Bent Håvard Hellum
About
Publications
2017
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Hellum, Bent Håvard.
(2017)
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product.
Pharmacology Research & Perspectives
Academic article
2016
-
Thu, Ole Kristian Forstrønen;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products.
Pharmaceutical Biology
Academic article
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
European Journal of Clinical Pharmacology
Academic article
-
Syrstad, Ingvild Helø;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2016)
In vitro inhibition of CYP3A4 by VitaePro.
NTNU-trykk
Thesis at a second degree level
-
Gustavsen, Marita;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Simultaneous determination of in vitro CYP-activities in human microsomes usin hops as a CYP trial inhibitor. A method development study.
NTNU
Masters thesis
2015
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard.
(2015)
Bruk av og holdninger til kommersielle naturprodukter hos medisin- og sykepleierstudenter.
NTNU-trykk
Thesis at a second degree level
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg;
Spigset, Olav.
(2015)
Cytochrome P-450 (CYP) inhibition by commercial Rhodiola rosea products in vitro and in humans and the relevance of their constituents.
NTNU-trykk
Medical Student Research Thesis
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2015)
Inhibitory mechanisms of human CYPs by three alkaloids isolated from traditional Chinese herbs.
Phytotherapy Research
Academic article
2014
-
Bjørneboe, Lars H;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2014)
In vitro CYP3A4 inhibition by fractionated Rhodiola rosea extracts.
Drug metabolism reviews (Softcover ed.)
Abstract
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products.
Drug metabolism reviews (Softcover ed.)
Abstract
-
Djuv, Ane;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism.
Drug metabolism reviews (Softcover ed.)
Abstract
2013
-
Ystenæs, Charlotte;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2013)
A comparison of the in vitro inhibitory effect of ginger (Zingiber Officinale) on the CYP3A4 and CYP3A5 mediated metabolism of testosterone. Student thesis (hovedoppgave) in medicine.
NTNU-trykk
Thesis at a second degree level
2012
-
Bjørnebo, Lars Henrik;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2012)
The Inhibitory Effect of Fractioned Rhodioala Rosea on CYP3A4 Mediated Metabolism-in Vitro. Student thesis in medicine.
NTNU trykk
Thesis at a second degree level
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2012)
The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.
Phytotherapy Research
Academic article
2011
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2011)
Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje's cocktail.
Toxicology Letters
Abstract
2010
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2010)
Bioanalytical method validation for measuring Indinavir in plasma by LCMSMS.
NTH trykk
Report
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2010)
Validation document of analytical assays used in the "Inje cocktail" for phenotyping of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A.
NTNU TRYKK
Report
-
Hellum, Bent Håvard;
Tøsse, Anita;
Høybakk, Kathrine;
Thomsen, Mette;
Rohloff, Jens;
Nilsen, Odd Georg.
(2010)
Potent in vitro Inhibition of CYP3A4 and P-Glycoprotein by Rhodiola rosea.
Planta Medica
Academic article
2009
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2009)
Trade Herbal Products and Induction of CYP2C19 and CYP2E1 in Cultured Human Hepatocytes.
Basic & Clinical Pharmacology & Toxicology
Academic article
2008
-
Nilsen, Odd Georg;
Engdal, Silje;
Hellum, Bent Håvard.
(2008)
Farlige forbindelser.
Athene
Popular scientific article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
Urters virkning på omsetning av legemidler i kroppen.
Interaksjonsforskningsgruppen
Compendium
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.
Basic & Clinical Pharmacology & Toxicology
Academic article
2007
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2007)
The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
DOKTORGRADSAVHANDLING: In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport.
Universitetsforlaget
Universitetsforlaget
Doctoral dissertation
Journal publications
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Hellum, Bent Håvard.
(2017)
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product.
Pharmacology Research & Perspectives
Academic article
-
Thu, Ole Kristian Forstrønen;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products.
Pharmaceutical Biology
Academic article
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
European Journal of Clinical Pharmacology
Academic article
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2015)
Inhibitory mechanisms of human CYPs by three alkaloids isolated from traditional Chinese herbs.
Phytotherapy Research
Academic article
-
Bjørneboe, Lars H;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2014)
In vitro CYP3A4 inhibition by fractionated Rhodiola rosea extracts.
Drug metabolism reviews (Softcover ed.)
Abstract
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products.
Drug metabolism reviews (Softcover ed.)
Abstract
-
Djuv, Ane;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism.
Drug metabolism reviews (Softcover ed.)
Abstract
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2012)
The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.
Phytotherapy Research
Academic article
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2011)
Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje's cocktail.
Toxicology Letters
Abstract
-
Hellum, Bent Håvard;
Tøsse, Anita;
Høybakk, Kathrine;
Thomsen, Mette;
Rohloff, Jens;
Nilsen, Odd Georg.
(2010)
Potent in vitro Inhibition of CYP3A4 and P-Glycoprotein by Rhodiola rosea.
Planta Medica
Academic article
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2009)
Trade Herbal Products and Induction of CYP2C19 and CYP2E1 in Cultured Human Hepatocytes.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Nilsen, Odd Georg;
Engdal, Silje;
Hellum, Bent Håvard.
(2008)
Farlige forbindelser.
Athene
Popular scientific article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2007)
The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.
Basic & Clinical Pharmacology & Toxicology
Academic article
Report
-
Syrstad, Ingvild Helø;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2016)
In vitro inhibition of CYP3A4 by VitaePro.
NTNU-trykk
Thesis at a second degree level
-
Gustavsen, Marita;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Simultaneous determination of in vitro CYP-activities in human microsomes usin hops as a CYP trial inhibitor. A method development study.
NTNU
Masters thesis
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard.
(2015)
Bruk av og holdninger til kommersielle naturprodukter hos medisin- og sykepleierstudenter.
NTNU-trykk
Thesis at a second degree level
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg;
Spigset, Olav.
(2015)
Cytochrome P-450 (CYP) inhibition by commercial Rhodiola rosea products in vitro and in humans and the relevance of their constituents.
NTNU-trykk
Medical Student Research Thesis
-
Ystenæs, Charlotte;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2013)
A comparison of the in vitro inhibitory effect of ginger (Zingiber Officinale) on the CYP3A4 and CYP3A5 mediated metabolism of testosterone. Student thesis (hovedoppgave) in medicine.
NTNU-trykk
Thesis at a second degree level
-
Bjørnebo, Lars Henrik;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2012)
The Inhibitory Effect of Fractioned Rhodioala Rosea on CYP3A4 Mediated Metabolism-in Vitro. Student thesis in medicine.
NTNU trykk
Thesis at a second degree level
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2010)
Bioanalytical method validation for measuring Indinavir in plasma by LCMSMS.
NTH trykk
Report
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2010)
Validation document of analytical assays used in the "Inje cocktail" for phenotyping of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A.
NTNU TRYKK
Report
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
Urters virkning på omsetning av legemidler i kroppen.
Interaksjonsforskningsgruppen
Compendium
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
DOKTORGRADSAVHANDLING: In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport.
Universitetsforlaget
Universitetsforlaget
Doctoral dissertation
Teaching
Courses
Knowledge Transfer
2018
-
LectureHellum, Bent Håvard. (2018) How can TADM be utilized. Hamilton Robotics User meeting Hamilton Robotics , Copenhagen 2018-05-14 - 2018-05-15
2017
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LectureHellum, Bent Håvard. (2017) Pille- og urtebruk, kan det kombineres?. Førde pensjonistforening Årsmøte Førde pensjonistforening , Førde 2017-02-15 - 2017-02-15
2016
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PosterSyrstad, Ingvild Helø; Nilsen, Odd Georg; Hellum, Bent Håvard. (2016) In vitro inhibition of human CYP3A4 by VitaePro . Norwegian Society for Pharmacology and Toxicology Annual Winter Meeting NSFT , Beitostølen 2016-01-28 - 2016-01-31
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Academic lectureThu, Ole Kristian Forstrønen; Nilsen, Odd Georg; Spigset, Olav; Hellum, Bent Håvard. (2016) Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Norwegian Society for Pharmacology and Toxicology Annual Winter Meeting NSFT , Beitostølen 2016-01-28 - 2016-01-31
-
PosterGustavsen, Marita; Nilsen, Odd Georg; Hellum, Bent Håvard. (2016) In vitro inhibition of human CYP enzymes by hops (Humulus lupulus). A “cocktail” study . Norwegian Society for Pharmacology and Toxicology Annual Winter Meeting NSFT , Beitostølen 2016-01-28 - 2016-01-31
2015
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LectureHellum, Bent Håvard. (2015) Pasienter og urtebruk: finnes det farlige legemiddel-urt kombinasjoner?. Kreftforeningen Vårmøte Brystkreftforeningen , Bærum 2015-04-14 - 2015-04-14
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LectureHellum, Bent Håvard. (2015) Samvirkninger av kjemikalier i kroppen. Norsk Yrkeshygienisk Forening Konferanse Norsk Yrkeshygienisk Forening , Trondheim 2015-10-31 - 2015-10-31
2013
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LectureNilsen, Odd Georg; Djuv, Ane; Langhammer, Astrid Jordet; Thu, Ole Kristian; Hellum, Bent Håvard. (2013) Possible significance of CYP inhibition for acetaminophen/other drugs toxicity and increase of clinical efficacy of indinavir in patients in and outside of general practice. Internal meeting at China Academy of Chinese Medical Sciences , Beijing 2013-12-10 - 2013-12-10
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PosterDjuv, Ane; Hellum, Bent Håvard; Nilsen, Odd Georg. (2013) Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism. International Society for the Study of Xenobiotics 10th International ISSX Meeting, Toronto , Toronto 2013-09-29 - 2013-10-03
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PosterBjørneboe, Lars H; Nilsen, Odd Georg; Hellum, Bent Håvard. (2013) In vitro CYP3A4 inhibition by fractionated Rhodeola rosea extracts. International Society for the Study on Xenobiotics 10th International ISSX Meeting, Toronto , Toronto 2013-09-29 - 2013-10-03
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PosterThu, Ole Kristian F.; Hellum, Bent Håvard; Nilsen, Odd Georg. (2013) Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products. International Society for the Study of Xenobiotics 10th International ISSX Meeting, Toronto , Toronto 2013-09-29 - 2013-10-03
2011
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PosterHellum, Bent Håvard; Nilsen, Odd Georg; Spigset, Olav. (2011) Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje’s cocktail. European Societies of Toxicology Eurotox 2011 , Paris 2011-08-28 - 2011-08-31
2010
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Academic lectureHellum, Bent Håvard. (2010) An in vivo cocktail approach for evaluating herb-drug interactions -validation of bioanalytical methods. Research group for molecular biology Monday meeting , Trondheim 2010-10-18 - 2010-10-18
2008
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PosterHøybakk, Kathrine; Tøsse, Anita; Nilsen, T.; Engdal, Silje; Hellum, Bent Håvard; Rohloff, Jens. (2008) Effect of Goldenroot (Rhodiola rosea) on P-glycoprotein and CYP3A4 in vitro. Norwegian Society for Pharmacology and Toxicology Annual Winter Meeting NSFT , Beitostølen 2008-01-24 - 2008-01-27
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InterviewHellum, Bent Håvard; Engdal, Silje; Nilsen, Odd Georg; Monsen, Tor Harald. (2008) Advarer mot urtemedisin. www.forskning.no www.forskning.no [Internet] 2008-02-15
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Lundh, Francis. (2008) Naturmedisin til kreftpasienter kan være farlig. VG VG [Internet] 2008-10-02
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Brækhus, Leni Aurora. (2008) Naturmidler påvirker kreftbehandling. ABC Nyheter ABC Nyheter [Internet] 2008-10-02
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InterviewNilsen, Odd Georg; Engdal, Silje; Hellum, Bent Håvard; Hasle, Inger. (2008) Farlige forbindelser. www.ffb.no www.ffb.no [Internet] 2008-12-11
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InterviewNilsen, Odd Georg; Hellum, Bent Håvard; Engdal, Silje; Steenstrup, Anne. (2008) Interesse for helsekostforskning. Innsida DMF Innsida DMF [Internet] 2008-12-19
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Academic lectureHellum, Bent Håvard. (2008) Legemiddel-urt interaksjoner. IKM Tirsdagsmøte for DMF, NTNU og St. Olavs Hospital , Trondheim 2008-04-22 -
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InterviewHellum, Bent Håvard; Engdal, Silje; Nilsen, Odd Georg; Moseng, Marianne. (2008) Advarer mot naturlegemidler- farlig i miks med medisiner. Dagbladet Dagbladet [Newspaper] 2008-02-15
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DocumentaryEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Steenstrup, Anne. (2008) Intervju med IKM stipendiat om naturmidler og kreftbehandling. Innsida, Det medisinske fakultet Innsida, Det medisinske fakultet [Internet] 2008-10-02
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PosterHellum, Bent Håvard; Nilsen, Odd Georg. (2008) Comparison of the in vitro inhibition potential of six trade herbal products on CYP3A4 metabolism and P-glycoprotein efflux transport. Norwegian Society for Pharmacology and Toxicology Annual winter meeting NSFT , Beitostølen 2008-01-24 - 2008-01-27
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PosterEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg. (2008) In Vitro Inhibition of CYP3A4 by Herbal Remedies. International Society for the Study of Xenobiotics 15th North American Regional ISSX metting, San Diego , San Diego 2008-10-12 - 2008-10-16
2007
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Gråberg, Marte. (2007) Kreftmedisin og naturpreparater - en farlig kombinasjon?. Kreftforeningen.no Kreftforeningen.no [Internet] 2007-06-29
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Moseng, Marianne. (2007) Naturmidler kan forsterke medisiner. Dagbladet Dagbladet [Newspaper] 2007-05-25
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InterviewHellum, Bent Håvard; Engdal, Silje; Djuv, Ane; Nilsen, Odd Georg; Tilseth, Trond Ola. (2007) Viagra -og grapefruktjuice, potensielt farlig blanding av naturmedisin og legemiddel. Adresseavisen Adresseavisen [Newspaper] 2007-07-11
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InterviewHellum, Bent Håvard; Engdal, Silje; Nilsen, Odd Georg; Solberg, Dag. (2007) Advarer mot sex-miks. Cupido Cupido [Newspaper] 2007-07-15
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Tunstad, Hege J.. (2007) Farlige forbindelser. GEMINI GEMINI [Newspaper] 2007-05-01
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg. (2007) Grapefrukt og viagra kan være livsfarlig. NTB NTB [Internet] 2007-06-18
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PosterHellum, Bent Håvard; Nilsen, Odd Georg. (2007) CYP2D6 inhibition by medicinal herbs. Norwegian Society of Pharmaciology and Toxicology Annual Winter Meeting NSFT , Beitostølen 2007-01-25 - 2007-01-28
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PosterHellum, Bent Håvard; Nilsen, Odd Georg. (2007) CYP2D6 inhibition by herbal products. International Pharmaceutical Federation Pharmaceutical Science World Congress, Amsterdam. , Amsterdam 2007-04-22 - 2007-04-25
2006
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Academic lectureHellum, Bent Håvard. (2006) Cytochrome P450 forskning i Trondheim. Statens legemiddelverk og prosjektfaggruppe Seminar Statens legemiddelverk , Oslo 2006-10-12 - 2006-10-12
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PosterHellum, Bent Håvard; Yang, Shu; Hu, Zhuohan; Nilsen, Odd Georg. (2006) The induction of CYP1A2 and 3A4 by six trade herbal products in primary human hepatocytes. NSFT Annual Meeting The Norwegian Society of Pharmacology and Toxicology, Beito , Beito 2006-01-26 - 2006-01-29
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PosterHellum, Bent Håvard; Nilsen, Odd Georg; Yang, Shu; Fang, Sishi; Mao, Yuchang; Tan, Jinxing. (2006) An In Vitro Evaluation of the Inductive Potential of St. Johns Wort, Horse Chestnut, Common Sage, Gingko Biloba, Common Valerian and Echinacea Purpurea on Cytochrome P450 Activities in Human Primary Hepatocytes. International Society for the Study of Xenobiotics (ISSX) 1st Asia/ Pacific International Society for the Study of Xenobiotics Meeting , Jeju Island 2006-05-24 - 2006-05-27
2005
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Academic lectureHellum, Bent Håvard; Yang, Shu; Fang, Sishi; Mao, Yuchang; Wang, Min; Hu, Zhuohan. (2005) Inductive potentials of six natural products marked in Norway on CYP1A2, 2D6 and 3A4 by using human primary hepatocytes. ISSX and China Pharmacology Society III-International Conference on Drug Metabolism , Hangzhou 2005-10-17 - 2005-10-20
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PosterHellum, Bent Håvard; Skålvoll, Anja Kristina; Nilsen, Odd Georg. (2005) In vitro cytochrome P-450 isoform assays for evaluation of drug-herb metabolic interactions. Norwegian society of pharmacology and toxicology Annual Meeting The Norwegian Society of Pharmacology and Toxicology, Beito , Beitostølen 2005-01-27 - 2005-01-29