Per Bruheim
About
Bruheim group focuses on Deep Phenotyping of prokaryotic and eukaryotic model systems using Advanced Cultivation Technology and Mass Spectrometry based Metabolomics, Fluxomics and Lipidomics (https://www.ntnu.edu/ibt/research/micphys#/view/about). Bruheim is scientific leader of the NV faculty Mass Spectrometry lab. We have developed a suite of target and non-target MS methods, which we apply on a range of biological model systems and research questions.
Teaching
Bruheim is leader of the 2-years and 5-years study programs in Biotechnology (MSBIOTECH and MBIOT5). He teaches in TBT4140 Biochemical Engineering, TBT4110 Microbiology, TKP4170/71 Process Designs, Projects Biochemical Engineering Plant Design, BT8120 Prokaryote Molecular Biology and Synthetic Biology, MEDT8010 Metabolomics - Methods and Applications
Current projects:
Trond Mohn Stiftelse: “Targeting AMR by inhibition of bacterial stress responses” (2019-2023)
NTNU Biotechnology programme: “Chemically defined cell culture media” (2019-2022)
NTNU IBT PhD: “Inhibition of antibiotic resistance development through targeting bacterial translesion synthesis mechanism with novel peptide drugs” (2017-2022)
8-10 ad hoc Metabolomics/ Fluxomics Lipidomics projects (NT-faculty, NTNU, National, International)
Publications
2024
-
Juell, Mathilde Fredrikke Haneborg;
Bruheim, Per.
(2024)
Exploring the sustainable docosahexaenoic acid production in Auraontiochytrium limacinum SR21 using residual raw materials.
NTNU
Masters thesis
-
Haaland, Karen Lund;
Bruheim, Per.
(2024)
The Effect of High Plasmid Copy Number and Oxygen Limitation on Growth and mCherry Production in Escherichia coli BL21 A3-mCherry.
NTNU
Masters thesis
-
Melbye, Kristin Soleim;
Bruheim, Per.
(2024)
Production of Single Cell Protein from Kluyveromyces marxianus Utilising Whey and Fish Hydrolysate as Substrates.
NTNU
Masters thesis
-
Nedreås, Pia Moe-Nilssen;
Bruheim, Per.
(2024)
Optimization of chicken hydrolysate as a nitrogen source for Fusarium venenatum in submerged culture.
NTNU
Masters thesis
-
Tellsgård, Sunniva Christiansen;
Bruheim, Per.
(2024)
Research on Neurospora crassa cultivation using residual raw materials from the fish and poultry industry as organic nitrogen sources.
NTNU
Masters thesis
-
Gunnes, Sondre;
Bruheim, Per.
(2024)
Performance of Saccharomyces cerevisiae and Kluyveromyces
marxianus, Investigating the Impact of Carbon and Nitrogen Sources on Fermentation Characteristics.
.
NTNU
Masters thesis
-
Mjølnerød, Kristine;
Bruheim, Per.
(2024)
Kluyveromyces marxianus Single-Cell Protein production from Salmon Hydrolysate and Whey.
NTNU
Masters thesis
-
Bergum, Olaug Elisabeth Torheim;
Singleton, Amanda Holstad;
Røst, Lisa Marie Ivarsdatter;
Bodein, Antoine;
Scott-Boyer, Marie-Pier;
Rye, Morten Beck.
(2024)
SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.
Frontiers in Microbiology
Academic article
-
Rane, Divyata Vilas;
Garcia Calvo, Laura;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2024)
Zic-HILIC MS/MS Method for NADomics Provides Novel Insights into Redox Homeostasis in Escherichia coli BL21 Under Microaerobic and Anaerobic Conditions.
Metabolites
Academic article
2023
-
Hallan, Stein Ivar;
Øvrehus, Marius Altern;
Darshi, Manjula;
Montemayor, Daniel;
Langlo, Knut Asbjørn Rise;
Bruheim, Per.
(2023)
Metabolic Differences in Diabetic Kidney Disease Patients with Normoalbuminuria versus Moderately Increased Albuminuria.
Kidney360
Academic article
-
Singleton, Amanda Holstad;
Bergum, Olaug Elisabeth Torheim;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen.
(2023)
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates.
Frontiers in Microbiology
Academic article
-
Jaramillo-Jiménez, Alberto;
Melvær, Giil Lasse;
Borda, Miguel Germán;
Tovar-Rios, Diego Alejandro;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2023)
Serum TCA cycle metabolites in Lewy bodies dementia and Alzheimer's disease: Network analysis and cognitive prognosis.
Mitochondrion (Amsterdam. Print)
Academic article
-
Thorfinnsdottir, Lilja Brekke;
Hovde Bø, Gaute;
Booth, James Alexander;
Bruheim, Per.
(2023)
Survival of Escherichia coli after high-antibiotic stress is dependent on both the pregrown physiological state and incubation conditions.
.
Frontiers in Microbiology
Academic article
-
Garcia Calvo, Laura;
Rane, Divyata Vilas;
Everson, Nikalet;
Humlebrekk, Sigurd Tømmerberg;
Mathiassen, Lise Femanger;
Mæhlum, Astfrid Helene Morka.
(2023)
Central carbon metabolite profiling reveals vector-associated differences in the recombinant protein production host Escherichia coli BL21 .
Frontiers in Chemical Engineering
Academic article
-
Scheffold, Jana;
Bruheim, Per;
Kjesbu, Joachim Sebastian;
Jang, Mi.
(2023)
Serum-free alginate-C2C12 cells microcapsule as a model of alternative animal protein source.
Frontiers in Nutrition
Academic article
-
Øvrebø, Stinus Reklev;
Bruheim, Per.
(2023)
The effect of oxygen limitation on growth characteristics and the redox state of Escherichia coli BL21 during recombinant protein production.
NTNU
Masters thesis
-
Refsnes, Åse;
Bruheim, Per.
(2023)
Analysis of the consequences of oxygen limitation on the redox balance and overflow metabolites in Escherichia coli BL21 during recombinant protein production.
NTNU
Masters thesis
-
Rau, E-Ming;
Aasen, Inga Marie;
Bartosova, Zdenka;
Bruheim, Per;
Ertesvåg, Helga.
(2023)
Utilizing lipidomics and fatty acid synthase inhibitors to explore lipid accumulation in two thraustochytrid species.
Algal Research
Academic article
-
Eide, Marta;
Goksøyr, Anders;
Yadetie, Fekadu;
Gilabert, Alejandra;
Bartosova, Zdenka;
Frøysa, Håvard Guldbrandsen.
(2023)
Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod.
Frontiers in Physiology
Academic article
-
Thorfinnsdottir, Lilja Brekke;
Garcia Calvo, Laura;
Bø, Gaute Hovde;
Bruheim, Per;
Røst, Lisa Marie Ivarsdatter.
(2023)
Optimized Fast Filtration-based Sampling and Extraction Enables Precise and Absolute Quantification of the Escherichia coli Central Carbon Metabolome.
Metabolites
Academic article
-
Dankel, Simon Nitter;
Kalleklev, Tine-Lise;
Lunde, Siri;
Stafsnes, Marit Hallvardsdotter;
Bruheim, Per;
Aloysius, Thomas Aquinas.
(2023)
Changes in Plasma Pyruvate and TCA Cycle Metabolites upon
Increased Hepatic Fatty Acid Oxidation and Ketogenesis in
Male Wistar Rats.
International Journal of Molecular Sciences
Academic article
2022
-
Jang, Mi;
Scheffold, Jana;
Røst, Lisa M.;
Cheon, Hyejeong;
Bruheim, Per.
(2022)
Serum-free cultures of C2C12 cells show different muscle phenotypes which can be estimated by metabolic profiling.
Scientific Reports
Academic article
-
Simensen, Vetle;
Schulz, Christian;
Karlsen, Emil;
Bråtelund, Signe;
Burgos, Idun Maria Tokvam;
Thorfinnsdottir, Lilja Brekke.
(2022)
Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling.
PLOS ONE
Academic article
-
Kumar, Kanhaiya;
Bruheim, Per.
(2022)
A comparative study at bioprocess and metabolite levels of superhost strain Streptomyces coelicolor M1152 and its derivative M1581 heterologously expressing chloramphenicol biosynthetic gene cluster.
Biotechnology and Bioengineering
Academic article
-
Rau, E-Ming;
Bartosova, Zdenka;
Kristiansen, Kåre Andre;
Aasen, Inga Marie;
Bruheim, Per;
Ertesvåg, Helga.
(2022)
Overexpression of two new acyl-CoA:diacylglycerol acyltransferase 2-like acyl-CoA:sterol acyltransferases enhanced squalene accumulation in Aurantiochytrium limacinum.
Frontiers in Microbiology
Academic article
-
Kumar, Kanhaiya;
Bruheim, Per.
(2022)
Nutrient-depended metabolic switching during batch cultivation of Streptomyces coelicolor explored with absolute quantitative mass spectrometry based metabolite profiling.
3 Biotech
Academic article
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene
Academic article
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics
Academic article
-
Røst, Lisa M.;
Louet, Claire;
Bruheim, Per;
Flo, Trude Helen;
Gidon, Alexandre.
(2022)
Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control Mycobacterium avium Infection in Human Primary Macrophages.
Frontiers in Immunology
Academic article
-
Carracedo Huroz, Sergio;
Lirussi, Lisa;
Alsøe, Lene;
Segers, Filip;
Wang, Changliang;
Bartosova, Zdenka.
(2022)
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
DNA Repair
Academic article
-
Jang, Mi;
Pete, Ellen Sofie;
Bruheim, Per.
(2022)
The impact of serum-free culture on HEK293 cells: From the establishment of suspension and adherent serum-free adaptation cultures to the investigation of growth and metabolic profiles.
Frontiers in Bioengineering and Biotechnology
Academic article
-
Jang, Mi;
Scheffold, Jana;
Bruheim, Per.
(2022)
Isolation and cultivation of primary muscle cells from Lobster (Homarus gammarus).
In vitro Cellular & Developmental Biology-Animal
Academic article
2021
-
Rutkis, Reinis;
Strazdina, Inese;
Lasa, Zane;
Bruheim, Per;
Kalnenieks, Uldis.
(2021)
Ethanologenesis and respiration in a pyruvate decarboxylase-deficient Zymomonas mobilis.
BMC Research Notes
Academic article
-
Bartosova, Zdenka;
Villa Gonzalez, Susana;
Voigt, Andre;
Bruheim, Per.
(2021)
High throughput semi-quantitative UHPSFC-MS/MS lipid profiling and lipid class determination.
Journal of Chromatographic Science
Academic article
-
Jin, Yang;
Harvey, Thomas Nelson;
Bartosova, Zdenka;
Hassani, Sahar;
Bruheim, Per;
Sandve, Simen Rød.
(2021)
Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon.
Journal of Agricultural and Food Chemistry
Academic article
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules
Academic article
-
Pedersen, Eilif;
Eitungjerde, Sara;
André, Thea Harnes;
Bruheim, Per;
Grønflaten, Lars Trovatten;
Gundersen, Ingeborg Nævdal.
(2021)
Fremtidens teknologistudier (FTS), grupperapport: A3 - 5-årig master.
NTNU
Report
-
Skedsmo, Fredrik;
Espenes, Arild;
Tranulis, Michael A.;
Matiasek, Kaspar;
Gunnes, Gjermund;
Bjerkås, Inge.
(2021)
Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D.
Neuromuscular Disorders
Academic article
-
Kumar, Kanhaiya;
Bruheim, Per.
(2021)
Large dependency of intracellular NAD and CoA pools on cultivation conditions in Saccharomyces cerevisiae.
BMC Research Notes
Academic article
-
Gidon, Alexandre;
Louet, Claire;
Røst, Lisa M.;
Bruheim, Per;
Flo, Trude Helen.
(2021)
The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages.
mBio
Academic article
-
Fuchino, Katsuya;
Chan, Helena;
Hwang, Ling Chin;
Bruheim, Per.
(2021)
The Ethanologenic bacterium Zymomonas mobilis divides asymmetrically and exhibits heterogeneity in DNA content.
Applied and Environmental Microbiology
Academic article
-
Abdollahi, Pegah;
Vandsemb, Esten;
Elsaadi, Samah;
Røst, Lisa Marie;
Yang, Rui;
Hjort, Magnus Aassved.
(2021)
Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma.
The FASEB Journal
Academic article
-
Bartosova, Zdenka;
Ertesvåg, Helga;
Nyfløt, Eirin Lishaugen;
Kämpe, Kristoffer;
Aasen, Inga Marie;
Bruheim, Per.
(2021)
Combined Metabolome and Lipidome analyses for in-depth characterization of lipid accumulation in the DHA producing Aurantiochytrium sp. T66.
Metabolites
Academic article
-
Kumar, Kanhaiya;
Venkatraman, Vishwesh;
Bruheim, Per.
(2021)
Adaptation of central metabolite pools to variations in growth rate and cultivation conditions in Saccharomyces cerevisiae.
Microbial Cell Factories
Academic article
-
Nilsen, Mona Synnøve;
Lindquist, Carine;
Stafsnes, Marit Hallvardsdotter;
Bjørndal, Bodil;
Bruheim, Per;
Aloysius, Thomas Aquinas.
(2021)
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Academic article
2020
-
Røst, Lisa Marie;
Darestani, Armaghan Shafaei;
Fuchino, Katsuya;
Bruheim, Per.
(2020)
Zwitterionic HILIC tandem mass spectrometry with isotope dilution for rapid, sensitive and robust quantification of pyridine nucleotides in biological extracts.
Journal of chromatography. B
Academic article
-
Fuchino, Katsuya;
Bruheim, Per.
(2020)
An assessment of serial co-cultivation approach for generating novel Zymomonas mobilis strains.
BMC Research Notes
Academic article
-
Fontana, Diletta;
Mauri, Mario;
Renso, Rossella;
Docci, Mattia;
Crespiatico, Ilaria;
Røst, Lisa Marie.
(2020)
ETNK1 mutations induce a mutator phenotype that
can be reverted with phosphoethanolamine.
Nature Communications
Academic article
-
Fuchino, Katsuya;
Bruheim, Per.
(2020)
Increased salt tolerance in Zymomonas mobilis strain generated by adaptative evolution.
Microbial Cell Factories
Academic article
-
Fuchino, Katsuya;
Kalnenieks, Uldis;
Rutkis, Reinis;
Grube, Mara;
Bruheim, Per.
(2020)
Metabolic Profiling of Glucose-Fed Metabolically
Active Resting Zymomonas mobilis Strains.
Metabolites
Academic article
-
Røst, Lisa Marie;
Thorfinnsdottir, Lilja Brekke;
Kumar, Kanhaiya;
Fuchino, Katsuya;
Langørgen, Ida Eide;
Bartosova, Zdenka.
(2020)
Absolute Quantification of the Central Carbon
Metabolome in Eight Commonly Applied
Prokaryotic and Eukaryotic Model Systems.
Metabolites
Academic article
-
Røst, Lisa Marie;
Otterlei, Marit;
Bruheim, Per.
(2020)
Targeted Mass Spectrometric Metabolite Profiling for Studies of Central Carbon Metabolism.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Doctoral dissertation
2019
-
Øvrehus, Marius Altern;
Bruheim, Per;
Ju, Wenjun;
Zelnick, Leila R.;
Langlo, Knut Asbjørn Rise;
Sharma, Kumar.
(2019)
Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis.
Kidney International Reports
Academic article
-
Volkova, Yulia A.;
Averina, Elena B.;
Vasilenko, Dmitry A;
Sedenkova, Kseniya N;
Grishin, Yuri K.;
Bruheim, Per.
(2019)
Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 5-Nitroisoxazoles.
Journal of Organic Chemistry
Academic article
-
Navarro, Miguel Octavio Perez;
Simionato, Ane Stefano;
Perez, Juan Carlos Bedoya;
Barazetti, Andre Riedi;
Emiliano, Janaina;
Niekawa, Erika Tyemi Goya.
(2019)
Fluopsin C for treating multidrug-resistant infections: In vitro activity aganist clinically important strains and in vivo efficacy against carbapenemase-producing Klebsiella pneumoniae.
Frontiers in Microbiology
Academic article
-
Skedsmo, Fredrik Strebel;
Malachin, Giulia;
Våge, Dag Inge;
Hammervold, Mie Marie;
Salvesen, Øyvind;
Ersdal, Cecilie.
(2019)
Demyelinating polyneuropathy in goats lacking prion protein.
The FASEB Journal
Academic article
-
Kalnenieks, Uldis;
Balodite, Elina;
Strahler, Steffi;
Strazdina, Inese;
Rex, Julia;
Pentjuss, Agris.
(2019)
Improvement of acetaldehyde production in Zymomonas mobilis by engineering of its aerobic metabolism.
Frontiers in Microbiology
Academic article
2018
-
Johansen, Finn-Eirik;
Brautaset, Trygve;
Aune, Marie Hjelmseth;
Patriksson, Alexandra;
Falkenberg, Liv Eggset;
Kleppe, Rune.
(2018)
Centre for Digital Life Norway - Annual report 2017.
Senter for Digialt Liv Norge
Report
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget
Academic article
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio
Academic article
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients
Academic article
-
Stafsnes, Marit Hallvardsdotter;
Røst, Lisa Marie;
Bruheim, Per.
(2018)
Improved phosphometabolome profiling applying isotope dilution strategy and capillary ion chromatography-tandem mass spectrometry.
Journal of chromatography. B
Academic article
2015
-
Mühlroth, Alice;
Assimi, AE;
Røkke, Gunvor;
Despres, Julie;
Winge, Per;
Bruheim, Per.
(2015)
Transcriptional regulation of lipid accumulation in phosphorus limited Nannochloropsis oceanica.
European journal of phycology
Abstract
-
Janecková, Hana;
Kalivodova, Alzbeta;
Najdekr, Lukas;
Friedecký, David;
Hron, Karel;
Bruheim, Per.
(2015)
Untargeted metabolomic analysis of urine samples in the diagnosis of some inherited metabolic disorders.
Biomedical Papers of the Faculty of Medicine of Palacky University
Academic article
-
Giskeødegård, Guro F.;
Hansen, Ailin Falkmo;
Bertilsson, Helena;
Villa Gonzalez, Susana;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2015)
Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia.
British Journal of Cancer
Academic article
-
Lien, Stina Katrine;
Niedenführ, Sebastian;
Sletta, Håvard;
Nöh, Katharina;
Bruheim, Per.
(2015)
Fluxome study of Pseudomonas fluorescens reveals major reorganisation of carbon flux through central metabolic pathways in response to inactivation of the anti-sigma factor MucA.
BMC Systems Biology
Academic article
-
Kvitvang, Hans Fredrik Nyvold;
Bruheim, Per.
(2015)
Fast filtration sampling protocol for mammalian suspension cells tailored for phosphometabolome profiling by capillary ion chromatography - tandem mass spectrometry.
Journal of chromatography. B
Academic article
-
Sreevidya, Meesala;
Gopalakrishnan, Subramaniam;
Melø, Torun Margareta;
Simic, Nebojsa;
Bruheim, Per;
Sharma, Mamta.
(2015)
Biological control of Botrytis cinerea and plant growth promotion potential by Penicillim citrinum in chickpea (Cicer arietinum L.).
Biocontrol science and technology (Print)
Academic article
2014
-
Kvitvang, Hans Fredrik Nyvold;
Kristiansen, Kåre Andre;
Lien, Stina Katrine;
Bruheim, Per.
(2014)
Quantitative Analysis of Amino and Organic Acids by Methyl Chloroformate Derivatization and GC-MS/MS Analysis.
Springer Science+Business Media B.V.
Academic chapter/article/Conference paper
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology
Academic article
-
Kvitvang, Hans Fredrik Nyvold;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2014)
Assessment of capillary anion exchange ion chromatography tandem mass spectrometry for the quantitative profiling of the phosphometabolome and organic acids in biological extracts.
Journal of Chromatography A
Academic article
-
Pettersen, Ragnhild;
Johnsen, Geir;
Bruheim, Per;
Andreassen, Trygve.
(2014)
Development of hyperspectral imaging as a bio-optical taxonomic tool for pigmented marine organisms.
Organisms Diversity & Evolution
Academic article
2013
-
Borgos, Sven Even F.;
Bordel, Sergio;
Sletta, Håvard;
Ertesvåg, Helga;
Jakobsen, Øyvind Mejdell;
Bruheim, Per.
(2013)
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling.
BMC Systems Biology
Academic article
-
Bruheim, Per;
Kvitvang, Hans Fredrik Nyvold;
Villas-Boas, Silas G..
(2013)
Stable isotope coded derivatizing reagents as internal standards in metabolite profiling.
Journal of Chromatography A
Academic literature review
-
Stafsnes, Marit Hallvardsd;
Bruheim, Per.
(2013)
Pigmented Marine Heterotrophic Bacteria: Occurrence, Diversity, and Characterization of Pigmentation.
CRC Press
Academic chapter/article/Conference paper
-
Lien, Stina Katrine;
Sletta, Håvard;
Ellingsen, Trond Erling;
Valla, Svein;
Correa, Elon;
Goodacre, Royston.
(2013)
Investigating alginate production and carbon utilization in Pseudomonas fluorescens SBW25 using mass spectrometry-based metabolic profiling.
Metabolomics
Academic article
-
Stafsnes, Marit Hallvardsd;
Dybwad, Marius;
Brunsvik, Anders;
Bruheim, Per.
(2013)
Large scale MALDI-TOF MS based taxa identification to identify novel pigment producers in a marine bacterial culture collection.
Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology
Academic article
2012
-
Elde, Anette;
Pettersen, Ragnhild;
Bruheim, Per;
Järnegren, Johanna;
Johnsen, Geir.
(2012)
Pigmentation and Spectral Absorbance Signatures in Deep-Water Corals from the Trondheimsfjord, Norway.
Marine Drugs
Academic article
-
Lien, Stina Katrine;
Kvitvang, Hans Fredrik Nyvold;
Bruheim, Per.
(2012)
Utilization of a deuterated derivatization agent to synthesize internal standards for gas chromatography-tandem mass spectrometry quantification of silylated metabolites.
Journal of Chromatography A
Academic article
-
Wentzel, Alexander;
Sletta, Håvard;
Wellington, E.M.H.;
Ellingsen, Trond Erling;
Bruheim, Per.
(2012)
Intracellular metabolite pool changes in response to nutrient depletion induced metabolic switching in Streptomyces coelicolor.
Metabolites
Academic article
-
Dybwad, Marius;
Granum, Per Einar;
Bruheim, Per;
Blatny, Janet Martha.
(2012)
Characterization of airborne bacteria at an underground subway station.
Applied and Environmental Microbiology
Academic article
-
Tøndervik, Anne;
Bruheim, Per;
Berg, Laila;
Ellingsen, Trond Erling;
Kotlar, Hans Kristian;
Valla, Svein.
(2012)
Ralstonia sp U2 naphthalene dioxygenase and Comamonas sp JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes.
Journal of Bioscience and Bioengineering
Academic article
-
Janecková, Hana;
Hron, Karel;
Wojtowicz, Petr;
Hlídková, Eva;
Baresová, Anna;
Friedecký, David.
(2012)
Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders.
Journal of Chromatography A
Academic article
-
Wojtowicz, Petr;
Zrostlíková, Jitka;
Šťastná, Veronika;
Dostálová, Eva;
Zídková, Lenka;
Bruheim, Per.
(2012)
Comprehensive Two-Dimensional Gas Chromatography Coupled to Time-of-Flight Mass Spectrometry in Human Metabolomics.
IntechOpen
Academic chapter/article/Conference paper
-
Almaas, Eivind;
Bruheim, Per;
Lale, Rahmi;
Valla, Svein.
(2012)
Dynamics and robustness of metabolic networks: A systems biology review of Escherichia coli metabolism.
Caister Academic Press
Academic chapter/article/Conference paper
-
Fremstedal, Ane Sofia Viset;
Bruheim, Per;
Sletta, Håvard;
Johnsen, Geir.
(2012)
Utvikling og optimalisering av protokoll for massespektrometrisk metabolsk profilering av adherente humane celler.
NTNU Master theses
Masters thesis
-
Wentzel, Alexander;
Bruheim, Per;
Øverby, Anders;
Jakobsen, Øyvind Mejdell;
Sletta, Håvard;
Omara, Walid A.M..
(2012)
Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2).
BMC Systems Biology
Academic article
2011
-
Vijayabharathi, Rajendran;
Bruheim, Per;
Andreassen, Trygve;
Raja, Duraisamy Senthil;
Devi, Palanisamy Bruntha;
Sathyabama, Sathyaseelan.
(2011)
Assessment of resistomycin, as an anticancer compound isolated and characterized from Streptomyces aurantiacus AAA5.
Journal of Microbiology
Academic article
-
Klinkenberg, Geir;
Sletta, Håvard;
Fjærvik, Espen;
Zahlsen, Kolbjørn;
Bruheim, Per.
(2011)
Two-dimensional LC-MS fractioning and cross-matching of mass spectrometric data for rational identification of bioactive compounds in crude extracts.
Journal of Separation Science
Academic article
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods
Academic article
-
Kvitvang, Hans Fredrik Nyvold;
Andreassen, Trygve;
Adam, Tomas;
Villas-Boas, Silas G.;
Bruheim, Per.
(2011)
Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.
Analytical Chemistry
Academic article
-
Bruheim, Per.
(2011)
“We focus most on the approximately 2000 baker's yeast genes that are closest to human genes.”.
Gemini
Popular scientific article
-
Svee, Kristin;
Eftedal, Ingrid;
Bruheim, Per.
(2011)
Genetisk disposisjon for dykkersyke? Uttrykk av hypoksirelaterte gener i abdominal aorta fra rotte etter simulerte dykk.
NTNU
Masters thesis
2010
-
Bruheim, Per.
(2010)
Gjær som pasienter.
Gemini
Popular scientific article
-
Bruheim, Per.
(2010)
Med gjær som kreftpasient.
Forskning.no
Interview Journal
-
Nieselt, Kay;
Battke, Florian;
Herbig, Alexander;
Bruheim, Per;
Wentzel, Alexander;
Jakobsen, Øyvind Mejdell.
(2010)
The dynamic architecture of the metabolic switch in Streptomyces coelicolor.
BMC Genomics
Academic article
-
Stafsnes, Marit Hallvardsdotter;
Josefsen, Kjell D.;
Kildahl-Andersen, Geir;
Valla, Svein;
Ellingsen, Trond E.;
Bruheim, Per.
(2010)
Isolation and Characterization of Marine Pigmented Bacteria from Norwegian Coastal Waters and Screening for Carotenoids with UVA-Blue Light Absorbing Properties.
Journal of Microbiology
Academic article
-
Volkova, Yulia A.;
Averina, Elena B.;
Grishin, Yuri K.;
Bruheim, Per;
Kuznetsova, Tamara S.;
Zefirov, Nikolai S..
(2010)
Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 3-Nitroisoxazoles.
Journal of Organic Chemistry
Academic article
-
Netzer, Roman;
Stafsnes, Marit Hallvardsdotter;
Andreassen, Trygve;
Goksøyr, Audun;
Bruheim, Per;
Brautaset, Trygve.
(2010)
Biosynthetic Pathway for g-Cyclic Sarcinaxanthin in Micrococcus luteus: Heterologous Expression and Evidence for Diverse and Multiple Catalytic Functions of C50 Carotenoid Cyclases.
Journal of Bacteriology
Academic article
-
Mørkved, Eva Henmo;
Andreassen, Trygve;
Fröhlich, Roland;
Mo, Frode;
Bruheim, Per.
(2010)
Unsymmetrical zinc azaphthalocyanines, peripherally substituted with thiophen-2-yl and 2-functionalized phenoxy groups.
Polyhedron
Academic article
2009
-
Jørgensen, Hanne;
Fjærvik, Espen;
Hakvåg, Sigrid;
Bruheim, Per;
Bredholt, Harald;
Klinkenberg, Geir.
(2009)
Candicidin Biosynthesis Gene Cluster Is Widely Distributed among Streptomyces spp. Isolated from the Sediments and the Neuston Layer of the Trondheim Fjord, Norway.
Applied and Environmental Microbiology
Academic article
-
Stockmann, Vegar;
Bakke, Jan Magnus;
Bruheim, Per;
Fiksdahl, Anne.
(2009)
Formation of new 4-isocyanobut-2-enenitriles by thermal ring cleavage of 3-pyridyl azides.
Tetrahedron
Academic article
-
Mørkved, Eva Henmo;
Andreassen, Trygve;
Bruheim, Per.
(2009)
Zinc azaphthalocyanines with pyridin-3-yloxy peripheral substituents.
Polyhedron
Academic article
-
Jørgensen, Hanne;
Degnes, Kristin;
Sletta, Håvard;
Fjærvik, Espen;
Dikiy, Alexander;
Dikiy, Alexander.
(2009)
Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
Chemistry and Biology
Academic article
-
Bruheim, Per;
Sletta, Håvard;
Zahlsen, Kolbjørn;
Bathen, Tone Frost;
Gribbestad, Ingrid S.
(2009)
metabolomics - et spennende verktøy i medisinsk og biologisk forskning.
NBS-nytt
Popular scientific article
2008
-
Simon, Sebastien Charles;
Nordgård, Erland;
Bruheim, Per;
Sjøblom, Johan.
(2008)
Determination of C-80 tetra-acid content in calcium naphthenate deposits.
Journal of Chromatography A
Academic article
-
Fuglseth, Erik;
Sundby, Eirik;
Bruheim, Per;
Hoff, Bård Helge.
(2008)
Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols.
Tetrahedron: asymmetry
Academic article
-
Fuglseth, Erik;
Sundby, Eirik;
Bruheim, Per;
Hoff, Bård Helge.
(2008)
Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols.
Tetrahedron: asymmetry
Academic article
2007
-
Villas-Boas, Silas G.;
Bruheim, Per.
(2007)
The potential of metabolomics tools in bioremediation studies.
Omics
Academic literature review
-
Villas-Boas, Silas G.;
Bruheim, Per.
(2007)
Cold glycerol–saline: The promising quenching solution for accurate intracellular metabolite analysis of microbial cells.
Analytical Biochemistry
Academic article
2006
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy.
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science
Academic article
-
Holtan, Synnøve;
Bruheim, Per;
Skjåk-Bræk, Gudmund.
(2006)
Mode of action and subsite studies of the guluronan block forming mannuronan C-5 epimerases AlgE1 and AlgE6.
Biochemical Journal
Academic article
2005
-
Sletta, Håvard;
Bruheim, Per;
Borgos, Sven Even F.;
Sekurova, Olga;
Grasdalen, Hans;
Aune, Randi.
(2005)
Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.
Antimicrobial Agents and Chemotherapy
Academic article
2004
-
Bruheim, Per;
Borgos, Sven Even F.;
Tsan, Pascale;
Sletta, Håvard;
Ellingsen, Trond Erling;
Lancelin, Jean-Marc.
(2004)
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
Antimicrobial Agents and Chemotherapy
Academic article
2003
-
Butler, M.;
Takano, E.;
Bruheim, Per;
Jovetic, Srdjan;
Marinelli, Flavia;
Bibb, Mervyn J..
(2003)
Deletion of scbA enhances antibiotic production in Streptomyces lividans.
Applied Microbiology and Biotechnology
Academic article
-
Gunnarsson, Nina;
Bruheim, Per;
Nielsen, Jens.
(2003)
Production of the glycopeptide antibiotic A40926 by Nonomuraea sp. ATCC 39727: influence of medium composition in batch fermentation.
Journal of Industrial Microbiology & Biotechnology
Academic article
-
Robin, J.;
Bruheim, Per;
Nielsen, M.L.;
Noorman, H.;
Nielsen, Jens.
(2003)
Continuous cultivations of a Pencillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetyoxycephalosporanic acid and byproduct formations.
Biotechnology and Bioengineering
Academic article
2002
-
Bruheim, Per;
Butler, M.;
Ellingsen, Trond E..
(2002)
A theoretical analysis of the biosynthesis of actinorhodin in a hyper-producing Streptomyces lividans strain cultivated on various carbon sources.
Applied Microbiology and Biotechnology
Academic article
-
Bruheim, Per;
Sletta, Håvard;
Bibb, M.J.;
White, J.;
Levine, David William.
(2002)
High-yield actinorhodin production in fed-batch culture by a Streptomyces lividans strain overexpressing the pathway-specific activator gene actII-ORF4.
Journal of Industrial Microbiology & Biotechnology
Academic article
-
Brautaset, Trygve;
Bruheim, Per;
Sletta, Håvard;
Hagen, Lars;
Ellingsen, Trond E.;
Strøm, Arne Reidar.
(2002)
Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455.
Chemistry and Biology
Academic article
-
Butler, M.;
Bruheim, Per;
Jovetic, Srdjan;
Marinelli, Flavia;
Postma, Pieter W.;
Bibb, Mervyn J..
(2002)
Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans.
Applied and Environmental Microbiology
Academic article
-
Bredholt, Harald;
Bruheim, Per;
Potocky, Martin;
Eimhjellen, Kjell.
(2002)
Hydrophobicity development, alkane oxidation, and crude-oil emulsification in a Rhodococcus species.
Canadian Journal of Microbiology (print)
Academic article
2000
-
Bruheim, Per;
Eimhjellen, Kjell.
(2000)
Effects of non-ionic surfactants on the uptake and hydrolysis of fluoresceindiacetate by alkane-oxidizing bacteria.
Canadian Journal of Microbiology (print)
Academic article
-
Bruheim, Per.
(2000)
Metabolic engineering - fremtidens verktøy for utvikling av industrielle bioteknologiske prosesser?.
NBS-nytt
Popular scientific article
1999
-
Bruheim, Per;
Bredholt, Harald;
Eimhjellen, Kjell.
(1999)
Effects of surfactant mixtures, including Corexit 9527, on bacterial oxidation of acetate and alkanes in crude oil.
Applied and Environmental Microbiology
Academic article
1998
-
Bredholt, Harald;
Josefsen, Kjell;
Vatland, Arild;
Bruheim, Per;
Eimhjellen, Kjell.
(1998)
Emulsification of crude oil by an alkane-oxidizing Rhodococcus species isolated from seawater.
Canadian Journal of Microbiology (print)
Academic article
-
Bruheim, Per;
Eimhjellen, Kjell.
(1998)
Chemically emulsified crude oil as substrate for bacterial oxdidation : differences in species response.
Canadian Journal of Microbiology (print)
Academic article
1997
-
Bruheim, Per;
Bredholt, Harald;
Eimhjellen, Kjell.
(1997)
Bacterial degradation of emulsified crude oil and the effect of various surfactants.
Canadian Journal of Microbiology (print)
Academic article
1996
-
Thu, Beate;
Bruheim, Per;
Espevik, Terje;
Smidsrød, Olav;
Soon-Shiong, P.;
Skjåk-Bræk, Gudmund.
(1996)
Alginate polycation microcapsules. I, Interaction between alginate and polycation.
Biomaterials
Academic article
-
Thu, Beate;
Bruheim, Per;
Espevik, Terje;
Smidsrød, Olav;
Soon-Shiong, Patrick;
Skjåk-Bræk, Gudmund.
(1996)
Alginate polycation microcapsules. II, Some functional properties.
Biomaterials
Academic article
1991
-
Stokke, Bjørn Torger;
Smidsrød, Olav;
Bruheim, Per;
Skjåk-Bræk, Gudmund.
(1991)
Distribution of uronate residues in alginate chains in relation to alginate gelling properties.
Macromolecules
Academic article
Journal publications
-
Bergum, Olaug Elisabeth Torheim;
Singleton, Amanda Holstad;
Røst, Lisa Marie Ivarsdatter;
Bodein, Antoine;
Scott-Boyer, Marie-Pier;
Rye, Morten Beck.
(2024)
SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.
Frontiers in Microbiology
Academic article
-
Rane, Divyata Vilas;
Garcia Calvo, Laura;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2024)
Zic-HILIC MS/MS Method for NADomics Provides Novel Insights into Redox Homeostasis in Escherichia coli BL21 Under Microaerobic and Anaerobic Conditions.
Metabolites
Academic article
-
Hallan, Stein Ivar;
Øvrehus, Marius Altern;
Darshi, Manjula;
Montemayor, Daniel;
Langlo, Knut Asbjørn Rise;
Bruheim, Per.
(2023)
Metabolic Differences in Diabetic Kidney Disease Patients with Normoalbuminuria versus Moderately Increased Albuminuria.
Kidney360
Academic article
-
Singleton, Amanda Holstad;
Bergum, Olaug Elisabeth Torheim;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen.
(2023)
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates.
Frontiers in Microbiology
Academic article
-
Jaramillo-Jiménez, Alberto;
Melvær, Giil Lasse;
Borda, Miguel Germán;
Tovar-Rios, Diego Alejandro;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2023)
Serum TCA cycle metabolites in Lewy bodies dementia and Alzheimer's disease: Network analysis and cognitive prognosis.
Mitochondrion (Amsterdam. Print)
Academic article
-
Thorfinnsdottir, Lilja Brekke;
Hovde Bø, Gaute;
Booth, James Alexander;
Bruheim, Per.
(2023)
Survival of Escherichia coli after high-antibiotic stress is dependent on both the pregrown physiological state and incubation conditions.
.
Frontiers in Microbiology
Academic article
-
Garcia Calvo, Laura;
Rane, Divyata Vilas;
Everson, Nikalet;
Humlebrekk, Sigurd Tømmerberg;
Mathiassen, Lise Femanger;
Mæhlum, Astfrid Helene Morka.
(2023)
Central carbon metabolite profiling reveals vector-associated differences in the recombinant protein production host Escherichia coli BL21 .
Frontiers in Chemical Engineering
Academic article
-
Scheffold, Jana;
Bruheim, Per;
Kjesbu, Joachim Sebastian;
Jang, Mi.
(2023)
Serum-free alginate-C2C12 cells microcapsule as a model of alternative animal protein source.
Frontiers in Nutrition
Academic article
-
Rau, E-Ming;
Aasen, Inga Marie;
Bartosova, Zdenka;
Bruheim, Per;
Ertesvåg, Helga.
(2023)
Utilizing lipidomics and fatty acid synthase inhibitors to explore lipid accumulation in two thraustochytrid species.
Algal Research
Academic article
-
Eide, Marta;
Goksøyr, Anders;
Yadetie, Fekadu;
Gilabert, Alejandra;
Bartosova, Zdenka;
Frøysa, Håvard Guldbrandsen.
(2023)
Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod.
Frontiers in Physiology
Academic article
-
Thorfinnsdottir, Lilja Brekke;
Garcia Calvo, Laura;
Bø, Gaute Hovde;
Bruheim, Per;
Røst, Lisa Marie Ivarsdatter.
(2023)
Optimized Fast Filtration-based Sampling and Extraction Enables Precise and Absolute Quantification of the Escherichia coli Central Carbon Metabolome.
Metabolites
Academic article
-
Dankel, Simon Nitter;
Kalleklev, Tine-Lise;
Lunde, Siri;
Stafsnes, Marit Hallvardsdotter;
Bruheim, Per;
Aloysius, Thomas Aquinas.
(2023)
Changes in Plasma Pyruvate and TCA Cycle Metabolites upon
Increased Hepatic Fatty Acid Oxidation and Ketogenesis in
Male Wistar Rats.
International Journal of Molecular Sciences
Academic article
-
Jang, Mi;
Scheffold, Jana;
Røst, Lisa M.;
Cheon, Hyejeong;
Bruheim, Per.
(2022)
Serum-free cultures of C2C12 cells show different muscle phenotypes which can be estimated by metabolic profiling.
Scientific Reports
Academic article
-
Simensen, Vetle;
Schulz, Christian;
Karlsen, Emil;
Bråtelund, Signe;
Burgos, Idun Maria Tokvam;
Thorfinnsdottir, Lilja Brekke.
(2022)
Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling.
PLOS ONE
Academic article
-
Kumar, Kanhaiya;
Bruheim, Per.
(2022)
A comparative study at bioprocess and metabolite levels of superhost strain Streptomyces coelicolor M1152 and its derivative M1581 heterologously expressing chloramphenicol biosynthetic gene cluster.
Biotechnology and Bioengineering
Academic article
-
Rau, E-Ming;
Bartosova, Zdenka;
Kristiansen, Kåre Andre;
Aasen, Inga Marie;
Bruheim, Per;
Ertesvåg, Helga.
(2022)
Overexpression of two new acyl-CoA:diacylglycerol acyltransferase 2-like acyl-CoA:sterol acyltransferases enhanced squalene accumulation in Aurantiochytrium limacinum.
Frontiers in Microbiology
Academic article
-
Kumar, Kanhaiya;
Bruheim, Per.
(2022)
Nutrient-depended metabolic switching during batch cultivation of Streptomyces coelicolor explored with absolute quantitative mass spectrometry based metabolite profiling.
3 Biotech
Academic article
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene
Academic article
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics
Academic article
-
Røst, Lisa M.;
Louet, Claire;
Bruheim, Per;
Flo, Trude Helen;
Gidon, Alexandre.
(2022)
Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control Mycobacterium avium Infection in Human Primary Macrophages.
Frontiers in Immunology
Academic article
-
Carracedo Huroz, Sergio;
Lirussi, Lisa;
Alsøe, Lene;
Segers, Filip;
Wang, Changliang;
Bartosova, Zdenka.
(2022)
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
DNA Repair
Academic article
-
Jang, Mi;
Pete, Ellen Sofie;
Bruheim, Per.
(2022)
The impact of serum-free culture on HEK293 cells: From the establishment of suspension and adherent serum-free adaptation cultures to the investigation of growth and metabolic profiles.
Frontiers in Bioengineering and Biotechnology
Academic article
-
Jang, Mi;
Scheffold, Jana;
Bruheim, Per.
(2022)
Isolation and cultivation of primary muscle cells from Lobster (Homarus gammarus).
In vitro Cellular & Developmental Biology-Animal
Academic article
-
Rutkis, Reinis;
Strazdina, Inese;
Lasa, Zane;
Bruheim, Per;
Kalnenieks, Uldis.
(2021)
Ethanologenesis and respiration in a pyruvate decarboxylase-deficient Zymomonas mobilis.
BMC Research Notes
Academic article
-
Bartosova, Zdenka;
Villa Gonzalez, Susana;
Voigt, Andre;
Bruheim, Per.
(2021)
High throughput semi-quantitative UHPSFC-MS/MS lipid profiling and lipid class determination.
Journal of Chromatographic Science
Academic article
-
Jin, Yang;
Harvey, Thomas Nelson;
Bartosova, Zdenka;
Hassani, Sahar;
Bruheim, Per;
Sandve, Simen Rød.
(2021)
Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon.
Journal of Agricultural and Food Chemistry
Academic article
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules
Academic article
-
Skedsmo, Fredrik;
Espenes, Arild;
Tranulis, Michael A.;
Matiasek, Kaspar;
Gunnes, Gjermund;
Bjerkås, Inge.
(2021)
Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D.
Neuromuscular Disorders
Academic article
-
Kumar, Kanhaiya;
Bruheim, Per.
(2021)
Large dependency of intracellular NAD and CoA pools on cultivation conditions in Saccharomyces cerevisiae.
BMC Research Notes
Academic article
-
Gidon, Alexandre;
Louet, Claire;
Røst, Lisa M.;
Bruheim, Per;
Flo, Trude Helen.
(2021)
The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages.
mBio
Academic article
-
Fuchino, Katsuya;
Chan, Helena;
Hwang, Ling Chin;
Bruheim, Per.
(2021)
The Ethanologenic bacterium Zymomonas mobilis divides asymmetrically and exhibits heterogeneity in DNA content.
Applied and Environmental Microbiology
Academic article
-
Abdollahi, Pegah;
Vandsemb, Esten;
Elsaadi, Samah;
Røst, Lisa Marie;
Yang, Rui;
Hjort, Magnus Aassved.
(2021)
Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma.
The FASEB Journal
Academic article
-
Bartosova, Zdenka;
Ertesvåg, Helga;
Nyfløt, Eirin Lishaugen;
Kämpe, Kristoffer;
Aasen, Inga Marie;
Bruheim, Per.
(2021)
Combined Metabolome and Lipidome analyses for in-depth characterization of lipid accumulation in the DHA producing Aurantiochytrium sp. T66.
Metabolites
Academic article
-
Kumar, Kanhaiya;
Venkatraman, Vishwesh;
Bruheim, Per.
(2021)
Adaptation of central metabolite pools to variations in growth rate and cultivation conditions in Saccharomyces cerevisiae.
Microbial Cell Factories
Academic article
-
Nilsen, Mona Synnøve;
Lindquist, Carine;
Stafsnes, Marit Hallvardsdotter;
Bjørndal, Bodil;
Bruheim, Per;
Aloysius, Thomas Aquinas.
(2021)
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Academic article
-
Røst, Lisa Marie;
Darestani, Armaghan Shafaei;
Fuchino, Katsuya;
Bruheim, Per.
(2020)
Zwitterionic HILIC tandem mass spectrometry with isotope dilution for rapid, sensitive and robust quantification of pyridine nucleotides in biological extracts.
Journal of chromatography. B
Academic article
-
Fuchino, Katsuya;
Bruheim, Per.
(2020)
An assessment of serial co-cultivation approach for generating novel Zymomonas mobilis strains.
BMC Research Notes
Academic article
-
Fontana, Diletta;
Mauri, Mario;
Renso, Rossella;
Docci, Mattia;
Crespiatico, Ilaria;
Røst, Lisa Marie.
(2020)
ETNK1 mutations induce a mutator phenotype that
can be reverted with phosphoethanolamine.
Nature Communications
Academic article
-
Fuchino, Katsuya;
Bruheim, Per.
(2020)
Increased salt tolerance in Zymomonas mobilis strain generated by adaptative evolution.
Microbial Cell Factories
Academic article
-
Fuchino, Katsuya;
Kalnenieks, Uldis;
Rutkis, Reinis;
Grube, Mara;
Bruheim, Per.
(2020)
Metabolic Profiling of Glucose-Fed Metabolically
Active Resting Zymomonas mobilis Strains.
Metabolites
Academic article
-
Røst, Lisa Marie;
Thorfinnsdottir, Lilja Brekke;
Kumar, Kanhaiya;
Fuchino, Katsuya;
Langørgen, Ida Eide;
Bartosova, Zdenka.
(2020)
Absolute Quantification of the Central Carbon
Metabolome in Eight Commonly Applied
Prokaryotic and Eukaryotic Model Systems.
Metabolites
Academic article
-
Øvrehus, Marius Altern;
Bruheim, Per;
Ju, Wenjun;
Zelnick, Leila R.;
Langlo, Knut Asbjørn Rise;
Sharma, Kumar.
(2019)
Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis.
Kidney International Reports
Academic article
-
Volkova, Yulia A.;
Averina, Elena B.;
Vasilenko, Dmitry A;
Sedenkova, Kseniya N;
Grishin, Yuri K.;
Bruheim, Per.
(2019)
Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 5-Nitroisoxazoles.
Journal of Organic Chemistry
Academic article
-
Navarro, Miguel Octavio Perez;
Simionato, Ane Stefano;
Perez, Juan Carlos Bedoya;
Barazetti, Andre Riedi;
Emiliano, Janaina;
Niekawa, Erika Tyemi Goya.
(2019)
Fluopsin C for treating multidrug-resistant infections: In vitro activity aganist clinically important strains and in vivo efficacy against carbapenemase-producing Klebsiella pneumoniae.
Frontiers in Microbiology
Academic article
-
Skedsmo, Fredrik Strebel;
Malachin, Giulia;
Våge, Dag Inge;
Hammervold, Mie Marie;
Salvesen, Øyvind;
Ersdal, Cecilie.
(2019)
Demyelinating polyneuropathy in goats lacking prion protein.
The FASEB Journal
Academic article
-
Kalnenieks, Uldis;
Balodite, Elina;
Strahler, Steffi;
Strazdina, Inese;
Rex, Julia;
Pentjuss, Agris.
(2019)
Improvement of acetaldehyde production in Zymomonas mobilis by engineering of its aerobic metabolism.
Frontiers in Microbiology
Academic article
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget
Academic article
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio
Academic article
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients
Academic article
-
Stafsnes, Marit Hallvardsdotter;
Røst, Lisa Marie;
Bruheim, Per.
(2018)
Improved phosphometabolome profiling applying isotope dilution strategy and capillary ion chromatography-tandem mass spectrometry.
Journal of chromatography. B
Academic article
-
Mühlroth, Alice;
Assimi, AE;
Røkke, Gunvor;
Despres, Julie;
Winge, Per;
Bruheim, Per.
(2015)
Transcriptional regulation of lipid accumulation in phosphorus limited Nannochloropsis oceanica.
European journal of phycology
Abstract
-
Janecková, Hana;
Kalivodova, Alzbeta;
Najdekr, Lukas;
Friedecký, David;
Hron, Karel;
Bruheim, Per.
(2015)
Untargeted metabolomic analysis of urine samples in the diagnosis of some inherited metabolic disorders.
Biomedical Papers of the Faculty of Medicine of Palacky University
Academic article
-
Giskeødegård, Guro F.;
Hansen, Ailin Falkmo;
Bertilsson, Helena;
Villa Gonzalez, Susana;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2015)
Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia.
British Journal of Cancer
Academic article
-
Lien, Stina Katrine;
Niedenführ, Sebastian;
Sletta, Håvard;
Nöh, Katharina;
Bruheim, Per.
(2015)
Fluxome study of Pseudomonas fluorescens reveals major reorganisation of carbon flux through central metabolic pathways in response to inactivation of the anti-sigma factor MucA.
BMC Systems Biology
Academic article
-
Kvitvang, Hans Fredrik Nyvold;
Bruheim, Per.
(2015)
Fast filtration sampling protocol for mammalian suspension cells tailored for phosphometabolome profiling by capillary ion chromatography - tandem mass spectrometry.
Journal of chromatography. B
Academic article
-
Sreevidya, Meesala;
Gopalakrishnan, Subramaniam;
Melø, Torun Margareta;
Simic, Nebojsa;
Bruheim, Per;
Sharma, Mamta.
(2015)
Biological control of Botrytis cinerea and plant growth promotion potential by Penicillim citrinum in chickpea (Cicer arietinum L.).
Biocontrol science and technology (Print)
Academic article
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology
Academic article
-
Kvitvang, Hans Fredrik Nyvold;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2014)
Assessment of capillary anion exchange ion chromatography tandem mass spectrometry for the quantitative profiling of the phosphometabolome and organic acids in biological extracts.
Journal of Chromatography A
Academic article
-
Pettersen, Ragnhild;
Johnsen, Geir;
Bruheim, Per;
Andreassen, Trygve.
(2014)
Development of hyperspectral imaging as a bio-optical taxonomic tool for pigmented marine organisms.
Organisms Diversity & Evolution
Academic article
-
Borgos, Sven Even F.;
Bordel, Sergio;
Sletta, Håvard;
Ertesvåg, Helga;
Jakobsen, Øyvind Mejdell;
Bruheim, Per.
(2013)
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling.
BMC Systems Biology
Academic article
-
Bruheim, Per;
Kvitvang, Hans Fredrik Nyvold;
Villas-Boas, Silas G..
(2013)
Stable isotope coded derivatizing reagents as internal standards in metabolite profiling.
Journal of Chromatography A
Academic literature review
-
Lien, Stina Katrine;
Sletta, Håvard;
Ellingsen, Trond Erling;
Valla, Svein;
Correa, Elon;
Goodacre, Royston.
(2013)
Investigating alginate production and carbon utilization in Pseudomonas fluorescens SBW25 using mass spectrometry-based metabolic profiling.
Metabolomics
Academic article
-
Stafsnes, Marit Hallvardsd;
Dybwad, Marius;
Brunsvik, Anders;
Bruheim, Per.
(2013)
Large scale MALDI-TOF MS based taxa identification to identify novel pigment producers in a marine bacterial culture collection.
Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology
Academic article
-
Elde, Anette;
Pettersen, Ragnhild;
Bruheim, Per;
Järnegren, Johanna;
Johnsen, Geir.
(2012)
Pigmentation and Spectral Absorbance Signatures in Deep-Water Corals from the Trondheimsfjord, Norway.
Marine Drugs
Academic article
-
Lien, Stina Katrine;
Kvitvang, Hans Fredrik Nyvold;
Bruheim, Per.
(2012)
Utilization of a deuterated derivatization agent to synthesize internal standards for gas chromatography-tandem mass spectrometry quantification of silylated metabolites.
Journal of Chromatography A
Academic article
-
Wentzel, Alexander;
Sletta, Håvard;
Wellington, E.M.H.;
Ellingsen, Trond Erling;
Bruheim, Per.
(2012)
Intracellular metabolite pool changes in response to nutrient depletion induced metabolic switching in Streptomyces coelicolor.
Metabolites
Academic article
-
Dybwad, Marius;
Granum, Per Einar;
Bruheim, Per;
Blatny, Janet Martha.
(2012)
Characterization of airborne bacteria at an underground subway station.
Applied and Environmental Microbiology
Academic article
-
Tøndervik, Anne;
Bruheim, Per;
Berg, Laila;
Ellingsen, Trond Erling;
Kotlar, Hans Kristian;
Valla, Svein.
(2012)
Ralstonia sp U2 naphthalene dioxygenase and Comamonas sp JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes.
Journal of Bioscience and Bioengineering
Academic article
-
Janecková, Hana;
Hron, Karel;
Wojtowicz, Petr;
Hlídková, Eva;
Baresová, Anna;
Friedecký, David.
(2012)
Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders.
Journal of Chromatography A
Academic article
-
Wentzel, Alexander;
Bruheim, Per;
Øverby, Anders;
Jakobsen, Øyvind Mejdell;
Sletta, Håvard;
Omara, Walid A.M..
(2012)
Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2).
BMC Systems Biology
Academic article
-
Vijayabharathi, Rajendran;
Bruheim, Per;
Andreassen, Trygve;
Raja, Duraisamy Senthil;
Devi, Palanisamy Bruntha;
Sathyabama, Sathyaseelan.
(2011)
Assessment of resistomycin, as an anticancer compound isolated and characterized from Streptomyces aurantiacus AAA5.
Journal of Microbiology
Academic article
-
Klinkenberg, Geir;
Sletta, Håvard;
Fjærvik, Espen;
Zahlsen, Kolbjørn;
Bruheim, Per.
(2011)
Two-dimensional LC-MS fractioning and cross-matching of mass spectrometric data for rational identification of bioactive compounds in crude extracts.
Journal of Separation Science
Academic article
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods
Academic article
-
Kvitvang, Hans Fredrik Nyvold;
Andreassen, Trygve;
Adam, Tomas;
Villas-Boas, Silas G.;
Bruheim, Per.
(2011)
Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.
Analytical Chemistry
Academic article
-
Bruheim, Per.
(2011)
“We focus most on the approximately 2000 baker's yeast genes that are closest to human genes.”.
Gemini
Popular scientific article
-
Bruheim, Per.
(2010)
Gjær som pasienter.
Gemini
Popular scientific article
-
Bruheim, Per.
(2010)
Med gjær som kreftpasient.
Forskning.no
Interview Journal
-
Nieselt, Kay;
Battke, Florian;
Herbig, Alexander;
Bruheim, Per;
Wentzel, Alexander;
Jakobsen, Øyvind Mejdell.
(2010)
The dynamic architecture of the metabolic switch in Streptomyces coelicolor.
BMC Genomics
Academic article
-
Stafsnes, Marit Hallvardsdotter;
Josefsen, Kjell D.;
Kildahl-Andersen, Geir;
Valla, Svein;
Ellingsen, Trond E.;
Bruheim, Per.
(2010)
Isolation and Characterization of Marine Pigmented Bacteria from Norwegian Coastal Waters and Screening for Carotenoids with UVA-Blue Light Absorbing Properties.
Journal of Microbiology
Academic article
-
Volkova, Yulia A.;
Averina, Elena B.;
Grishin, Yuri K.;
Bruheim, Per;
Kuznetsova, Tamara S.;
Zefirov, Nikolai S..
(2010)
Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 3-Nitroisoxazoles.
Journal of Organic Chemistry
Academic article
-
Netzer, Roman;
Stafsnes, Marit Hallvardsdotter;
Andreassen, Trygve;
Goksøyr, Audun;
Bruheim, Per;
Brautaset, Trygve.
(2010)
Biosynthetic Pathway for g-Cyclic Sarcinaxanthin in Micrococcus luteus: Heterologous Expression and Evidence for Diverse and Multiple Catalytic Functions of C50 Carotenoid Cyclases.
Journal of Bacteriology
Academic article
-
Mørkved, Eva Henmo;
Andreassen, Trygve;
Fröhlich, Roland;
Mo, Frode;
Bruheim, Per.
(2010)
Unsymmetrical zinc azaphthalocyanines, peripherally substituted with thiophen-2-yl and 2-functionalized phenoxy groups.
Polyhedron
Academic article
-
Jørgensen, Hanne;
Fjærvik, Espen;
Hakvåg, Sigrid;
Bruheim, Per;
Bredholt, Harald;
Klinkenberg, Geir.
(2009)
Candicidin Biosynthesis Gene Cluster Is Widely Distributed among Streptomyces spp. Isolated from the Sediments and the Neuston Layer of the Trondheim Fjord, Norway.
Applied and Environmental Microbiology
Academic article
-
Stockmann, Vegar;
Bakke, Jan Magnus;
Bruheim, Per;
Fiksdahl, Anne.
(2009)
Formation of new 4-isocyanobut-2-enenitriles by thermal ring cleavage of 3-pyridyl azides.
Tetrahedron
Academic article
-
Mørkved, Eva Henmo;
Andreassen, Trygve;
Bruheim, Per.
(2009)
Zinc azaphthalocyanines with pyridin-3-yloxy peripheral substituents.
Polyhedron
Academic article
-
Jørgensen, Hanne;
Degnes, Kristin;
Sletta, Håvard;
Fjærvik, Espen;
Dikiy, Alexander;
Dikiy, Alexander.
(2009)
Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
Chemistry and Biology
Academic article
-
Bruheim, Per;
Sletta, Håvard;
Zahlsen, Kolbjørn;
Bathen, Tone Frost;
Gribbestad, Ingrid S.
(2009)
metabolomics - et spennende verktøy i medisinsk og biologisk forskning.
NBS-nytt
Popular scientific article
-
Simon, Sebastien Charles;
Nordgård, Erland;
Bruheim, Per;
Sjøblom, Johan.
(2008)
Determination of C-80 tetra-acid content in calcium naphthenate deposits.
Journal of Chromatography A
Academic article
-
Fuglseth, Erik;
Sundby, Eirik;
Bruheim, Per;
Hoff, Bård Helge.
(2008)
Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols.
Tetrahedron: asymmetry
Academic article
-
Fuglseth, Erik;
Sundby, Eirik;
Bruheim, Per;
Hoff, Bård Helge.
(2008)
Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols.
Tetrahedron: asymmetry
Academic article
-
Villas-Boas, Silas G.;
Bruheim, Per.
(2007)
The potential of metabolomics tools in bioremediation studies.
Omics
Academic literature review
-
Villas-Boas, Silas G.;
Bruheim, Per.
(2007)
Cold glycerol–saline: The promising quenching solution for accurate intracellular metabolite analysis of microbial cells.
Analytical Biochemistry
Academic article
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy.
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science
Academic article
-
Holtan, Synnøve;
Bruheim, Per;
Skjåk-Bræk, Gudmund.
(2006)
Mode of action and subsite studies of the guluronan block forming mannuronan C-5 epimerases AlgE1 and AlgE6.
Biochemical Journal
Academic article
-
Sletta, Håvard;
Bruheim, Per;
Borgos, Sven Even F.;
Sekurova, Olga;
Grasdalen, Hans;
Aune, Randi.
(2005)
Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.
Antimicrobial Agents and Chemotherapy
Academic article
-
Bruheim, Per;
Borgos, Sven Even F.;
Tsan, Pascale;
Sletta, Håvard;
Ellingsen, Trond Erling;
Lancelin, Jean-Marc.
(2004)
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
Antimicrobial Agents and Chemotherapy
Academic article
-
Butler, M.;
Takano, E.;
Bruheim, Per;
Jovetic, Srdjan;
Marinelli, Flavia;
Bibb, Mervyn J..
(2003)
Deletion of scbA enhances antibiotic production in Streptomyces lividans.
Applied Microbiology and Biotechnology
Academic article
-
Gunnarsson, Nina;
Bruheim, Per;
Nielsen, Jens.
(2003)
Production of the glycopeptide antibiotic A40926 by Nonomuraea sp. ATCC 39727: influence of medium composition in batch fermentation.
Journal of Industrial Microbiology & Biotechnology
Academic article
-
Robin, J.;
Bruheim, Per;
Nielsen, M.L.;
Noorman, H.;
Nielsen, Jens.
(2003)
Continuous cultivations of a Pencillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetyoxycephalosporanic acid and byproduct formations.
Biotechnology and Bioengineering
Academic article
-
Bruheim, Per;
Butler, M.;
Ellingsen, Trond E..
(2002)
A theoretical analysis of the biosynthesis of actinorhodin in a hyper-producing Streptomyces lividans strain cultivated on various carbon sources.
Applied Microbiology and Biotechnology
Academic article
-
Bruheim, Per;
Sletta, Håvard;
Bibb, M.J.;
White, J.;
Levine, David William.
(2002)
High-yield actinorhodin production in fed-batch culture by a Streptomyces lividans strain overexpressing the pathway-specific activator gene actII-ORF4.
Journal of Industrial Microbiology & Biotechnology
Academic article
-
Brautaset, Trygve;
Bruheim, Per;
Sletta, Håvard;
Hagen, Lars;
Ellingsen, Trond E.;
Strøm, Arne Reidar.
(2002)
Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455.
Chemistry and Biology
Academic article
-
Butler, M.;
Bruheim, Per;
Jovetic, Srdjan;
Marinelli, Flavia;
Postma, Pieter W.;
Bibb, Mervyn J..
(2002)
Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans.
Applied and Environmental Microbiology
Academic article
-
Bredholt, Harald;
Bruheim, Per;
Potocky, Martin;
Eimhjellen, Kjell.
(2002)
Hydrophobicity development, alkane oxidation, and crude-oil emulsification in a Rhodococcus species.
Canadian Journal of Microbiology (print)
Academic article
-
Bruheim, Per;
Eimhjellen, Kjell.
(2000)
Effects of non-ionic surfactants on the uptake and hydrolysis of fluoresceindiacetate by alkane-oxidizing bacteria.
Canadian Journal of Microbiology (print)
Academic article
-
Bruheim, Per.
(2000)
Metabolic engineering - fremtidens verktøy for utvikling av industrielle bioteknologiske prosesser?.
NBS-nytt
Popular scientific article
-
Bruheim, Per;
Bredholt, Harald;
Eimhjellen, Kjell.
(1999)
Effects of surfactant mixtures, including Corexit 9527, on bacterial oxidation of acetate and alkanes in crude oil.
Applied and Environmental Microbiology
Academic article
-
Bredholt, Harald;
Josefsen, Kjell;
Vatland, Arild;
Bruheim, Per;
Eimhjellen, Kjell.
(1998)
Emulsification of crude oil by an alkane-oxidizing Rhodococcus species isolated from seawater.
Canadian Journal of Microbiology (print)
Academic article
-
Bruheim, Per;
Eimhjellen, Kjell.
(1998)
Chemically emulsified crude oil as substrate for bacterial oxdidation : differences in species response.
Canadian Journal of Microbiology (print)
Academic article
-
Bruheim, Per;
Bredholt, Harald;
Eimhjellen, Kjell.
(1997)
Bacterial degradation of emulsified crude oil and the effect of various surfactants.
Canadian Journal of Microbiology (print)
Academic article
-
Thu, Beate;
Bruheim, Per;
Espevik, Terje;
Smidsrød, Olav;
Soon-Shiong, P.;
Skjåk-Bræk, Gudmund.
(1996)
Alginate polycation microcapsules. I, Interaction between alginate and polycation.
Biomaterials
Academic article
-
Thu, Beate;
Bruheim, Per;
Espevik, Terje;
Smidsrød, Olav;
Soon-Shiong, Patrick;
Skjåk-Bræk, Gudmund.
(1996)
Alginate polycation microcapsules. II, Some functional properties.
Biomaterials
Academic article
-
Stokke, Bjørn Torger;
Smidsrød, Olav;
Bruheim, Per;
Skjåk-Bræk, Gudmund.
(1991)
Distribution of uronate residues in alginate chains in relation to alginate gelling properties.
Macromolecules
Academic article
Part of book/report
-
Kvitvang, Hans Fredrik Nyvold;
Kristiansen, Kåre Andre;
Lien, Stina Katrine;
Bruheim, Per.
(2014)
Quantitative Analysis of Amino and Organic Acids by Methyl Chloroformate Derivatization and GC-MS/MS Analysis.
Springer Science+Business Media B.V.
Academic chapter/article/Conference paper
-
Stafsnes, Marit Hallvardsd;
Bruheim, Per.
(2013)
Pigmented Marine Heterotrophic Bacteria: Occurrence, Diversity, and Characterization of Pigmentation.
CRC Press
Academic chapter/article/Conference paper
-
Wojtowicz, Petr;
Zrostlíková, Jitka;
Šťastná, Veronika;
Dostálová, Eva;
Zídková, Lenka;
Bruheim, Per.
(2012)
Comprehensive Two-Dimensional Gas Chromatography Coupled to Time-of-Flight Mass Spectrometry in Human Metabolomics.
IntechOpen
Academic chapter/article/Conference paper
-
Almaas, Eivind;
Bruheim, Per;
Lale, Rahmi;
Valla, Svein.
(2012)
Dynamics and robustness of metabolic networks: A systems biology review of Escherichia coli metabolism.
Caister Academic Press
Academic chapter/article/Conference paper
Report
-
Juell, Mathilde Fredrikke Haneborg;
Bruheim, Per.
(2024)
Exploring the sustainable docosahexaenoic acid production in Auraontiochytrium limacinum SR21 using residual raw materials.
NTNU
Masters thesis
-
Haaland, Karen Lund;
Bruheim, Per.
(2024)
The Effect of High Plasmid Copy Number and Oxygen Limitation on Growth and mCherry Production in Escherichia coli BL21 A3-mCherry.
NTNU
Masters thesis
-
Melbye, Kristin Soleim;
Bruheim, Per.
(2024)
Production of Single Cell Protein from Kluyveromyces marxianus Utilising Whey and Fish Hydrolysate as Substrates.
NTNU
Masters thesis
-
Nedreås, Pia Moe-Nilssen;
Bruheim, Per.
(2024)
Optimization of chicken hydrolysate as a nitrogen source for Fusarium venenatum in submerged culture.
NTNU
Masters thesis
-
Tellsgård, Sunniva Christiansen;
Bruheim, Per.
(2024)
Research on Neurospora crassa cultivation using residual raw materials from the fish and poultry industry as organic nitrogen sources.
NTNU
Masters thesis
-
Gunnes, Sondre;
Bruheim, Per.
(2024)
Performance of Saccharomyces cerevisiae and Kluyveromyces
marxianus, Investigating the Impact of Carbon and Nitrogen Sources on Fermentation Characteristics.
.
NTNU
Masters thesis
-
Mjølnerød, Kristine;
Bruheim, Per.
(2024)
Kluyveromyces marxianus Single-Cell Protein production from Salmon Hydrolysate and Whey.
NTNU
Masters thesis
-
Øvrebø, Stinus Reklev;
Bruheim, Per.
(2023)
The effect of oxygen limitation on growth characteristics and the redox state of Escherichia coli BL21 during recombinant protein production.
NTNU
Masters thesis
-
Refsnes, Åse;
Bruheim, Per.
(2023)
Analysis of the consequences of oxygen limitation on the redox balance and overflow metabolites in Escherichia coli BL21 during recombinant protein production.
NTNU
Masters thesis
-
Pedersen, Eilif;
Eitungjerde, Sara;
André, Thea Harnes;
Bruheim, Per;
Grønflaten, Lars Trovatten;
Gundersen, Ingeborg Nævdal.
(2021)
Fremtidens teknologistudier (FTS), grupperapport: A3 - 5-årig master.
NTNU
Report
-
Røst, Lisa Marie;
Otterlei, Marit;
Bruheim, Per.
(2020)
Targeted Mass Spectrometric Metabolite Profiling for Studies of Central Carbon Metabolism.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Doctoral dissertation
-
Johansen, Finn-Eirik;
Brautaset, Trygve;
Aune, Marie Hjelmseth;
Patriksson, Alexandra;
Falkenberg, Liv Eggset;
Kleppe, Rune.
(2018)
Centre for Digital Life Norway - Annual report 2017.
Senter for Digialt Liv Norge
Report
-
Fremstedal, Ane Sofia Viset;
Bruheim, Per;
Sletta, Håvard;
Johnsen, Geir.
(2012)
Utvikling og optimalisering av protokoll for massespektrometrisk metabolsk profilering av adherente humane celler.
NTNU Master theses
Masters thesis
-
Svee, Kristin;
Eftedal, Ingrid;
Bruheim, Per.
(2011)
Genetisk disposisjon for dykkersyke? Uttrykk av hypoksirelaterte gener i abdominal aorta fra rotte etter simulerte dykk.
NTNU
Masters thesis
Outreach
2024
-
PosterThorsen, Inga Marie Horntvedt; Øyaas, Jorun; Porcellato, Davide; Bruheim, Per; Sletta, Håvard. (2024) The effect of oxygen on DVI starter cultures growth and metabolism for cheese production. IDF= International Dairy Federation IDF Cheese Science and Technology symposium 2024 , Bergen 2024-05-04 - 2024-05-05
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PosterRane, Divyata Vilas; Garcia Calvo, Laura; Kristiansen, Kåre Andre; Bruheim, Per. (2024) Comprehensive profiling of NAD+ biosynthesis and utilization using zwitterionic HILIC MS/MS to explore redox balance in Escherichia coli. University of Turku The fourth nordic metabolomics conference 2024 , Turku 2024-08-26 - 2024-08-28
2020
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Academic lectureEide, Marta; Goksøyr, Anders; Yadetie, Fekadu; Gilabert, Alejandra; Bartosova, Zdenka; Frøysa, Håvard G. (2020) A multi-omics approach to study Ppar-mediated regulation of lipid metabolism in Atlantic cod (Gadus morhua). 8th Norwegian Environemntal Toxicology Symposium (NETS) 2020 , Digital 2020-11-04 - 2020-11-05
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Academic lectureNilsen, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas. (2020) Low 3-hydroxyisobutyrate (3-HIB) and high methylmalonic acid (MMA) levels in plasma reflect increased hepatic fatty acid oxidation. World Mitochondria Society 11th World Congress on Targeting Mitochondria 2020 2020-10-28 - 2020-10-30
2019
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Academic lectureThorfinnsdottir, Lilja Brekke; Bruheim, Per. (2019) Development of an unbiased method to study persistent bacteria. Norwegian Society for Microbiology NFM meeting , Trondheim 2019-06-11 - 2019-06-12
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PosterFuchino, Katsuya; Bruheim, Per. (2019) Improved acetaldehyde production by engineered Zymomonas mobilis strains. EMBL new approaches and concepts in microbiology 2019-07-10 - 2019-07-13
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PosterErtesvåg, Helga; Haslene-Hox, Hanne; Aasen, Inga Marie; Almaas, Eivind; Bartosova, Zdenka; Heggeset, Tonje Marita Bjerkan. (2019) Industrial microbiology – 'omics methods and modelling as tools for process optimization . Digital Life Norway DigitalLife 2019 , Tromsø 2019-09-05 - 2019-09-06
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Academic lectureAasen, Inga Marie; Haslene-Hox, Hanne; Stafsnes, Marit Hallvardsdotter; Heggeset, Tonje Marita Bjerkan; Bruheim, Per. (2019) Lipid accumulation and DHA synthesis in Aurantiochytrium sp, elucidated by transcriptome, proteome and metabolome analyses. BIOPROSP_19 , Tromsø 2019-02-25 - 2019-02-27
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Academic lectureAasen, Inga Marie; Haslene-Hox, Hanne; Ertesvåg, Helga; Heggeset, Tonje Marita Bjerkan; Bruheim, Per. (2019) Fatty acid synthesis in Aurantiochytrium sp, revealed by analyses of growth and production kinetics and global proteomes. . First International Conference on Labyrinthulean Protists (ICoLP) , Kobe 2019-08-28 - 2019-08-30
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PosterStafsnes, Marit Hallvardsdotter; Bartosova, Zdenka; Bruheim, Per. (2019) Metabolomics and fluxomics - essential approaches in optimization of bioprocesses. DLN Digital Life Norway 2019 , Tromsø 2019-09-05 - 2019-09-06
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Academic lectureAasen, Inga Marie; Bartosova, Zdenka; Haslene-Hox, Hanne; Heggeset, Tonje Marita Bjerkan; Stafsnes, Marit Hallvardsdotter; Bruheim, Per. (2019) Elucidating lipid accumulation and DHA synthesis in Aurantiochytrium sp. strain T66 using -omics technologies. Norsk forening for Mikrobiologi NFM Meeting, Applied and Environmental Microbiology , Trondheim 2019-06-11 - 2019-06-12
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PosterKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2019) Studying the metabolism of Streptomyces coelicolor during antibiotic production in submerged batch fermentations. 8th Congress of European Microbiologists - FEMS2019 , Glasgow, Scotland 2019-07-07 - 2019-07-11
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LectureKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2019) Deciphering the carbon distribution in metabolic pathways during antibiotic production by Streptomyces superhost strains using 13C-isotope-labeling experiments. Minisymposia at NBS Winter meeting 2019 , Røros 2019-01-24 - 2019-01-26
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PosterSchulz, Christian; Karlsen, Emil; Kumar, Kanhaiya; Bartosova, Zdenka; Schmid, Jochen; Bruheim, Per. (2019) Measuring Biomass Composition for Modelling. DLN anual conference 2019-09-05 - 2019-09-06
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PosterThorfinnsdottir, Lilja Brekke; Bruheim, Per. (2019) Antibiotic tolerance vs persistence: How to assay and distinguish the terms. Norwegian Biochemical Society Norwegian Biochemical Society 55th Contact Meeting , Røros 2019-01-24 - 2019-01-27
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Academic lectureWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre. (2019) Expanding the (meta)genomics toolbox for the discovery and production of novel natural products from microbial resources. SINTEF/NTNU Functional Metageomics 2019 , Trondheim 2019-06-16 - 2019-09-19
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Academic lectureWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre. (2019) Expanding the (meta)genomics toolbox for the discovery and production of novel natural products from microbial resources. Fusion Conferences 2nd Synthetic Biology for Natural Products Conference , Puerto Vallarta 2019-06-02 - 2019-06-05
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PosterBartosova, Zdenka; Gonzalez, Susana Villa; Bruheim, Per. (2019) High-throughput method for lipidomic analysis and semi-quantification of lipid classes. Norsk Biokjemisk Selskap NBS Kontaktmøte 2019 , Røros 2019-01-24 - 2019-01-27
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PosterBartosova, Zdenka; Stafsnes, Marit Hallvardsdotter; Voigt, Andre; Bruheim, Per. (2019) Supercritical fluid chromatography with mass spectrometry: A versatile tool for lipid profiling and lipid class quantitation. Digital Life Norway DigitalLife 2019 , Tromsø 2019-09-05 - 2019-09-06
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PosterKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2019) Studying the metabolism of Streptomyces coelicolor during antibiotic production using 13C-isotope-labeling experiments . NTNU, UiO and UiB 3rd annual Biotechnology Research and Innovation conference , Tromsø 2019-09-04 - 2019-09-05
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PosterKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2019) Carbon distribution within metabolic pathways during antibiotic production by Streptomyces superhost strains . 3rd Open Conference of Functional Metagenomics International FUNCTIONAL METAGENOMICS 2019 , Trondheim 2019-06-16 - 2019-06-19
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PosterRøst, Lisa Marie; Løkken, Erle Gustavsen; Otterlei, Marit; Bruheim, Per. (2019) Glioblastoma cells respond to hypoxia by increased cell growth and altered TCA-cycle progression. Norsk Biokjemisk Selskap Trondheim NBS Vintermøte , Røros 2019-01-24 - 2019-01-27
2018
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PosterBartosova, Zdenka; Stafsnes, Marit Hallvardsdotter; Gjuvsland, Arne Bjørke; Harvey, Thomas Nelson; Nanton, Dominic; Sandve, Simen Rød. (2018) Mass spectrometry based profiling of the salmon lipidome. Centre for Digital Life Norway DigitalLife 2018 , Bergen 2018-03-20 - 2018-03-21
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PosterOlaisen, Camilla; Røst, Lisa Marie; Nedal, Aina; Petrovic, Voin; Kvitvang, Hans Fredrik Nyvold; Bruheim, Per. (2018) Proliferating Cell Nuclear Antigen (PCNA) has a Central Role in Regulation of the Glycolysis in Haematological Cancer Cells. American Association of Cancer Research Metabolism and Cancer , Marriott New York Brooklyn Bridge 2018-09-28 - 2018-10-01
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PosterKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2018) Intracellular metabolite profiling of Streptomyces coelicolor A3(2) during antibiotic production in nutrient stressed batch fermentation. Digital Life Workshop , Bergen 2018-03-20 - 2018-03-21
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PosterFuchino, Katsuya; Bruheim, Per. (2018) A novel bacterial system with integrated micro-bubble distillation for the production of acetaldehyde. Digital life Norway Digital life 2018 annual conference , Bergen 2018-03-20 - 2018-03-21
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LectureKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2018) Intracellular metabolite profiling of Streptomyces coelicolor A3(2) in nutrient stressed batch fermentation for antibiotic production. European Federation of Biotechnology European Congress of Biotechnology 2018 , Geneva 2018-07-01 - 2018-07-04
2017
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LectureWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre. (2017) New bioactive compounds from environmental microbial resources by an integrated functional (meta)genomics approach. FUSION conferences Synthetic Biology of Natural Products , Hotel Fiesta Americana Condesa, Cancun 2017-03-05 - 2017-03-08
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LectureWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre. (2017) New bioactive compounds from environmental microbial resources by an integrated functional (meta)genomics approach. SINTEF, RG Biotechnology Meeting with the ReDig project , SINTEF, RG Biotechnology 2017-09-19 - 2017-09-19
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LectureWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre. (2017) New bioactive compounds from environmental microbial resources by an integrated functional (meta)genomics approach. UiT BioProsp 2017, the 8th International Conference on Marine Biotechnology , UiT, Tromsø 2017-03-08 - 2017-03-10
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PosterBösl, Korbinian; Røst, Lisa Marie; Giambelluca, Miriam; Bruheim, Per; Kandasamy, Richard Kumaran. (2017) Integrative analysis of the inflammatory signalling kinome landscape. Centre for Digital Life Norway Digital Life 2017 , Oslo 2017-03-20 - 2017-03-21
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LectureWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre. (2017) New bioactive compounds from environmental microbial resources by an integrated functional (meta)genomics approach. Centre for Digital Life Norway Centre for Digital Life Norway - Annual conference , Hotel Bristol, Oslo 2017-03-20 - 2017-03-21
2016
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PosterRøst, Lisa Marie; Olaisen, Camilla; Petrovic, Voin; Otterlei, Marit; Bruheim, Per. (2016) Blocking the Stress-specific APIM-PCNA Interaction in Multiple Myeloma Cells Cause Significant Changes in Central Carbon Metabolism. International Society of Cancer Metabolism ISCaM 2016: Metabolic Networks in Cancer , Brussel 2016-10-26 - 2016-10-29
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PosterHeggeset, Tonje Marita Bjerkan; Lewin, Anna; Nguyen, Giang-Son; Nordborg, Anna; Degnes, Kristin Fløgstad; Sletta, Håvard. (2016) INBioPharm - Integrated Novel Natural Product Discovery and Production Platform for Accelerated Biopharmaceutical Innovation from Microbial Biodiversity. SINTEF Functional Metagenomics 2016 , Jægtvolden Fjordhotell, Inderøy 2016-09-25 - 2016-09-28
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PosterBösl, Korbinian; Røst, Lisa Marie; Giambelluca, Miriam; Bruheim, Per; Kandasamy, Richard Kumaran. (2016) Integrative analysis of the inflammatory signalling kinome landscape. National Graduate School in Infection Biology and and Antimi National Graduate School in Infection Biology and and Antimicrobial Kick-Off meeting , Oslo 2016-11-14 - 2016-11-15
2015
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PosterMühlroth, Alice; Bones, Atle M.; Vadstein, Olav; Hohmann-Marriott, Martin; El-Assimi, Aimen; Røkke, Gunvor. (2015) Investigation of transcriptional regulation in microalgae Nannochloropsis oceanica CCMP1779 under induced TAG accumulation by phosphate deficiency. EPC6 european phylogeny congress 6 2015-08-23 - 2015-08-28
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InterviewBruheim, Per. (2015) Utdanning og forskning innen ølbrygging ved NTNU. NRK P1 Her og Nå NRK P1 Her og Nå [Radio] 2015-04-17
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Programme participationBruheim, Per; Vadstein, Olav. (2015) Utdanning og forskning innen ølbrygging ved NTNU. NRK1 Scrødingers katt NRK1 Scrødingers katt [TV] 2015-04-10
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InterviewBruheim, Per; Vadstein, Olav. (2015) Nå kan du studere ølbrygging på NTNU. Forskning.no Forskning.no [Internet] 2015-04-10
2014
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Academic lectureStafsnes, Marit Hallvardsdotter; Bruheim, Per. (2014) Deep Phenotyping using Mass Spectrometry based Metabolomics and Fluxomics. NTNU NTNU - Bioinformatics Network Seminar 2014 , Trondheim 2014-12-08 - 2014-12-08
2012
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Academic lectureBruheim, Per. (2012) Quantitative metabolomics for analysis of biological extracts. 20. Norske Symposium i Kromatografi , Sandefjord 2012-01-08 - 2012-01-10
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PosterJanecková, Hana; Friedecky, D.; Wojtowicz, P.; Hron, Karel; Brunsvik, A.; Correa, E.. (2012) Untargeted metabolomics for diagnosing inherited metabolic diseases. 27th International Symposium on MicroScale Bioseparations and Analyses , Geneva 2012-02-12 - 2012-02-15
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Academic lectureBruheim, Per. (2012) Insights into bacterial metabolism by using mass spectrometric metabolomics tools. NBS Avdeling Trondheim "Oppdalsmøte" , Storlien 2012-04-16 - 2012-04-17
2011
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Academic lectureBruheim, Per. (2011) A new GC-MS/MS method for quantitative Metabolite Profilng of amino and carboxyilic acid containing metabolites. The Norwegian Biochemical Society 47th Contact Meeting , Tromsø 2011-02-03 - 2011-02-06
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PosterKvitvang, Hans Fredrik Nyvold; Andreassen, Trygve; Adam, Tomas; Villas-Boas, Silas G.; Bruheim, Per. (2011) High sensitive GC-MS/MS method for absolute quantitation of amino and non-amino organic acids. Norsk Selskap for Massespektrometri (NSMS) 2011-01-23 - 2011-01-26
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PosterLien, Stina Katrine; Sletta, Håvard; Vernstad, Kai; Valla, Svein; Bruheim, Per. (2011) Mass spectrometry based Metabolome analysis of the alginate producing bacterium Pseudomonas fluorescens. Norsk selskap for massespektrometri (NSMS) Det 14. Norske seminar i massespektrometri , Hafjell 2011-01-23 - 2011-01-26
2010
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InterviewBruheim, Per; Andersen, Steinar Q.. (2010) Her utvikles kreftvaksine ved hjelp av bakegjær. VG VG [Newspaper] 2010-12-15
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PosterFriedecky, D.; Krätschmerova, H.; Micova, K.; Wojtowicz, P.; Adamova, K.; Brunsvik, A.. (2010) Diagnosing of inherited metabolic disorders by LC-QTOF analysis of cultured skin fibroblasts. Advances in Metabolite Profiling , Firenze 2010-11-09 - 2010-11-10
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Academic lectureØvrehus, Marius Altern; Bruheim, Per; Zahlsen, Kolbjørn; Hallan, Stein. (2010) Nye biomarkører for nyresvikt. Norsk Nyremedisinsk Forening Vårmøtet til Norsk Nyremedisinsk Forening , Arendal 2010-06-09 - 2010-06-11
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Academic lectureWentzel, Alexander; Øverby, Anders; Hoel, Sunniva; Bruheim, Per; Sletta, Håvard; Ellingsen, Trond E.. (2010) High reproducibility system for submerged batch cultivations of Streptomyces coelicolor as the basis for systems biology research in Streptomycetes. 11th International Symposium on the Genetics of Industrial Microorganisms , Melbourne 2010-06-28 - 2010-07-01
2009
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Academic lectureJørgensen, Hanne; Engelhardt, Kerstin; Sletta, Håvard; Fjærvik, Espen; Klinkenberg, Geir; Degnes, Kristin F.. (2009) Streptomycetes and other actinobacteria from the Trondheim fjord (Norway): diversity, secondary metabolites, and genes for their biosynthesis. Symposium on the Biology of Streptomyces , Muenster 2009-10-07 - 2009-10-11
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Academic lectureZotchev, Sergey; Jørgensen, Hanne; Degnes, Kristin F.; Sletta, Håvard; Fjærvik, Espen; Dikiy, Alexander. (2009) SMALL-RING MACROLACTAMS WITH ACYL SIDE CHAIN: NEW INSIGHTS INTO THE BIOSYNTHESIS AND ITS EVOLUTION. 15th International Symposium on the Biology of Actinomycetes , Shanghai 2009-08-20 - 2009-08-25
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Academic lectureWentzel, Alexander; Jakobsen, Øyvind M.; Øverby, Anders; Hoel, Sunniva; Bruheim, Per; Sletta, Håvard. (2009) A systems biology approach towards understanding metabolic switching from primary to secondary metabolism in Streptomyces coelicolor. Norsk Biokjemisk Selskap NBS Vintermøte , Røros 2009-01-29 - 2009-02-01
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PosterMærk, Mali; Lien, Stina Katrine; Ertesvåg, Helga; Bruheim, Per; Valla, Svein. (2009) An Entner-Doudoroff pathway mutation in Pseudomonas fluorescens causes cell death during alginate production. Norsk Biokjemisk Selskap The Norwegian Biochemical Society 45th Contact Meeting , Røros 2009-01-29 - 2009-02-01
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PosterBruheim, Per; Sletta, Håvard; Klinkenberg, Geir; Ellingsen, Trond Erling; Krokan, Hans Einar; Otterlei, Marit. (2009) Systems biology and high resolution genome-wide phenotyping of yeast used for identification of cellular and molecular effects of DNA damaging agents. 3rd US-EU Workshop "Systems level understanding of DNA damage responses" , Egmond aan Zee 2009-03-30 - 2009-04-01
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PosterJørgensen, Hanne; Degnes, Kristin F.; Sletta, Håvard; Fjærvik, Espen; Dikiy, Alexander; Herfindal, Lars. (2009) The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit. The Fifteenth International Symposium on the Biology of Actinomycetes 2009 (ISBA15) 2009-08-20 - 2009-08-25
2008
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PosterStavne, Tonje; Mærk, Mali; Bruheim, Per; Engelhardt, Kerstin. (2008) Mikrobiell og industriell bioteknologi. Norges Forskningsråd Researchers' Night Trondheim , Trondheim 2008-09-26 - 2008-09-26
2007
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Academic lectureBruheim, Per. (2007) Microbial metabolomics. AgResearch , Grasslands and Massey Univerisity, Palmerston North 2007-06-01 - 2007-06-01
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PosterJørgensen, Hanne; Fjærvik, Espen; Hakvåg, Sigrid; Bruheim, Per; Bredholt, Harald; Klinkenberg, Geir. (2007) Spread of antibiotic biosynthesis genes among streptomycetes in the Trondheim fjord possibly involves mobile genetic elements. The Fourteenth International Symposium on the Biology of Actinomycetes 2007 (ISBA14) , Newcastle 2007-08-26 - 2007-08-30
2004
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Academic lectureBorgos, Sven Even F.; Bruheim, Per; Sletta, Håvard; Sekurova, Olga; Ellingsen, Trond Erling; Zotchev, Sergey. (2004) Generation of novel antibiotics via manipulation of the nystatin biosynthetic gene cluster in the bacterium Streptomyces noursei. 2nd International Conference "Genomics, Proteomics and Bioinformatics for Medicine" , Moskva 2004-07-14 - 2004-07-19
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PosterBruheim, Per; Borgos, Sven Even F.; Sletta, Håvard; Tsan, Pascale; Ellingsen, Trond Erling; Lancelin, Jean-Marc. (2004) Nystatin biosynthesis: natural and engineered diversity of polyene macrolides produced by Streptomyces noursei. Genetics and Molecular Biology of Industrial Microorganisms conference , San Diego 2004-11-14 - 2004-11-18
2003
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PosterBrautaset, Trygve; Bruheim, Per; Sekurova, Olga; Borgos, Sven Even F.; Sletta, Håvard; Ellingsen, Trond E.. (2003) Nystatin biosynthesis in Streptomyces noursei: lessons learned from the gene knockout experiments. Biology of Streptomycetes , Münster, Germany 2003-03-03 -
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Academic lectureOtterlei, Marit; Bruheim, Per; Byungchan, Ahn; Baynton, Kathy; Opresko, Patricia; Seeberg, E.. (2003) DNA damage causing replication arrest leads to a relocation of WRN hekicase to complexes containing proteins from the RAD52 epistasis group: RAD52, RAD51, RAD54 and RAD54B. Possible role for WRN in regulation of HR. International Workshop on Werner Syndrome , Lansdowne 2003-05-31 -
2002
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Academic lectureBrautaset, Trygve; Bruheim, Per; Sekurova, Olga; Sletta, Håvard; Ellingsen, Trond E.; Strøm, Arne Reidar. (2002) Nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455: mutational analysis, and future perspectives for genetic manipulation. 9th International Symposium on the Genetics of Industrial Microorganisms, , Gjeongju, South Korea 2002-07-05 -
2001
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PosterBrautaset, Trygve; Bruheim, Per; Sletta, Håvard; Ellingsen, T.E.; Strøm, Arne Reidar; Valla, Svein. (2001) Novel polyene antibiotics via genetic manipulation of the nystatin polyketide synthase. ISBA møte , Vancouver 2001-08-10 -
1998
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Academic lectureBruheim, Per. (1998) Actinorhodin production by Streptomyces liridans: activation of the biosynthetic pathway related to growth, morphology and medium composition. Biokjemisk kontaktmøte , Lillehammer