Navigation

  • Skip to Content
NTNU Home NTNU Home

ntnu.edu

  • Studies
    • Master's programmes in English
    • For exchange students
    • PhD opportunities
    • All programmes of study
    • Courses
    • Financing
    • Language requirements
    • Application process
    • Academic calendar
    • FAQ
  • Research and innovation
    • NTNU research
    • Research excellence
    • Strategic research areas
    • Innovation resources
    • PhD opportunities
  • Life and housing
    • Student in Trondheim
    • Student in Gjøvik
    • Student in Ålesund
    • For researchers
    • Life and housing
  • About NTNU
    • Contact us
    • Faculties and departments
    • Libraries
    • International researcher support
    • Vacancies
    • About NTNU
    • Maps
  1. Employees

Språkvelger

Norsk

Felicity Jayne Ashcroft

Download press photo
Download press photo
Foto:

Felicity Jayne Ashcroft

Researcher
Department of Biology

felicity.ashcroft@ntnu.no
Realfagbygget, Gløshaugen
About Publications Teaching Outreach

About

I am currently working as a post-doc in the department of Biology at NTNU as part of a collaboration with Coegin Pharma to develop treatments for chronic inflammatory diseases.   After completing a Ph.D. in Cell and Molecular Biology in the Physiology department at the University of Liverpool, UK, I worked at Baylor College of Medicine, Houston, Texas, where I completed my post-doctoral fellowship in the department of Molecular and Cell Biology establishing high-content imaging approaches to identify and characterize environmental estrogens.

My research has spanned several fields of cell biology but with the common goal of understanding how signaling events are coordinated to control cell fate decisions in human health and disease. I am particularly interested in the development of cell-based assays to enable improved characterization of complex cell behaviors in response to endogenous and exogenous perturbations, while reducing the use of experimental animals.

Research projects

My current research concerns understanding the cellular and molecular mechanisms that regulate inflammation. Ongoing projects include...

  • Investigating cytosolic phospholipase A2α (cPLA2α) as a druggable target for treating  psoriasis.
  • Studying the regulation of macrophage fate by lipid signaling mediators.
  • Investigating the pro-inflammatory effects of nano and microplastics at the cell and molecular level.
  •  

    Publications

    Stossi F, Bolt MJ, Ashcroft FJ, Lamerdin JE, Melnick JS, Powell RT, Dandekar RD, Mancini MG, Walker CL, Westwick JK, Mancini MA. Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays. Chem Biol. 2014 Jun 19;21(6):743-53

    Ashcroft FJ, Newberg JY, Jones ED, Mikic I, Mancini MA. High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes. Gene. 2011 May 15;477(1-2):42-52

    Chao WT, Ashcroft F, Daquinag AC, Vadakkan T, Wei Z, Zhang P, Dickinson ME, Kunz J. Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis. Mol Cell Biol. 2010 Sep;30(18):4463-79

    Chao WT, Daquinag AC, Ashcroft F, Kunz J. Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. J Cell Biol. 2010 Jul 26;190(2):247-62. Erratum in: J Cell Biol. 2010 Aug 9;190(3):479

    Long W, Yi P, Amazit L, LaMarca HL, Ashcroft F, Kumar R, Mancini MA, Tsai SY, Tsai MJ, O'Malley BW. SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration. Mol Cell. 2010 Feb 12;37(3):321-32

    Nedjadi T, Kitteringham N, Campbell F, Jenkins RE, Park BK, Navarro P, Ashcroft F, Tepikin A, Neoptolemos JP, Costello E. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer. 2009 Oct 6;101(7):1145-54

    Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A, Jenkins RE, Lemoine NR, Crnogorac-Jurcevic T, Yin HL, Costello E. Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. Gut. 2007 Jan;56(1):95-106

    Ashcroft FJ, Varro A, Dimaline R, Dockray GJ. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochem J ;381:397-403

    Pagliocca A, Wroblewski LE, Ashcroft FJ, Noble, PJ, Dockray, GJ, & Varro A. (2002). Stimulation of the gastrin-cholecystokinin(B) receptor promotes branching morphogenesis in gastric AGS cells. Am.J.Physiol Gastrointest.Liver Physiol 283, G292-G299

    Publications

    • Chronological
    • By category
    • See all publications in Cristin

    2025

    • Johansen, Berit; Naini, Said Movahedini; Selvik, Linn-Karina M.; Feuerherm, Astrid Jullumstrø; Ashcroft, Felicity; Wang, C. (2025) Group IVA cytosolic phospholipase A2 (cPLA2α): pharmacological inhibition attenuates kidney inflammation and fibrosis. Journal of the American Society of Nephrology
      Academic article
    • Ashcroft, Felicity Jayne; Bourmpoula, Asimina; Mahammad, Nur; Barbayianni, Efrosini; Feuerherm, Astrid Jullumstrø; Nguyen, Thank Thuy Thi. (2025) Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A<inf>2</inf> α for targeted cancer therapy. Nature Communications
      Academic article
    • McPartland, Molly; Ashcroft, Felicity Jayne; Wagner, Martin. (2025) Plastic chemicals disrupt molecular circadian rhythms via adenosine 1 receptor in vitro. Environment International
      Academic article

    2024

    • Dahl, Amalie; Ashcroft, Felicity Jayne; Nymark, Marianne; Johansen, Berit. (2024) Investigating the photoprotective properties of marine microalgal pigments in skin. NTNU
      Masters thesis
    • Nymark, Marianne; Ashcroft, Felicity Jayne; Wild, Richard J.; Häger, Wiebke; Sirovic, Ana; Sueldo, Daniela Jorgelina. (2024) Fosna-Folkets nyhetsstudio - Det var overaskende å se hvor mye som var kommet i løpet av vinteren. Fosna-Folket
      Popular scientific article
    • Johansen, Berit; Duvold, Tore; Feuerherm, Astrid Jullumstrø; Ashcroft, Felicity Jayne. (2024) Aktinic keratosis treatment.
      Other product

    2023

    • Nymark, Marianne; Finazzi, Giovanni; Volpe, Charlotte; Serif, Manuel Philipp; Fonseca, Davi de Miranda; Sharma, Animesh. (2023) Loss of CpFTSY Reduces Photosynthetic Performance and Affects Insertion of PsaC of PSI in Diatoms. Plant and Cell Physiology
      Academic article

    2022

    • Ortner, Vinzent Kevin; Johansen, Berit; Kilov, Kim; Castillo Mondragón, Alejandro; Duvold, Tore; Kihl, Jesper. (2022) The Copenhagen Actinic Keratosis Study (COAKS). A decentralised clinical trial to evaluate tolerability, safety and efficacy of daily field-directed topical treatment with cytosolic phospholipase A<inf>2</inf> inhibitor, AVX001, in participants with actinic keratosis: protocol for a randomised controlled phase I/IIa trial. BMJ Open
      Academic article
    • Nymark, Marianne; Serif, Manuel; Ticha, Tereza; Sueldo, Daniela; Bartosova, Zdenka; Völker, Johannes . (2022) Forskerne sjekket plastforurensing. Da fant de en overraskende gjenstand. Fosna-Folket
      Popular scientific article
    • Völker, Johannes ; Ashcroft, Felicity; Vedøy, Åsa; Zimmermann, Lisa; Wagner, Martin. (2022) Adipogenic Activity of Chemicals Used in Plastic Consumer Products. Environmental Science and Technology
      Academic article

    2021

    • Mahammad, Nur; Ashcroft, Felicity; Feuerherm, Astrid Jullumstrø; Elsaadi, Samah; Vandsemb, Esten Nymoen; Børset, Magne. (2021) Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells. Molecules
      Academic article
    • Tsirvouli, Eirini; Ashcroft, Felicity; Johansen, Berit; Kuiper, Martin. (2021) Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes. iScience
      Academic article
    • Nymark, Marianne; Völker, Johannes ; Ticha, Tereza; Ashcroft, Felicity; Bartosova, Zdenka; Serif, Manuel. (2021) NTNU-forskere plukket plast. Fosna-Folket
      Popular scientific article

    2020

    • Ashcroft, Felicity; Mahammad, Nur; Flatekvål, Helene Midtun; Feuerherm, Astrid Jullumstrø; Johansen, Berit. (2020) cPLA2α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation. Biomolecules
      Academic article

    Journal publications

    • Johansen, Berit; Naini, Said Movahedini; Selvik, Linn-Karina M.; Feuerherm, Astrid Jullumstrø; Ashcroft, Felicity; Wang, C. (2025) Group IVA cytosolic phospholipase A2 (cPLA2α): pharmacological inhibition attenuates kidney inflammation and fibrosis. Journal of the American Society of Nephrology
      Academic article
    • Ashcroft, Felicity Jayne; Bourmpoula, Asimina; Mahammad, Nur; Barbayianni, Efrosini; Feuerherm, Astrid Jullumstrø; Nguyen, Thank Thuy Thi. (2025) Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A<inf>2</inf> α for targeted cancer therapy. Nature Communications
      Academic article
    • McPartland, Molly; Ashcroft, Felicity Jayne; Wagner, Martin. (2025) Plastic chemicals disrupt molecular circadian rhythms via adenosine 1 receptor in vitro. Environment International
      Academic article
    • Nymark, Marianne; Ashcroft, Felicity Jayne; Wild, Richard J.; Häger, Wiebke; Sirovic, Ana; Sueldo, Daniela Jorgelina. (2024) Fosna-Folkets nyhetsstudio - Det var overaskende å se hvor mye som var kommet i løpet av vinteren. Fosna-Folket
      Popular scientific article
    • Nymark, Marianne; Finazzi, Giovanni; Volpe, Charlotte; Serif, Manuel Philipp; Fonseca, Davi de Miranda; Sharma, Animesh. (2023) Loss of CpFTSY Reduces Photosynthetic Performance and Affects Insertion of PsaC of PSI in Diatoms. Plant and Cell Physiology
      Academic article
    • Ortner, Vinzent Kevin; Johansen, Berit; Kilov, Kim; Castillo Mondragón, Alejandro; Duvold, Tore; Kihl, Jesper. (2022) The Copenhagen Actinic Keratosis Study (COAKS). A decentralised clinical trial to evaluate tolerability, safety and efficacy of daily field-directed topical treatment with cytosolic phospholipase A<inf>2</inf> inhibitor, AVX001, in participants with actinic keratosis: protocol for a randomised controlled phase I/IIa trial. BMJ Open
      Academic article
    • Nymark, Marianne; Serif, Manuel; Ticha, Tereza; Sueldo, Daniela; Bartosova, Zdenka; Völker, Johannes . (2022) Forskerne sjekket plastforurensing. Da fant de en overraskende gjenstand. Fosna-Folket
      Popular scientific article
    • Völker, Johannes ; Ashcroft, Felicity; Vedøy, Åsa; Zimmermann, Lisa; Wagner, Martin. (2022) Adipogenic Activity of Chemicals Used in Plastic Consumer Products. Environmental Science and Technology
      Academic article
    • Mahammad, Nur; Ashcroft, Felicity; Feuerherm, Astrid Jullumstrø; Elsaadi, Samah; Vandsemb, Esten Nymoen; Børset, Magne. (2021) Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells. Molecules
      Academic article
    • Tsirvouli, Eirini; Ashcroft, Felicity; Johansen, Berit; Kuiper, Martin. (2021) Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes. iScience
      Academic article
    • Nymark, Marianne; Völker, Johannes ; Ticha, Tereza; Ashcroft, Felicity; Bartosova, Zdenka; Serif, Manuel. (2021) NTNU-forskere plukket plast. Fosna-Folket
      Popular scientific article
    • Ashcroft, Felicity; Mahammad, Nur; Flatekvål, Helene Midtun; Feuerherm, Astrid Jullumstrø; Johansen, Berit. (2020) cPLA2α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation. Biomolecules
      Academic article

    Report

    • Dahl, Amalie; Ashcroft, Felicity Jayne; Nymark, Marianne; Johansen, Berit. (2024) Investigating the photoprotective properties of marine microalgal pigments in skin. NTNU
      Masters thesis

    PRODUKT

    • Johansen, Berit; Duvold, Tore; Feuerherm, Astrid Jullumstrø; Ashcroft, Felicity Jayne. (2024) Aktinic keratosis treatment.
      Other product

    Teaching

    Courses

    • BI2012 - Cellebiologi

    Outreach

    2024

    • Lecture
      Ashcroft, Felicity Jayne; Brembu, Tore. (2024) The transcriptome behind Coscinodiscus girdle bands. Silicamics 2024 2024-10-14 - 2024-10-18
    • Academic lecture
      Dahl, Amalie; Nymark, Marianne; Bartosova, Zdenka; Johansen, Berit; Ashcroft, Felicity Jayne. (2024) Investigating the use of marine microalgal pigments for the prevention of skin cancer. 59th Contact Meeting of the Norwegian Bioscience Society 2024-01-18 - 2024-01-21

    NTNU – Norwegian University of Science and Technology

    • For employees
    • |
    • For students
    • |
    • Intranet
    • |
    • Blackboard

    Studies

    • Master's programmes in English
    • For exchange students
    • PhD opportunities
    • Courses
    • Career development
    • Continuing education
    • Application process

    News

    • NTNU News
    • Vacancies

    About NTNU

    • About the university
    • Libraries
    • NTNU's strategy
    • Research excellence
    • Strategic research areas
    • Organizational chart

    Contact

    • Contact NTNU
    • Employees
    • Find experts
    • Press contacts
    • Researcher support
    • Maps

    NTNU in three cities

    • NTNU in Gjøvik
    • NTNU in Trondheim
    • NTNU in Ålesund

    About this website

    • Use of cookies
    • Accessibility statement
    • Privacy policy
    • Editorial responsibility
    Facebook Instagram Linkedin Snapchat Tiktok Youtube
    Sign In
    NTNU logo