2025

• Zhang, Boyao; Orning, Pontus; Lehman, Jesse W.; Dinis, Alexandre; Torres-Ulloa, Leslie; Elling, Roland. (2025) Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
  Academic article

2024

• Jena, Kautilya K.; Mambu, Julien; Boehmer, Daniel; Sposito, Benedetta; Millet, Virginie; de Sousa Casal, Joshua. (2024) Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Cell
  Academic article

2023

• Nilsen, Kaja Elisabeth; Zhang, Boyao; Skjesol, Astrid; Ryan, Liv; Vagle, Hilde; Bøe, Maren Helene. (2023) Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo. Life Science Alliance (LSA)
  Academic article
• Lentini, Germana; Famà, Agata; De Gaetano, Giuseppe Valerio; Coppolino, Francesco; Mahjoub, Ahlem Khachroub; Ryan, Liv. (2023) Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation. Cell Reports Medicine
  Academic article

2022

• Torp, May-Kristin; Ranheim, Trine; Schjalm, Camilla; Hjorth, Marit; Heiestad, Christina Mathisen; Dalen, Knut Tomas. (2022) Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis. Frontiers in Immunology
  Academic article

2021

• Zelic, Matija; Pontarelli, Fabrizio; Woodworth, Lisa; Zhu, Cheng; Mahan, Amy; Ren, Yi. (2021) RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis. Cell reports
  Academic article

2020

• Tao, Liang; Yi, Yuguo; Chen, Yuxin; Zhang, Haibing; Ørning, Mathias Pontus; Lien, Egil. (2020) RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages. Cell Death and Differentiation
  Academic article
• Shahini, Negar; Schjalm, Camilla; Nilsson, Per; Holt, Margrethe Flesvig; Øgaard, Jonas; Lien, Egil. (2020) Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling. Biochemical and Biophysical Research Communications - BBRC
  Academic article
• Choudhury, Asmita; Bullock, Daniel; Lim, Arlene; Argemi, Josepmaria; Ørning, Mathias Pontus; Lien, Egil. (2020) Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury. Alcoholism: Clinical and Experimental Research
  Academic article
• Ørning, Mathias Pontus; Lien, Egil. (2020) Multiple roles of caspase-8 in cell death, inflammation, and innate immunity. Journal of Leukocyte Biology
  Academic literature review

2019

• Ørning, Mathias Pontus; Lien, Egil; Fitzgerald, Katherine A.. (2019) Gasdermins and their role in immunity and inflammation. Journal of Experimental Medicine (JEM)
  Academic literature review
• Hancz, Dora; Westerlund, Elsa; Valfridsson, Christine; Aemero, Getachew Melkamu; Bastiat-Sempe, Benedicte; Ørning, Mathias Pontus. (2019) Streptolysin O Induces the Ubiquitination and Degradation of Pro-IL-1β. Journal of Innate Immunity
  Academic article
• Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili. (2019) NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity. Frontiers in Immunology
  Academic article

2018

• Ørning, Mathias Pontus Andreas; Weng, Dan; Starheim, Kristian K.; Ratner, Dmitry; Best, Zachary; Lee, Bettina. (2018) Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science
  Academic article
• Ørning, Mathias Pontus Andreas; Flo, Trude Helen; Lien, Egil. (2018) A Sugar Rush for Innate Immunity. Cell Host and Microbe
  Academic article
• Ørning, Mathias Pontus Andreas; Lien, Egil; Fitzgerald, Katherine A.. (2018) Host Defense Mechanisms Against Bacterial Secretion Systems – Linking Cell Death to Inflammation. Doktoravhandlinger ved NTNU (382)
  Doctoral dissertation
• Sokolova, Marina; Sahraoui, Afaf; Høyem, Merete; Øgaard, Jonas; Lien, Egil; Aukrust, Pål. (2018) NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction. American Journal of Physiology. Endocrinology and Metabolism
  Academic article

2017

• Sokolova, Marina; Vinge, Leif Erik; Alfsnes, Katrine; Olsen, Maria Belland; Eide, Lars; Kaasbøll, Ole Jørgen. (2017) Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
  Academic article
• Ratner, Dmitry; Ørning, Mathias Pontus; Lien, Egil. (2017) Bacterial secretion systems and regulation of inflammasome activation. Journal of Leukocyte Biology
  Academic literature review

2016

• Ratner, Dmitry; Ørning, Mathias Pontus; Starheim, Kristian K.; Marty-Roix, Robyn; Proulx, MK; Goguen, JD. (2016) Manipulation of IL-1β and IL-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence. Journal of Biological Chemistry
  Academic article
• Ratner, Dmitry; Ørning, Mathias Pontus; Proulx, MK; Wang, Donghai; Gavrilin, Mikhail; Wewers, Mark. (2016) The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. PLoS Pathogens
  Academic article
• Marty-Roix, Robyn; Vladimer, Gregory; Pouliot, Kimberly; Weng, Dan; Buglione-Corbett, Rachel; West, Kim. (2016) Identification of QS-21 as an inflammasome-activating molecular component of saponin adjuvants. Journal of Biological Chemistry
  Academic article
• Martinez, Núria; Ketheesan, Natkunam; Martens, Gregory W; West, Kim; Lien, Egil; Kornfeld, Hardy. (2016) Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice. Microbes and infection
  Academic article
• Ratner, Dmitry; Ørning, Mathias Pontus; Starheim, Kristian Kobbenes; Marty-Roix, Robyn; Proulx, MK; Goguen, JD. (2016) Manipulation of interleukin-1β and interleukin-18 production by yersinia pestis effectors YopJ and YopM and redundant impact on virulence. Journal of Biological Chemistry
  Academic article

2015

• Ystgaard, Martin Bogale; Sejersted, Yngve; Løberg, Else Marit; Lien, Egil; Yndestad, Arne; Saugstad, Ola Didrik. (2015) Early upregulation of NLRP3 in the brain of neonatal mice exposed to hypoxia-ischemia: No early neuroprotective effects of NLRP3 deficiency. Neonatology
  Academic article
• Wilks, Jessica; Lien, Egil; Jacobson, Amy N; Fischbach, Michael A.; Qureshi, Nilofer; Chervonsky, Alexander V. (2015) Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission. Cell Host and Microbe
  Academic article
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine. (2015) Absence of the inflammasone adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology
  Academic article
• Nilsen, Nadra; Gregory I., Vladimer; Stenvik, Jørgen; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit. (2015) A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling. Journal of Biological Chemistry
  Academic article
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine. (2015) Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology
  Academic article

2014

• Weng, D; Marty-Roix, R; Ganesan, S; Proulx, MK; Vladimer, G; Kaiser, WJ. (2014) Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
  Academic article
• Pouliot, K; Buglione-Corbett, R; Marty-Roix, R; Montminy-Paquette, S; West, K; Wang, S. (2014) Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime-protein boost HIV-1 vaccine. Vaccine
  Academic article

2013

• Sandanger, Øystein; Ranheim, Trine; Vinge, Leif Erik; Bliksøen, Marte; Alfsnes, Katrine; Finsen, Alexandra. (2013) The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovascular Research (CVR)
  Academic article
• Vladimer, G; Marty-Roix, R; Ghosh, S; Weng, D; Lien, Egil. (2013) Inflammasomes and host defenses against bacterial infections. Current Opinion in Microbiology
  Academic literature review
• Lien, Egil. (2013) Pest og plager - kva er samanhengen mellom pest og overvekt?.
  Website (informational material)
• Lien, Egil. (2013) Plagues and illness – what’s the connection between the plague and being overweight?.
  Website (informational material)
• Marty-Roix, Robyn; Lien, Egil. (2013) De-oiling inflammasomes. Immunity
  Short communication

2012

• Johnsen, Ingvild Bjellmo; Nguyen, Thuy Thi Thu; Bergstrøm, Bjarte; Lien, Egil; Anthonsen, Marit Walbye. (2012) Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-β mRNA. Cytokine
  Academic article
• Vladimer, G; Weng, D; Paquette, SWM; Vanaja, SK; Rathinam, VAK; Aune, Marie Hjelmseth. (2012) The NLRP12 Inflammasome Recognizes Yersinia pestis. Immunity
  Academic article

2010

• Husebye, Harald; Aune, Marie Hjelmseth; Stenvik, Jørgen; Samstad, Eivind Ottersen; Skjeldal, Frode Miltzow; Halaas, Øyvind. (2010) The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes. Immunity
  Academic article
• Duewell, P; Kono, H; Rayner, KJ; Sirois, CM; Vladimer, G; Bauernfeind, FG. (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature
  Academic article
• Nguyen, Thuy Tranh; Johnsen, Ingvild Bjellmo; Knetter, CF; Drabløs, Finn; Fitzgerald, KA; Lien, E. (2010) Differential Gene Expression Downstream of Toll-like Receptors (TLRs) ROLE OF c-Src AND ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3). Journal of Biological Chemistry
  Academic article

2009

• Damås, Jan Kristian; Davi, Giovanni; Jensenius, M; Santilli, F; Otterdal, K; Ueland, T. (2009) Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. Journal of Infection
  Academic article

2008

• Nilsen, Nadra; Deininger, S; Nonstad, Unni; Skjeldal, F; Husebye, Harald; Rodionov, D. (2008) Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36. Journal of Leukocyte Biology
  Academic article
• Nilsen, Nadra; Espevik, Terje; Lien, Egil. (2008) Toll-like receptor 2 expression, regulation and signaling. Tapir Akademisk Forlag Tapir Akademisk Forlag
  Doctoral dissertation

2006

• Espevik, Terje; Lien, Egil. (2006) Vaksine mot svartedauen. Gemini
  Popular scientific article
• Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Ringdal, Monika; Tryggestad, AM; Bakke, Oddmund; Lien, Egil. (2006) Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO Journal
  Academic article
• Montminy, Sara W; Khan, Naseema; McGrath, Sara; Walkowicz, Mitchell J; Sharp, Fiona; Conlon, Joseph. (2006) Virulence Factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nature Immunology
  Academic article

2004

• Heggelund, L; Flo, Trude Helen; Berg, K.; Lien, E; Espevik, Terje. (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London)
  Academic article
• Nilsen, N; Nonstad, U; Khan, N; Knetter, Cathrine; Akira, S; Sundan, Anders. (2004) Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88. Journal of Biological Chemistry
  Academic article
• Latz, E; Schoenemeyer, A; Visintin, A; Fitzgerald, KA; Monks, BG; Knetter, Cathrine. (2004) TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nature Immunology
  Academic article
• Heggelund, L; Muller, F; Lien, E; Yndestad, A; Ueland, T; Kristiansen, KI. (2004) Increased expression of Toll-like receptor 2 on monocytes in HIV infection: Possible roles in inflammation and viral replication. Clinical Infectious Diseases
  Academic article
• Heggelund, L; Damås, Jan Kristian; Damas, JK; Yndestad, A; Holm, AM; Muller, F. (2004) Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences. Clinical and Experimental Immunology
  Academic article
• Nilsen, Nadra; Nonstad, Unni; Kahn, Naseema; Knetter, Cathrine; Akira, Shizuo; Sundan, Anders. (2004) Lipopolysaccharide and Double-stranded RNA Up-regulate Toll-like Receptor 2 Independently of Myeloid Differentiation Factor 88. Journal of Biological Chemistry
  Academic article

2003

• Latz, E; Visintin, A; Lien, E; Fitzgerald, KA; Espevik, Terje; Golenbock, DT. (2003) The LPS receptor generates inflammatory signals from the cell surface. Journal of Endotoxin Research
  Academic article
• Espevik, Terje; Latz, Eicke; Lien, Egil; Monks, Brian G.. (2003) Cell distribution and functions of Toll-like receptor 4 studied by fluorescent gene constructs. Scandinavian Journal of Infectious Diseases
  Academic article
• Mori, Y; Yoshimura, A; Ukai, T; Lien, Egil; Espevik, Terje; Hara, Y. (2003) Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis. Oral Microbiology and Immunology
  Academic article
• Nordøy, Ingvild; Rollag, Halvor; Lien, Egil; Sindre, Hilde; Degre, Miklos; Aukrust, Pål. (2003) Cytomegalovirus infection induces production of human interleukin-10 in macrophages. European Journal of Clinical Microbiology and Infectious Diseases
  Academic article

2002

• Dybdahl, Brit; Lien, Egil; Flo, Trude Helen; Espevik, Terje; Sundan, Anders; Wahba, Alexander. (2002) Heat Shock Proteins and Endotoxin Combined as a Trigger for Inflammatory Cytokine Release During Cardiopulmonary Bypass: A Possible Third Way? Letter til artikkel. Circulation
  Academic article
• Flo, Trude Helen; Ryan, Liv; Latz, Eicke; Takeuchi, Osamu; Monks, Brian G.; Lien, Egil. (2002) Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. Journal of Biological Chemistry
  Academic article
• Latz, Eicke; Visintin, A; Lien, Egil; Fitzgerald, KA; Monks, Brian G.; Kurt-Jones, EA. (2002) Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the Toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. Journal of Biological Chemistry
  Academic article
• Dybdahl, Brit; Wahba, Alexander; Lien, Egil; Flo, Trude Helen; Waage, Anders; Sellevold, Olav F Münter. (2002) Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation
  Academic article
• Kristo, C.; Godang, Kristin; Ueland, Thor; Lien, Egil; Aukrust, Pål; Frøland, Stig Sophus. (2002) Raised serum levels of interleukin (IL)-8 and IL-18 in relation to bone metabolism in endogenous Cushing's syndrome. European Journal of Endocrinology (EJE)
  Academic article

2001

• Lien, Egil; Chow, Jesse C.; Hawkins, Lynn D.; McGuinness, Pamela D.; Miyake, Kensuke; Espevik, Terje. (2001) A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/Toll-like receptor 4 signaling pathway. Journal of Biological Chemistry
  Academic article
• Lien, Egil; Ingalls, Robin. (2001) Toll receptors. Critical Care Medicine
  Academic article
• Schromm, Andra; Lien, Egil; Henneke, Philipp; Chow, Jesse C; et, al.. (2001) Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. Journal of Experimental Medicine (JEM)
  Academic article
• Ingalls, Robin; Lien, Egil; Golenbock, D. (2001) Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through Toll-like receptor 2. Infection and Immunity
  Academic article
• Liabakk, Nina-Beate; Waage, Anders; Lien, Egil; Stenvik, Jørgen; Espevik, Terje. (2001) Cytokine bioassays. Methods in Molecular Medicine
  Academic article
• Medvedev, Andrei; Henneke, Philipp; Schromm, Andra; Lien, Egil; Ingalls, Robin; et, al.. (2001) Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4. Journal of Immunology
  Academic article
• Gullestad, Lars; Fjeld, Jan G.; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein. (2001) Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure. Circulation
  Academic article
• Flo, Trude Helen; Halaas, Øyvind; Torp, Sverre Helge; Ryan, Liv; Lien, Egil; Dybdahl, Brit. (2001) Differential expression of Toll-like receptor 2 in human cells. Journal of Leukocyte Biology
  Academic article
• Gullestad, Lars; Aass, Halfdan; Lien, Egil. (2001) Immunmodulerende behandling ved avansert hjertesvikt - effekt av intravenøs immunoglobulin. Tidsskrift for Den norske legeforening (Tidsskriftet)
  Academic article
• Gullestad, Lars; Aass, Halfdan; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John. (2001) Immunmodulerende behandling ved avansert hjertesvikt - effekt av intravenøs immunglobin. Tidsskrift for Den norske legeforening (Tidsskriftet)
  Academic article
• Aukrust, Pål; Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.. (2001) Increase in anti-inflammatory cytokine levels in chronic heart failure: a measure of treatment success or failure? (Reply to a letter to the editor). Circulation
  Academic article
• Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan. (2001) Immunomodulating Therapy With Intravenous Immunoglobulin in Patients With Chronic Heart Failure. Circulation
  Academic article
• Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan. (2001) Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure. Circulation
  Academic article
• Gullestad, Lars; Aass, Halfdan; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John. (2001) Immunmodulerende behandling ved avansert hjertesvikt: effekt av intravenøs immunglobulin. Tidsskrift for Den norske legeforening (Tidsskriftet)
  Academic article
• Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan. (2001) Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure. Circulation
  Academic article
• Gullestad, Lars; Aass, Halfdan; Andreassen, Arne K.; Ihlen, Halfdan; Simonsen, Svein; Kjekshus, John. (2001) Immunmodulerende behandling ved avansert hjertesvikt - effekt av intravenøs immunglobulin. Tidsskrift for Den norske legeforening (Tidsskriftet)
  Academic article
• Gullestad, Lars; Aass, Halfdan; Fjeld, Jan Gunnar; Wikeby, Lisbeth; Andreassen, Arne K.; Ihlen, Halfdan. (2001) An increase in anti-inflammatory cytokine leves in chronic heart failure: a measure of treatment success or failure?. Circulation
  Reader opinion piece

2000

• Lien, Egil; Means, Terry K; Heine, Holger; Yoshimura, Atsutoshi; Kusumoto, Shoichi; Fukase, Koichi. (2000) Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. The Journal of Clinical Investigation
  Academic article
• Flo, Trude Helen; Halaas, Øyvind; Lien, Egil; Ryan, Liv; Teti, Guiseppe; Golenbock, Douglas T.. (2000) Human Toll-like Receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. Journal of Immunology
  Academic article
• Ingalls, Robin; Lien, Egil; Golenbock, D. (2000) Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of neisseria meningitidis. Journal of Endotoxin Research
  Academic article
• Nordøy, I.; Müller, F.; Nordal, K.P.; Rollag, H.; Lien, E.; Aukrust, P.. (2000) The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients. Journal of Infectious Diseases
  Academic article
• Nordøy, Ingvild; Muller, Fredrik; Nordal, Knut P.; Rollag, Halvor; Lien, Egil; Aukrust, Pål. (2000) The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients. Journal of Infectious Diseases
  Academic article
• Lien, E.; Espevik, Terje. (2000) Toll-lignende reseptorer - kroppens sensorer for infeksjon. NBS-nytt
  Popular scientific article

1999

• Aukrust, Pål; Müller, Fredrik; Lien, Egil; Nordøy, Ingvild; Liabakk, Nina-Beate; Kvale, Dag. (1999) Tumor necrosis factor (TNF) system levels in human immunodificiency virus-infected patients during highly active antiretroviral therapy: Perisistent TNF activation is associated with virologic and immunologic treatment failure. Journal of Infectious Diseases
  Academic article
• Nordøy, Ingvild; Muller, Fredrik; Nordal, Knut P.; Rollag, Halvor; Lien, Egil; Aukrust, Pål. (1999) Immunologic parameters as predictive factors of cytomegalovirus disease in renal allograft recipients. Journal of Infectious Diseases
  Academic article
• Aukrust, Pål; Haug, Charlotte J.; Ueland, Thor; Lien, Egil; Muller, Fredrik; Espevik, T. (1999) Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: indication of normalization of the bone-remodeling process during highly active antiretroviral therapy. Journal of Clinical Endocrinology and Metabolism (JCEM)
  Academic article
• Aukrust, Pål; Ueland, Thor; Lien, Egil; Bendtzen, Klaus; Muller, Fredrik; Andreassen, Arne K.. (1999) Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. American Journal of Cardiology
  Academic article
• Aukrust, Pål; Muller, Fredrik; Lien, Egil; Nordøy, Ingvild; Liabakk, Nina-Beate; Kvale, Dag. (1999) Tumor necrosis factor (TNF) system in human immunodeficiency virus-infected patients during highly active antiretroviral therapy (HAART): Persistent TNF activation is associated with virologic and immunologic treatment failure. Journal of Infectious Diseases
  Academic article
• Ingalls, Robin R.; Heine, Holger; Lien, Egil; Yoshimura, Atsutoshi; Golenbock, Douglas. (1999) Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors. Infectious Disease Clinics of North America
  Academic article
• Nordøy, Ingvild; Müller, Fredrik; Nordahl, Knut P; Rollag, Halvor; Lien, Egil; Aukrust, Pål. (1999) Immunologic parameters as predictive factors of cytomegalovirus disease in renal allograft recipients. Journal of Infectious Diseases
  Academic article
• Yoshimura, Atsutoshi; Lien, Egil; Ingalls, Robin R.; Tuomanen, Elaine; Dziarski, Roman; Golenbock, Douglas. (1999) Cutting edge : recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. Journal of Immunology
  Academic article
• Means, Terry K.; Lien, Egil; Yoshimura, Atsutoshi; Wang, Shuyan; Golenbock, Douglas T.; Fenton, Matthew J.. (1999) The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for toll-like receptors. Journal of Immunology
  Academic article
• Means, Terry K.; Wang, Shuyan; Lien, Egil; Yoshimura, Atsutoshi; Golenbock, Douglas T.; Fenton, Matthew J.. (1999) Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. Journal of Immunology
  Academic article
• Heine, Holger; Kirschning, Carsten J.; Lien, Egil; Monks, Brian G.; Rothe, Mike; Golenbock, Douglas T.. (1999) Cutting edge : cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin. Journal of Immunology
  Academic article
• Lien, Egil; Sellati, Timothy J.; Yoshimura, Atsutosi; Flo, Trude Helen; Rawadi, Georges; Finberg, Robert W.. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. Journal of Biological Chemistry
  Academic article
• Aukrust, Pål; Haug, Charlotte J.; Ueland, Thor; Lien, Egil; Müller, Fredrik; Espevik, Terje. (1999) Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: Indication of normalization of the bone-remodeling process during highly active antiretroviral therapy. Journal of Clinical Endocrinology and Metabolism (JCEM)
  Academic article
• Lønning, P.Ø.; Lien, Egil; Tveter, Kjell; Christoffersen, Thoralf. (1999) Cytostatika Medikamentell kreftbehandling kap. 18 Hormoner og hormonantagonister. Cytostatika -Medikamentell kreftbehandling
  Non-fiction book
• Lien, Egil; Heine, H.; Golenbock, Douglas T.. (1999) LPS receptors. Springer
  Academic chapter/article/Conference paper

1998

• Lien, E; Sundan, A; Aukrust, P; Frøland, S; Espevik, Terje. (1998) Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events. Blood
  Academic article
• Døllner, H; Arntzen, K.J; Lien, E; Hæreid, P.E; Brubakk, A.M; Aag, S.. (1998) Increased serum concentrations of soluble tumor necrosis factor receptors p55 and p75 in early onset neonatal sepsis. Early Human Development
  Academic article
• Muller, Fredrik; Aukrust, Pål; Lien, Egil; Haug, Charlotte J.; Frøland, Stig Sophus. (1998) Enhanced interleukin-10 production in response to Mycobacterium avium products in mononuclear cells from patients with human immunodeficiency virus infection. Journal of Infectious Diseases
  Academic article
• Aukrust, Pål; Ueland, Thor; Lien, Egil. (1998) The cytokine network in congstive heart failure-dysbalance between inflammatory and anti-inflammatory mediators. European Heart Journal
  Academic article
• Lien, Egil; Aukrust, Pål; Sundan, Andreas; Muller, Fredrik; Frøland, Stig Sophus; Espevik, T. (1998) Elevated levels of serum-soluble CD14 in human immonudeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events. Blood
  Academic article

1997

• Aukrust, Pål; Hestad, Kjetil; Lien, Egil; Bjerkeli, Vigdis; Nordøy, Ingvild; Espevik, T. (1997) Effects of intravenous immunoglobulin in vivo on abnormally increased tumor necrosis factor-_a activity in human immunodeficiency virus type 1 infection. Journal of Infectious Diseases
  Academic article
• Hestad, Kjetil; Aukrust, Pål; Muller, Fredrik; Lien, Egil; Bjerkeli, Vigdis; Espevik, T. (1997) Dysregulation of membrane-bound tumor necrosis factor-_a and tumor necrosis factor receptors on mononuclear cells in human immunodeficiency virus type 1  infection: Low percentage of p75-tumor necrosis factor receptor positive cells in patients with advanced disease and high viral load. Blood
  Academic article
• Hestdal, Kjetil; Aukrust, Pål; Müller, Fredrik; Lien, Egil; Bjerkeli, Vigdis; Espevik, Terje. (1997) Dysregulation of membrane-bound tumor necrosis factor-_a and tumor necrosis factor receptors on mononuclear cells in human immunodeficiency virus type 1 infection : low percentage of p75-tumor necrosis factor receptor positive cells in patients with advanced disease and high viral load. Blood
  Academic article
• Aukrust, Pål; Hestdal, Ketil; Lien, Egil; Bjerkeli, Vigdis; Nordøy, Ingvild; Espevik, Terje. (1997) Effects of intravenous immunoglobulin in vivo on abnormally increased tumor necrosis factor-alpha activity in human immunodeficiency virus type 1 infection. Journal of Infectious Diseases
  Academic article
• Arntzen, Knut Jørgen; Lien, Egil; Austgulen, Rigmor. (1997) Maternal serum levels of interleukin-6 and clinical characteristics of normal delivery at term. Acta Obstetricia et Gynecologica Scandinavica
  Academic article
• Jackson, A.M.; Lien, Egil; Alexandroff, A.B.; Espevik, Terje; James, K.; Selby, P.J.. (1997) Soluble urinary CD14 after intravesical bacille Calmette-Guérin immunotherapy for carcinoma in situ. British Journal of Urology
  Academic article
• Austgulen, Rigmor; Lien, Egil; Vince, Gill; Redman, Chris W.G.. (1997) Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia. European Journal of Obstetrics, Gynecology, and Reproductive Biology
  Academic article
• Austgulen, Rigmor; Lien, E; Vince, G; Redman, CWG. (1997) Increased levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in serum from women with pre-eclampsia. European Journal of Obstetrics, Gynecology, and Reproductive Biology
  Academic article

1996

• Lien, Egil; Liabakk, Nina-Beate; Austgulen, Rigmor. (1996) Detection of soluble receptors for tumor necrosis factor, interleukin-2 and interleukin-6 in retroplacental serum from normal pregnant women. Gynecologic and Obstetric Investigation
  Academic article
• Børset, Magne; Lien, Egil; Espevik, Terje; Helseth, Eirik; Waage, Anders; Sundan, Anders. (1996) Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines. Journal of Biological Chemistry
  Academic article
• Haug, Charlotte J.; Aukrust, Pål; Lien, Egil; Müller, Fredrik; Espevik, Terje; Frøland, Stig S.. (1996) Disseminated Mycobacterium avium complex infection in AIDS : immunopathogenic significance of an activated tumor necrosis factor system and depressed serum levels of 1,25 dihydroxyvitamin D. Journal of Infectious Diseases
  Academic article
• Aukrust, Pål; Lien, Egil; Kristoffersen, Anne K.; Müller, Fredrik; Haug, Charlotte J.; Espevik, Terje. (1996) Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency : possible immunologic and clinical consequences. Blood
  Academic article
• Aukrust, Pål; Lien, Egil; Kristoffersen, Anne Karin; Muller, Fredrik; Haug, Charlotte J.; Espevik, T. (1996) Persistant Activation of The Tumor Nevcrosis Factor System in a Subgroup of Patients With Common Varable Immunodeficincy - Possible Immunological and Clinical and Consequences. Blood
  Academic article
• Haug, Charlotte J.; Aukrust, Pål; Lien, Egil; Muller, Fredrik; Espevik, T; Frøland, Stig Sophus. (1996) Disseminated Mycobacterium avium complex (MAC) infection in AIDS: Immunopathogenic significance of an activated tumor necrosis factor (TNF) system and depressed serum levels of 1,25-dihydroxyvitamin D. Journal of Infectious Diseases
  Academic article
• Aukrust, Pål; Lien, Egil; Kristoffersen, Anne Karin; Muller, Fredrik; Haug, Charlotte J.; Espevik, T. (1996) Persistent activation of tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency - Possible immunologic and clinical concensus. Blood
  Academic article

1995

• Lien, Egil; Liabakk, Nina-Beate; Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Nonstad, Unni; Sundan, Anders. (1995) Polymorphonuclear granulocytes enhance lipopolysaccharide-induced p75 tumor necrosis factor receptor release from mononuclear cells. European Journal of Immunology
  Academic article

1994

• Austgulen, Rigmor; Lien, E; Liabakk, N-B; Jacobsen, G.; Arntzen, KJ. (1994) Increased levels of cytokine activity modifiers in normal pregnancy. European Journal of Obstetrics, Gynecology, and Reproductive Biology
  Academic article

1993

• Austgulen, Rigmor; Liabakk, N-B; Lien, E; Espevik, Terje. (1993) Increased levels of soluble TNF-alpha receptors in serum from pregnant women, and in serum and urine samples from newborns. Pediatric Research
  Academic article
• Liabakk, N-B; Lien, E; Sundan, A; Sunde, A; Austgulen, Rigmor; Espevik, Terje. (1993) High concentrations of the soluble p55 tumor necrosis factor receptor in human seminal plasma. Human Reproduction
  Academic article