Markus Hovd
Markus Hovd
Markus Hovd is a researcher at the K.G. Jebsen Centre for Brain Fluid research. He holds a PhD in pharmacology from the University of Oslo, and is a pharmacist by training. His main research focus is in pharmacometrics, combining mathematical and statistical modelling with pharmacokinetic studies. In particular, he performs research in new methods for non-parametric population pharmacokinetic modeling, with applications to therapeutic drug monitoring and personalized dosing.
At the K.G. Jebsen Centre for Brain Fluid Research, these models are applied to studies of intrathecally administered tracers for the estimation of glymphatic clearance, with the aim of improving both diagnostics of and therapeutics for patients with cerebrospinal fluid disorders.
As a researcher at the Department of Transplantation medicine, Oslo University Hospital, he is involved in several projects investigating the factors associated with patient survival following kidney transplantation. Additionally, he is developing new population pharmacokinetic models and tools for therapeutic drug monitoring and dose optimization of immunosuppressive drugs.
He also holds a teaching position at the Department of Pharmacy, University of Oslo, in the subjects of basic pharmacology and applied pharmacokinetics.
Position
Researcher at the K.G. Jebsen Centre for Brain Fluid Research
Researcher at the Department of Transplantation Medicine, Oslo University Hospital. Senior Lecturer at the Department of Pharmacy, University of Oslo
Selected Publications
Markus Hovd; Anders Åsberg; Ludvig A. Munthe; Kristian Heldal; Anna V. Reisæter; John T. Vaage; Fridtjof Lund-Johansen; Karsten Midtvedt. Humoral vaccine response and breakthrough infections in kidney transplant recipients during the COVID-19 pandemic: a nationwide cohort study. Lancet eClinicalMedicine, 2023. https://doi.org/10.1016/j.eclinm.2023.102035
Markus Herberg Hovd; Espen Mariussen; Hilde Uggerud; Aslan Lashkarivand; Hege Christensen; Geir Ringstad; Per Kristian Eide. Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders. Fluids and Barriers of the CNS, 2022. https://doi.org/10.1186/s12987-022-00352-w
Per Kristian Eide; Aslan Lashkarivand; Are Pripp; Lars Magnus Valnes; Markus Herberg Hovd; Geir Ringstad; Kaj Blennow; Henrik Zetterberg. Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders. Nature Communications, 2023. https://doi.org/10.1038/s41467-023-37685-5
Per K. Eide; Espen Mariussen; Hilde Uggerud; Are H. Pripp; Aslan Lashkarivand; Bjørnar Hassel; Hege Christensen; Markus Herberg Hovd; Geir Ringstad. Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood. JCI Insight, 2021. https://doi.org/10.1172/jci.insight.147063
Project involvement
Pharmacokinetic modelling of intrathecally administered drugs for the quantification of glymphatic clearance.
Development of new non-parametric algorithms for population pharmacokinetic modelling, in collaboration with the Laboratory of Applied Pharmacokinetics and Bioinformatincs, Los Angeles, USA.
Machine learning algorithms for the prediction of patient- and graft survival in kidney transplant recipients.