Melanie Rae Simpson

About

Positions: Study programme leader at the Office for Medical Education (OME / Enhet for legeutdanning). Associate professor in medican statistics at the Department of Public Health and Nursing.

Qualifications

Bachelor of Medicine 2008 (Newcastle University, Australia)
Bachelor of Medical Science 2006 (Newcastle University)
Masters in Medical Statistics, 2015 (Newcastle University)
PhD i medicine, 2018 (NTNU - Norwegian University of Science and Technology)
Thesis: Preventing atopic dermatitis with probiotic supplementation - the role of selected breast milk components: The Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) study

Research interests

Allergy related disease
Prevention
Immunological components of breast milk
Breastfeeding
Clinical trials

Research

Ongoing research:

My current research involves a combination of epidemiological, clinical and translational studies investigating the prevention of allergy related diseases. I primarily work with data from the Prevention of Allergy among Children in Trondheim (PACT) study, and the associated substudies. I am also involved research into the immunological components of breast milk, and how these contribute to the development of the microbiota, gastrointestinal system and immune system of newborn infants.

Probtiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) Study

>The ProPACT study is a randomised, placebo contolled study which investigated the use of probiotic supplementation given to women during the last 4 weeks of pregnancy until 3 months after birth. At 2 years of age, we observed that women born to mothers in the probiotic group had a 40 % reduction in the cumulative incidence of eczema. The biological mechanisms behind this preventive effect are incompletely understood. We are using samples collected during the ProPACT study to investigate these biological mechanisms from different angles.

The ProPACT Study is a substudy of the larger population intervention study (PACT) which aimed to reduce childhood allergy related diseases through reducing environmental smoke and damp/mold exposure and increasing fish consumption during pregnancy and early infancy.

Publications

2024

Talmo, Maren Sophie Aaserud; Fløysand, Ingvild Skogedal; Nilsen, Guro Ørndal; Løvvik, Tone Shetelig; Ødegård, Rønnaug Astri; Juliusson, Pétur Benedikt. (2024) Growth Restriction in the Offspring of Mothers With Polycystic Ovary Syndrome. JAMA Network Open
Academic article
Høyen, Karina Sagmo; Prestmo, Astrid; Simpson, Melanie Rae; Cohen, Lisa Janet; Solem, Stian; Medås, Kamilla. (2024) Symptoms of the suicide crisis syndrome and therapist emotional responses: associations to self-harm and death by suicide within 18-months post-discharge among patients at an acute psychiatric department. Journal of Mental Health
Academic article
Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta. (2024) Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Zakiudin, Dinastry Pramadita; Thyssen, Jacob P.; Zachariae, Claus; Videm, Vibeke; Øien, Torbjørn; Simpson, Melanie Rae. (2024) Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation. Acta Dermato-Venereologica
Academic article
Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann. (2024) Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Ottestad, Inger ; Bye, Asta; Greil, Christine; Arends, Jann. (2024) Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Husby, Anne Engtrø; Simpson, Melanie Rae; Dalbye, Rebecka; Larsen, Marit; Vanky, Eszter Ilona; Løvvik, Tone Shetelig. (2024) Childbirth experiences in women with polycystic ovary syndrome: A cohort study. Acta Obstetricia et Gynecologica Scandinavica
Academic article
Myklebust, Åsne; Simpson, Melanie Rae; Valand, Jonas; Langaas, Vibeke Stenhaug; Jartti, Tuomas; Døllner, Henrik. (2024) Bronchial reactivity and asthma at school age after early-life metapneumovirus infection. European Respiratory Journal Open Research (ERJ Open Research)
Academic article
Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann. (2024) Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Haugan, Ingvild; Husby, Marit Gudrun; Skjøtskift, Bjørg; Mostue, Dorothea Aamnes; Brun, Andreas; Olsen, Lene Christin. (2024) Enteroaggregative Escherichia coli in mid-Norway: A prospective, case control study. PLOS ONE
Academic article
Granviken, Fredrik; Meisingset, Ingebrigt; Bach, Kerstin; Bones, Anita Formo; Simpson, Melanie Rae; Hill, Jonathan C.. (2024) Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project). Pain
Academic article

2023

Prescott, Marcus Glenton; Iakovleva, Ekaterina; Simpson, Melanie Rae; Pedersen, Sindre Andre; Munblit, Daniel; Vallersnes, Odd Martin. (2023) Intranasal analgesia for acute moderate to severe pain in children – a systematic review and meta-analysis. BMC Pediatrics
Academic article
Nilsen, Guro Ørndal; Simpson, Melanie Rae; Hanem, Liv Guro Engen; Løvvik, Tone Shetelig; Ødegård, Rønnaug Astri; Stokkeland, Live Marie T. (2023) Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero. Acta Obstetricia et Gynecologica Scandinavica
Academic article
Golubovic, Jelena; Baker, Felicity; Simpson, Melanie Rae; Neerland, Bjørn Erik. (2023) Live and recorded music interventions for management of delirium symptoms in acute geriatric patients: Protocol for a randomized feasibility trial. Nordic journal of music therapy
Academic article
Haugen, Tina; Halvorsen, Joar Øveraas; Friborg, Oddgeir; Simpson, Melanie Rae; Mork, Paul Jarle; Mikkelsen, Gustav. (2023) Modified prolonged exposure therapy as Early Intervention after Rape (The EIR-study): study protocol for a multicenter randomized add-on superiority trial. Trials
Academic article
McDonald, James; Sayers, Judith; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Baracos, Vickie. (2023) Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Jamtøy, Kent Are; Thorstensen, Wenche Moe; Stovner, Lars Jacob; Rosén, Annika; Maarbjerg, Stine; Bratbak, Daniel Fossum. (2023) Onabotulinum toxin A block of the sphenopalatine ganglion in patients with persistent idiopathic facial pain: a randomized, triple-blind, placebo-controlled, exploratory, cross-over study. Cephalalgia
Academic article
Zakiudin, Dinastry Pramadita; Rø, Anne Dorthea Bjerkenes; Videm, Vibeke; Øien, Torbjørn; Simpson, Melanie Rae. (2023) Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention. Clinical and Molecular Allergy
Academic article
Ahlberg, Emelie; Al-Kaabawi, Ahmed; Thune, Rebecka; Simpson, Melanie Rae; Pedersen, Sindre Andre; Cione, Erika. (2023) Breast milk microRNAs: Potential players in oral tolerance development. Frontiers in Immunology
Academic literature review
Cheung, Ka Yan; Petrou, Loukia; Helfer, Bartosz; Porubayeva, Erika; Dolgikh, Elena; Ali, Sana. (2023) Health and nutrition claims for infant formula: international cross sectional survey. The BMJ
Academic article
Chalise, Pratibha; Manandhar, Pratibha; Infanti, Jennifer Jean; Campbell, Jacquelyn C; Henriksen, Lena; Joshi, Sunil Kumar. (2023) Addressing Domestic Violence in Antenatal Care Environments in Nepal (ADVANCE) – study protocol for a randomized controlled trial evaluating a video intervention on domestic violence among pregnant women. BMC Public Health
Academic article
Hernholm, Mathilde; Kristiansen, Veronica; Simpson, Melanie Rae; Bråthen, Geir; Meisingset, Tore Wergeland. (2023) Alkoholvaner blant NTNU-studenter 2007-19. Tidsskrift for Den norske legeforening
Academic article
Skarpsno, Eivind Schjelderup; Simpson, Melanie Rae; Seim, Arnfinn; Hrozanova, Maria; Bakøy, Marthe Alida; Klevanger, Nina Elisabeth. (2023) App-Delivered Cognitive-Behavioral Therapy for Insomnia Among Patients with Comorbid Musculoskeletal Complaints and Insomnia Referred to 4-Week Inpatient Multimodal Rehabilitation: Protocol for a Randomized Clinical Trial. Nature and Science of Sleep
Academic article
Haugen, Tina; Halvorsen, Joar Øveraas; Friborg, Oddgeir; Simpson, Melanie Rae; Mork, Paul Jarle; Mikkelsen, Gustav. (2023) Erratum: Correction: Modified prolonged exposure therapy as Early Intervention after Rape (The EIR-study): study protocol for a multicenter randomized add-on superiority trial (Trials (2023) 24 1 (126)). Trials
Errata
Moholdt, Trine; Ashby, Emily Rose; Tømmerdal, Karina Hammer; Lemoine, Maeliss Cynthia Chloe; Holm, Rebecca Lyng; Sætrom, Pål. (2023) Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial . BMJ Open sport & exercise medicine
Academic article

2022

Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija. (2022) Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology. Frontiers in medicine
Academic article
Gamirova, Aysylu; Berbenyuk, Anna; Levina, Daria; Peshko, Dmitrii; Simpson, Melanie Rae; Azad, Meghan B.. (2022) Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic Review. Journal of Allergy and Clinical Immunology: In Practice
Academic article
Rosvold, Elin Olaug; Dahl, Christen Peder; Simpson, Melanie Rae; Wiker, Harald Gotten. (2022) Fastlegevikar uten LIS1 er feil bruk av nye leger. Dagens medisin
Feature article
Aukan, Marthe Isaksen; Coutinho, Silvia; Pedersen, Sindre Andre; Simpson, Melanie Rae; Martins, Catia. (2022) Differences in gastrointestinal hormones and appetite ratings between individuals with and without obesity—A systematic review and meta-analysis. Obesity Reviews
Academic literature review
Neerland, Bjørn Erik; Busund, Rolf; Haaverstad, Rune; Helbostad, Jorunn L.; Landsverk, Svein A.; Martinaityte, Ieva. (2022) Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial. BMJ Open
Article in business/trade/industry journal
Simmonds, Emily Grace; Adjei, Kwaku Peprah; Andersen, Christoffer Wold; Aspheim, Janne Cathrin Hetle; Battistin, Claudia; Bulso, Nicola. (2022) Insights into the quantification and reporting of model-related uncertainty across different disciplines. iScience
Academic article
Løset, Mari; Thomas, Laurent Francois; Brumpton, Ben Michael; Modalsli, Ellen Heilmann; Gabrielsen, Maiken Elvestad; Solvin, Åshild Øksnevad. (2022) Discovering novel genes and causal relationships for psoriasis: The HUNT study. Acta Dermato-Venereologica
Abstract
Mehta, Shriya; Allen, Hilary I.; Campbell, Dianne E.; Arntsen, Karoline Fagerli; Simpson, Melanie Rae; Boyle, Robert J.. (2022) Trends in use of specialized formula for managing cow's milk allergy in young children. Clinical and Experimental Allergy
Academic article

2021

Schei, Kasper; Simpson, Melanie Rae; Øien, Torbjørn; Salamati, Saideh; Rudi, Knut; Ødegård, Rønnaug. (2021) Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children. Clinical and Translational Allergy
Academic article
Vestergaard, Cecilie Lund; Vedaa, Øystein; Simpson, Melanie Rae; Faaland, Patrick; Vethe, Daniel; Kjørstad, Kaia. (2021) The effect of sleep-wake intraindividual variability in digital cognitive behavioral therapy for insomnia: a mediation analysis of a large-scale RCT. Sleep
Academic article
Tingö, Lina; Ahlberg, Emelie; Johansson, Lovisa; Pedersen, Sindre Andre; Chawla, Konika; Sætrom, Pål. (2021) Non-coding RNAs in human breast milk: A systematic review. Frontiers in Immunology
Academic literature review
Ekelund, Louise; Gloppen, Inga; Øien, Torbjørn; Simpson, Melanie Rae. (2021) Duration of breastfeeding, age at introduction of complementary foods and allergy-related diseases: a prospective cohort study. International Breastfeeding Journal
Academic article
O'Reilly, Daniel; Dorodnykh, Denis; Avdeenko, Nina V.; Nekliudov, Nikita A.; Garssen, Johan; Elolimy, Ahmed A.. (2021) Reply to J Zempleni. Advances in Nutrition
Academic article
Kallestad, Håvard; Saksvik, Simen Berg; Vedaa, Øystein; Langsrud, Knut; Morken, Gunnar; Lydersen, Stian. (2021) Digital cognitive-behavioural therapy for insomnia compared with digital patient education about insomnia in individuals referred to secondary mental health services in Norway: Protocol for a multicentre randomised controlled trial. BMJ Open
Academic article

2020

Schei, Kasper; Simpson, Melanie Rae; Avershina, Ekaterina; Rudi, Knut; Øien, Torbjørn; Juliusson, Petur Benedikt. (2020) Early gut fungal and bacterial microbiota and childhood growth. Frontiers in pediatrics
Academic article
O'Reilly, Daniel; Dorodnykh, Denis; Avdeenko, Nina; Nekliudov, Nikita A.; Garssen, Johan; Elolimy, Ahmed. (2020) Perspective: The Role of Human Breast-Milk Extracellular Vesicles in Child Health and Disease. Advances in Nutrition
Academic literature review

2016

Simpson, Melanie Rae; Øien, Torbjørn. (2016) Probiotiske bakterier i forebygging av atopisk dermatitt. Hud og Helse
Popular scientific article
Simpson, Melanie Rae; Øien, Torbjørn. (2016) Probiotiske bakterier i forebygging av atopisk dermatitt. BestPractice Dermatologi
Article in business/trade/industry journal
Simpson, Melanie Rae. (2016) Systems biology: Impressions from a newcomer graduate student in 2016. Advances in Physiology Education
Academic article
Simpson, Melanie Rae; Rø, Anne Dorthea; Grimstad, Øystein; Johnsen, Roar; Storrø, Ola; Øien, Torbjørn. (2016) Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-β. Clinical and Translational Allergy
Academic article

2015

Dotterud, Christian; Avershina, Ekaterina; Sekelja, Monika; Simpson, Melanie Rae; Rudi, Knut; Storrø, Ola. (2015) Does maternal perinatal probiotic supplementation alter the intestinal microbiota of mother and child?. Journal of Pediatric Gastroenterology and Nutrition - JPGN
Academic article
Simpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Johnsen, Roar; Storrø, Ola; Sætrom, Pål. (2015) Human breast milk miRNA, maternal probiotic supplementation and atopic dermatitis in offspring. PLOS ONE
Academic article
Simpson, Melanie Rae; Dotterud, Christian Kvikne; Storrø, Ola; Johnsen, Roar; Øien, Torbjørn. (2015) Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatology
Academic article

2014

Rø, Anne Dorthea; Simpson, Melanie Rae; Storrø, Ola; Johnsen, Roar; Videm, Vibeke; Øien, Torbjørn. (2014) The predictive value of allergen skin prick tests and IgE tests at pre-school age: The PACT study. Pediatric Allergy and Immunology
Academic article

2013

Dotterud, Christian Kvikne; Storrø, Ola; Simpson, Melanie Rae; Johnsen, Roar; Øien, Torbjørn. (2013) The impact of pre- and postnatal exposures on allergy related diseases in childhood: a controlled multicentre intervention study in primary health care. BMC Public Health
Academic article

Journal publications

Talmo, Maren Sophie Aaserud; Fløysand, Ingvild Skogedal; Nilsen, Guro Ørndal; Løvvik, Tone Shetelig; Ødegård, Rønnaug Astri; Juliusson, Pétur Benedikt. (2024) Growth Restriction in the Offspring of Mothers With Polycystic Ovary Syndrome. JAMA Network Open
Academic article
Høyen, Karina Sagmo; Prestmo, Astrid; Simpson, Melanie Rae; Cohen, Lisa Janet; Solem, Stian; Medås, Kamilla. (2024) Symptoms of the suicide crisis syndrome and therapist emotional responses: associations to self-harm and death by suicide within 18-months post-discharge among patients at an acute psychiatric department. Journal of Mental Health
Academic article
Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta. (2024) Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Zakiudin, Dinastry Pramadita; Thyssen, Jacob P.; Zachariae, Claus; Videm, Vibeke; Øien, Torbjørn; Simpson, Melanie Rae. (2024) Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation. Acta Dermato-Venereologica
Academic article
Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann. (2024) Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Ottestad, Inger ; Bye, Asta; Greil, Christine; Arends, Jann. (2024) Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Husby, Anne Engtrø; Simpson, Melanie Rae; Dalbye, Rebecka; Larsen, Marit; Vanky, Eszter Ilona; Løvvik, Tone Shetelig. (2024) Childbirth experiences in women with polycystic ovary syndrome: A cohort study. Acta Obstetricia et Gynecologica Scandinavica
Academic article
Myklebust, Åsne; Simpson, Melanie Rae; Valand, Jonas; Langaas, Vibeke Stenhaug; Jartti, Tuomas; Døllner, Henrik. (2024) Bronchial reactivity and asthma at school age after early-life metapneumovirus infection. European Respiratory Journal Open Research (ERJ Open Research)
Academic article
Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann. (2024) Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Haugan, Ingvild; Husby, Marit Gudrun; Skjøtskift, Bjørg; Mostue, Dorothea Aamnes; Brun, Andreas; Olsen, Lene Christin. (2024) Enteroaggregative Escherichia coli in mid-Norway: A prospective, case control study. PLOS ONE
Academic article
Granviken, Fredrik; Meisingset, Ingebrigt; Bach, Kerstin; Bones, Anita Formo; Simpson, Melanie Rae; Hill, Jonathan C.. (2024) Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project). Pain
Academic article
Prescott, Marcus Glenton; Iakovleva, Ekaterina; Simpson, Melanie Rae; Pedersen, Sindre Andre; Munblit, Daniel; Vallersnes, Odd Martin. (2023) Intranasal analgesia for acute moderate to severe pain in children – a systematic review and meta-analysis. BMC Pediatrics
Academic article
Nilsen, Guro Ørndal; Simpson, Melanie Rae; Hanem, Liv Guro Engen; Løvvik, Tone Shetelig; Ødegård, Rønnaug Astri; Stokkeland, Live Marie T. (2023) Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero. Acta Obstetricia et Gynecologica Scandinavica
Academic article
Golubovic, Jelena; Baker, Felicity; Simpson, Melanie Rae; Neerland, Bjørn Erik. (2023) Live and recorded music interventions for management of delirium symptoms in acute geriatric patients: Protocol for a randomized feasibility trial. Nordic journal of music therapy
Academic article
Haugen, Tina; Halvorsen, Joar Øveraas; Friborg, Oddgeir; Simpson, Melanie Rae; Mork, Paul Jarle; Mikkelsen, Gustav. (2023) Modified prolonged exposure therapy as Early Intervention after Rape (The EIR-study): study protocol for a multicenter randomized add-on superiority trial. Trials
Academic article
McDonald, James; Sayers, Judith; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Baracos, Vickie. (2023) Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series. Journal of Cachexia, Sarcopenia and Muscle
Academic literature review
Jamtøy, Kent Are; Thorstensen, Wenche Moe; Stovner, Lars Jacob; Rosén, Annika; Maarbjerg, Stine; Bratbak, Daniel Fossum. (2023) Onabotulinum toxin A block of the sphenopalatine ganglion in patients with persistent idiopathic facial pain: a randomized, triple-blind, placebo-controlled, exploratory, cross-over study. Cephalalgia
Academic article
Zakiudin, Dinastry Pramadita; Rø, Anne Dorthea Bjerkenes; Videm, Vibeke; Øien, Torbjørn; Simpson, Melanie Rae. (2023) Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention. Clinical and Molecular Allergy
Academic article
Ahlberg, Emelie; Al-Kaabawi, Ahmed; Thune, Rebecka; Simpson, Melanie Rae; Pedersen, Sindre Andre; Cione, Erika. (2023) Breast milk microRNAs: Potential players in oral tolerance development. Frontiers in Immunology
Academic literature review
Cheung, Ka Yan; Petrou, Loukia; Helfer, Bartosz; Porubayeva, Erika; Dolgikh, Elena; Ali, Sana. (2023) Health and nutrition claims for infant formula: international cross sectional survey. The BMJ
Academic article
Chalise, Pratibha; Manandhar, Pratibha; Infanti, Jennifer Jean; Campbell, Jacquelyn C; Henriksen, Lena; Joshi, Sunil Kumar. (2023) Addressing Domestic Violence in Antenatal Care Environments in Nepal (ADVANCE) – study protocol for a randomized controlled trial evaluating a video intervention on domestic violence among pregnant women. BMC Public Health
Academic article
Hernholm, Mathilde; Kristiansen, Veronica; Simpson, Melanie Rae; Bråthen, Geir; Meisingset, Tore Wergeland. (2023) Alkoholvaner blant NTNU-studenter 2007-19. Tidsskrift for Den norske legeforening
Academic article
Skarpsno, Eivind Schjelderup; Simpson, Melanie Rae; Seim, Arnfinn; Hrozanova, Maria; Bakøy, Marthe Alida; Klevanger, Nina Elisabeth. (2023) App-Delivered Cognitive-Behavioral Therapy for Insomnia Among Patients with Comorbid Musculoskeletal Complaints and Insomnia Referred to 4-Week Inpatient Multimodal Rehabilitation: Protocol for a Randomized Clinical Trial. Nature and Science of Sleep
Academic article
Haugen, Tina; Halvorsen, Joar Øveraas; Friborg, Oddgeir; Simpson, Melanie Rae; Mork, Paul Jarle; Mikkelsen, Gustav. (2023) Erratum: Correction: Modified prolonged exposure therapy as Early Intervention after Rape (The EIR-study): study protocol for a multicenter randomized add-on superiority trial (Trials (2023) 24 1 (126)). Trials
Errata
Moholdt, Trine; Ashby, Emily Rose; Tømmerdal, Karina Hammer; Lemoine, Maeliss Cynthia Chloe; Holm, Rebecca Lyng; Sætrom, Pål. (2023) Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial . BMJ Open sport & exercise medicine
Academic article
Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija. (2022) Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology. Frontiers in medicine
Academic article
Gamirova, Aysylu; Berbenyuk, Anna; Levina, Daria; Peshko, Dmitrii; Simpson, Melanie Rae; Azad, Meghan B.. (2022) Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic Review. Journal of Allergy and Clinical Immunology: In Practice
Academic article
Rosvold, Elin Olaug; Dahl, Christen Peder; Simpson, Melanie Rae; Wiker, Harald Gotten. (2022) Fastlegevikar uten LIS1 er feil bruk av nye leger. Dagens medisin
Feature article
Aukan, Marthe Isaksen; Coutinho, Silvia; Pedersen, Sindre Andre; Simpson, Melanie Rae; Martins, Catia. (2022) Differences in gastrointestinal hormones and appetite ratings between individuals with and without obesity—A systematic review and meta-analysis. Obesity Reviews
Academic literature review
Neerland, Bjørn Erik; Busund, Rolf; Haaverstad, Rune; Helbostad, Jorunn L.; Landsverk, Svein A.; Martinaityte, Ieva. (2022) Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial. BMJ Open
Article in business/trade/industry journal
Simmonds, Emily Grace; Adjei, Kwaku Peprah; Andersen, Christoffer Wold; Aspheim, Janne Cathrin Hetle; Battistin, Claudia; Bulso, Nicola. (2022) Insights into the quantification and reporting of model-related uncertainty across different disciplines. iScience
Academic article
Løset, Mari; Thomas, Laurent Francois; Brumpton, Ben Michael; Modalsli, Ellen Heilmann; Gabrielsen, Maiken Elvestad; Solvin, Åshild Øksnevad. (2022) Discovering novel genes and causal relationships for psoriasis: The HUNT study. Acta Dermato-Venereologica
Abstract
Mehta, Shriya; Allen, Hilary I.; Campbell, Dianne E.; Arntsen, Karoline Fagerli; Simpson, Melanie Rae; Boyle, Robert J.. (2022) Trends in use of specialized formula for managing cow's milk allergy in young children. Clinical and Experimental Allergy
Academic article
Schei, Kasper; Simpson, Melanie Rae; Øien, Torbjørn; Salamati, Saideh; Rudi, Knut; Ødegård, Rønnaug. (2021) Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children. Clinical and Translational Allergy
Academic article
Vestergaard, Cecilie Lund; Vedaa, Øystein; Simpson, Melanie Rae; Faaland, Patrick; Vethe, Daniel; Kjørstad, Kaia. (2021) The effect of sleep-wake intraindividual variability in digital cognitive behavioral therapy for insomnia: a mediation analysis of a large-scale RCT. Sleep
Academic article
Tingö, Lina; Ahlberg, Emelie; Johansson, Lovisa; Pedersen, Sindre Andre; Chawla, Konika; Sætrom, Pål. (2021) Non-coding RNAs in human breast milk: A systematic review. Frontiers in Immunology
Academic literature review
Ekelund, Louise; Gloppen, Inga; Øien, Torbjørn; Simpson, Melanie Rae. (2021) Duration of breastfeeding, age at introduction of complementary foods and allergy-related diseases: a prospective cohort study. International Breastfeeding Journal
Academic article
O'Reilly, Daniel; Dorodnykh, Denis; Avdeenko, Nina V.; Nekliudov, Nikita A.; Garssen, Johan; Elolimy, Ahmed A.. (2021) Reply to J Zempleni. Advances in Nutrition
Academic article
Kallestad, Håvard; Saksvik, Simen Berg; Vedaa, Øystein; Langsrud, Knut; Morken, Gunnar; Lydersen, Stian. (2021) Digital cognitive-behavioural therapy for insomnia compared with digital patient education about insomnia in individuals referred to secondary mental health services in Norway: Protocol for a multicentre randomised controlled trial. BMJ Open
Academic article
Schei, Kasper; Simpson, Melanie Rae; Avershina, Ekaterina; Rudi, Knut; Øien, Torbjørn; Juliusson, Petur Benedikt. (2020) Early gut fungal and bacterial microbiota and childhood growth. Frontiers in pediatrics
Academic article
O'Reilly, Daniel; Dorodnykh, Denis; Avdeenko, Nina; Nekliudov, Nikita A.; Garssen, Johan; Elolimy, Ahmed. (2020) Perspective: The Role of Human Breast-Milk Extracellular Vesicles in Child Health and Disease. Advances in Nutrition
Academic literature review
Blyuss, Oleg; Cheung, Ka Yan; Chen, Jessica; Parr, Callum; Petrou, Loukia; Komarova, Alina. (2019) Statistical approaches in the studies assessing associations between human milk immune composition and allergic diseases: A scoping review. Nutrients
Academic article
Øien, Torbjørn; Schjelvaag, Astrid; Storrø, Ola; Johnsen, Roar; Simpson, Melanie Rae. (2019) Fish Consumption at One Year of Age Reduces the Risk of Eczema, Asthma and Wheeze at Six Years of Age. Nutrients
Academic article
Avershina, Ekaterina; Angell, Inga Leena; Simpson, Melanie Rae; Storrø, Ola; Øien, Torbjørn; Johnsen, Roar. (2018) Low maternal microbiota sharing across gut, breast milk and vagina, as revealed by 16s rRNA gene and reduced metagenomic sequencing. Genes
Academic article
Rø, Anne Dorthea; Simpson, Melanie Rae; Rø, Torstein Baade; Storrø, Ola; Johnsen, Roar; Videm, Vibeke. (2017) Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation. Clinical and Experimental Allergy
Academic article
Simpson, Melanie Rae; Avershina, Ekaterina; Storrø, Ola; Johnsen, Roar; Rudi, Knut; Øien, Torbjørn. (2017) Breastfeeding associated microbiota in human milk following supplementation with Lactobacillus rhamnosus GG, Lactobacillus acidophilus La-5 and Bifidobacterium animalis subspecies lactis Bb-12. Journal of Dairy Science (JDS)
Academic article
Avershina, Ekaterina; Slangsvold, Silje; Simpson, Melanie Rae; Storrø, Ola; Johnsen, Roar; Øien, Torbjørn. (2017) Diversity of vaginal microbiota increases by the time of labor onset. Scientific Reports
Academic article
Simpson, Melanie Rae; Øien, Torbjørn. (2016) Probiotiske bakterier i forebygging av atopisk dermatitt. Hud og Helse
Popular scientific article
Simpson, Melanie Rae; Øien, Torbjørn. (2016) Probiotiske bakterier i forebygging av atopisk dermatitt. BestPractice Dermatologi
Article in business/trade/industry journal
Simpson, Melanie Rae. (2016) Systems biology: Impressions from a newcomer graduate student in 2016. Advances in Physiology Education
Academic article
Simpson, Melanie Rae; Rø, Anne Dorthea; Grimstad, Øystein; Johnsen, Roar; Storrø, Ola; Øien, Torbjørn. (2016) Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-β. Clinical and Translational Allergy
Academic article
Dotterud, Christian; Avershina, Ekaterina; Sekelja, Monika; Simpson, Melanie Rae; Rudi, Knut; Storrø, Ola. (2015) Does maternal perinatal probiotic supplementation alter the intestinal microbiota of mother and child?. Journal of Pediatric Gastroenterology and Nutrition - JPGN
Academic article
Simpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Johnsen, Roar; Storrø, Ola; Sætrom, Pål. (2015) Human breast milk miRNA, maternal probiotic supplementation and atopic dermatitis in offspring. PLOS ONE
Academic article
Simpson, Melanie Rae; Dotterud, Christian Kvikne; Storrø, Ola; Johnsen, Roar; Øien, Torbjørn. (2015) Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatology
Academic article
Rø, Anne Dorthea; Simpson, Melanie Rae; Storrø, Ola; Johnsen, Roar; Videm, Vibeke; Øien, Torbjørn. (2014) The predictive value of allergen skin prick tests and IgE tests at pre-school age: The PACT study. Pediatric Allergy and Immunology
Academic article
Dotterud, Christian Kvikne; Storrø, Ola; Simpson, Melanie Rae; Johnsen, Roar; Øien, Torbjørn. (2013) The impact of pre- and postnatal exposures on allergy related diseases in childhood: a controlled multicentre intervention study in primary health care. BMC Public Health
Academic article

Teaching

Courses

Knowledge Transfer

2023

Academic lecture

Meisingset, Ingebrigt; Granviken, Fredrik; Bach, Kerstin; Bones, Anita Formo; Klevanger, Nina Elisabeth; Simpson, Melanie Rae. (2023) Advancing from stratified to personalized AI-based management of MSK patients in Norwegian primary care . EFIC EFIC 2023-09-20 - 2023-09-22
Poster

Granviken, Fredrik; Meisingset, Ingebrigt; Bach, Kerstin; Bones, Anita Formo; Simpson, Melanie Rae; Hill, Jonathan C.. (2023) Optimising the management of musculoskeletal pain disorders in primary physiotherapy care: a cluster randomised controlled trial (The SupportPrim Project). International Forum for Back and Neck Pain Research The 18th International Forum for Back and Neck Pain Research in Primary Care , Groningen, Netherlands 2023-08-30 - 2023-09-01
Poster

Granviken, Fredrik; Meisingset, Ingebrigt; Bach, Kerstin; Bones, Anita Formo; Simpson, Melanie Rae; Hill, Jonathan C.. (2023) Optimising the management of musculoskeletal pain disorders in primary physiotherapy care: a cluster randomised controlled trial (The SupportPrim Project). EFIC 13th Congress of the European Pain Federation EFIC - Pain in Europe XIII (EFIC 2023) , Budapest, Hungary 2023-09-20 - 2023-09-22
Lecture

Zakiudin, Dinastry Pramadita; Rø, Anne Dorthea Bjerkenes; Øien, Torbjørn; Simpson, Melanie Rae. (2023) The effect of maternal probiotic supplementation on biomarkers of systemic allergic inflammation in 2-year-old children. The European Academy of Allergy and Clinical Immunology EAACI Congress 2023 , Hamburg, Germany 2023-06-09 - 2023-06-11
Academic lecture

Austad, Bjarne; Prescott, Marcus Glenton; Iakovleva, Ekaterina; Simpson, Melanie Rae; Pedersen, Sindre Andre; Munblit, Daniel. (2023) Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis. Wonca World Wonca World Sydney , Sydney 2023-10-28 - 2023-10-28

2022

Poster

Haugen, Tina; Halvorsen, Joar Øveraas; Hagemann, Cecilie Therese; Schei, Berit; Friborg, Oddgeir; Mork, Paul Jarle. (2022) Early intervention after rape- poster presentation. Forskerkurs, Elementær forskningsmetodikk for psykiatri, NTNU Posterwalk Østmarka, St. Olavs hospital , Trondheim 2022-12-13 - 2022-12-13
Academic lecture

Løset, Mari; Thomas, Laurent Francois; Brumpton, Ben Michael; Modalsli, Ellen Heilmann; Gabrielsen, Maiken Elvestad; Solvin, Åshild Øksnevad. (2022) Discovering novel genes and causal relationships for psoriasis: The HUNT study. Nordic Dermatology Association 35th Nordic Congres of Dermatology and Venereology , København 2022-04-19 - 2022-04-22

2017

Lecture

Simpson, Melanie Rae. (2017) Probiotiske bakterier i forebygging av atopisk dermatitt - kunnskap og kunnskapshull. Helsedirektoratet AllergiFrisk , Oslo 2017-11-22 - 2017-11-23

2016

Lecture

Rø, Anne Dorthea; Øien, Torbjørn; Simpson, Melanie Rae; Rø, Torstein Baade; Storrø, Ola; Johnsen, Roar. (2016) The proportion of Th22 cells in infants is reduced following maternal probiotic supplementation, and is associated with atopic dermatitis. European Society of clinical Cell analysis ESCCA 2016 , Edinburgh 2016-09-11 - 2016-09-14

2015

Interview

Simpson, Melanie Rae. (2015) Intervju angående resultatene publisert i artikkelen: "Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial". Midt nytt, Dagsrevyen 21 (NRK) Midt nytt, Dagsrevyen 21 (NRK) [TV] 2015-09-21
Programme participation

Simpson, Melanie Rae. (2015) Fra mors tarm til barnets hud, er morsmelk et sendebud?. Forsker Grand Prix regonalefinale 2015 Trondheim Forsker Grand Prix regonalefinale 2015 Trondheim [TV] 2015-12-27
Academic lecture

Simpson, Melanie Rae; Øien, Torbjørn; Storrø, Ola; Dotterud, Christian; Johnsen, Roar. (2015) Perinatal probiotics and eczema in school aged children (oral presentation). Children's Environmental Health Network (CEHN) Children: Food and the Environment , Austin, Texas 2015-02-04 - 2015-02-06
Academic lecture

Simpson, Melanie Rae; Dotterud, Christian; Avershina, Ekaterina; Sekelja, Monika; Rudi, Knut; Storrø, Ola. (2015) Probiotics to mothers - impact on diversity in offspring (oral presentation). Children's Environmental Health Network (CEHN) Children: Food and the Environment , Austin, Texas 2015-02-04 - 2015-02-06
Academic lecture

Simpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Storrø, Ola; Johnsen, Roar; Sætrom, Pål. (2015) Human breast milk miRNA, maternal probiotic supplementation and atopic dermatitis (oral presentation). International Milk Genomics Consortium 12th International Symposium on Milk Genomics and Human Health , Sydney 2015-10-26 - 2015-10-28
Poster

Simpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Storrø, Ola; Johnsen, Roar; Sætrom, Pål. (2015) Human breast milk miRNA, maternal probiotics supplementation and atopic dermatitis in offspring (poster). International Milk Genomics Consortium 12th International Symposium on Milk Genomics and Human Health , Sydney 2015-10-26 - 2015-10-28
Popular scientific lecture

Simpson, Melanie Rae. (2015) Fra mors tarm til barnets hud, er morsmelk et sendebud?. Norske Forskningsrådet Forsker Grand Prix, regionale finalen 2015 Trondheim , Byscenen, Trondheim 2015-09-24 - 2015-09-24

Språkvelger

Melanie Rae Simpson