Anja Bye
+4793232057
AHL-senteret, 344.03.010.10.2, Øya, Prinsesse Kristinas gate
About
Professor in Medicine. Head of the interdisiplinary research group in Cardiogenomics, which is part of the Cardiac Exercise Research Group (CERG) at the Department of Circulation and Imaging, NTNU.
Expertise: Disease prevention, lifestyle related diseases, exercise as medicine, genetics and biomarkers.
Cardiogenomics, the application of advanced genomics and genetics in cardiology is, a relatively young field, with the aim to improve patient care in cardiovascular diseases (CVDs). The initial rationale behind this field is that monogenetic or polygenetic polymorphisms are the root or contributors to several CVDs. The field of cardiogenomics gained importance when Brown and Goldstein received in 1985 the Nobel Prize for the discovery of the genetic mutations affecting the low-density lipoprotein (LDL) receptor cause hypercholesterolemia and early-onset myocardial infarction, which eventually led to LDL cholesterol–lowering therapies that reduce the risk of cardiovascular events. However, most of the complex CVDs are polygenic disorders arising as a result of DNA variants in multiple genes contributing to the development of the disease. Hence, the identification of critical single nucleotide polymorphisms (SNPs) is of high importance for the elucidation of the molecular mechanisms underlying the pathogenesis of various CVDs. Deciphering the molecular pathogenesis underlying the pathology of a cardiac disease is key to apply precision cardiac care.
Our research group aim to better understand the contribution of the genetic variants to the molecular mechanisms underlying the pathogenesis of CVDs for both, designing more accurate diagnostic tools and more effective treatments. To achieve this aim, we perform large-scale data analysis that involves different omics levels: genomics, transcriptomics, proteomics, and metabolomics. By combining these omics categories of data with cardiac phenotypes and outcomes we can explore and establish the relationship between the genotype and cardiac phenotype, potentially leading to better understanding the role and impact of known genes on susceptibility, timing of onset, and clinical progression of CVDs.
Main ongoing projects:
CorFemina – Prevention of CVD in women
Cardiovascular disease (CVD) is the leading cause of death worldwide, and the prevalence is expected to increase dramatically during the next decades. CVD have sex-specific differences in prevalence, presentation, management, and outcomes. Still, most of the landmark studies of CVD have failed to appropriately consider women. Thus, much of the standard care for CVD is based on findings from studies conducted predominantly on middle-aged men, which may result in less effective diagnosis and treatment in women. Given that a large part of women who die from a myocardial infarction were not on treatment for any risk factors, distinct strategies are urgently needed to tackle inequality in awareness, diagnosis, prevention and treatment of CVD in women.
In CorFemina, we will combine our unique access to large-scaled digitalized health data and comprehensive biobanks with the most recent methods in biotechnology and machine learning to identify biomarkers, risk factors and molecular mechanisms triggering CVD in women. We aim to use this data to develop a CVD risk prediction algorithm for women and to propose female-specific molecular mechanisms representing new drug targets for CVD that can potentially contribute to new treatment strategies for both genders. As personal awareness of CVD risk is the first step towards successful preventive measures, we will also explore the current awareness of CVD in women and the attention to preventive measures in the primary care setting.
CardioFit: Does low aerobic fitness increase the risk of cardiovascular disease?
Low aerobic fitness is one of the most important risk factors for CVD and premature death. In fact, low aerobic fitness is a stronger predictor of morbidity and mortality than traditional risk factors like diabetes, hypertension, BMI and cholesterol. For other established risk factors, numerous genetic association studies have been performed, revealing promising genetic risk markers for CVD. However, there is little information available on genetic determinants of aerobic fitness level, as only small-scale studies have been performed. Thus, identification of genetic determinants of low aerobic fitness holds extraordinary promise for discovering new risk markers capable of improving the currently available risk prediction algorithms for CVD. Within CardioFit, we will take advantage of our unique access to one of the world’s largest and most complete population based cohorts (HUNT) to identify genetic markers associated with the important CVD-risk factor, low aerobic fitness. Next, we will use these genetic markers to determine the causal effects of aerobic fitness level on CVD development using new statistical applications (Mendelian randomization). Finally, we will determine the ability of genetic markers to improve risk prediction algorithms for CVD.
Research
CorFemina: Forebygging av hjertesykdom hos kvinner
CorFemina er et tverrfaglig forskningsprosjekt som fokuserer på hjertesykdom hos kvinner. Prosjektet tar sikte på å identifisere kjønnsspesifikke biologiske og sosiale faktorer som bidrar til sykdomsutvikling hos kvinner.
LipidEx - Effekten av trening på lipødem
LipidEx underesøker effekten av trening på lipødem, en kronisk tilstand preget av unormal fettfordeling, spesielt i beina og armene. Lipødem rammer hovedsakelig kvinner og kan føre til smerte, hevelse og nedsatt livskvalitet.
Publications
2022
-
Taraldsen, Maria Dalen;
Wiseth, Rune;
Videm, Vibeke;
Bye, Anja;
Madssen, Erik.
(2022)
Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise.
Physiological Genomics
Academic article
-
Nodeland, Markus;
Klevjer, Marie;
Sæther, Julie Caroline;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Wisløff, Ulrik.
(2022)
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study.
Atherosclerosis
Academic article
-
Benegiamo, Giorgia;
Bou Sleiman, Maroun;
Wohlwend, Martin;
Rodríguez-López, Sandra;
Goeminne, Ludger J. E.;
Laurila, Pirkka-Pekka.
(2022)
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Nature Metabolism
Academic article
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Hansen, Ailin Falkmo;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2022)
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study.
Medicine & Science in Sports & Exercise
Academic article
2021
-
Rutkovskiy, Arkady;
Lyngbakken, Magnus;
Dahl, Mai Britt;
Bye, Anja;
Pedersen, Marit Holmefjord;
Wisløff, Ulrik.
(2021)
Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 Study.
Clinical Chemistry
Academic article
-
Williams, Camilla J.;
Li, Zhixiu;
Harvey, Nicholas;
Lea, Rodney A.;
Gurd, Brendon J.;
Bonafiglia, Jacob T..
(2021)
Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study.
Journal of Biomedical Science
Academic article
2020
-
Bye, Anja;
Klevjer, Marie;
Ryeng, Einar;
Silva, Gustavo Jose Justo;
Moreira, Jose Bianco Nascimento;
Stensvold, Dorthe.
(2020)
Identification of novel genetic variants associated with cardiorespiratory fitness.
Progress in cardiovascular diseases
Academic literature review
-
Gigante, Bruna;
Papa, Laura;
Bye, Anja;
Kunderfranco, Paolo;
Viviani, Chiara;
Roncarati, Roberta.
(2020)
MicroRNA signatures predict early major coronary events in middle-aged men and women.
Cell Death & Disease
Academic article
-
Halle, Kari Krizak;
Bakke, Øyvind;
Djurovic, Srdjan;
Bye, Anja;
Ryeng, Einar;
Wisløff, Ulrik.
(2020)
Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear models.
Scandinavian Journal of Statistics
Academic article
2019
-
Williams, Camilla J.;
Gurd, Brendon J.;
Bonafiglia, Jacob T.;
Voisin, Sarah;
Li, Zhixiu;
Harvey, Nicholas.
(2019)
A multi-center comparison of vO2peak trainability between interval training and moderate intensity continuous training .
Frontiers in Physiology
Academic article
-
Thomsen, Ruth Stoklund;
Nilsen, Tom Ivar Lund;
Haugeberg, Glenn;
Bye, Anja;
Kavanaugh, Arthur;
Hoff, Mari.
(2019)
Impact of high-intensity interval training on disease activity and disease in patients with psoriatic arthritis: A randomized controlled trial.
Arthritis care & research
Academic article
-
Velle-Forbord, Torbjørn;
Eidlaug, Maria;
Debik, Julia Barbara;
Sæther, Julie Caroline;
Follestad, Turid;
Nauman, Javaid.
(2019)
Circulating microRNAs as predictive biomarkers of myocardial infarction: Evidence from the HUNT study.
Atherosclerosis
Academic article
2018
-
Bjørnland, Thea;
Bye, Anja;
Ryeng, Einar;
Wisløff, Ulrik;
Langaas, Mette.
(2018)
Powerful extreme phenotype sampling designs and score tests for genetic association studies.
Statistics in Medicine
Academic article
-
Thomsen, Ruth Stoklund;
Nilsen, Tom Ivar Lund;
Haugeberg, Glenn;
Bye, Anja;
Kavanaugh, Arthur;
Hoff, Mari.
(2018)
Effect of high-intensity interval training on cardiovascular disease risk factors and body composition in psoriatic arthritis: A randomised controlled trial.
RMD Open
Academic article
2017
-
Silva, Gustavo Jose Justo;
Bye, Anja;
el Azzouzi, Hamid;
Wisløff, Ulrik.
(2017)
MicroRNAs as Important Regulators of Exercise Adaptation.
Progress in cardiovascular diseases
Academic literature review
2016
-
Bye, Anja.
(2016)
Trening og hjerteflimmer.
Hjerte og hjerne
Feature article
-
Bye, Anja.
(2016)
Trening og hvilepuls.
Hjerte og hjerne
Feature article
-
Bye, Anja.
(2016)
Inaktivitet og risiko for hjertesykdom.
Hjerte og hjerne
Feature article
-
Bye, Anja.
(2016)
Trening i arbeidstiden.
Hjerte og hjerne
Feature article
-
Bye, Anja;
Røsjø, Helge;
Nauman, Javaid;
Silva, Gustavo Jose Justo;
Follestad, Turid;
Omland, Torbjørn.
(2016)
Circulating microRNAs predict future fatal myocardial infarction in healthy individuals - The HUNT study.
Journal of Molecular and Cellular Cardiology
Academic article
2015
-
Moreira, Jose Bianco Nascimento;
Wohlwend, Martin;
Alves, Marcia Netto Magalhaes;
Wisløff, Ulrik;
Bye, Anja.
(2015)
A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
Journal of Translational Medicine
Academic article
-
Sandstad, Janne;
Stensvold, Dorthe;
Hoff, Mari;
Nes, Bjarne;
Arbo, Ingerid Brænne;
Bye, Anja.
(2015)
The effects of high intensity interval training in women with rheumatic disease: a pilot study.
European Journal of Applied Physiology
Academic article
2014
-
Slagsvold, Katrine Hordnes;
Moreira, Jose Bianco Nascimento;
Rognmo, Øivind;
Høydal, Morten;
Bye, Anja;
Wisløff, Ulrik.
(2014)
Remote ischemic preconditioning preserves mitochondrial function and activates pro-survival protein kinase Akt in the left ventricle during cardiac surgery: A randomized trial.
International Journal of Cardiology
Academic article
-
Bye, Anja.
(2014)
Skreddersydd trening til ditt DNA.
Website (informational material)
-
Bye, Anja.
(2014)
Vin har god effekt på hjertet – men bare om du trener.
Website (informational material)
-
Bye, Anja.
(2014)
Vin og mosjon.
Brochure
-
Bye, Anja.
(2014)
Kjøttfri mandag for folkehelsa.
Brochure
-
Røsjø, Helge;
Dahl, Mai Britt;
Bye, Anja;
Andreassen, Johanna;
Jørgensen, Marit;
Wisløff, Ulrik.
(2014)
Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis.
PLOS ONE
Academic article
-
Bye, Anja.
(2014)
GENER OG TRENING
.
VG : Verdens gang
Interview Journal
2013
-
Bye, Anja.
(2013)
Kan microRNA forutsi sykdom?.
Website (informational material)
-
Bye, Anja.
(2013)
Kosttilskudd med omega 3 - ikke så sunt som vi tror?.
Website (informational material)
-
Bye, Anja;
Røsjø, Helge;
Aspenes, Stian Thoresen;
Condorelli, Gianluigi;
Omland, Torbjørn;
Wisløff, Ulrik.
(2013)
Circulating MicroRNAs and Aerobic Fitness - The HUNT-Study.
PLOS ONE
Academic article
-
Moreira, JBN;
Alves, Marcia;
Britton, Steven L.;
Koch, Leif Grenager;
Wisloff, U;
Bye, Anja.
(2013)
Pi3k modulates cardiomyocyte phenotype in rats selected for low aerobic capacity.
European Heart Journal
Abstract
2012
-
Bye, Anja;
Vettukattil, Riyas M;
Aspenes, Stian Thoresen;
Giskeødegård, Guro F.;
Gribbestad, Ingrid S;
Wisløff, Ulrik.
(2012)
Serum Levels of Choline-Containing Compounds Are Associated with Aerobic Fitness Level: The HUNT-Study.
PLOS ONE
Academic article
-
Bye, Anja;
Vettukattil, Riyas M;
Aspenes, Stian Thoresen;
Giskeødegård, Guro F.;
Gribbestad, Ingrid S;
Wisløff, Ulrik.
(2012)
Choline and phosphatidylcholine are associated with aerobic capacity: the HUNT-Study.
Cardiovascular Research (CVR)
Abstract
2011
-
Tjønna, Arnt Erik;
Rognmo, Øivind;
Bye, Anja;
Stølen, Tomas;
Wisløff, Ulrik.
(2011)
Time course of endothelial adaptation after acute and chronic exercise in patients with metabolic syndrome.
Journal of Strength and Conditioning Research
Academic article
2009
-
Tjønna, Arnt Erik;
Rognmo, Øivind;
Stølen, Tomas;
Bye, Anja;
Haram, Per Magnus;
Loennechen, Jan Pål.
(2009)
Response to Letter Regarding Article, "Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: A Pilot Study".
Circulation
Reader opinion piece
-
Bye, Anja;
Tjønna, Arnt Erik;
Stølen, Tomas;
Røsbjørgen, Ragnhild;
Wisløff, Ulrik.
(2009)
Transcriptional changes in blood after aerobic interval training in patients with the metabolic syndrome.
European Journal of Cardiovascular Prevention & Rehabilitation
Academic article
-
Tjønna, Arnt Erik;
Stølen, Tomas;
Bye, Anja;
Volden, Marte;
Slørdahl, Stig Arild;
Ødegård, Rønnaug A.
(2009)
Aerobic interval training reduces cardiovascular risk factors more than a multi treatment approach in overweight adolescents.
Clinical Science
Academic article
-
Moholdt, Trine;
Amundsen, Brage H.;
Rustad, Lene Anette;
Wahba, Alexander;
Løvø, Kjersti T;
Gullikstad, Lisbeth.
(2009)
Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: A randomized study of cardiovascular effects and quality of life.
American Heart Journal
Academic article
2008
-
Schjerve, Inga Ekeberg;
Tyldum, Gjertrud Aunet;
Tjønna, Arnt Erik;
Stølen, Tomas;
Loennechen, Jan Pål;
Mølmen Hansen, Harald Edvard.
(2008)
Both aerobic endurance and strength training programs improve cardiovascular health in obese adults.
Clinical Science
Academic article
-
Tjønna, Arnt Erik;
Lee, Sang Jun;
Rognmo, Øivind;
Stølen, Tomas;
Bye, Anja;
Haram, Per Magnus.
(2008)
Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome A Pilot Study.
Circulation
Academic article
-
Bye, Anja;
Høydal, Morten;
Catalucci, D;
Langaas, Mette;
Kemi, OJ;
Beisvåg, Vidar.
(2008)
Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max.
Physiological Genomics
Academic article
-
Rognmo, Øivind;
Bjørnstad, Tor-Halvor;
Kahrs, Christian;
Tjønna, Arnt Erik;
Bye, Anja;
Haram, Per Magnus.
(2008)
ENDOTHELIAL FUNCTION IN HIGHLY ENDURANCE-TRAINED MEN: EFFECTS OF ACUTE EXERCISE.
Journal of Strength and Conditioning Research
Academic article
-
Medby, Christian;
Bye, Anja;
Wisløff, Ulrik;
Brubakk, Alf O.
(2008)
Heat shock increases survival in rats exposed to hyperbaric pressure.
Diving and Hyperbaric Medicine
Academic article
-
Bye, Anja;
Sørhaug, Sveinung;
Ceci, Marcello;
Høydal, Morten;
Stølen, Tomas;
Heinrich, Garrett.
(2008)
Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy.
Inhalation Toxicology
Academic article
-
Bye, Anja;
Langaas, Mette;
Høydal, Morten;
Kemi, Ole Johan;
Heinrich, Garrett;
Koch, Lauren G.
(2008)
Aerobic capacity-dependent differences in cardiac gene expression.
Physiological Genomics
Academic article
2007
-
Tjønna, Arnt Erik;
Bye, Anja;
Haram, Per Magnus;
Loennechen, Jan Pål;
Rognmo, Øivind;
Slørdahl, Stig Arild.
(2007)
Superior cardiovascular effect of interval training versus moderate exercise in patients with the metabolic syndrome.
Medicine & Science in Sports & Exercise
Abstract
-
Bye, Anja;
Høydal, Morten;
Kemi, Ole Johan;
Langaas, Mette;
Britton, Steven;
Koch, Lauren G.
(2007)
Aerobe capacity-dependant changes in cardiac gene expression.
Medicine & Science in Sports & Exercise
Abstract
-
Stølen, Thomas;
Kemi, Ole J.;
Høydal, Morten A.;
Bye, Anja;
Tjonna, Arnt E.;
Hafstad, Anne Dragøy.
(2007)
Reversed Ryr-leakage And Improved Contractile Function In Cardiomyocytes From Type-2 Diabetic Heart After Exercise Training.
Medicine & Science in Sports & Exercise
Abstract
-
Bye, Anja;
Langaas, Mette;
Høydal, Morten;
Kemi, Ole Johan;
Heinrich, Garrett;
Koch, Lauren G.
(2007)
Aerobic capacity-dependent differences in cardiac gene expression.
European Journal of Cardiovascular Prevention & Rehabilitation
Abstract
-
Wisløff, Ulrik;
Støylen, Asbjørn;
Loennechen, Jan Pål;
Bruvold, Morten;
Rognmo, Øivind;
Haram, Per Magnus.
(2007)
Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study.
Circulation
Academic article
2006
-
Bye, Anja;
Sørhaug, Sveinung;
Stølen, Tomas;
Tjønna, Arnt Erik;
Høydal, Morten Andre;
Ellingsen, Øyvind.
(2006)
The effects of long-term carbon monoxide exposure on the cardiovascular system in rats.
Atherosclerosis Supplements
Abstract
-
Tjønna, Arnt Erik;
Rognmo, Øivind;
Stølen, Tomas;
Bye, Anja;
Loennechen, Jan Pål;
Slørdahl, Stig Arild.
(2006)
Endothelial function in individuals with Metabolic Syndrome: effects of acute and chronic aerobic exercise.
European Journal of Cardiovascular Prevention & Rehabilitation
Abstract
-
Bye, Anja;
Sørhaug, Sveinung;
Stølen, Tomas;
Tjønna, Arnt Erik;
Høydal, Morten Andre;
Ellingsen, Øyvind.
(2006)
The effect of long-term carbon monoxide exposure on cardiovascular function in rats.
European Journal of Cardiovascular Prevention & Rehabilitation
Abstract
-
Rognmo, Øyvind;
Kahrs, Christian;
Bjørnstad, Tor-Halvor;
Tjønna, Arnt Erik;
Bye, Anja;
Stølen, Tomas.
(2006)
Endothalial function in highly endurance-trained and sedentary young men: effects of acute aerobic exercise.
European Journal of Cardiovascular Prevention & Rehabilitation
Abstract
Journal publications
-
Taraldsen, Maria Dalen;
Wiseth, Rune;
Videm, Vibeke;
Bye, Anja;
Madssen, Erik.
(2022)
Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise.
Physiological Genomics
Academic article
-
Nodeland, Markus;
Klevjer, Marie;
Sæther, Julie Caroline;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Wisløff, Ulrik.
(2022)
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study.
Atherosclerosis
Academic article
-
Benegiamo, Giorgia;
Bou Sleiman, Maroun;
Wohlwend, Martin;
Rodríguez-López, Sandra;
Goeminne, Ludger J. E.;
Laurila, Pirkka-Pekka.
(2022)
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Nature Metabolism
Academic article
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Hansen, Ailin Falkmo;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2022)
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study.
Medicine & Science in Sports & Exercise
Academic article
-
Rutkovskiy, Arkady;
Lyngbakken, Magnus;
Dahl, Mai Britt;
Bye, Anja;
Pedersen, Marit Holmefjord;
Wisløff, Ulrik.
(2021)
Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 Study.
Clinical Chemistry
Academic article
-
Williams, Camilla J.;
Li, Zhixiu;
Harvey, Nicholas;
Lea, Rodney A.;
Gurd, Brendon J.;
Bonafiglia, Jacob T..
(2021)
Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study.
Journal of Biomedical Science
Academic article
-
Bye, Anja;
Klevjer, Marie;
Ryeng, Einar;
Silva, Gustavo Jose Justo;
Moreira, Jose Bianco Nascimento;
Stensvold, Dorthe.
(2020)
Identification of novel genetic variants associated with cardiorespiratory fitness.
Progress in cardiovascular diseases
Academic literature review
-
Gigante, Bruna;
Papa, Laura;
Bye, Anja;
Kunderfranco, Paolo;
Viviani, Chiara;
Roncarati, Roberta.
(2020)
MicroRNA signatures predict early major coronary events in middle-aged men and women.
Cell Death & Disease
Academic article
-
Halle, Kari Krizak;
Bakke, Øyvind;
Djurovic, Srdjan;
Bye, Anja;
Ryeng, Einar;
Wisløff, Ulrik.
(2020)
Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear models.
Scandinavian Journal of Statistics
Academic article
-
Williams, Camilla J.;
Gurd, Brendon J.;
Bonafiglia, Jacob T.;
Voisin, Sarah;
Li, Zhixiu;
Harvey, Nicholas.
(2019)
A multi-center comparison of vO2peak trainability between interval training and moderate intensity continuous training .
Frontiers in Physiology
Academic article
-
Thomsen, Ruth Stoklund;
Nilsen, Tom Ivar Lund;
Haugeberg, Glenn;
Bye, Anja;
Kavanaugh, Arthur;
Hoff, Mari.
(2019)
Impact of high-intensity interval training on disease activity and disease in patients with psoriatic arthritis: A randomized controlled trial.
Arthritis care & research
Academic article
-
Velle-Forbord, Torbjørn;
Eidlaug, Maria;
Debik, Julia Barbara;
Sæther, Julie Caroline;
Follestad, Turid;
Nauman, Javaid.
(2019)
Circulating microRNAs as predictive biomarkers of myocardial infarction: Evidence from the HUNT study.
Atherosclerosis
Academic article
-
Bjørnland, Thea;
Bye, Anja;
Ryeng, Einar;
Wisløff, Ulrik;
Langaas, Mette.
(2018)
Powerful extreme phenotype sampling designs and score tests for genetic association studies.
Statistics in Medicine
Academic article
-
Thomsen, Ruth Stoklund;
Nilsen, Tom Ivar Lund;
Haugeberg, Glenn;
Bye, Anja;
Kavanaugh, Arthur;
Hoff, Mari.
(2018)
Effect of high-intensity interval training on cardiovascular disease risk factors and body composition in psoriatic arthritis: A randomised controlled trial.
RMD Open
Academic article
-
Silva, Gustavo Jose Justo;
Bye, Anja;
el Azzouzi, Hamid;
Wisløff, Ulrik.
(2017)
MicroRNAs as Important Regulators of Exercise Adaptation.
Progress in cardiovascular diseases
Academic literature review
-
Bye, Anja.
(2016)
Trening og hjerteflimmer.
Hjerte og hjerne
Feature article
-
Bye, Anja.
(2016)
Trening og hvilepuls.
Hjerte og hjerne
Feature article
-
Bye, Anja.
(2016)
Inaktivitet og risiko for hjertesykdom.
Hjerte og hjerne
Feature article
-
Bye, Anja.
(2016)
Trening i arbeidstiden.
Hjerte og hjerne
Feature article
-
Bye, Anja;
Røsjø, Helge;
Nauman, Javaid;
Silva, Gustavo Jose Justo;
Follestad, Turid;
Omland, Torbjørn.
(2016)
Circulating microRNAs predict future fatal myocardial infarction in healthy individuals - The HUNT study.
Journal of Molecular and Cellular Cardiology
Academic article
-
Moreira, Jose Bianco Nascimento;
Wohlwend, Martin;
Alves, Marcia Netto Magalhaes;
Wisløff, Ulrik;
Bye, Anja.
(2015)
A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
Journal of Translational Medicine
Academic article
-
Sandstad, Janne;
Stensvold, Dorthe;
Hoff, Mari;
Nes, Bjarne;
Arbo, Ingerid Brænne;
Bye, Anja.
(2015)
The effects of high intensity interval training in women with rheumatic disease: a pilot study.
European Journal of Applied Physiology
Academic article
-
Slagsvold, Katrine Hordnes;
Moreira, Jose Bianco Nascimento;
Rognmo, Øivind;
Høydal, Morten;
Bye, Anja;
Wisløff, Ulrik.
(2014)
Remote ischemic preconditioning preserves mitochondrial function and activates pro-survival protein kinase Akt in the left ventricle during cardiac surgery: A randomized trial.
International Journal of Cardiology
Academic article
-
Røsjø, Helge;
Dahl, Mai Britt;
Bye, Anja;
Andreassen, Johanna;
Jørgensen, Marit;
Wisløff, Ulrik.
(2014)
Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis.
PLOS ONE
Academic article
-
Bye, Anja.
(2014)
GENER OG TRENING
.
VG : Verdens gang
Interview Journal
-
Bye, Anja;
Røsjø, Helge;
Aspenes, Stian Thoresen;
Condorelli, Gianluigi;
Omland, Torbjørn;
Wisløff, Ulrik.
(2013)
Circulating MicroRNAs and Aerobic Fitness - The HUNT-Study.
PLOS ONE
Academic article
-
Moreira, JBN;
Alves, Marcia;
Britton, Steven L.;
Koch, Leif Grenager;
Wisloff, U;
Bye, Anja.
(2013)
Pi3k modulates cardiomyocyte phenotype in rats selected for low aerobic capacity.
European Heart Journal
Abstract
-
Bye, Anja;
Vettukattil, Riyas M;
Aspenes, Stian Thoresen;
Giskeødegård, Guro F.;
Gribbestad, Ingrid S;
Wisløff, Ulrik.
(2012)
Serum Levels of Choline-Containing Compounds Are Associated with Aerobic Fitness Level: The HUNT-Study.
PLOS ONE
Academic article
-
Bye, Anja;
Vettukattil, Riyas M;
Aspenes, Stian Thoresen;
Giskeødegård, Guro F.;
Gribbestad, Ingrid S;
Wisløff, Ulrik.
(2012)
Choline and phosphatidylcholine are associated with aerobic capacity: the HUNT-Study.
Cardiovascular Research (CVR)
Abstract
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Tjønna, Arnt Erik;
Rognmo, Øivind;
Bye, Anja;
Stølen, Tomas;
Wisløff, Ulrik.
(2011)
Time course of endothelial adaptation after acute and chronic exercise in patients with metabolic syndrome.
Journal of Strength and Conditioning Research
Academic article
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Tjønna, Arnt Erik;
Rognmo, Øivind;
Stølen, Tomas;
Bye, Anja;
Haram, Per Magnus;
Loennechen, Jan Pål.
(2009)
Response to Letter Regarding Article, "Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: A Pilot Study".
Circulation
Reader opinion piece
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Bye, Anja;
Tjønna, Arnt Erik;
Stølen, Tomas;
Røsbjørgen, Ragnhild;
Wisløff, Ulrik.
(2009)
Transcriptional changes in blood after aerobic interval training in patients with the metabolic syndrome.
European Journal of Cardiovascular Prevention & Rehabilitation
Academic article
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Tjønna, Arnt Erik;
Stølen, Tomas;
Bye, Anja;
Volden, Marte;
Slørdahl, Stig Arild;
Ødegård, Rønnaug A.
(2009)
Aerobic interval training reduces cardiovascular risk factors more than a multi treatment approach in overweight adolescents.
Clinical Science
Academic article
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Moholdt, Trine;
Amundsen, Brage H.;
Rustad, Lene Anette;
Wahba, Alexander;
Løvø, Kjersti T;
Gullikstad, Lisbeth.
(2009)
Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: A randomized study of cardiovascular effects and quality of life.
American Heart Journal
Academic article
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Schjerve, Inga Ekeberg;
Tyldum, Gjertrud Aunet;
Tjønna, Arnt Erik;
Stølen, Tomas;
Loennechen, Jan Pål;
Mølmen Hansen, Harald Edvard.
(2008)
Both aerobic endurance and strength training programs improve cardiovascular health in obese adults.
Clinical Science
Academic article
-
Tjønna, Arnt Erik;
Lee, Sang Jun;
Rognmo, Øivind;
Stølen, Tomas;
Bye, Anja;
Haram, Per Magnus.
(2008)
Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome A Pilot Study.
Circulation
Academic article
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Bye, Anja;
Høydal, Morten;
Catalucci, D;
Langaas, Mette;
Kemi, OJ;
Beisvåg, Vidar.
(2008)
Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max.
Physiological Genomics
Academic article
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Rognmo, Øivind;
Bjørnstad, Tor-Halvor;
Kahrs, Christian;
Tjønna, Arnt Erik;
Bye, Anja;
Haram, Per Magnus.
(2008)
ENDOTHELIAL FUNCTION IN HIGHLY ENDURANCE-TRAINED MEN: EFFECTS OF ACUTE EXERCISE.
Journal of Strength and Conditioning Research
Academic article
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Medby, Christian;
Bye, Anja;
Wisløff, Ulrik;
Brubakk, Alf O.
(2008)
Heat shock increases survival in rats exposed to hyperbaric pressure.
Diving and Hyperbaric Medicine
Academic article
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Bye, Anja;
Sørhaug, Sveinung;
Ceci, Marcello;
Høydal, Morten;
Stølen, Tomas;
Heinrich, Garrett.
(2008)
Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy.
Inhalation Toxicology
Academic article
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Bye, Anja;
Langaas, Mette;
Høydal, Morten;
Kemi, Ole Johan;
Heinrich, Garrett;
Koch, Lauren G.
(2008)
Aerobic capacity-dependent differences in cardiac gene expression.
Physiological Genomics
Academic article
-
Tjønna, Arnt Erik;
Bye, Anja;
Haram, Per Magnus;
Loennechen, Jan Pål;
Rognmo, Øivind;
Slørdahl, Stig Arild.
(2007)
Superior cardiovascular effect of interval training versus moderate exercise in patients with the metabolic syndrome.
Medicine & Science in Sports & Exercise
Abstract
-
Bye, Anja;
Høydal, Morten;
Kemi, Ole Johan;
Langaas, Mette;
Britton, Steven;
Koch, Lauren G.
(2007)
Aerobe capacity-dependant changes in cardiac gene expression.
Medicine & Science in Sports & Exercise
Abstract
-
Stølen, Thomas;
Kemi, Ole J.;
Høydal, Morten A.;
Bye, Anja;
Tjonna, Arnt E.;
Hafstad, Anne Dragøy.
(2007)
Reversed Ryr-leakage And Improved Contractile Function In Cardiomyocytes From Type-2 Diabetic Heart After Exercise Training.
Medicine & Science in Sports & Exercise
Abstract
-
Bye, Anja;
Langaas, Mette;
Høydal, Morten;
Kemi, Ole Johan;
Heinrich, Garrett;
Koch, Lauren G.
(2007)
Aerobic capacity-dependent differences in cardiac gene expression.
European Journal of Cardiovascular Prevention & Rehabilitation
Abstract
-
Wisløff, Ulrik;
Støylen, Asbjørn;
Loennechen, Jan Pål;
Bruvold, Morten;
Rognmo, Øivind;
Haram, Per Magnus.
(2007)
Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients - A randomized study.
Circulation
Academic article
-
Bye, Anja;
Sørhaug, Sveinung;
Stølen, Tomas;
Tjønna, Arnt Erik;
Høydal, Morten Andre;
Ellingsen, Øyvind.
(2006)
The effects of long-term carbon monoxide exposure on the cardiovascular system in rats.
Atherosclerosis Supplements
Abstract
-
Tjønna, Arnt Erik;
Rognmo, Øivind;
Stølen, Tomas;
Bye, Anja;
Loennechen, Jan Pål;
Slørdahl, Stig Arild.
(2006)
Endothelial function in individuals with Metabolic Syndrome: effects of acute and chronic aerobic exercise.
European Journal of Cardiovascular Prevention & Rehabilitation
Abstract
-
Bye, Anja;
Sørhaug, Sveinung;
Stølen, Tomas;
Tjønna, Arnt Erik;
Høydal, Morten Andre;
Ellingsen, Øyvind.
(2006)
The effect of long-term carbon monoxide exposure on cardiovascular function in rats.
European Journal of Cardiovascular Prevention & Rehabilitation
Abstract
-
Rognmo, Øyvind;
Kahrs, Christian;
Bjørnstad, Tor-Halvor;
Tjønna, Arnt Erik;
Bye, Anja;
Stølen, Tomas.
(2006)
Endothalial function in highly endurance-trained and sedentary young men: effects of acute aerobic exercise.
European Journal of Cardiovascular Prevention & Rehabilitation
Abstract
INFORMASJONSMATR
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Bye, Anja.
(2014)
Skreddersydd trening til ditt DNA.
Website (informational material)
-
Bye, Anja.
(2014)
Vin har god effekt på hjertet – men bare om du trener.
Website (informational material)
-
Bye, Anja.
(2014)
Vin og mosjon.
Brochure
-
Bye, Anja.
(2014)
Kjøttfri mandag for folkehelsa.
Brochure
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Bye, Anja.
(2013)
Kan microRNA forutsi sykdom?.
Website (informational material)
-
Bye, Anja.
(2013)
Kosttilskudd med omega 3 - ikke så sunt som vi tror?.
Website (informational material)
Teaching
Courses
- KLMED8009 - Clinical Research
- MDV6025 - Exercise Training and Cardiovascular Health
- KLMED8012 - Good Clinical Practice (GCP) 1
- KLMED8013 - Good Clinical Practice (GCP) 2
- KLH3901 - Master's Thesis in Clinical Health Science
- KLMED8020 - Clinical trials and good clinical practice (GCP)
- KLH3206 - Clinical intervention studies - Research methodology
Knowledge Transfer
2020
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Academic lectureKlevjer, Marie; Brumpton, Ben Michael; Madssen, Erik; Bye, Anja. (2020) Identifying new genetic markers for maximal oxygen uptake. EPINOR EPINOR Online Conference 2020-11-09 - 2020-11-09
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PosterKlevjer, Marie; Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna. (2020) LDL-5 are elevated in patients with coronary atherosclerosis, despite no increase in total levels of LDL-cholesterol. European Society of Cardiology ESC Congress 2020 - The digital experience 2020-08-29 - 2020-09-01
2019
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PosterSæther, Julie Caroline; Madssen, Erik; Vesterbekkmo, Elisabeth Kleivhaug; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna. (2019) Circulating lipoprotein subfractions as new non-invasive biomarkers of coronary atherosclerosis. 17th Annual CHFR Symposium on Heart Research , Holmenkollen Park Hotell 2019-08-18 - 2019-08-20
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Interview
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Academic lectureBye, Anja; Klevjer, Marie; Ryeng, Einar; da Silva, Gustavo Justo; Moreira, Jose Bianco Nascimento; Stensvold, Dorthe. (2019) Identification of genetic variants associated with the cardiovascular disease risk factor, low aerobic fitness - The HUNT study. European Society of Cardiology European Society of Cardiology Congress 2019 , Paris 2019-08-30 - 2019-09-05
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PosterMadssen, Erik; Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Giskeødegård, Guro F.; Gjære, Sigrid; Myhra, Marthe. (2019) Circulating lipoprotein subfractions as new non-invasive biomarkers of coronary atherosclerosis. European Society of Cardiology European Society of Cardiology Congress 2019 , Paris 2019-08-30 - 2019-09-05
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InterviewBye, Anja. (2019) Kari (39) ville få maks ut av treningen. En gentest ble løsningen. Aftenposten Aftenposten [Newspaper] 2019-07-07
2018
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InterviewBye, Anja. (2018) En av ti får ikke bedre kondis med trening. http://www.ingridkristiansen.com/2018/02/20/en-av-ti-far-ikk http://www.ingridkristiansen.com/2018/02/20/en-av-ti-far-ikk [Internet] 2018-02-20
2016
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InterviewWisløff, Ulrik; Bye, Anja. (2016) Hos hele 18 prosent av befolkningen i Norge fungerer ikke dette genet som det skal. dn.no dn.no [Internet] 2016-04-12
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Interview
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InterviewBye, Anja. (2016) Hos hele 18 prosent av befolkningen i Norge fungerer ikke dette genet som det skal. Dagens Næringsliv Dagens Næringsliv [Newspaper] 2016-04-12
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Interview
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InterviewBye, Anja. (2016) New method to reveal heart attack risk. India Online India Online [Internet] 2016-06-29
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InterviewBye, Anja. (2016) Circulating MicroRNAs Predict Future Fatal Myocardial Infarction. Lab Medical Lab Medical [Internet] 2016-07-13
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InterviewBye, Anja. (2016) Gener fra mor kan være avgjørende for utholdenheten din. Dagbladet Dagbladet [Newspaper] 2016-08-14
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Interview
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InterviewBye, Anja. (2016) Bio-marker to indicate risk of heart disease identified. Yahoo! India Yahoo! India [Internet] 2016-06-30
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InterviewBye, Anja. (2016) Your blood can reveal your risk for heart disease. Healthe Medicine Network Healthe Medicine Network [Internet] 2016-06-29
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InterviewBye, Anja. (2016) Markører i blod kan avsløre risiko for hjerteinfarkt. dagensmedisin.no dagensmedisin.no [Internet] 2016-06-28
2015
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InterviewBye, Anja. (2015) Arthisis: Exercise Helps Eas The Pain. Science world report Science world report [Internet] 2015-07-29
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InterviewBye, Anja; Wisløff, Ulrik; Stølen, Tomas. (2015) Hvorfor blir noen sprekere enn andre av samme trening?. Norsk Idrettsmedisin Norsk Idrettsmedisin [Business/trade/industry journal] 2015-06-17
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InterviewBye, Anja. (2015) Så tränar du för att lindra din ledvärk. Aftonbladet Aftonbladet [Newspaper] 2015-07-30
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InterviewBye, Anja. (2015) High-intensity training 'can offer pain relief for arthritis'. Arthrisis Research UK Arthrisis Research UK [Internet] 2015-07-30
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InterviewBye, Anja. (2015) Högintensiv träning bra mot ledvärken. Helsingborgs Dagblad Helsingborgs Dagblad [Newspaper] 2015-08-19
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Interview
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Interview
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InterviewBye, Anja. (2015) Hardtrening reduserer hjerterisiko ved revmatisk sykdom. Unikard Unikard [Internet] 2015-09-17
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InterviewBye, Anja. (2015) Exercise can improve your arthrisis. myinforms.com myinforms.com [Internet] 2015-09-22
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Interview
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InterviewStensvold, Dorthe; Bye, Anja. (2015) Syklet seg til mindre leddgikt. Gemini Gemini [Business/trade/industry journal] 2015-06-25
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InterviewStensvold, Dorthe; Bye, Anja. (2015) Høyintensitets intervalltrening (HIIT) og leddgikt. Norsk idresttsmedisin Norsk idresttsmedisin [Business/trade/industry journal] 2015-10-20
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InterviewBye, Anja. (2015) Dårlig respons på utholdenhetstrening kan skyldes genfeil. Dagens Næringsliv Dagens Næringsliv [Newspaper] 2015-05-08
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InterviewBye, Anja; Wisløff, Ulrik; Stølen, Tomas. (2015) Dårlig respons på utholdenhetstrening kan skyldes genfeil. Dagens næringsliv Dagens næringsliv [Internet] 2015-05-08
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PosterBye, Anja. (2015) Circulating microRNAs can predict future fatal myocardial infarction in healthy asymptomatic individuals . European Society of Cardiology Euro Prevent , Lisboa 2015-05-13 - 2015-05-16
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PosterBye, Anja. (2015) Genetic determinants of aerobic fitness. CERG, NTNU Exercise in Medicine , Trondheim 2015-12-17 - 2015-12-18
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InterviewBye, Anja. (2015) Trening er bra for hjernen. Hjerte og Hjerne Hjerte og Hjerne [Journal] 2015-07-20
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InterviewBye, Anja. (2015) Test kondisen din på en enkel måte. Hjerte og Hjerne Hjerte og Hjerne [Journal] 2015-03-16
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Interview
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InterviewBye, Anja. (2015) Rigorous exercise may cut arthritis risk. New Kerala New Kerala [Internet] 2015-07-30
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InterviewBye, Anja. (2015) High Intensity Exercise Eases Arthisis Pain. Medical express.com Medical express.com [Internet] 2015-07-29
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InterviewBye, Anja. (2015) Hard trening ga god effekt på leddgikt. Fysioterapauten Fysioterapauten [Business/trade/industry journal] 2015-08-21
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InterviewBye, Anja. (2015) Högintensiv träning bra mot ledvärken. Sydsvenskan Sydsvenskan [Internet] 2015-08-19
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InterviewBye, Anja; Stensvold, Dorthe. (2015) Høyintensitets intervalltrening (HIIT) og leddgikt. Norsk Idrettsmedisin Norsk Idrettsmedisin [Internet] 2015-10-20
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Interview
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Interview
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Interview
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InterviewBye, Anja; Stensvold, Dorthe; Hoff, Mari. (2015) Hardtrening er bra for leddgikt. Adresseavisen Adresseavisen [Newspaper] 2015-06-26
2014
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Academic lectureSlagsvold, Katrine Hordnes; Moreira, JBN; Høydal, Morten; Rognmo, Øivind; Wisløff, Ulrik; Bye, Anja. (2014) Fjern iskemisk prekondisjonering aktiverer protein kinase B i venstre ventrikkel hos pasienter som gjennomgår koronarkirurgi. NKF Kirurgisk Høstmøtet , Oslo 2014-10-24 -
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Programme participation
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InterviewBye, Anja. (2014) Genforsker advarer mot å kjøpe gentest. Bergens Tidende Bergens Tidende [Newspaper] 2014-06-02
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Interview
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LectureBye, Anja. (2014) Skreddersydd trening og kostholdsprogram til ditt DNA. Norges Idrettshøgskole Norges Idrettshøgskoles Fitness Convention , Sognsvann, Oslo 2014-11-14 - 2014-11-16
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LectureWohlwend, Martin; Andenæs, Kine; Shahab, Ali; Moreira, Jose Bianco Nascimento; Hassel, Erlend; Bye, Anja. (2014) Exercise modality specific adaptations in skeletal muscle of elderly people. Joint IUMBM/MiP Symposium on Mitochondrial Physiology 2014-09-08 - 2014-09-12
2013
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InterviewBye, Anja. (2013) Vi er ikke fanget av genene våre. Bergens Tidende Bergens Tidende [Internet] 2013-01-10
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Interview
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InterviewBye, Anja. (2013) Can microRNAs tell you how fit you are?. http://www.exiqon.com/ls/Pages/Anja-Bye.aspx http://www.exiqon.com/ls/Pages/Anja-Bye.aspx [Internet] 2013-10-01
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InterviewBye, Anja. (2013) Gener og trening. NRK P1 - Norgesglasset NRK P1 - Norgesglasset [Radio] 2013-01-04
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Academic lectureBye, Anja. (2013) Trening og genetikk. Norges Idrettshøgskole Norges Idrettshøgskoles Fitness Convention , Sognsvann, Oslo 2013-11-15 - 2013-11-17
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Interview
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InterviewBye, Anja. (2013) Effekten av omega-3 er sterkt overdrevet. Dagens Næringsliv Dagens Næringsliv [Internet] 2013-03-01
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InterviewBye, Anja. (2013) Ekstreme genkombinasjoner hos Birkentoppene. Dagens Næringsliv Dagens Næringsliv [Newspaper] 2013-03-14
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InterviewWisløff, Ulrik; Bye, Anja. (2013) Sjekk hvor like de er i og utenfor sporet. Dagens Næringsliv Dagens Næringsliv [Internet] 2013-03-14
2012
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PosterBye, Anja; Vettukattil, Riyas M; Aspenes, Stian Thoresen; Giskeødegård, Guro F.; Gribbestad, Ingrid S; Wisløff, Ulrik. (2012) Choline and phosphatidylcholine are associated with aerobic capacity: the HUNT-Study. Frontiers in CardioVascular Biology (FCVB) 2012-03-29 - 2012-04-01
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InterviewBye, Anja; Andenæs, Kine. (2012) «Genene vil gi svar på hva du bør trene og spise». Bergens tidene Bergens tidene [Newspaper] 2012-12-21
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InterviewBye, Anja; Andenæs, Kine. (2012) Genene vil gi svar på hva du bør trene og spise. Aftenposten Aftenposten [Newspaper] 2012-12-21
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Academic lectureBye, Anja. (2012) “Omics” analysis of participants in the Fitness Project in HUNT3. Norsk Bioinformatikk Forum Norwegian Bioinformatics Forum , NTNU, Trondheim 2012-10-18 - 2012-10-19
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InterviewBye, Anja; Tjønna, Arnt Erik. (2012) Jakten på kondisgenet. NRK, Schrødingers Katt NRK, Schrødingers Katt [TV] 2012-04-19
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InterviewBye, Anja; Andenæs, Kine. (2012) «Begge trente hardt i 60 dager. Bare én fikk framgang. Hvorfor?». Adresseavisen Adresseavisen [Newspaper] 2012-12-21
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Interview