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Clifford George Kentros

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Clifford George Kentros

Professor
Kavli Institute for Systems Neuroscience

clifford.kentros@ntnu.no
+4773598290 MTFS, del 2, Øya
About Publications Outreach

About

Professor of Medicine and leader of the Kentros research group at the Kavli Institute of Systems Neuroscience, NTNU.

Kentros’ laboratory takes advantage of his dual molecular and neurophysiological background by combining the anatomical specificity of molecular genetics with in vivo electrophysiological recordings and anatomical analysis.

The lab uses mice capable of driving the expression of transgenes in particular subsets of neurons in brain areas involved in learning and memory to determine their precise connectivity and to modulate their neural activity while recording from other cell types. In this way, the lab investigates the anatomical and functional circuitry underlying learning and memory.

Research Statement:

Using molecular genetic techniques to investigate the neural circuitry of memory

The one feature above all that differentiates the mammalian brain from from all other biological structures is its anatomical complexity: the human brain contains an estimated 100 billion neurons, each connected to an average of 10,000 other neurons and organized into innumerable distinct cell types. One cannot understand electronic circuits without a detailed circuit diagram and the ability to manipulate single circuit elements while recording from others. Similarly, it is impossible to fully understand brain function without being able to identify and manipulate specific neuronal cell types while recording from other circuit elements. For this reason, my laboratory both performs ​in vivo​ recordings from awake, behaving animals, and attempts to generate novel molecular genetic tools capable of driving transgene in specific neuronal cell types, particularly in those parts of the brain involved in learning and memory. Recent years have seen remarkable advances in molecular genetic tools for the elucidation and manipulation of neural circuits, but the means to deliver such transgenes with the requisite specificity has lagged far behind. One can only address the manifest complexity of the brain by co-oping the genetic machinery which underlies it, but while most genes are expressed in the brain, they are unfortunately almost always expressed in multiple cell types. My laboratory has recently taken a novel tactic to address this problem by using transcriptional ​cis​-regulatory sequences specific to particular microdissected brain regions to drive transgene expression in particular cell types of that region, an approach we call Enhancer-Driven Gene Expression (EDGE). Our recent work has shown that EDGE yields anatomical specificity of transgene expression far surpassing that of the parent gene... i.e. one can obtain high degrees of anatomical specificity from ​nonspecific​ genes. Moreover, these enhancers are typically small enough to fit inside viral vectors, obviating the need for transgenic animals and opening up such anatomically-specific approaches to any species. This last feature not only will bring circuit-specific manipulations to any model species, it has the promise to open up entirely new circuit-specific therapeutic avenues to pathologies of the brain.

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2025

  • Butola, Tanvi; Hernández-Frausto, Melissa; Blankvoort, Stefan Matthias Adriaan; Flatset, Marcus Sandbukt; Peng, Lulu; Hairston, Ariel. (2025) Hippocampus shapes entorhinal cortical output through a direct feedback circuit. Nature Neuroscience
    Academic article

2024

  • Potenza, Maria Letizia; Blankvoort, Stefan Matthias Adriaan; Carvalho, Miguel; Grimstvedt, Joachim Schweder; Di Maria, Valentina; Moan, Kristian Magnus. (2024) Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection. Frontiers in Neuroscience
    Academic article

2023

  • Kobro-Flatmoen, Asgeir; Battistin, Claudia; Raveendran Nair, Rajeevkumar; Bjorkli, Christiana; Skender, Belma; Kentros, Clifford George. (2023) Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β. Brain Communications
    Academic article
  • Grimstvedt, Joachim Schweder; Shelton, Andrew M; Hoerder-Suabedissen, Anna; Oliver, David K; Berndtsson, Christin Høiberget; Blankvoort, Stefan Matthias Adriaan. (2023) A multifaceted architectural framework of the mouse claustrum complex. Journal of Comparative Neurology
    Academic article

2022

  • Bauer, Ulrich Stefan; Fiskum, Vegard; Raveendran Nair, Rajeevkumar; Wijdeven, Rosanne Francisca van de; Kentros, Clifford; Sandvig, Ioanna. (2022) Validation of Functional Connectivity of Engineered Neuromuscular Junction With Recombinant Monosynaptic Pseudotyped ΔG-Rabies Virus Tracing. Frontiers in Integrative Neuroscience
    Academic article
  • Blankvoort, Stefan; Olsen, Lene Christin; Kentros, Clifford. (2022) Single Cell Transcriptomic and Chromatin Profiles Suggest Layer Vb Is the Only Layer With Shared Excitatory Cell Types in the Medial and Lateral Entorhinal Cortex. Frontiers in Neural Circuits
    Academic article
  • Doublet, Thomas; Nosrati, Mona; Kentros, Clifford. (2022) Social Learning of a Spatial Task by Observation Alone. Frontiers in Behavioral Neuroscience
    Academic article

2021

  • Chadney, Oscar Michael Thornton; Blankvoort, Stefan; Grimstvedt, Joachim Schweder; Utz, Annika; Kentros, Clifford. (2021) Multiplexing viral approaches to the study of the neuronal circuits. Journal of Neuroscience Methods
    Academic literature review
  • Ohara, Shinya; Blankvoort, Stefan; Nair Raveendran, Rajeevkumar; Nigro, Maximiliano Jose; Nilssen, Eirik Stamland; Kentros, Clifford. (2021) Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex. eLIFE
    Academic article

2020

  • Blankvoort, Stefan; Descamps, Lucie; Kentros, Clifford. (2020) Enhancer-Driven Gene Expression (EDGE) enables the generation of cell type specific tools for the analysis of neural circuits. Neuroscience research
    Academic literature review
  • Nair Raveendran, Rajeevkumar; Blankvoort, Stefan; Donate Lagartos, Maria Jose; Kentros, Clifford. (2020) Enhancer-Driven Gene Expression (EDGE) Enables the Generation of Viral Vectors Specific to Neuronal Subtypes. iScience
    Academic article

2019

  • Bauer, Ulrich Stefan; van de Wijdeven, Rosanne Francisca; Raveendran Nair, Rajeevkumar; Fiskum, Vegard; Kentros, Clifford; Sandvig, Ioanna. (2019) Modelling functional human neuromuscular junctions in a differentially-perturbable microfluidic environment, validated through recombinant monosynaptic pseudotyped ΔG-rabies virus tracing. bioRxiv
    Academic article

2018

  • Blankvoort, Stefan; Witter, Menno; Noonan, James; Cotney, Justin; Kentros, Clifford. (2018) Marked Diversity of Unique Cortical Enhancers Enables Neuron-Specific Tools by Enhancer-Driven Gene Expression. Current Biology
    Academic article
  • Rowland, David Clayton; Obenhaus, Horst-Andreas; Skytøen, Emilie; Zhang, Qiangwei; Kentros, Clifford; Moser, Edvard Ingjald. (2018) Functional properties of stellate cells in medial entorhinal cortex layer II. . eLIFE
    Academic article
  • Nilssen, Eirik Stamland; Jacobsen, Bente; Nair Raveendran, Rajeevkumar; Fjeld, Gunhild; Blankvoort, Stefan; Kentros, Clifford. (2018) Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex. Journal of Neuroscience
    Academic article

2017

  • Tomorsky, Johanna; DeBlander, Leah; Kentros, Clifford; Doe, Chris Q; Niell, Cristopher M. (2017) TU-tagging: A method for identifying layer-enriched neuronal genes in developing mouse visual cortex. eNeuro
    Academic article
  • Kanter, Benjamin Richard; Lykken, Christine Marie; Avesar, Daniel; Weible, Aldis; Dickinson, Jasmine; Dunn, Benjamin Adric. (2017) A Novel Mechanism for the Grid-to-Place Cell Transformation Revealed by Transgenic Depolarization of Medial Entorhinal Cortex Layer II. Neuron
    Academic article

2014

  • Lykken, Christine; Kentros, Clifford. (2014) Beyond the bolus: Transgenic tools for investigating the neurophysiology of learning and memory. Learning & memory (Cold Spring Harbor, N.Y.)
    Academic literature review
  • Moser, Edvard Ingjald; Roudi, Yasser; Witter, Menno; Kentros, Clifford; Bonhoeffer, Tobias; Moser, May-Britt. (2014) Grid cells and cortical representation. Nature Reviews Neuroscience
    Academic literature review
  • Aikath, D; Weible, AP; Rowland, David Clayton; Kentros, Clifford. (2014) Role of self-generated odor cues in contextual representation. Hippocampus
    Academic article
  • Weible, AP; Moore, AK; Liu, C; DeBlander, L; Wu, H; Kentros, Clifford. (2014) Perceptual gap detection is mediated by gap termination responses in auditory cortex. Current Biology
    Academic article

2013

  • Rowland, David Clayton; Weible, AP; Wickersham, IR; Wu, HY; Mayford, M; Witter, Menno. (2013) Transgenically Targeted Rabies Virus Demonstrates a Major Monosynaptic Projection from Hippocampal Area CA2 to Medial Entorhinal Layer II Neurons. Journal of Neuroscience
    Academic article

2009

  • Muzzio, Isabel; Kentros, Clifford; Kandel, ER. (2009) What is remembered? Role of attention on the encoding and retrieval of hippocampal representations. Journal of Physiology
    Academic article

2004

  • Agnihotri, Naveen; Hawkins, Robert; Kandel, ER; Kentros, Clifford. (2004) The long-term stability of new hippocampal place fields requires new protein synthesis. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
    Academic article

Journal publications

  • Butola, Tanvi; Hernández-Frausto, Melissa; Blankvoort, Stefan Matthias Adriaan; Flatset, Marcus Sandbukt; Peng, Lulu; Hairston, Ariel. (2025) Hippocampus shapes entorhinal cortical output through a direct feedback circuit. Nature Neuroscience
    Academic article
  • Potenza, Maria Letizia; Blankvoort, Stefan Matthias Adriaan; Carvalho, Miguel; Grimstvedt, Joachim Schweder; Di Maria, Valentina; Moan, Kristian Magnus. (2024) Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection. Frontiers in Neuroscience
    Academic article
  • Kobro-Flatmoen, Asgeir; Battistin, Claudia; Raveendran Nair, Rajeevkumar; Bjorkli, Christiana; Skender, Belma; Kentros, Clifford George. (2023) Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β. Brain Communications
    Academic article
  • Grimstvedt, Joachim Schweder; Shelton, Andrew M; Hoerder-Suabedissen, Anna; Oliver, David K; Berndtsson, Christin Høiberget; Blankvoort, Stefan Matthias Adriaan. (2023) A multifaceted architectural framework of the mouse claustrum complex. Journal of Comparative Neurology
    Academic article
  • Bauer, Ulrich Stefan; Fiskum, Vegard; Raveendran Nair, Rajeevkumar; Wijdeven, Rosanne Francisca van de; Kentros, Clifford; Sandvig, Ioanna. (2022) Validation of Functional Connectivity of Engineered Neuromuscular Junction With Recombinant Monosynaptic Pseudotyped ΔG-Rabies Virus Tracing. Frontiers in Integrative Neuroscience
    Academic article
  • Blankvoort, Stefan; Olsen, Lene Christin; Kentros, Clifford. (2022) Single Cell Transcriptomic and Chromatin Profiles Suggest Layer Vb Is the Only Layer With Shared Excitatory Cell Types in the Medial and Lateral Entorhinal Cortex. Frontiers in Neural Circuits
    Academic article
  • Doublet, Thomas; Nosrati, Mona; Kentros, Clifford. (2022) Social Learning of a Spatial Task by Observation Alone. Frontiers in Behavioral Neuroscience
    Academic article
  • Chadney, Oscar Michael Thornton; Blankvoort, Stefan; Grimstvedt, Joachim Schweder; Utz, Annika; Kentros, Clifford. (2021) Multiplexing viral approaches to the study of the neuronal circuits. Journal of Neuroscience Methods
    Academic literature review
  • Ohara, Shinya; Blankvoort, Stefan; Nair Raveendran, Rajeevkumar; Nigro, Maximiliano Jose; Nilssen, Eirik Stamland; Kentros, Clifford. (2021) Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex. eLIFE
    Academic article
  • Blankvoort, Stefan; Descamps, Lucie; Kentros, Clifford. (2020) Enhancer-Driven Gene Expression (EDGE) enables the generation of cell type specific tools for the analysis of neural circuits. Neuroscience research
    Academic literature review
  • Nair Raveendran, Rajeevkumar; Blankvoort, Stefan; Donate Lagartos, Maria Jose; Kentros, Clifford. (2020) Enhancer-Driven Gene Expression (EDGE) Enables the Generation of Viral Vectors Specific to Neuronal Subtypes. iScience
    Academic article
  • Bauer, Ulrich Stefan; van de Wijdeven, Rosanne Francisca; Raveendran Nair, Rajeevkumar; Fiskum, Vegard; Kentros, Clifford; Sandvig, Ioanna. (2019) Modelling functional human neuromuscular junctions in a differentially-perturbable microfluidic environment, validated through recombinant monosynaptic pseudotyped ΔG-rabies virus tracing. bioRxiv
    Academic article
  • Blankvoort, Stefan; Witter, Menno; Noonan, James; Cotney, Justin; Kentros, Clifford. (2018) Marked Diversity of Unique Cortical Enhancers Enables Neuron-Specific Tools by Enhancer-Driven Gene Expression. Current Biology
    Academic article
  • Rowland, David Clayton; Obenhaus, Horst-Andreas; Skytøen, Emilie; Zhang, Qiangwei; Kentros, Clifford; Moser, Edvard Ingjald. (2018) Functional properties of stellate cells in medial entorhinal cortex layer II. . eLIFE
    Academic article
  • Nilssen, Eirik Stamland; Jacobsen, Bente; Nair Raveendran, Rajeevkumar; Fjeld, Gunhild; Blankvoort, Stefan; Kentros, Clifford. (2018) Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex. Journal of Neuroscience
    Academic article
  • Tomorsky, Johanna; DeBlander, Leah; Kentros, Clifford; Doe, Chris Q; Niell, Cristopher M. (2017) TU-tagging: A method for identifying layer-enriched neuronal genes in developing mouse visual cortex. eNeuro
    Academic article
  • Kanter, Benjamin Richard; Lykken, Christine Marie; Avesar, Daniel; Weible, Aldis; Dickinson, Jasmine; Dunn, Benjamin Adric. (2017) A Novel Mechanism for the Grid-to-Place Cell Transformation Revealed by Transgenic Depolarization of Medial Entorhinal Cortex Layer II. Neuron
    Academic article
  • Lykken, Christine; Kentros, Clifford. (2014) Beyond the bolus: Transgenic tools for investigating the neurophysiology of learning and memory. Learning & memory (Cold Spring Harbor, N.Y.)
    Academic literature review
  • Moser, Edvard Ingjald; Roudi, Yasser; Witter, Menno; Kentros, Clifford; Bonhoeffer, Tobias; Moser, May-Britt. (2014) Grid cells and cortical representation. Nature Reviews Neuroscience
    Academic literature review
  • Aikath, D; Weible, AP; Rowland, David Clayton; Kentros, Clifford. (2014) Role of self-generated odor cues in contextual representation. Hippocampus
    Academic article
  • Weible, AP; Moore, AK; Liu, C; DeBlander, L; Wu, H; Kentros, Clifford. (2014) Perceptual gap detection is mediated by gap termination responses in auditory cortex. Current Biology
    Academic article
  • Rowland, David Clayton; Weible, AP; Wickersham, IR; Wu, HY; Mayford, M; Witter, Menno. (2013) Transgenically Targeted Rabies Virus Demonstrates a Major Monosynaptic Projection from Hippocampal Area CA2 to Medial Entorhinal Layer II Neurons. Journal of Neuroscience
    Academic article
  • Muzzio, Isabel; Kentros, Clifford; Kandel, ER. (2009) What is remembered? Role of attention on the encoding and retrieval of hippocampal representations. Journal of Physiology
    Academic article
  • Agnihotri, Naveen; Hawkins, Robert; Kandel, ER; Kentros, Clifford. (2004) The long-term stability of new hippocampal place fields requires new protein synthesis. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
    Academic article

Outreach

2021

  • Poster
    Bjorkli, Christiana; Hemler, Mary Elisabeth; Ebbesen, Nora Cecilie; Nair, Rajeevkumar Raveendran; Witter, Menno; Kentros, Clifford. (2021) Linking molecular biomarkers and behavior in preclinical models and patients with Alzheimer's disease. SfN SfN Global Connectome , Virtual 2021-01-11 - 2021-01-13

2020

  • Poster
    Bjorkli, Christiana; Hemler, MB; Raveendran Nair, Rajeevkumar; Kobro-Flatmoen, Asgeir; Witter, Menno; Kentros, Clifford. (2020) Linking molecular biomarkers and behavior in rodents and patients with Alzheimer’s disease . Federation of European Neuroscience Societies FENS Virtual Forum 2020 2020-07-11 - 2020-07-15

2019

  • Poster
    Bjorkli, Christiana; Sandvig, Ioanna; Sandvig, Axel; Kentros, Clifford; Witter, Menno; Kobro-Flatmoen, Asgeir. (2019) Linking molecular biomarkers and behaviour in animal models and humans with Alzheimer´s disease. 3rd Nordic Neuroscience Meeting , Helsinki 2019-06-12 - 2019-06-14

2018

  • Poster
    Blankvoort, Stefan; Thomas, Laurent; Witter, Menno; Sætrom, Pål; cotney, Justin; Kentros, Clifford. (2018) The marked diversity of unique cortical enhancers enables neuron-specific tools by Enhancer-Driven Gene Expression (EDGE). Federation of European Neuroscience FENS 2018 , Berlin 2018-07-07 - 2018-07-11
  • Poster
    Jacobsen, R. Irene; Donato, Flavio; Raveendran Nair, Rajeevkumar; Kentros, Clifford; Moser, May-Britt; Moser, Edvard Ingjald. (2018) How is a place field generated? Developing a method for the functional identification of inputs to a single hippocampal neuron. Grid cells and cognitive maps meeting , London 2018-05-21 - 2018-05-22
  • Poster
    Nair Raveendran, Rajeevkumar; Blankvoort, Stefan; Kentros, Clifford. (2018) Using enhancer-driven gene expression (EDGE) to generate viral vectors capable of driving transgene expression in particular cell types of targeted brain regions in any species. Society for Neuroscience Society for Neuroscience conference, Neuroscience 2018 San Diego, USA , San Diego, USA 2018-11-03 - 2018-11-07
  • Poster
    Raveendran Nair, Rajeevkumar; Blankvoort, Stefan; Kentros, Clifford. (2018) Viruses made with entorhinal cortex-specific (EC) enhancers enable transgene expression restricted to particular EC celltypes in two species of wildtype animals. FENS FENS Forum 2018, Berlin, Germany. , Berlin, Germany 2018-07-07 - 2018-07-11

2016

  • Poster
    Blankvoort, Stefan; Witter, Menno; Noonan, James; Cotney, Justin; Kentros, Clifford. (2016) Enhanced transgenics: a novel means to generate neuroanatomically-specific genetic tools. Society for Neuroscience SfN 2016 , San Diego 2016-11-12 - 2016-11-16

2014

  • Poster
    Rowland, David Clayton; Skytøen, Emilie R; Kentros, Clifford; Moser, May-Britt; Moser, Edvard Ingjald. (2014) Towards a functional identification of stellate cells in medial entorhinal cortex layer II. Society for Neuroscience , Washington DC 2014-11-15 - 2014-11-19
  • Interview
    Moser, May-Britt; Kentros, Clifford. (2014) Vil løyse Alzheimer-gåta med norsk forsking. NRK NRK [Internet] 2014-10-16
  • Interview
    Kentros, Clifford; Whitlock, Jonathan; Roudi, Yasser. (2014) A village of neuroscientists. [Internet] 2014-12-07

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