Denis Kaynov

About

Denis Kainov received his doctorate at the University of Helsinki in 2005. He was a postdoctoral researcher at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) from 2005 to 2007 and at CRP-Santé Luxembourg from 2007 to 2009. He was a researcher and project manager at the University of Helsinki from 2010 to 2016. Now he's a professor at NTNU, Norway.

Research

Our group develops antiviral drug cocktails to target a wide range of viruses and their drug-resistant variants.

Publications

2024

Ianevski, Aleksandr; Frøysa, Irene Trøen; Lysvand, Hilde; Calitz, Carlemi; Smura, Teemu; Nilsen, Hans-Johnny. (2024) The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants. Antiviral Research
Academic article
Halabitska, Iryna; Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Oleksandr. (2024) The interplay of gut microbiota, obesity, and depression: insights and interventions. Cellular and Molecular Life Sciences (CMLS)
Academic literature review

2023

Ravlo, Erlend; Ianevski, Aleksandr; Starheim, Eirin Johannessen; Wang, Wei; Ji, Ping; Lysvand, Hilde. (2023) Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study. International Journal of Infectious Diseases
Article in business/trade/industry journal
Benjakul, Sopisa; Anthi, Aina Karen; Kolderup, Heidi Anette; Vaysburd, Marina; Lode, Heidrun Elisabeth; Mallery, D. (2023) A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery. PNAS Nexus
Academic article
Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi. (2023) Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response. iScience
Academic article
Hermet, Paule; Delache, Benoît; Herate, Cecile; Wolf, Esther; Kivi, Gaily; Juronen, Erkki. (2023) Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates. PLoS Pathogens
Academic article
Kamyshnyi, Aleksandr; Koval, Halyna; Kobevko, Olha; Buchynskyi, Mykhailo; Oksenych, Valentyn; Kaynov, Denis. (2023) Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience. International Journal of Molecular Sciences
Academic article
Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Aleksandr. (2023) Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment. Pharmaceuticals
Academic article

2022

Nordbø, Svein Arne; Linh, Hoang; Krokstad, Sidsel; Kainov, Denis; Sagvik, Eli Oline. (2022) Rask eliminasjon av SARS-CoV-2 hos fullvaksinert pasient. www.tidsskriftet.no
Short communication
Oksenych, Valentyn; Kainov, Denis. (2022) Broad-Spectrum Antivirals and Antiviral Drug Combinations. Viruses
Editorial
Li, Pengfei; Li, Yunlong; Wang, Yijin; Liu, Jiaye; Lavrijsen, Marla; Li, Yang. (2022) Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids. Science Advances
Academic article
Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.. (2022) Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells. iScience
Academic article
Ianevski, Aleksandr; Yao, Rouan; Simonsen, Ronja Meyer; Myhre, Vegard; Ravlo, Erlend; Kaynova, Gerda D.. (2022) Mono- and combinational drug therapies for global viral pandemic preparedness. iScience
Academic literature review
Ravlo, Erlend; Evensen, Lasse; Sanson, Gorm; Hildonen, Siri; Ianevski, Aleksandr; Skjervold, Per Olav. (2022) Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection. Viruses
Academic article
Ianevski, Aleksandr; Simonsen, Ronja Meyer; Myhre, Vegard; Tenson, Tanel; Oksenych, Valentyn; Bjørås, Magnar. (2022) DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs). Nucleic Acids Research (NAR)
Academic article
Kainov, Denis; Oksenych, Valentyn. (2022) Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update. Viruses
Editorial
Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil. (2022) Novel Synergistic Anti-Enteroviral Drug Combinations. Viruses
Academic article
Ianevski, Aleksandr; Ahmad, Shahzaib; Anunnitipat, Kraipit; Oksenych, Valentyn; Zusinaite, Eva; Tenson, Tanel. (2022) Seven classes of antiviral agents. Cellular and Molecular Life Sciences (CMLS)
Academic literature review

2021

Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lysvand, Hilde; Oksenych, Valentyn; Tenson, Tanel. (2021) Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study. Viruses
Academic article
Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis. (2021) Neural signaling modulates metabolism of gastric cancer. iScience
Academic article
White, Judith M.; Schiffer, Joshua T.; Bender Ignacio, Rachel A.; Xu, Shuang; Kainov, Denis; Ianevski, Aleksandr. (2021) Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses. mBio
Academic literature review
Yao, Rouan; Ianevski, Aleksandr; Kainov, Denis. (2021) Safe-in-Man Broad Spectrum Antiviral Agents. Springer
Academic chapter/article/Conference paper
Li, Yunlong; Miao, Zhijiang; Li, Pengfei; Zhang, Ruyi; Kainov, Denis; Ma, Zhongren. (2021) Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1. Archives of Virology
Academic article
Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji. (2021) Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections. Viruses
Academic article
Kainov, Denis; Oksenych, Valentyn. (2021) DNA Damage Response. Biomolecules
Editorial
Meehyun, Ko; Chang, Soo Young; Byun, Soo Young; Ianevski, Aleksandr; Choi, Inhee; Pham Hung, Anne-Laure. (2021) Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19. Viruses
Academic article
Yang, Jaewon; König, Alexander; Park, Soonju; Jo, Eunji; Sung, Pil Soo; Yoon, Seung Kew. (2021) A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals. JHEP Reports
Academic article
Ianevski, Aleksandr; Yao, Rouan; Lysvand, Hilde; Grødeland, Gunnveig; Legrand, Nicolas; Oksenych, Valentyn. (2021) Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host tmprss2. Viruses
Academic article
Ladner, Jason T.; Henson, Sierra N.; Boyle, Annalee S.; Engelbrektson, Anna L.; Fink, Zane W.; Rahee, Fatima. (2021) Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses. Cell Reports Medicine
Academic article
Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik. (2021) Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer. Frontiers in Pharmacology
Academic article
Oksenych, Valentyn; Kainov, Denis. (2021) DNA Damage Response. Biomolecules
Editorial

2020

Anderssen, Petter Inge; Ianevski, Aleksandr; Lysvand, Hilde; Vitkauskiene, Astra; Oksenych, Valentyn; Bjørås, Magnar. (2020) Discovery and development of safe-in-man broad-spectrum antiviral agents. International Journal of Infectious Diseases
Academic literature review
Chen, Sunrui; Wang, Yining; Li, Pengfei; Yin, Yuebang; Bijvelds, Marcel J.; de Jonge, Hugo R.. (2020) Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway. Antiviral Research
Academic article
Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli. (2020) Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. Viruses
Academic article
Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily. (2020) Identification and Tracking of Antiviral Drug Combinations. Viruses
Academic article
Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii. (2020) Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis. Cancers
Academic article
Li, Yunlong; Li, Pengfei; Li, Yang; Zhang, Ruyi; Yu, Peifa; Ma, Zhongren. (2020) Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation. Antiviral Research
Academic article

2019

Ianevski, Aleksandr; Anderssen, Petter Inge; Merits, Andres; Bjørås, Magnar; Kainov, Denis. (2019) Expanding the activity spectrum of antiviral agents. Drug Discovery Today
Academic literature review
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu. (2019) Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018. Viruses
Academic article
Anderssen, Petter Inge; Krpina, Klara; Ianevski, Aleksandr; Shtaida, Nastassia; Jo, Eunji; Yang, Jaewon. (2019) Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine. Viruses
Academic article
Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Anderssen, Petter Inge; Kuivanen, Suvi; Teppor, Mona. (2019) Common nodes of virus-host interaction revealed through an integrated network analysis. Frontiers in Immunology
Academic article

2018

Zusinaite, Eva; Ianevski, Aleksandr; Niukkanen, Diana; Poranen, Minna M.; Bjørås, Magnar; Afset, Jan Egil. (2018) A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses
Academic literature review
Loevenich, Simon; Ianevski, Aleksandr; Oitmaa, Eneli; Kainov, Denis; Anthonsen, Marit Walbye. (2018) Single passage of human metapneumovirus in LLCMK2 cells does not affect viral protein-coding capacity. Microbiology Resource Announcements (MRA)
Short communication
Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Mårten; Lysvand, Hilde; Teppor, Mona. (2018) Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research
Academic article

2017

Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik. (2017) Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses
Academic article
Gaelings, Lana; Söderholm, Sandra; Bugai, Andrii; Fu, Yu; Nandania, Jatin; Schepens, Bert. (2017) Regulation of kynurenine biosynthesis during influenza virus infection. The FEBS Journal
Academic article
Shim, Jung Min; Kim, Jinhee; Tenson, Tanel; Min, Ji-Young; Kainov, Denis. (2017) Influenza virus infection, interferon response, viral counter-response, and apoptosis. Viruses
Academic literature review

2016

Nyman, Tuula Anneli; Söderholm, Sandra; Kainov, Denis; Ohman, Tiina; Denisova, Oxana V.; Schepens, Bert. (2016) Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Molecular & Cellular Proteomics
Academic article
Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Söderholm, Sandra; Gaelings, Lana. (2016) Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
Academic article
Söderholm, Sandra; Kainov, Denis E.; Öhman, Tiina; Denisova, Oxana V.; Schepens, Bert; Kulesskiy, Evgeny. (2016) Phosphoproteomics to characterize host response during influenza a virus infection of human macrophages. Molecular & Cellular Proteomics
Academic article

Journal publications

Ianevski, Aleksandr; Frøysa, Irene Trøen; Lysvand, Hilde; Calitz, Carlemi; Smura, Teemu; Nilsen, Hans-Johnny. (2024) The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants. Antiviral Research
Academic article
Halabitska, Iryna; Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Oleksandr. (2024) The interplay of gut microbiota, obesity, and depression: insights and interventions. Cellular and Molecular Life Sciences (CMLS)
Academic literature review
Ravlo, Erlend; Ianevski, Aleksandr; Starheim, Eirin Johannessen; Wang, Wei; Ji, Ping; Lysvand, Hilde. (2023) Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study. International Journal of Infectious Diseases
Article in business/trade/industry journal
Benjakul, Sopisa; Anthi, Aina Karen; Kolderup, Heidi Anette; Vaysburd, Marina; Lode, Heidrun Elisabeth; Mallery, D. (2023) A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery. PNAS Nexus
Academic article
Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi. (2023) Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response. iScience
Academic article
Hermet, Paule; Delache, Benoît; Herate, Cecile; Wolf, Esther; Kivi, Gaily; Juronen, Erkki. (2023) Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates. PLoS Pathogens
Academic article
Kamyshnyi, Aleksandr; Koval, Halyna; Kobevko, Olha; Buchynskyi, Mykhailo; Oksenych, Valentyn; Kaynov, Denis. (2023) Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience. International Journal of Molecular Sciences
Academic article
Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Aleksandr. (2023) Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment. Pharmaceuticals
Academic article
Nordbø, Svein Arne; Linh, Hoang; Krokstad, Sidsel; Kainov, Denis; Sagvik, Eli Oline. (2022) Rask eliminasjon av SARS-CoV-2 hos fullvaksinert pasient. www.tidsskriftet.no
Short communication
Oksenych, Valentyn; Kainov, Denis. (2022) Broad-Spectrum Antivirals and Antiviral Drug Combinations. Viruses
Editorial
Li, Pengfei; Li, Yunlong; Wang, Yijin; Liu, Jiaye; Lavrijsen, Marla; Li, Yang. (2022) Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids. Science Advances
Academic article
Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.. (2022) Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells. iScience
Academic article
Ianevski, Aleksandr; Yao, Rouan; Simonsen, Ronja Meyer; Myhre, Vegard; Ravlo, Erlend; Kaynova, Gerda D.. (2022) Mono- and combinational drug therapies for global viral pandemic preparedness. iScience
Academic literature review
Ravlo, Erlend; Evensen, Lasse; Sanson, Gorm; Hildonen, Siri; Ianevski, Aleksandr; Skjervold, Per Olav. (2022) Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection. Viruses
Academic article
Ianevski, Aleksandr; Simonsen, Ronja Meyer; Myhre, Vegard; Tenson, Tanel; Oksenych, Valentyn; Bjørås, Magnar. (2022) DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs). Nucleic Acids Research (NAR)
Academic article
Kainov, Denis; Oksenych, Valentyn. (2022) Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update. Viruses
Editorial
Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil. (2022) Novel Synergistic Anti-Enteroviral Drug Combinations. Viruses
Academic article
Ianevski, Aleksandr; Ahmad, Shahzaib; Anunnitipat, Kraipit; Oksenych, Valentyn; Zusinaite, Eva; Tenson, Tanel. (2022) Seven classes of antiviral agents. Cellular and Molecular Life Sciences (CMLS)
Academic literature review
Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lysvand, Hilde; Oksenych, Valentyn; Tenson, Tanel. (2021) Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study. Viruses
Academic article
Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis. (2021) Neural signaling modulates metabolism of gastric cancer. iScience
Academic article
White, Judith M.; Schiffer, Joshua T.; Bender Ignacio, Rachel A.; Xu, Shuang; Kainov, Denis; Ianevski, Aleksandr. (2021) Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses. mBio
Academic literature review
Li, Yunlong; Miao, Zhijiang; Li, Pengfei; Zhang, Ruyi; Kainov, Denis; Ma, Zhongren. (2021) Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1. Archives of Virology
Academic article
Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji. (2021) Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections. Viruses
Academic article
Kainov, Denis; Oksenych, Valentyn. (2021) DNA Damage Response. Biomolecules
Editorial
Meehyun, Ko; Chang, Soo Young; Byun, Soo Young; Ianevski, Aleksandr; Choi, Inhee; Pham Hung, Anne-Laure. (2021) Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19. Viruses
Academic article
Yang, Jaewon; König, Alexander; Park, Soonju; Jo, Eunji; Sung, Pil Soo; Yoon, Seung Kew. (2021) A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals. JHEP Reports
Academic article
Ianevski, Aleksandr; Yao, Rouan; Lysvand, Hilde; Grødeland, Gunnveig; Legrand, Nicolas; Oksenych, Valentyn. (2021) Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host tmprss2. Viruses
Academic article
Ladner, Jason T.; Henson, Sierra N.; Boyle, Annalee S.; Engelbrektson, Anna L.; Fink, Zane W.; Rahee, Fatima. (2021) Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses. Cell Reports Medicine
Academic article
Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik. (2021) Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer. Frontiers in Pharmacology
Academic article
Oksenych, Valentyn; Kainov, Denis. (2021) DNA Damage Response. Biomolecules
Editorial
Anderssen, Petter Inge; Ianevski, Aleksandr; Lysvand, Hilde; Vitkauskiene, Astra; Oksenych, Valentyn; Bjørås, Magnar. (2020) Discovery and development of safe-in-man broad-spectrum antiviral agents. International Journal of Infectious Diseases
Academic literature review
Chen, Sunrui; Wang, Yining; Li, Pengfei; Yin, Yuebang; Bijvelds, Marcel J.; de Jonge, Hugo R.. (2020) Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway. Antiviral Research
Academic article
Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli. (2020) Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. Viruses
Academic article
Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily. (2020) Identification and Tracking of Antiviral Drug Combinations. Viruses
Academic article
Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii. (2020) Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis. Cancers
Academic article
Li, Yunlong; Li, Pengfei; Li, Yang; Zhang, Ruyi; Yu, Peifa; Ma, Zhongren. (2020) Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation. Antiviral Research
Academic article
Ianevski, Aleksandr; Anderssen, Petter Inge; Merits, Andres; Bjørås, Magnar; Kainov, Denis. (2019) Expanding the activity spectrum of antiviral agents. Drug Discovery Today
Academic literature review
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu. (2019) Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018. Viruses
Academic article
Anderssen, Petter Inge; Krpina, Klara; Ianevski, Aleksandr; Shtaida, Nastassia; Jo, Eunji; Yang, Jaewon. (2019) Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine. Viruses
Academic article
Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Anderssen, Petter Inge; Kuivanen, Suvi; Teppor, Mona. (2019) Common nodes of virus-host interaction revealed through an integrated network analysis. Frontiers in Immunology
Academic article
Zusinaite, Eva; Ianevski, Aleksandr; Niukkanen, Diana; Poranen, Minna M.; Bjørås, Magnar; Afset, Jan Egil. (2018) A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses
Academic literature review
Loevenich, Simon; Ianevski, Aleksandr; Oitmaa, Eneli; Kainov, Denis; Anthonsen, Marit Walbye. (2018) Single passage of human metapneumovirus in LLCMK2 cells does not affect viral protein-coding capacity. Microbiology Resource Announcements (MRA)
Short communication
Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Mårten; Lysvand, Hilde; Teppor, Mona. (2018) Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research
Academic article
Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik. (2017) Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses
Academic article
Gaelings, Lana; Söderholm, Sandra; Bugai, Andrii; Fu, Yu; Nandania, Jatin; Schepens, Bert. (2017) Regulation of kynurenine biosynthesis during influenza virus infection. The FEBS Journal
Academic article
Shim, Jung Min; Kim, Jinhee; Tenson, Tanel; Min, Ji-Young; Kainov, Denis. (2017) Influenza virus infection, interferon response, viral counter-response, and apoptosis. Viruses
Academic literature review
Nyman, Tuula Anneli; Söderholm, Sandra; Kainov, Denis; Ohman, Tiina; Denisova, Oxana V.; Schepens, Bert. (2016) Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Molecular & Cellular Proteomics
Academic article
Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Söderholm, Sandra; Gaelings, Lana. (2016) Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
Academic article
Söderholm, Sandra; Kainov, Denis E.; Öhman, Tiina; Denisova, Oxana V.; Schepens, Bert; Kulesskiy, Evgeny. (2016) Phosphoproteomics to characterize host response during influenza a virus infection of human macrophages. Molecular & Cellular Proteomics
Academic article

Part of book/report

Yao, Rouan; Ianevski, Aleksandr; Kainov, Denis. (2021) Safe-in-Man Broad Spectrum Antiviral Agents. Springer
Academic chapter/article/Conference paper