Eirini Tsirvouli
About
I am a Researcher in the Department of Clinical and Molecular Medicine.
My work involves the multi-omics analysis and the logical modeling of various biological systems in normal and diseased human cells, with a specific focus on gastroenterological cancers and pro-inflammatory systems, such as psoriasis.
Background
PhD in Biology, Norwegian University of Science and Technology, 2019-2024
MSc in Biotechnology, Norwegian University of Science and Technology, 2017-2019
Integrated MSc in Agricultural Bioengineering, Agricultural University of Athens, 2011-2016
Publications
2024
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Niarakis, Anna;
Ostaszewski, Marek;
Mazein, Alexander;
Kuperstein, Inna;
Kutmon, Martina;
Gillespie, Marc E..
(2024)
Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches.
Frontiers in Immunology
Academic article
-
Tsirvouli, Eirini;
Noël, Vincent;
Flobak, Åsmund;
Calzone, Laurence;
Kuiper, Martin.
(2024)
Dynamic Boolean modeling of molecular and cellular interactions in psoriasis predicts drug target candidates.
iScience
Academic article
2023
-
Heck, Kathleen;
Lindholm, Håvard Takle;
Niederdorfer, Barbara;
Tsirvouli, Eirini;
Kuiper, Martin;
Flobak, Åsmund.
(2023)
Characterisation of Colorectal Cancer Cell Lines through Proteomic Profiling of Their Extracellular Vesicles.
Proteomes
Academic article
-
Müller-Dott, Sophia;
Tsirvouli, Eirini;
Vazquez, Miguel;
Ramirez Flores, Ricardo O;
Badia-I-Mompel, Pau;
Fallegger, Robin.
(2023)
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities.
Nucleic Acids Research (NAR)
Academic article
2022
-
Hadzic, Maida;
Sun, Yitong;
Tomic, Nikolina;
Tsirvouli, Eirini;
Kuiper, Martin;
Pojskic, Lejla.
(2022)
Halogenated boroxine increases propensity to apoptosis in leukemia (UT-7) but not non-tumor cells in vitro.
FEBS Open Bio
Academic article
2021
-
Tsirvouli, Eirini;
Ashcroft, Felicity;
Johansen, Berit;
Kuiper, Martin.
(2021)
Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes.
iScience
Academic article
2020
-
Nymark, Marianne;
Grønbech Hafskjold, Marthe Caroline;
Volpe, Charlotte;
Fonseca, Davi de Miranda;
Sharma, Animesh;
Tsirvouli, Eirini.
(2020)
Functional studies of CpSRP54 in diatoms show that the mechanism of thylakoid protein insertion differ from that in plants and green algae.
The Plant Journal
Academic article
-
Tsirvouli, Eirini;
Touré, Vasundra;
Niederdorfer, Barbara;
Vazquez Garcia, Miguel;
Flobak, Åsmund;
Kuiper, Martin.
(2020)
A middle-out modeling strategy to extend a colon cancer logical model improves drug synergy predictions in epithelial-derived cancer cell lines.
Frontiers in Molecular Biosciences
Academic article
Journal publications
-
Niarakis, Anna;
Ostaszewski, Marek;
Mazein, Alexander;
Kuperstein, Inna;
Kutmon, Martina;
Gillespie, Marc E..
(2024)
Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches.
Frontiers in Immunology
Academic article
-
Tsirvouli, Eirini;
Noël, Vincent;
Flobak, Åsmund;
Calzone, Laurence;
Kuiper, Martin.
(2024)
Dynamic Boolean modeling of molecular and cellular interactions in psoriasis predicts drug target candidates.
iScience
Academic article
-
Heck, Kathleen;
Lindholm, Håvard Takle;
Niederdorfer, Barbara;
Tsirvouli, Eirini;
Kuiper, Martin;
Flobak, Åsmund.
(2023)
Characterisation of Colorectal Cancer Cell Lines through Proteomic Profiling of Their Extracellular Vesicles.
Proteomes
Academic article
-
Müller-Dott, Sophia;
Tsirvouli, Eirini;
Vazquez, Miguel;
Ramirez Flores, Ricardo O;
Badia-I-Mompel, Pau;
Fallegger, Robin.
(2023)
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities.
Nucleic Acids Research (NAR)
Academic article
-
Hadzic, Maida;
Sun, Yitong;
Tomic, Nikolina;
Tsirvouli, Eirini;
Kuiper, Martin;
Pojskic, Lejla.
(2022)
Halogenated boroxine increases propensity to apoptosis in leukemia (UT-7) but not non-tumor cells in vitro.
FEBS Open Bio
Academic article
-
Tsirvouli, Eirini;
Ashcroft, Felicity;
Johansen, Berit;
Kuiper, Martin.
(2021)
Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes.
iScience
Academic article
-
Nymark, Marianne;
Grønbech Hafskjold, Marthe Caroline;
Volpe, Charlotte;
Fonseca, Davi de Miranda;
Sharma, Animesh;
Tsirvouli, Eirini.
(2020)
Functional studies of CpSRP54 in diatoms show that the mechanism of thylakoid protein insertion differ from that in plants and green algae.
The Plant Journal
Academic article
-
Tsirvouli, Eirini;
Touré, Vasundra;
Niederdorfer, Barbara;
Vazquez Garcia, Miguel;
Flobak, Åsmund;
Kuiper, Martin.
(2020)
A middle-out modeling strategy to extend a colon cancer logical model improves drug synergy predictions in epithelial-derived cancer cell lines.
Frontiers in Molecular Biosciences
Academic article
Knowledge Transfer
2020
-
Academic lectureBermúdez, Viviam; Fariñas, Marco; Tsirvouli, Eirini; Kuiper, Martin. (2020) From COVID-19 Disease Map molecular mechanisms to executable cell-specific logical models. Anna Niarakis, Univ Evry, University of Paris-Saclay; FR 2020 Disease Maps Community Meeting , Luxembourg 2020-11-12 - 2020-11-14
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LectureBermúdez, Viviam; Tsirvouli, Eirini; Fariñas, Marco; Sridhar, Arun; Johansen, Berit; Pestana, Carolina. (2020) Modelo lógico de la activación de macrófagos y la asociación del metabolismo de ecosanoides en la polarización de los distintos fenotipos. Universidad Técnica de Manabí Cuarta Convención Científica Internacional de la Universidad Técnica de Manabí , University of Manabi, Ecuador 2020-10-21 - 2020-10-23