Bilde_Sulen

André Sulen

André Sulen

Sulen is a postdoctoral fellow at KG Jebsen Center for autoimmune disorders at Universitetet i Bergen (UiB). During his PhD project at UiB he employed phospho-specific flow- and mass-cytometry to study immune cell signaling in the context of environmental exposure. This led to the novel characterization of a p38-dependent leukocyte signaling pathway for hydrogen sulfide, a key gasotransmitter and a possible pollutant. In addition to shining a light on the role of hydrogen sulfide in inflammation, the PhD-project also triggered Sulen’s interest in the use of single-cell methodologies to study our immune system. During a 3-year postdoctoral stay at Karolinska Institutet he delved into the role of macrophages in adipose tissue and liver during obesity and insulin resistance. By using mass cytometry and single-cell RNA sequencing, he focused on the changes occurring in the adipose tissue during obesity in humans as well as mice. These experiences have provided Sulen with a cutting-edge skillset to study how our immune system affects human health.

Position

Position


 

Selected publications

Selected publications


Sulen A, Gullaksen SE, Bader L, McClymont DW, Skavland J, Gavasso S, et al. Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells. Pharmacol Res. 2016;113(Pt A):216-27.

Sulen A, Lygre SH, Hjelle SM, Hollund BE, Gjertsen BT. Elevated monocyte phosphorylated p38 in nearby employees after a chemical explosion. Sci Rep. 2016;6:29060.

Petrus P, Lecoutre S, Dollet L, Wiel C, Sulen A, Gao H, et al. Glutamine Links Obesity to Inflammation in Human White Adipose Tissue. Cell Metab. 2020;31(2):375-390.e11.

Project involvement

Project involvement


Sulen is focusing on autoimmune adrenal disease (Addison’s disease) in the group of Prof. Eystein Husebye. He aims to employ his skillset so that we can better understand Addison’s disease and its etiology, and also improve therapy.