
(2025)
Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A<inf>2</inf> α for targeted cancer therapy.
Nature Communications
Academic article
-
McPartland, Molly;
Ashcroft, Felicity Jayne;
Wagner, Martin.
(2025)
Plastic chemicals disrupt molecular circadian rhythms via adenosine 1 receptor in vitro.
Environment International
Academic article
2024
-
Dahl, Amalie;
Ashcroft, Felicity Jayne;
Nymark, Marianne;
Johansen, Berit.
(2024)
Investigating the photoprotective properties of marine microalgal pigments in skin.
NTNU
Masters thesis
-
Nymark, Marianne;
Ashcroft, Felicity Jayne;
Wild, Richard J.;
Häger, Wiebke;
Sirovic, Ana;
Sueldo, Daniela Jorgelina.
(2024)
Fosna-Folkets nyhetsstudio - Det var overaskende å se hvor mye som var kommet i løpet av vinteren.
Fosna-Folket
Popular scientific article
-
Johansen, Berit;
Duvold, Tore;
Feuerherm, Astrid Jullumstrø;
Ashcroft, Felicity Jayne.
(2024)
Aktinic keratosis treatment.
Other product
2023
-
Nymark, Marianne;
Finazzi, Giovanni;
Volpe, Charlotte;
Serif, Manuel Philipp;
Fonseca, Davi de Miranda;
Sharma, Animesh.
(2023)
Loss of CpFTSY Reduces Photosynthetic Performance and Affects Insertion of PsaC of PSI in Diatoms.
Plant and Cell Physiology
Academic article
2022
-
Ortner, Vinzent Kevin;
Johansen, Berit;
Kilov, Kim;
Castillo Mondragón, Alejandro;
Duvold, Tore;
Kihl, Jesper.
(2022)
The Copenhagen Actinic Keratosis Study (COAKS). A decentralised clinical trial to evaluate tolerability, safety and efficacy of daily field-directed topical treatment with cytosolic phospholipase A<inf>2</inf> inhibitor, AVX001, in participants with actinic keratosis: protocol for a randomised controlled phase I/IIa trial.
BMJ Open
Academic article
-
Nymark, Marianne;
Serif, Manuel;
Ticha, Tereza;
Sueldo, Daniela;
Bartosova, Zdenka;
Völker, Johannes .
(2022)
Forskerne sjekket plastforurensing. Da fant de en overraskende gjenstand.
Fosna-Folket
Popular scientific article
-
Völker, Johannes ;
Ashcroft, Felicity;
Vedøy, Åsa;
Zimmermann, Lisa;
Wagner, Martin.
(2022)
Adipogenic Activity of Chemicals Used in Plastic Consumer Products.
Environmental Science and Technology
Academic article
2021
-
Mahammad, Nur;
Ashcroft, Felicity;
Feuerherm, Astrid Jullumstrø;
Elsaadi, Samah;
Vandsemb, Esten Nymoen;
Børset, Magne.
(2021)
Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells.
Molecules
Academic article
-
Tsirvouli, Eirini;
Ashcroft, Felicity;
Johansen, Berit;
Kuiper, Martin.
(2021)
Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes.
iScience
Academic article
-
Nymark, Marianne;
Völker, Johannes ;
Ticha, Tereza;
Ashcroft, Felicity;
Bartosova, Zdenka;
Serif, Manuel.
(2021)
NTNU-forskere plukket plast.
Fosna-Folket
Popular scientific article
2020
-
Ashcroft, Felicity;
Mahammad, Nur;
Flatekvål, Helene Midtun;
Feuerherm, Astrid Jullumstrø;
Johansen, Berit.
(2020)
cPLA2α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation.
Biomolecules
Academic article
Journal publications
-
Johansen, Berit;
Naini, Said Movahedini;
Selvik, Linn-Karina M.;
Feuerherm, Astrid Jullumstrø;
Ashcroft, Felicity;
Wang, C.
(2025)
Group IVA cytosolic phospholipase A2 (cPLA2α): pharmacological
inhibition attenuates kidney inflammation and fibrosis.
Journal of the American Society of Nephrology
Academic article
-
Ashcroft, Felicity Jayne;
Bourmpoula, Asimina;
Mahammad, Nur;
Barbayianni, Efrosini;
Feuerherm, Astrid Jullumstrø;
Nguyen, Thank Thuy Thi.
(2025)
Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A<inf>2</inf> α for targeted cancer therapy.
Nature Communications
Academic article
-
McPartland, Molly;
Ashcroft, Felicity Jayne;
Wagner, Martin.
(2025)
Plastic chemicals disrupt molecular circadian rhythms via adenosine 1 receptor in vitro.
Environment International
Academic article
-
Nymark, Marianne;
Ashcroft, Felicity Jayne;
Wild, Richard J.;
Häger, Wiebke;
Sirovic, Ana;
Sueldo, Daniela Jorgelina.
(2024)
Fosna-Folkets nyhetsstudio - Det var overaskende å se hvor mye som var kommet i løpet av vinteren.
Fosna-Folket
Popular scientific article
-
Nymark, Marianne;
Finazzi, Giovanni;
Volpe, Charlotte;
Serif, Manuel Philipp;
Fonseca, Davi de Miranda;
Sharma, Animesh.
(2023)
Loss of CpFTSY Reduces Photosynthetic Performance and Affects Insertion of PsaC of PSI in Diatoms.
Plant and Cell Physiology
Academic article
-
Ortner, Vinzent Kevin;
Johansen, Berit;
Kilov, Kim;
Castillo Mondragón, Alejandro;
Duvold, Tore;
Kihl, Jesper.
(2022)
The Copenhagen Actinic Keratosis Study (COAKS). A decentralised clinical trial to evaluate tolerability, safety and efficacy of daily field-directed topical treatment with cytosolic phospholipase A<inf>2</inf> inhibitor, AVX001, in participants with actinic keratosis: protocol for a randomised controlled phase I/IIa trial.
BMJ Open
Academic article
-
Nymark, Marianne;
Serif, Manuel;
Ticha, Tereza;
Sueldo, Daniela;
Bartosova, Zdenka;
Völker, Johannes .
(2022)
Forskerne sjekket plastforurensing. Da fant de en overraskende gjenstand.
Fosna-Folket
Popular scientific article
-
Völker, Johannes ;
Ashcroft, Felicity;
Vedøy, Åsa;
Zimmermann, Lisa;
Wagner, Martin.
(2022)
Adipogenic Activity of Chemicals Used in Plastic Consumer Products.
Environmental Science and Technology
Academic article
-
Mahammad, Nur;
Ashcroft, Felicity;
Feuerherm, Astrid Jullumstrø;
Elsaadi, Samah;
Vandsemb, Esten Nymoen;
Børset, Magne.
(2021)
Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells.
Molecules
Academic article
-
Tsirvouli, Eirini;
Ashcroft, Felicity;
Johansen, Berit;
Kuiper, Martin.
(2021)
Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes.
iScience
Academic article
-
Nymark, Marianne;
Völker, Johannes ;
Ticha, Tereza;
Ashcroft, Felicity;
Bartosova, Zdenka;
Serif, Manuel.
(2021)
NTNU-forskere plukket plast.
Fosna-Folket
Popular scientific article
-
Ashcroft, Felicity;
Mahammad, Nur;
Flatekvål, Helene Midtun;
Feuerherm, Astrid Jullumstrø;
Johansen, Berit.
(2020)
cPLA2α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation.
Biomolecules
Academic article
Report
-
Dahl, Amalie;
Ashcroft, Felicity Jayne;
Nymark, Marianne;
Johansen, Berit.
(2024)
Investigating the photoprotective properties of marine microalgal pigments in skin.
NTNU
Masters thesis
PRODUKT
-
Johansen, Berit;
Duvold, Tore;
Feuerherm, Astrid Jullumstrø;
Ashcroft, Felicity Jayne.
(2024)
Aktinic keratosis treatment.
Other product
Teaching
Courses
Outreach
2024
-
LectureAshcroft, Felicity Jayne; Brembu, Tore. (2024) The transcriptome behind Coscinodiscus girdle bands. Silicamics 2024 2024-10-14 - 2024-10-18
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Academic lectureDahl, Amalie; Nymark, Marianne; Bartosova, Zdenka; Johansen, Berit; Ashcroft, Felicity Jayne. (2024) Investigating the use of marine microalgal pigments for the prevention of skin cancer. 59th Contact Meeting of the Norwegian Bioscience Society 2024-01-18 - 2024-01-21