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Daniel Machado

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Daniel Machado

Associate Professor
Department of Biotechnology and Food Science

daniel.machado@ntnu.no
Kjemi 3, 126, Gløshaugen
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About Research Publications Teaching Outreach

About

Daniel Machado joined NTNU in September 2020 as Associate Professor of Computational Biology. He has a Bsc/Msc in Mathematics and Computer Science (University of Minho, Portugal) and PhD in Bioengineering and Biotechnology (MIT-Portugal Program).

Competencies

  • Computational Biology
  • Metabolism
  • Modeling

Research

Our research aims to unlock the potential of microbes to address multiple societal challenges. We use computational models to understand how microbes work together in their natural habitats. These so-called microbial communities are everywhere, with some playing an important role in the health of our bodies, and others in the health of our planet. We follow an interdisciplinary approach, combining computational models and biological data, which gives us the ability to design synthetic communities to apply in multiple biotechnological applications and create more sustainable industries.

For more information check our website: 

  • Machado Lab

Cell4Chem

Designing synthetic microbial communities for conversion of lignocellulose waste products into medium-chain carboxylates

SFI - Industrial Biotechnology:

A research-based innovation centre aiming to boost the competitiveness of the Norwegian biotech industry

ELIXIR Norway

ELIXIR Norway is a national node of ELIXIR, the pan-European infrastructure for biological information, supporting life science research and its translation to medicine, environment, the bioindustries and society.

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2025

  • Burgos, Idun Maria Tokvam; Øyås, Ove; Moutinho Luz Machado, Carlos Daniel. (2025) Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass. bioRxiv
    Academic article

2024

  • Stallvik, Andrea; Moutinho Luz Machado, Carlos Daniel. (2024) Designing microbial consortia using metabolic modelling. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Moutinho Luz Machado, Carlos Daniel. (2024) A benchmark of optimization solvers for genome-scale metabolic modeling of organisms and communities. mSystems
    Academic article

2023

  • van Eggelen, Marieke Cecilia; Moutinho Luz Machado, Carlos Daniel. (2023) Predicting metabolic fluxes from gene expression data using machine learning . Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Røed, Elin Sandertun; Moutinho Luz Machado, Carlos Daniel; Márquez-Zavala, Elisa. (2023) Predicting Allosteric Regulation at Genome Scale. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Melkonian, Chrats; Zorrilla, Francisco; Kjærbølling, Inge; Blasche, Sonja; Moutinho Luz Machado, Carlos Daniel; Junge, Mette. (2023) Microbial interactions shape cheese flavour formation. Nature Communications
    Academic article

2022

  • Merkesvik, Jenny; Moutinho Luz Machado, Carlos Daniel. (2022) Towards genotype—phenotype association: Leveraging multiple-source microbial data and genome annotations to infer trait attributes for the uncultured microbiome. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Lien, Martin Eide; Moutinho Luz Machado, Carlos Daniel. (2022) Metabolic network layout using biochemical coordinates . Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • van den Berg, Naomi Iris; Machado, Daniel; Santos, Sophia; Rocha, Isabel; Chacón, Jeremy; Harcombe, William. (2022) Ecological modelling approaches for predicting emergent properties in microbial communities. Nature Ecology and Evolution
    Academic literature review
  • Cerca, José; Petersen, Bent; Lazaro-Guevara, José Miguel; Rivera-Colón, Angel G.; Birkeland, Siri; Vizueta, Joel. (2022) The genomic basis of the plant island syndrome in Darwin’s giant daisies. Nature Communications
    Academic article
  • Machado, Daniel; Patil, Kiran R.. (2022) Reply to: Erroneous predictions of auxotrophies by CarveMe. Nature Ecology and Evolution
    Letter to the editor

2021

  • Alloul, Abbas; Spanoghe, Janne; Machado, Daniel; Vlaeminck, Siegfried E.. (2021) Unlocking the genomic potential of aerobes and phototrophs for the production of nutritious and palatable microbial food without arable land or fossil fuels. Microbial Biotechnology
    Academic article
  • Shechter, Ksenija Radic; Kafkia, Eleni; Zirngibl, Katharina; Gawrzak, Sylwia; Alladin, Ashna; Machado, Daniel. (2021) Metabolic memory underlying minimal residual disease in breast cancer. Molecular Systems Biology
    Academic article
  • Machado, Daniel; Maistrenko, Oleksandr M.; Andrejev, Sergej; Kim, Yongkyu; Bork, Peer; Patil, Kaustubh R.. (2021) Polarization of microbial communities between competitive and cooperative metabolism. Nature Ecology and Evolution
    Academic article
  • Blasche, Sonja; Kim, Yongkyu; Mars, Ruben A.T.; Machado, Daniel; Maansson, Maria; Kafkia, Eleni. (2021) Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community. Nature Microbiology
    Academic article

2020

  • Lieven, Christian; Beber, Moritz E.; Olivier, Brett G.; Bergmann, Frank T.; Ataman, Meric; Babaei, Parizad. (2020) MEMOTE for standardized genome-scale metabolic model testing. Nature Biotechnology
    Academic article

Journal publications

  • Burgos, Idun Maria Tokvam; Øyås, Ove; Moutinho Luz Machado, Carlos Daniel. (2025) Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass. bioRxiv
    Academic article
  • Moutinho Luz Machado, Carlos Daniel. (2024) A benchmark of optimization solvers for genome-scale metabolic modeling of organisms and communities. mSystems
    Academic article
  • Melkonian, Chrats; Zorrilla, Francisco; Kjærbølling, Inge; Blasche, Sonja; Moutinho Luz Machado, Carlos Daniel; Junge, Mette. (2023) Microbial interactions shape cheese flavour formation. Nature Communications
    Academic article
  • van den Berg, Naomi Iris; Machado, Daniel; Santos, Sophia; Rocha, Isabel; Chacón, Jeremy; Harcombe, William. (2022) Ecological modelling approaches for predicting emergent properties in microbial communities. Nature Ecology and Evolution
    Academic literature review
  • Cerca, José; Petersen, Bent; Lazaro-Guevara, José Miguel; Rivera-Colón, Angel G.; Birkeland, Siri; Vizueta, Joel. (2022) The genomic basis of the plant island syndrome in Darwin’s giant daisies. Nature Communications
    Academic article
  • Machado, Daniel; Patil, Kiran R.. (2022) Reply to: Erroneous predictions of auxotrophies by CarveMe. Nature Ecology and Evolution
    Letter to the editor
  • Alloul, Abbas; Spanoghe, Janne; Machado, Daniel; Vlaeminck, Siegfried E.. (2021) Unlocking the genomic potential of aerobes and phototrophs for the production of nutritious and palatable microbial food without arable land or fossil fuels. Microbial Biotechnology
    Academic article
  • Shechter, Ksenija Radic; Kafkia, Eleni; Zirngibl, Katharina; Gawrzak, Sylwia; Alladin, Ashna; Machado, Daniel. (2021) Metabolic memory underlying minimal residual disease in breast cancer. Molecular Systems Biology
    Academic article
  • Machado, Daniel; Maistrenko, Oleksandr M.; Andrejev, Sergej; Kim, Yongkyu; Bork, Peer; Patil, Kaustubh R.. (2021) Polarization of microbial communities between competitive and cooperative metabolism. Nature Ecology and Evolution
    Academic article
  • Blasche, Sonja; Kim, Yongkyu; Mars, Ruben A.T.; Machado, Daniel; Maansson, Maria; Kafkia, Eleni. (2021) Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community. Nature Microbiology
    Academic article
  • Lieven, Christian; Beber, Moritz E.; Olivier, Brett G.; Bergmann, Frank T.; Ataman, Meric; Babaei, Parizad. (2020) MEMOTE for standardized genome-scale metabolic model testing. Nature Biotechnology
    Academic article

Report

  • Stallvik, Andrea; Moutinho Luz Machado, Carlos Daniel. (2024) Designing microbial consortia using metabolic modelling. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • van Eggelen, Marieke Cecilia; Moutinho Luz Machado, Carlos Daniel. (2023) Predicting metabolic fluxes from gene expression data using machine learning . Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Røed, Elin Sandertun; Moutinho Luz Machado, Carlos Daniel; Márquez-Zavala, Elisa. (2023) Predicting Allosteric Regulation at Genome Scale. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Merkesvik, Jenny; Moutinho Luz Machado, Carlos Daniel. (2022) Towards genotype—phenotype association: Leveraging multiple-source microbial data and genome annotations to infer trait attributes for the uncultured microbiome. Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis
  • Lien, Martin Eide; Moutinho Luz Machado, Carlos Daniel. (2022) Metabolic network layout using biochemical coordinates . Norges teknisk-naturvitenskapelige universitet Norges teknisk-naturvitenskapelige universitet
    Masters thesis

Teaching

Courses

  • BT8120 - Prokaryot molekylærbiologi og syntetisk biologi
  • BT2100 - Beregningsbasert bioteknologi

Outreach

Finding Genius Podcast

Harnessing the Ecology of Microbial Communities with Daniel Machado

2024

  • Poster
    Marquez Zavala, Elisa; Di Bartolomeo, Francesca; Moutinho Luz Machado, Carlos Daniel. (2024) Automated Data Retrieval and Analysis for Enhanced Product Production. Centre for Digital Life Norway Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
  • Poster
    Alves Magalhaes Teixeira, Miguel; Moutinho Luz Machado, Carlos Daniel. (2024) Trust the universe - enlightening microbial metabolism with CarveMe’s new universal model. International Society for Microbial Ecology 19th International Symposium on Microbial Ecology , Cape Town, South Africa 2024-08-18 - 2024-08-23
  • Lecture
    Burgos, Idun Maria Tokvam; Øyås, Ove; Moutinho Luz Machado, Carlos Daniel. (2024) Elucidating the roles of bacteria in cellulose- and xylan-enriched communities with genome-scale metabolic models. Centre for Digital Life Norway Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30
  • Poster
    Stallvik, Andrea; Burgos, Idun Maria Tokvam; Moutinho Luz Machado, Carlos Daniel. (2024) Designing microbial consortia using metabolic modelling – possibilities and limitations. Centre for Digital Life Norway Norwegian Bioinformatics Days 2024 , Bergen, Norway 2024-05-28 - 2024-05-30

2023

  • Poster
    Alves Magalhaes Teixeira, Miguel; Moutinho Luz Machado, Carlos Daniel. (2023) CarveMe roadmap: expanding genome-scale metabolic model reconstructions. International Society for Computational Biology ISMB/ECCB 2023 , Lyon, France 2023-07-23 - 2023-07-27
  • Poster
    Stallvik, Andrea; Moutinho Luz Machado, Carlos Daniel. (2023) Synthetic Microbial Communities for the Production of High-Value Compounds. Norwegian Biochemical Society 58th Norwegian Biochemical Society Meeting , Ås, Norway 2023-01-19 - 2023-01-22

2022

  • Poster
    Teixeira, Miguel; Machado, Daniel. (2022) CarveMe roadmap: expanding genome-scale metabolic models’ reconstruction. International Society for Microbial Ecology ISME 18 , Lausanne, Switzerland 2022-08-14 - 2022-08-19
  • Poster
    Burgos, Idun Maria Tokvam; Machado, Daniel. (2022) Modeling The Conversion Of Lignocellulose Into Medium-chain Carboxylates. International Society for Microbial Ecology ISME 18 , Lausanne, Switzerland 2022-08-14 - 2022-08-19

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