Andreas Romaine
Andreas Romaine
Romaine is a postdoctoral researcher at the K. G. Jebsen Center for Cardiac Research, working on understanding the development of heart failure using cutting-edge molecular analysis. Using models of heart disease and human biopsy material, he aims to identify new molecular targets of heart failure that can be translated into treatment options.
Romaine holds a Masters and Bachelor’s degree in immunology from the prestigious Imperial College London, where he gained strong competence in the use of molecular techniques including flow cytometry and confocal microscopy whilst studying integrin receptor function. He continued his focus on integrin biology in the context of cardiac disease and in 2020 graduated with a PhD in cardiovascular research from the University of Oslo, in the award-winning group of Professor Geir Christensen based at the Institute for Experimental Medical Research (IEMR).
As a postdoctoral researcher, Romaine’s research is focused on elucidating the alterations in the cell surface receptor repertoire that occurs in heart failure progression. Two receptors families, the integrins and syndecans, in particular are promising candidates for therapeutic targeting to reduce the fibrotic and hypertrophic responses that occur in the heart when transitioning to a diseased state.
Position
Researcher (UiO profile)
Selected publications
Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G. Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin. J Am Heart Assoc 2020 Feb 4;9(3):e013518. doi: 10.1161/JAHA.119.013518.
Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang L, Sjaastad I, Lunde IG, Christensen G. A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice. Cardiovasc Res 2018 Oct 1;114(12):1680-1690.
Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen G, Gullberg D. Overexpression of integrin α11 induces cardiac fibrosis in mice. Acta Physiol (Oxf) 2018 Feb;222(2).
Project involvement
Novel concept for treating heart failure. Dr Maria Vistnes MD, PhD and Professor Geir Christensen MD PhD.