Shiva Dahal-Koirala
Photo: UiO/Øystein H. Horgmo
Shiva Dahal-Koirala
Dahal-Koirala is a Postdoctoral fellow at K.G. Jebsen Coeliac Disease Research Centre (J CoDiRC). Her previous work has dealt with the T-cell receptor recognition of peptide-MHC complexes that are relevant to coeliac disease – work that has resulted in several high profiled papers. Currently, her research focuses on exploring the diagnostic potential of sequencing T-cell receptors directly from peripheral blood.
Position
Postdoctoral Fellow (UiO profile)
Selected publications
Ting YT*, Dahal-Koirala S*, Kim HSK, Qiao SW, Neumann RS, Lundin KEA, Petersen J, Reid HH, Sollid LM, Rossjohn J.(2020) A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease, Proc Natl Acad Sci U S A. 117(6) doi:10.1073/pnas.1914308117
Dahal-Koirala S*, Ciacchi L*, Petersen J, Risnes LF, Neumann RS, Christophersen A, Lundin KEA, Reid HH, Qiao SW, Rossjohn J, Sollid LM. (2019) Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes, J Biol Chem. 294(3) doi:10.1074/jbc.RA118.005736
Risnes LF*, Christophersen A*, Dahal-Koirala S*, Neumann RS, Sandve GK, Sarna VK, Lundin KE, Qiao SW, Sollid LM.(2018) Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease, J Clin Invest. 128(6):2642-2650. doi:10.1172/JCI98819
*Shared first authors
Project involvement
Dahal-Koirala currently works in the research group of Ludvig Sollid where she leads a research project that aims to develop a diagnostic test for coeliac disease based on detection of gluten specific T-cell receptor sequences directly from blood samples. This project involves several members of the Sollid group and Sandve group at J CoDiRC as well as Associate professor Eivind-Ness Jensen at the K.G. Jebsen Center for Genetic Epidemiology.